Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4+ Th Cells
B cell lymphoma-6 (Bcl-6) is a transcriptional repressor that is required for the differentiation of T follicular helper (TFH) cell populations. Currently, the molecular mechanisms underlying the transcriptional regulation of Bcl-6 expression are unclear. In this study, we have identified the Ikaros...
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| Published in | The Journal of immunology (1950) Vol. 199; no. 7; pp. 2377 - 2387 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Association of Immunologists
01.10.2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-1767 1550-6606 1550-6606 |
| DOI | 10.4049/jimmunol.1700106 |
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| Abstract | B cell lymphoma-6 (Bcl-6) is a transcriptional repressor that is required for the differentiation of T follicular helper (TFH) cell populations. Currently, the molecular mechanisms underlying the transcriptional regulation of Bcl-6 expression are unclear. In this study, we have identified the Ikaros zinc finger transcription factors Aiolos and Ikaros as novel regulators of Bcl-6. We found that increased expression of Bcl-6 in CD4+ Th cell populations correlated with enhanced enrichment of Aiolos and Ikaros at the Bcl6 promoter. Furthermore, overexpression of Aiolos or Ikaros, but not the related family member Eos, was sufficient to induce Bcl6 promoter activity. Intriguingly, STAT3, a known Bcl-6 transcriptional regulator, physically interacted with Aiolos to form a transcription factor complex capable of inducing the expression of Bcl6 and the TFH-associated cytokine receptor Il6ra. Importantly, in vivo studies revealed that the expression of Aiolos was elevated in Ag-specific TFH cells compared with that observed in non-TFH effector Th cells generated in response to influenza infection. Collectively, these data describe a novel regulatory mechanism through which STAT3 and the Ikaros zinc finger transcription factors Aiolos and Ikaros cooperate to regulate Bcl-6 expression. |
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| AbstractList | B cell lymphoma-6 (Bcl-6) is a transcriptional repressor that is required for the differentiation of T follicular helper (TFH) cell populations. Currently, the molecular mechanisms underlying the transcriptional regulation of Bcl-6 expression are unclear. In this study, we have identified the Ikaros zinc finger transcription factors Aiolos and Ikaros as novel regulators of Bcl-6. We found that increased expression of Bcl-6 in CD4+ Th cell populations correlated with enhanced enrichment of Aiolos and Ikaros at the Bcl6 promoter. Furthermore, overexpression of Aiolos or Ikaros, but not the related family member Eos, was sufficient to induce Bcl6 promoter activity. Intriguingly, STAT3, a known Bcl-6 transcriptional regulator, physically interacted with Aiolos to form a transcription factor complex capable of inducing the expression of Bcl6 and the TFH-associated cytokine receptor Il6ra. Importantly, in vivo studies revealed that the expression of Aiolos was elevated in Ag-specific TFH cells compared with that observed in non-TFH effector Th cells generated in response to influenza infection. Collectively, these data describe a novel regulatory mechanism through which STAT3 and the Ikaros zinc finger transcription factors Aiolos and Ikaros cooperate to regulate Bcl-6 expression. B cell lymphoma-6 (Bcl-6) is a transcriptional repressor that is required for the differentiation of T follicular helper (T ) cell populations. Currently, the molecular mechanisms underlying the transcriptional regulation of Bcl-6 expression are unclear. In this study, we have identified the Ikaros zinc finger transcription factors Aiolos and Ikaros as novel regulators of Bcl-6. We found that increased expression of Bcl-6 in CD4 Th cell populations correlated with enhanced enrichment of Aiolos and Ikaros at the promoter. Furthermore, overexpression of Aiolos or Ikaros, but not the related family member Eos, was sufficient to induce promoter activity. Intriguingly, STAT3, a known Bcl-6 transcriptional regulator, physically interacted with Aiolos to form a transcription factor complex capable of inducing the expression of and the T -associated cytokine receptor Importantly, in vivo studies revealed that the expression of Aiolos was elevated in Ag-specific T cells compared with that observed in non-T effector Th cells generated in response to influenza infection. Collectively, these data describe a novel regulatory mechanism through which STAT3 and the Ikaros zinc finger transcription factors Aiolos and Ikaros cooperate to regulate Bcl-6 expression. B cell lymphoma-6 (Bcl-6) is a transcriptional repressor that is required for the differentiation of T follicular helper (TFH) cell populations. Currently, the molecular mechanisms underlying the transcriptional regulation of Bcl-6 expression are unclear. In this study, we have identified the Ikaros zinc finger transcription factors Aiolos and Ikaros as novel regulators of Bcl-6. We found that increased expression of Bcl-6 in CD4+ Th cell populations correlated with enhanced enrichment of Aiolos and Ikaros at the Bcl6 promoter. Furthermore, overexpression of Aiolos or Ikaros, but not the related family member Eos, was sufficient to induce Bcl6 promoter activity. Intriguingly, STAT3, a known Bcl-6 transcriptional regulator, physically interacted with Aiolos to form a transcription factor complex capable of inducing the expression of Bcl6 and the TFH-associated cytokine receptor Il6ra Importantly, in vivo studies revealed that the expression of Aiolos was elevated in Ag-specific TFH cells compared with that observed in non-TFH effector Th cells generated in response to influenza infection. Collectively, these data describe a novel regulatory mechanism through which STAT3 and the Ikaros zinc finger transcription factors Aiolos and Ikaros cooperate to regulate Bcl-6 expression.B cell lymphoma-6 (Bcl-6) is a transcriptional repressor that is required for the differentiation of T follicular helper (TFH) cell populations. Currently, the molecular mechanisms underlying the transcriptional regulation of Bcl-6 expression are unclear. In this study, we have identified the Ikaros zinc finger transcription factors Aiolos and Ikaros as novel regulators of Bcl-6. We found that increased expression of Bcl-6 in CD4+ Th cell populations correlated with enhanced enrichment of Aiolos and Ikaros at the Bcl6 promoter. Furthermore, overexpression of Aiolos or Ikaros, but not the related family member Eos, was sufficient to induce Bcl6 promoter activity. Intriguingly, STAT3, a known Bcl-6 transcriptional regulator, physically interacted with Aiolos to form a transcription factor complex capable of inducing the expression of Bcl6 and the TFH-associated cytokine receptor Il6ra Importantly, in vivo studies revealed that the expression of Aiolos was elevated in Ag-specific TFH cells compared with that observed in non-TFH effector Th cells generated in response to influenza infection. Collectively, these data describe a novel regulatory mechanism through which STAT3 and the Ikaros zinc finger transcription factors Aiolos and Ikaros cooperate to regulate Bcl-6 expression. |
| Author | Read, Kaitlin A Oestreich, Kenneth J Sreekumar, Bharath K Bachus, Holly Ringel-Scaia, Veronica M Powell, Michael D Cooley, Ian D Baker, Chandra E Ballesteros-Tato, Andre Martin, R Emily Allen, Irving C |
| Author_xml | – sequence: 1 givenname: Kaitlin A surname: Read fullname: Read, Kaitlin A – sequence: 2 givenname: Michael D surname: Powell fullname: Powell, Michael D – sequence: 3 givenname: Chandra E surname: Baker fullname: Baker, Chandra E – sequence: 4 givenname: Bharath K surname: Sreekumar fullname: Sreekumar, Bharath K – sequence: 5 givenname: Veronica M orcidid: 0000-0002-7318-4096 surname: Ringel-Scaia fullname: Ringel-Scaia, Veronica M – sequence: 6 givenname: Holly orcidid: 0000-0003-4368-1734 surname: Bachus fullname: Bachus, Holly – sequence: 7 givenname: R Emily surname: Martin fullname: Martin, R Emily – sequence: 8 givenname: Ian D surname: Cooley fullname: Cooley, Ian D – sequence: 9 givenname: Irving C orcidid: 0000-0001-9573-5250 surname: Allen fullname: Allen, Irving C – sequence: 10 givenname: Andre surname: Ballesteros-Tato fullname: Ballesteros-Tato, Andre – sequence: 11 givenname: Kenneth J orcidid: 0000-0002-3004-072X surname: Oestreich fullname: Oestreich, Kenneth J |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28848064$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/ni.3226 10.4049/jimmunol.1004006 10.1126/science.1176676 10.1016/j.immuni.2013.01.013 10.1038/ni802 10.1371/journal.pone.0017739 10.1146/annurev-immunol-041015-055605 10.1016/S0065-2776(10)05007-8 10.1016/j.immuni.2008.05.009 10.1074/jbc.M113.481440 10.1126/science.1176077 10.1111/imm.12648 10.1126/science.1175870 10.1016/j.immuni.2009.05.001 10.1016/j.celrep.2016.01.038 10.1016/j.celrep.2015.09.004 10.3389/fimmu.2014.00630 10.1016/j.febslet.2005.07.018 10.1126/science.276.5312.589 10.1016/j.immuni.2011.07.015 10.1016/j.immuni.2014.10.004 10.4049/jimmunol.1500627 10.4049/jimmunol.1500780 10.1016/j.immuni.2009.04.016 10.1038/ni.2707 10.1038/ni.2242 10.1038/ni.3229 10.1016/j.immuni.2009.07.002 10.1016/j.molimm.2011.03.006 10.1016/j.tig.2015.05.003 10.1084/jem.20111174 10.4049/jimmunol.1600143 10.1038/ni.1837 10.1074/jbc.M111.324046 10.1038/nri3447 10.1016/j.immuni.2008.06.001 10.4049/jimmunol.0904028 10.1016/j.coi.2013.04.003 10.1016/S1074-7613(01)00101-7 10.1093/intimm/dxm007 10.1016/j.immuni.2007.02.009 10.1038/ni.2363 10.1016/j.immuni.2011.11.012 10.1007/s12185-014-1644-5 10.1111/j.1365-2141.2008.07065.x 10.1038/ni.2030 10.1038/ncomms10285 10.1038/ncomms4199 10.1016/j.immuni.2012.02.012 10.1084/jem.20102144 10.1016/j.it.2011.10.005 10.1126/science.1178334 10.1038/nri3824 10.1111/j.1600-065X.2010.00952.x 10.1182/blood-2012-08-448902 10.1128/MCB.01523-08 10.1016/j.coi.2012.01.014 10.1038/cr.2009.138 10.1182/blood-2008-05-078154 10.1038/ni.2037 10.1111/imr.12209 10.1146/annurev-immunol-030409-101212 10.4049/jimmunol.182.2.741 10.1038/ni.2985 10.1016/j.cell.2007.03.019 10.1016/j.celrep.2015.08.049 |
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| Copyright | Copyright © 2017 by The American Association of Immunologists, Inc. Copyright American Association of Immunologists Oct 1, 2017 |
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| References | Xu (2025030614463803100_r35) 2015; 16 Nurieva (2025030614463803100_r29) 2012; 287 McDonald (2025030614463803100_r28) 2016; 7 Vinuesa (2025030614463803100_r58) 2016; 34 Lu (2025030614463803100_r48) 2011; 35 Oestreich (2025030614463803100_r6) 2012; 33 Yu (2025030614463803100_r12) 2009; 31 Schmitt (2025030614463803100_r23) 2009; 31 Yoshida (2025030614463803100_r56) 2014; 100 Crotty (2025030614463803100_r57) 2014; 41 Kaplan (2025030614463803100_r4) 2015; 15 Sharma (2025030614463803100_r53) 2013; 38 Tangye (2025030614463803100_r67) 2013; 13 Ichii (2025030614463803100_r15) 2007; 19 Awe (2025030614463803100_r40) 2015; 195 Zhu (2025030614463803100_r8) 2010; 28 Vogelzang (2025030614463803100_r24) 2008; 29 Johnston (2025030614463803100_r26) 2012; 209 Schmitt (2025030614463803100_r22) 2013; 121 Wong (2025030614463803100_r39) 2013; 288 Basso (2025030614463803100_r14) 2010; 105 Oestreich (2025030614463803100_r41) 2011; 208 Laurence (2025030614463803100_r59) 2007; 26 Bottardi (2025030614463803100_r64) 2015; 31 Miller (2025030614463803100_r7) 2010; 238 Bonelli (2025030614463803100_r43) 2014; 381 Zhou (2025030614463803100_r46) 2009; 30 Bottardi (2025030614463803100_r65) 2009; 29 Read (2025030614463803100_r21) 2016; 149 Ballesteros-Tato (2025030614463803100_r25) 2012; 36 Quirion (2025030614463803100_r38) 2009; 182 Beaulieu (2025030614463803100_r9) 2011; 187 Keys (2025030614463803100_r66) 2008; 141 Choi (2025030614463803100_r32) 2015; 16 Oestreich (2025030614463803100_r17) 2014; 15 Wu (2025030614463803100_r34) 2015; 12 Nakayamada (2025030614463803100_r45) 2012; 24 Geginat (2025030614463803100_r44) 2014; 5 Nurieva (2025030614463803100_r20) 2008; 29 Evans (2025030614463803100_r62) 2014; 5 John (2025030614463803100_r36) 2011; 48 Nurieva (2025030614463803100_r11) 2009; 325 Velu (2025030614463803100_r50) 2016; 197 Thornton (2025030614463803100_r54) 2010; 184 Zhu (2025030614463803100_r3) 2008; 112 Yap (2025030614463803100_r63) 2005; 579 Crotty (2025030614463803100_r5) 2010; 11 Eto (2025030614463803100_r18) 2011; 6 Johnston (2025030614463803100_r10) 2009; 325 Ise (2025030614463803100_r33) 2011; 12 Rieder (2025030614463803100_r52) 2015; 195 Dege (2025030614463803100_r61) 2014; 261 Obeng-Adjei (2025030614463803100_r49) 2015; 13 Liao (2025030614463803100_r60) 2011; 12 Choi (2025030614463803100_r31) 2013; 25 Liu (2025030614463803100_r27) 2016; 14 Reiner (2025030614463803100_r2) 2007; 129 Oestreich (2025030614463803100_r30) 2012; 13 Nakayamada (2025030614463803100_r19) 2011; 35 Zhu (2025030614463803100_r47) 2010; 20 Pan (2025030614463803100_r51) 2009; 325 Schjerven (2025030614463803100_r55) 2013; 14 Quintana (2025030614463803100_r37) 2012; 13 O’Shea (2025030614463803100_r1) 2010; 327 McLemore (2025030614463803100_r42) 2001; 14 Dent (2025030614463803100_r13) 1997; 276 Ichii (2025030614463803100_r16) 2002; 3 |
| References_xml | – volume: 16 start-page: 980 year: 2015 ident: 2025030614463803100_r32 article-title: LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6 publication-title: Nat. Immunol. doi: 10.1038/ni.3226 – volume: 187 start-page: 2841 year: 2011 ident: 2025030614463803100_r9 article-title: The BTB-ZF family of transcription factors: key regulators of lineage commitment and effector function development in the immune system publication-title: J. Immunol. doi: 10.4049/jimmunol.1004006 – volume: 325 start-page: 1001 year: 2009 ident: 2025030614463803100_r11 article-title: Bcl6 mediates the development of T follicular helper cells publication-title: Science doi: 10.1126/science.1176676 – volume: 38 start-page: 998 year: 2013 ident: 2025030614463803100_r53 article-title: An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos publication-title: Immunity doi: 10.1016/j.immuni.2013.01.013 – volume: 3 start-page: 558 year: 2002 ident: 2025030614463803100_r16 article-title: Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells publication-title: Nat. Immunol. doi: 10.1038/ni802 – volume: 6 start-page: e17739 year: 2011 ident: 2025030614463803100_r18 article-title: IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation publication-title: PLoS One doi: 10.1371/journal.pone.0017739 – volume: 34 start-page: 335 year: 2016 ident: 2025030614463803100_r58 article-title: Follicular helper T cells publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-041015-055605 – volume: 105 start-page: 193 year: 2010 ident: 2025030614463803100_r14 article-title: BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis publication-title: Adv. Immunol. doi: 10.1016/S0065-2776(10)05007-8 – volume: 29 start-page: 138 year: 2008 ident: 2025030614463803100_r20 article-title: Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages publication-title: Immunity doi: 10.1016/j.immuni.2008.05.009 – volume: 288 start-page: 35170 year: 2013 ident: 2025030614463803100_r39 article-title: Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.481440 – volume: 325 start-page: 1142 year: 2009 ident: 2025030614463803100_r51 article-title: Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells publication-title: Science doi: 10.1126/science.1176077 – volume: 149 start-page: 253 year: 2016 ident: 2025030614463803100_r21 article-title: T follicular helper cell programming by cytokine-mediated events publication-title: Immunology doi: 10.1111/imm.12648 – volume: 381 start-page: 279 year: 2014 ident: 2025030614463803100_r43 article-title: Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes publication-title: Curr. Top. Microbiol. Immunol. – volume: 325 start-page: 1006 year: 2009 ident: 2025030614463803100_r10 article-title: Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation publication-title: Science doi: 10.1126/science.1175870 – volume: 30 start-page: 646 year: 2009 ident: 2025030614463803100_r46 article-title: Plasticity of CD4+ T cell lineage differentiation publication-title: Immunity doi: 10.1016/j.immuni.2009.05.001 – volume: 14 start-page: 1735 year: 2016 ident: 2025030614463803100_r27 article-title: Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper cell differentiation publication-title: Cell Reports doi: 10.1016/j.celrep.2016.01.038 – volume: 13 start-page: 425 year: 2015 ident: 2025030614463803100_r49 article-title: Circulating Th1-cell-type Tfh cells that exhibit impaired B cell help are preferentially activated during acute malaria in children publication-title: Cell Reports doi: 10.1016/j.celrep.2015.09.004 – volume: 5 start-page: 630 year: 2014 ident: 2025030614463803100_r44 article-title: Plasticity of human CD4 T cell subsets publication-title: Front. Immunol. doi: 10.3389/fimmu.2014.00630 – volume: 579 start-page: 4470 year: 2005 ident: 2025030614463803100_r63 article-title: STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells publication-title: FEBS Lett. doi: 10.1016/j.febslet.2005.07.018 – volume: 276 start-page: 589 year: 1997 ident: 2025030614463803100_r13 article-title: Control of inflammation, cytokine expression, and germinal center formation by BCL-6 publication-title: Science doi: 10.1126/science.276.5312.589 – volume: 35 start-page: 622 year: 2011 ident: 2025030614463803100_r48 article-title: Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells publication-title: Immunity doi: 10.1016/j.immuni.2011.07.015 – volume: 41 start-page: 529 year: 2014 ident: 2025030614463803100_r57 article-title: T follicular helper cell differentiation, function, and roles in disease publication-title: Immunity doi: 10.1016/j.immuni.2014.10.004 – volume: 195 start-page: 553 year: 2015 ident: 2025030614463803100_r52 article-title: Eos is redundant for regulatory T cell function but plays an important role in IL-2 and Th17 production by CD4+ conventional T cells publication-title: J. Immunol. doi: 10.4049/jimmunol.1500627 – volume: 195 start-page: 3705 year: 2015 ident: 2025030614463803100_r40 article-title: PU.1 expression in T follicular helper cells limits CD40L-dependent germinal center B cell development publication-title: J. Immunol. doi: 10.4049/jimmunol.1500780 – volume: 31 start-page: 158 year: 2009 ident: 2025030614463803100_r23 article-title: Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12 publication-title: Immunity doi: 10.1016/j.immuni.2009.04.016 – volume: 14 start-page: 1073 year: 2013 ident: 2025030614463803100_r55 article-title: Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros publication-title: Nat. Immunol. doi: 10.1038/ni.2707 – volume: 13 start-page: 405 year: 2012 ident: 2025030614463803100_r30 article-title: Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile publication-title: Nat. Immunol. doi: 10.1038/ni.2242 – volume: 16 start-page: 991 year: 2015 ident: 2025030614463803100_r35 article-title: The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection publication-title: Nat. Immunol. doi: 10.1038/ni.3229 – volume: 31 start-page: 457 year: 2009 ident: 2025030614463803100_r12 article-title: The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment publication-title: Immunity doi: 10.1016/j.immuni.2009.07.002 – volume: 48 start-page: 1272 year: 2011 ident: 2025030614463803100_r36 article-title: The Ikaros gene family: transcriptional regulators of hematopoiesis and immunity publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2011.03.006 – volume: 31 start-page: 500 year: 2015 ident: 2025030614463803100_r64 article-title: IKAROS: a multifunctional regulator of the polymerase II transcription cycle publication-title: Trends Genet. doi: 10.1016/j.tig.2015.05.003 – volume: 209 start-page: 243 year: 2012 ident: 2025030614463803100_r26 article-title: STAT5 is a potent negative regulator of TFH cell differentiation publication-title: J. Exp. Med. doi: 10.1084/jem.20111174 – volume: 197 start-page: 1832 year: 2016 ident: 2025030614463803100_r50 article-title: Induction of Th1-biased T follicular helper (Tfh) cells in lymphoid tissues during chronic simian immunodeficiency virus infection defines functionally distinct germinal center Tfh cells publication-title: J. Immunol. doi: 10.4049/jimmunol.1600143 – volume: 11 start-page: 114 year: 2010 ident: 2025030614463803100_r5 article-title: Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation publication-title: Nat. Immunol. doi: 10.1038/ni.1837 – volume: 287 start-page: 11234 year: 2012 ident: 2025030614463803100_r29 article-title: STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.324046 – volume: 13 start-page: 412 year: 2013 ident: 2025030614463803100_r67 article-title: The good, the bad and the ugly - TFH cells in human health and disease publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3447 – volume: 29 start-page: 127 year: 2008 ident: 2025030614463803100_r24 article-title: A fundamental role for interleukin-21 in the generation of T follicular helper cells publication-title: Immunity doi: 10.1016/j.immuni.2008.06.001 – volume: 184 start-page: 3433 year: 2010 ident: 2025030614463803100_r54 article-title: Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells publication-title: J. Immunol. doi: 10.4049/jimmunol.0904028 – volume: 25 start-page: 366 year: 2013 ident: 2025030614463803100_r31 article-title: Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2013.04.003 – volume: 14 start-page: 193 year: 2001 ident: 2025030614463803100_r42 article-title: STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation publication-title: Immunity doi: 10.1016/S1074-7613(01)00101-7 – volume: 19 start-page: 427 year: 2007 ident: 2025030614463803100_r15 article-title: Bcl6 is essential for the generation of long-term memory CD4+ T cells publication-title: Int. Immunol. doi: 10.1093/intimm/dxm007 – volume: 26 start-page: 371 year: 2007 ident: 2025030614463803100_r59 article-title: Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation publication-title: Immunity doi: 10.1016/j.immuni.2007.02.009 – volume: 13 start-page: 770 year: 2012 ident: 2025030614463803100_r37 article-title: Aiolos promotes TH17 differentiation by directly silencing Il2 expression publication-title: Nat. Immunol. doi: 10.1038/ni.2363 – volume: 35 start-page: 919 year: 2011 ident: 2025030614463803100_r19 article-title: Early Th1 cell differentiation is marked by a Tfh cell-like transition publication-title: Immunity doi: 10.1016/j.immuni.2011.11.012 – volume: 100 start-page: 220 year: 2014 ident: 2025030614463803100_r56 article-title: Ikaros fingers on lymphocyte differentiation publication-title: Int. J. Hematol. doi: 10.1007/s12185-014-1644-5 – volume: 141 start-page: 398 year: 2008 ident: 2025030614463803100_r66 article-title: A mechanism for Ikaros regulation of human globin gene switching publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.2008.07065.x – volume: 12 start-page: 551 year: 2011 ident: 2025030614463803100_r60 article-title: Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages publication-title: Nat. Immunol. doi: 10.1038/ni.2030 – volume: 7 start-page: 10285 year: 2016 ident: 2025030614463803100_r28 article-title: IL-7 signalling represses Bcl-6 and the TFH gene program publication-title: Nat. Commun. doi: 10.1038/ncomms10285 – volume: 5 start-page: 3199 year: 2014 ident: 2025030614463803100_r62 article-title: TNF-α blockade induces IL-10 expression in human CD4+ T cells publication-title: Nat. Commun. doi: 10.1038/ncomms4199 – volume: 36 start-page: 847 year: 2012 ident: 2025030614463803100_r25 article-title: Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation publication-title: Immunity doi: 10.1016/j.immuni.2012.02.012 – volume: 208 start-page: 1001 year: 2011 ident: 2025030614463803100_r41 article-title: The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns publication-title: J. Exp. Med. doi: 10.1084/jem.20102144 – volume: 33 start-page: 78 year: 2012 ident: 2025030614463803100_r6 article-title: T-bet employs diverse regulatory mechanisms to repress transcription publication-title: Trends Immunol. doi: 10.1016/j.it.2011.10.005 – volume: 327 start-page: 1098 year: 2010 ident: 2025030614463803100_r1 article-title: Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells publication-title: Science doi: 10.1126/science.1178334 – volume: 15 start-page: 295 year: 2015 ident: 2025030614463803100_r4 article-title: The development and in vivo function of T helper 9 cells publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3824 – volume: 238 start-page: 233 year: 2010 ident: 2025030614463803100_r7 article-title: Molecular mechanisms by which T-bet regulates T-helper cell commitment publication-title: Immunol. Rev. doi: 10.1111/j.1600-065X.2010.00952.x – volume: 121 start-page: 3375 year: 2013 ident: 2025030614463803100_r22 article-title: IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans publication-title: Blood doi: 10.1182/blood-2012-08-448902 – volume: 29 start-page: 1526 year: 2009 ident: 2025030614463803100_r65 article-title: Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01523-08 – volume: 24 start-page: 297 year: 2012 ident: 2025030614463803100_r45 article-title: Helper T cell diversity and plasticity publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2012.01.014 – volume: 20 start-page: 4 year: 2010 ident: 2025030614463803100_r47 article-title: Heterogeneity and plasticity of T helper cells publication-title: Cell Res. doi: 10.1038/cr.2009.138 – volume: 112 start-page: 1557 year: 2008 ident: 2025030614463803100_r3 article-title: CD4 T cells: fates, functions, and faults publication-title: Blood doi: 10.1182/blood-2008-05-078154 – volume: 12 start-page: 536 year: 2011 ident: 2025030614463803100_r33 article-title: The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells publication-title: Nat. Immunol. doi: 10.1038/ni.2037 – volume: 261 start-page: 126 year: 2014 ident: 2025030614463803100_r61 article-title: Mi-2/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function publication-title: Immunol. Rev. doi: 10.1111/imr.12209 – volume: 28 start-page: 445 year: 2010 ident: 2025030614463803100_r8 article-title: Differentiation of effector CD4 T cell populations (*) publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-030409-101212 – volume: 182 start-page: 741 year: 2009 ident: 2025030614463803100_r38 article-title: Cutting edge: Ikaros is a regulator of Th2 cell differentiation publication-title: J. Immunol. doi: 10.4049/jimmunol.182.2.741 – volume: 15 start-page: 957 year: 2014 ident: 2025030614463803100_r17 article-title: Bcl-6 directly represses the gene program of the glycolysis pathway publication-title: Nat. Immunol. doi: 10.1038/ni.2985 – volume: 129 start-page: 33 year: 2007 ident: 2025030614463803100_r2 article-title: Development in motion: helper T cells at work publication-title: Cell doi: 10.1016/j.cell.2007.03.019 – volume: 12 start-page: 2099 year: 2015 ident: 2025030614463803100_r34 article-title: TCF1 is required for the T follicular helper cell response to viral infection publication-title: Cell Reports doi: 10.1016/j.celrep.2015.08.049 |
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| Title | Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4+ Th Cells |
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