Polyelectrolyte complex of Aloe vera, chitosan, and alginate produced fibroblast and lymphocyte viabilities and migration
•Preparation of polyelectrolyte complexes of chitosan, alginate, Aloe vera pH 4 and 6.•FT-IR spectroscopy evidenced complexes formation and incorporation of Aloe vera.•ζ potential of complexes revealed that anionic surface charge and dynamic moduli were highly dependent on angular frequency.•Polyele...
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| Published in | Carbohydrate polymers Vol. 192; pp. 84 - 94 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
15.07.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0144-8617 1879-1344 1879-1344 |
| DOI | 10.1016/j.carbpol.2018.03.044 |
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| Abstract | •Preparation of polyelectrolyte complexes of chitosan, alginate, Aloe vera pH 4 and 6.•FT-IR spectroscopy evidenced complexes formation and incorporation of Aloe vera.•ζ potential of complexes revealed that anionic surface charge and dynamic moduli were highly dependent on angular frequency.•Polyelectrolyte complexes showed human fibroblast and lymphocyte viabilities (>90%).•Polyelectrolyte complexes prepared at pH 6 with Ca2+ produced fibroblast migration.
Chitosan, sodium alginate and gel of Aloe vera (Aloe barbadensis Miller) were employed for the preparation of polyelectrolyte complexes at pH 4 and 6. FT-IR spectroscopy analysis showed evidence on complexes formation and incorporation of the Aloe vera gel. The ζ potential determination of the polyelectrolyte complexes revealed the presence of surface charges in the range of −20 to −24 mV, which results in stable systems. The dynamic moduli exhibited a high dependence on angular frequency, which is commonly found in solutions of macromolecules. The materials showed human fibroblast and lymphocyte viabilities up to 90% in agreement with null cytotoxicity. The polyelectrolyte complexes at pH 6 with Ca2+ were stable, showed high water absorption, satisfactory morphology, pore size and rigidity, characteristics that allowed significant human fibroblast migration in wound closure in vitro assays. |
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| AbstractList | Chitosan, sodium alginate and gel of Aloe vera (Aloe barbadensis Miller) were employed for the preparation of polyelectrolyte complexes at pH 4 and 6. FT-IR spectroscopy analysis showed evidence on complexes formation and incorporation of the Aloe vera gel. The ζ potential determination of the polyelectrolyte complexes revealed the presence of surface charges in the range of −20 to −24 mV, which results in stable systems. The dynamic moduli exhibited a high dependence on angular frequency, which is commonly found in solutions of macromolecules. The materials showed human fibroblast and lymphocyte viabilities up to 90% in agreement with null cytotoxicity. The polyelectrolyte complexes at pH 6 with Ca2+ were stable, showed high water absorption, satisfactory morphology, pore size and rigidity, characteristics that allowed significant human fibroblast migration in wound closure in vitro assays. Chitosan, sodium alginate and gel of Aloe vera (Aloe barbadensis Miller) were employed for the preparation of polyelectrolyte complexes at pH 4 and 6. FT-IR spectroscopy analysis showed evidence on complexes formation and incorporation of the Aloe vera gel. The ζ potential determination of the polyelectrolyte complexes revealed the presence of surface charges in the range of -20 to -24 mV, which results in stable systems. The dynamic moduli exhibited a high dependence on angular frequency, which is commonly found in solutions of macromolecules. The materials showed human fibroblast and lymphocyte viabilities up to 90% in agreement with null cytotoxicity. The polyelectrolyte complexes at pH 6 with Ca2+ were stable, showed high water absorption, satisfactory morphology, pore size and rigidity, characteristics that allowed significant human fibroblast migration in wound closure in vitro assays.Chitosan, sodium alginate and gel of Aloe vera (Aloe barbadensis Miller) were employed for the preparation of polyelectrolyte complexes at pH 4 and 6. FT-IR spectroscopy analysis showed evidence on complexes formation and incorporation of the Aloe vera gel. The ζ potential determination of the polyelectrolyte complexes revealed the presence of surface charges in the range of -20 to -24 mV, which results in stable systems. The dynamic moduli exhibited a high dependence on angular frequency, which is commonly found in solutions of macromolecules. The materials showed human fibroblast and lymphocyte viabilities up to 90% in agreement with null cytotoxicity. The polyelectrolyte complexes at pH 6 with Ca2+ were stable, showed high water absorption, satisfactory morphology, pore size and rigidity, characteristics that allowed significant human fibroblast migration in wound closure in vitro assays. •Preparation of polyelectrolyte complexes of chitosan, alginate, Aloe vera pH 4 and 6.•FT-IR spectroscopy evidenced complexes formation and incorporation of Aloe vera.•ζ potential of complexes revealed that anionic surface charge and dynamic moduli were highly dependent on angular frequency.•Polyelectrolyte complexes showed human fibroblast and lymphocyte viabilities (>90%).•Polyelectrolyte complexes prepared at pH 6 with Ca2+ produced fibroblast migration. Chitosan, sodium alginate and gel of Aloe vera (Aloe barbadensis Miller) were employed for the preparation of polyelectrolyte complexes at pH 4 and 6. FT-IR spectroscopy analysis showed evidence on complexes formation and incorporation of the Aloe vera gel. The ζ potential determination of the polyelectrolyte complexes revealed the presence of surface charges in the range of −20 to −24 mV, which results in stable systems. The dynamic moduli exhibited a high dependence on angular frequency, which is commonly found in solutions of macromolecules. The materials showed human fibroblast and lymphocyte viabilities up to 90% in agreement with null cytotoxicity. The polyelectrolyte complexes at pH 6 with Ca2+ were stable, showed high water absorption, satisfactory morphology, pore size and rigidity, characteristics that allowed significant human fibroblast migration in wound closure in vitro assays. Chitosan, sodium alginate and gel of Aloe vera (Aloe barbadensis Miller) were employed for the preparation of polyelectrolyte complexes at pH 4 and 6. FT-IR spectroscopy analysis showed evidence on complexes formation and incorporation of the Aloe vera gel. The ζ potential determination of the polyelectrolyte complexes revealed the presence of surface charges in the range of -20 to -24 mV, which results in stable systems. The dynamic moduli exhibited a high dependence on angular frequency, which is commonly found in solutions of macromolecules. The materials showed human fibroblast and lymphocyte viabilities up to 90% in agreement with null cytotoxicity. The polyelectrolyte complexes at pH 6 with Ca were stable, showed high water absorption, satisfactory morphology, pore size and rigidity, characteristics that allowed significant human fibroblast migration in wound closure in vitro assays. |
| Author | Silva-Bermúdez, Phaedra Vázquez-Torres, Humberto Gallardo-Rivera, Raquel de los Ángeles Aguilar-Santamaría, María Shirai, Keiko Román-Guerrero, Angélica García-López, Julieta Tecante, Alberto Pérez-Alonso, César Velasquillo, Cristina |
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| Keywords | Isopropyl alcohol (PubChem CID: 3776) Dimethyl sulfoxide (PubChem CID: 679) Ethidium homodimer (PubChem CID: 12328897) Sodium alginate (PubChem CID: 91666323) Cell viability 3-(4,5-Dimethyl-thiazol-2-yl)-2-5-diphenyltetrazolium bromide (PubChem CID: 64965) Calcofluor white (PubChem CID: 6108780) Calcein-AM (PubChem CID:4126474) Chitosan (PubChem CID:71853) Aloe vera Chitosan Lymphocyte Fibroblast Polyelectrolyte complex |
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| Snippet | •Preparation of polyelectrolyte complexes of chitosan, alginate, Aloe vera pH 4 and 6.•FT-IR spectroscopy evidenced complexes formation and incorporation of... Chitosan, sodium alginate and gel of Aloe vera (Aloe barbadensis Miller) were employed for the preparation of polyelectrolyte complexes at pH 4 and 6. FT-IR... |
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| SubjectTerms | Alginates - chemistry Aloe - chemistry Aloe vera calcium Cell Movement - drug effects Cell Survival - drug effects Cell viability Chitosan Chitosan - chemistry cytotoxicity electrolytes Fibroblast fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fourier transform infrared spectroscopy gels Glucuronic Acid - chemistry Hexuronic Acids - chemistry Humans in vitro studies Lymphocyte Lymphocytes - cytology Lymphocytes - drug effects Polyelectrolyte complex Polyelectrolytes - chemistry Polyelectrolytes - pharmacology porosity Rheology sodium alginate water uptake zeta potential |
| Title | Polyelectrolyte complex of Aloe vera, chitosan, and alginate produced fibroblast and lymphocyte viabilities and migration |
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