Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters

• Published in: World journal of gastroenterology : WJG Vol. 14; no. 23; pp. 3739 - 3744
• Main Authors: Zhai, Bo, Yan, He-Xin, Liu, Shu-Qin, Chen, Lei, Wu, Meng-Chao, Wang, Hong-Yang
• Format: Journal Article
• Language: English
• Published: United States Department of Ultrasonic Intervention, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China%International Cooperation Laboratory on Signal Transduction, Eastern Hepatobilliary Surgery Institute, Second Military Medical University, Shanghai 200438, China 21.06.2008; The WJG Press and Baishideng
• Subjects: Adult; Aged; Bile Duct Neoplasms - chemistry; Bile Duct Neoplasms - mortality; Bile Duct Neoplasms - pathology; Bile Ducts, Intrahepatic - chemistry; Bile Ducts, Intrahepatic - pathology; Biomarkers, Tumor - analysis; Cadherins - analysis; Catenins; Cell Adhesion Molecules - analysis; Cholangiocarcinoma - chemistry; Cholangiocarcinoma - mortality; Cholangiocarcinoma - pathology; Down-Regulation; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; P120; Phosphoproteins - analysis; Prognosis; Proportional Hazards Models; Rapid Communication; 临床特征; 肝肿瘤; Clinicopathologic feature; P120; Survival; Invasion and metastasis; Intrahepatic cholangiocarcinoma
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.14.3739

AIM： To investigate the relationship between the expression of P120 and the clinicopathologic parameters in intrahepatic cholangiocarcinoma （ICC）. METHODS： An immunohistochemical study of E-cadherin and P120 catenin was performed on 42 specimens of ICC with a Dako Envision kit. RESULTS： The expression of E-cadherin and P120 was reduced in 27 cases （64.3%） and 31 cases （73.8%）, respectively. Both E-cadherin and P120 expressions were significantly correlated with the tumor histological grade （χ^2 = 9.333, P = 009 and χ^= 11.71, P = 0.003）, TNM stage （χ^= 8.627, P = 0.035 and χ^= 13.123, P = 0.004）, intrahepatic metastasis （χ^= 7.292, P = 0.007 and χ^= 4.657, P = 0.041, respectively） and patients′ survival （χ^= 6.351, P = 0.002 and χ^= 4.023, P = 0.000, respectively）. In addition, the expression of P120 was in concordance with that of E-cadherin （χ^ = 13.797, P = 0.000）, indicating that the expression of P120 may be dependent on that of E-cadherin. Finally, only P120 expression was found to be an independent prognostic factor in Cox regression model （r = 0.088, P = 0.049）. CONCLUSION： Down-regulated expression of E-cadherin and P120 occurs frequently in ICC and contributes to the progression and development of tumor. Both of them may be valuable biologic markers for predicting tumor invasion, metastasis and patients′ survival, but only P120 is an independent prognostic factor for ICC.