Roles of central orexinergic system on cardiovascular function and acupuncture on intervention of cardiovascular risk: Orexinergic system mediate the role of acupuncture?

• Published in: Neuropeptides (Edinburgh) Vol. 87; p. 102132
• Main Authors: Gao, He-Ren, Wu, Zi-Jian, Wu, Sheng-Bing, Gao, He-Yuan, Wang, Jie, Zhang, Jin-Li, Zhou, Mei-Qi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2021; Elsevier Science Ltd
• Subjects: Acupuncture; Cardiovascular activity; Cardiovascular disease; Cardiovascular diseases; Cardiovascular system; Central orexinergic system; Death; Hypertension; Hypothalamus; Orexins; Presynapse; Risk factors; Stress induced cardiovascular reactivity; Therapeutic targets; Hypertension; Cardiovascular activity; Acupuncture; Central orexinergic system; Stress induced cardiovascular reactivity
• ISSN: 0143-4179; 1532-2785; 1532-2785
• DOI: 10.1016/j.npep.2021.102132

Central orexinergic system contributes to the regulation of cardiovascular function. Orexinergic neurons receiving projections of nerve fibers from multiple structures of brain which involved in control and regulation of cardiovascular function locate in hypothalamus, and their axon terminals widely project to various central structures where orexins receptors are expressed. Here, we summarize the present knowledge that describes the influence of central orexinergic system on cardiovascular activity, the relevance of dysfunction in central orexinergic system with hypertension and psychological stress induced cardiovascular reactivity which are serious risk factors for cardiovascular disease and cardiovascular death. We propose that central orexinergic system may be potentially important targets for the prevention of cardiovascular disease and cardiovascular death, and different orexinergic system involved neuronal circuits may be involved in distinct cardiovascular functions. Acupuncture having bidirectional regulatory ability and a much lower incidence of side effects can prevent disease. We review the improvement of acupuncture on hypertension and psychological stress induced cardiovascular reactivity. We think that acupuncture intervenes hypertension and psychological stress induced cardiovascular reactivity to prevent cardiovascular disease and cardiovascular death. We also summarize relation between acupuncture and central orexinergic system. We propose a hypothesis that acupuncture improve hypertension and psychological stress induced cardiovascular reactivity through regulating central orexinergic system. The knowledge is beneficial for the development of potential therapeutic targets and methods to prevent cardiovascular disease and cardiovascular death.