APOE and immunity: Research highlights

INTRODUCTION At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in...

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Published inAlzheimer's & dementia Vol. 19; no. 6; pp. 2677 - 2696
Main Authors Kloske, Courtney M., Barnum, Christopher J., Batista, Andre F., Bradshaw, Elizabeth M., Brickman, Adam M., Bu, Guojun, Dennison, Jessica, Gearon, Mary D., Goate, Alison M., Haass, Christian, Heneka, Michael T., Hu, William T., Huggins, Lenique K. L., Jones, Nahdia S., Koldamova, Radosveta, Lemere, Cynthia A., Liddelow, Shane A., Marcora, Edoardo, Marsh, Samuel E., Nielsen, Henrietta M., Petersen, Kellen K., Petersen, Melissa, Piña‐Escudero, Stefanie D., Qiu, Wei Qiao, Quiroz, Yakeel T., Reiman, Eric, Sexton, Claire, Tansey, Malú Gámez, TCW, Julia, Teunissen, Charlotte E., Tijms, Betty M., Kant, Rik, Wallings, Rebecca, Weninger, Stacie C., Wharton, Whitney, Wilcock, Donna M., Wishard, Tyler James, Worley, Susan L, Zetterberg, Henrik, Carrillo, Maria C.
Format Journal Article
LanguageEnglish
Published United States 01.06.2023
Subjects
Alzheimer Disease - pathology
Alzheimer's disease
amyloid beta
APOE
Apolipoproteins E - genetics
astrocytes
biomarkers
dementia
Humans
Inflammation
microglia
Microglia - pathology
neurodegeneration
neuroglia
neuroinflammation
Neurosciences
Neurovetenskaper
tau
TREM2
biomarkers
neurodegeneration
tau
TREM2
amyloid beta
neuroglia
inflammation
neuroinflammation
dementia
APOE
astrocytes
Alzheimer's disease
microglia
Online AccessGet full text
ISSN1552-5260
1552-5279
1552-5279
DOI10.1002/alz.13020

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Abstract INTRODUCTION At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODS The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTS During the 4‐day meeting, presenters illuminated aspects of the cross‐talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.
AbstractList INTRODUCTION At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODS The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTS During the 4‐day meeting, presenters illuminated aspects of the cross‐talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.
At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias.INTRODUCTIONAt the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias.The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry.METHODSThe meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry.During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]).RESULTSDuring the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]).This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.DISCUSSIONThis manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.
At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.
INTRODUCTIONAt the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODSThe meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTSDuring the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor alpha [TNF alpha]). DISCUSSIONThis manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.
INTRODUCTION:  At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene ( APOE ) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODS:  The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTS:  During the 4-day meeting, presenters illuminated aspects of the cross-talk between  APOE  and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION:  This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.
Author Petersen, Kellen K.
TCW, Julia
Lemere, Cynthia A.
Weninger, Stacie C.
Tansey, Malú Gámez
Barnum, Christopher J.
Batista, Andre F.
Brickman, Adam M.
Huggins, Lenique K. L.
Tijms, Betty M.
Sexton, Claire
Jones, Nahdia S.
Teunissen, Charlotte E.
Koldamova, Radosveta
Piña‐Escudero, Stefanie D.
Dennison, Jessica
Bu, Guojun
Marcora, Edoardo
Wallings, Rebecca
Carrillo, Maria C.
Marsh, Samuel E.
Worley, Susan L
Goate, Alison M.
Reiman, Eric
Wishard, Tyler James
Hu, William T.
Nielsen, Henrietta M.
Haass, Christian
Zetterberg, Henrik
Qiu, Wei Qiao
Wharton, Whitney
Liddelow, Shane A.
Petersen, Melissa
Bradshaw, Elizabeth M.
Gearon, Mary D.
Wilcock, Donna M.
Kloske, Courtney M.
Quiroz, Yakeel T.
Heneka, Michael T.
Kant, Rik
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2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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Issue 6
Keywords biomarkers
neurodegeneration
tau
TREM2
amyloid beta
neuroglia
inflammation
neuroinflammation
dementia
APOE
astrocytes
Alzheimer's disease
microglia
Language English
License Attribution-NonCommercial-NoDerivs
2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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SecondaryResourceType review_article
Snippet INTRODUCTION At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research...
At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on...
INTRODUCTION:  At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research...
INTRODUCTIONAt the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research...
SourceID swepub
proquest
pubmed
crossref
wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 2677
SubjectTerms Alzheimer Disease - pathology
Alzheimer's disease
amyloid beta
APOE
Apolipoproteins E - genetics
astrocytes
biomarkers
dementia
Humans
Inflammation
microglia
Microglia - pathology
neurodegeneration
neuroglia
neuroinflammation
Neurosciences
Neurovetenskaper
tau
TREM2
Title APOE and immunity: Research highlights
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Falz.13020
https://www.ncbi.nlm.nih.gov/pubmed/36975090
https://www.proquest.com/docview/2825154866
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-219590
https://gup.ub.gu.se/publication/327516
Volume 19
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