Designing effective 'frustrated Lewis pair' hydrogenation catalysts
The past decade has seen the subject of transition metal-free catalytic hydrogenation develop incredibly rapidly, transforming from a largely hypothetical possibility to a well-established field that can be applied to the reduction of a diverse variety of functional groups under mild conditions. Thi...
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| Published in | Chemical Society reviews Vol. 46; no. 19; pp. 5689 - 57 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
02.10.2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0306-0012 1460-4744 1460-4744 |
| DOI | 10.1039/c7cs00154a |
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| Summary: | The past decade has seen the subject of transition metal-free catalytic hydrogenation develop incredibly rapidly, transforming from a largely hypothetical possibility to a well-established field that can be applied to the reduction of a diverse variety of functional groups under mild conditions. This remarkable change is principally attributable to the development of so-called 'frustrated Lewis pairs': unquenched combinations of bulky Lewis acids and bases whose dual reactivity can be exploited for the facile activation of otherwise inert chemical bonds. While a number of comprehensive reviews into frustrated Lewis pair chemistry have been published in recent years, this tutorial review aims to provide a focused guide to the development of efficient FLP hydrogenation catalysts, through identification and consideration of the key factors that govern their effectiveness. Following discussion of these factors, their importance will be illustrated using a case study from our own research, namely the development of FLP protocols for successful hydrogenation of aldehydes and ketones, and for related moisture-tolerant hydrogenation.
This review offers a rational guide to developing efficient FLP hydrogenation catalysts by considering the key factors governing their effectiveness. |
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| Bibliography: | and NH 2 Dr Matthew Fuchter is a Reader in Chemistry at Imperial College. The Fuchter group has a wide-ranging track record in the design, synthesis and application of organic molecules in chemistry, medicine and materials. Representative examples include the design and development of novel bioactive probes, the study of novel chiral semiconducting molecules, and the development of novel FLP catalysts. 3 4 Daniel Scott is an EPSRC doctoral prize fellow currently working in the group of Dr Andrew E. Ashley at Imperial College, where he had previously obtained his PhD studying the development of FLP catalysis. His current research focuses on the development of Fe-based catalysts for homogeneous N H fixation. Dr Andrew Ashley is a Royal Society University Research Fellow at the Department of Chemistry, Imperial College London. The research interests of the Ashley group focus on novel protocols for homogeneous hydrogenation catalysis, in particular the development of FLP-based technologies. Specific targets are the conversion of CO for renewable energy applications. In 2015 he was the recipient of the biennial BASF Catalysis Award. to liquid hydrocarbon fuels, and of N to N ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/c7cs00154a |