Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats - Amen, Axelle; Yoo, Randy; Fabra-García, Amanda; Bolscher, Judith; Stone, William JR; Bally, Isabelle; Dergan-Dylon, Sebastián; Kucharska, Iga; de Jong, Roos M; de Bruijni, Marloes; Bousema, Teun; King, C Richter; et al. (eLife, 2025)
Keywords: Animals; Antibodies; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - isolation & purification; Antibodies, Protozoan - immunology; Antibodies, Protozoan - isolation & purification; Antigens; Antigens, Protozoan - immunology; Blood parasites; Cell activation; Cell culture; Circumsporozoite protein; Cross Reactions; Crystal structure; Epitopes; Gametes; gametocytes; Glutamic Acid - immunology; homotypic interactions; Humans; Immune response (humoral); Immunoglobulins; Immunology and Inflammation; Life Cycle Stages; Malaria; Malaria, Falciparum - immunology; Malaria, Falciparum - parasitology; Microbiology and Infectious Disease; Monoclonal antibodies; monoclonal antibody; Mosquitoes; Parasites; Plasmodium falciparum; Plasmodium falciparum - growth & development; Plasmodium falciparum - immunology; Proteins; Proteomes; Protozoan Proteins - immunology; repeat motif; Sexual stages; transmission-blocking; Vaccines; repeat motif; homotypic interactions; gametocytes; infectious disease; inflammation; P. falciparum; gametes; microbiology; transmission-blocking; monoclonal antibody; immunology