DNA Methylation Patterns of Ulcer-Healing Genes Associated with the Normal Gastric Mucosa of Gastric Cancers
Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy individuals and cancer patients was evaluated. The methylation-variable sites of 14 genes, incl...
Saved in:
| Published in | Journal of Korean medical science Vol. 25; no. 3; pp. 405 - 417 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Academy of Medical Sciences
01.03.2010
대한의학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1011-8934 1598-6357 1598-6357 |
| DOI | 10.3346/jkms.2010.25.3.405 |
Cover
| Abstract | Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy individuals and cancer patients was evaluated. The methylation-variable sites of 14 genes, including ulcer-healing genes (TFF1, TFF2, CDH1, and PPARG), were chosen from the CpG-island margins or non-island CpGs near the transcription start sites. The healthy individuals as well as the normal gastric mucosa of 23 ulcer, 21 non-invasive cancer, and 53 cancer patients were examined by semiquantitative methylation-specific polymerase chain reaction (PCR) analysis. The ulcer-healing genes were concurrently methylated with other genes depending on the presence or absence of CpG-islands in the normal mucosa of healthy individuals. Both the TFF2 and PPARG genes were frequently undermethylated in ulcer patients. The over- or intermediate-methylated TFF2 and undermethylated PPARG genes was more common in stage-1 cancer patients (71%) than in healthy individuals (10%; odds ratio [OR], 21.9) and non-invasive cancer patients (21%; OR, 8.9). The TFF2-PPARG methylation pattern of cancer patients was stronger in the older-age group (> or =55 yr; OR, 43.6). These results suggest that the combined methylation pattern of ulcer-healing genes serves as a sensitive marker for predicting cancer-prone gastric mucosa. |
|---|---|
| AbstractList | Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy individuals and cancer patients was evaluated. The methylation-variable sites of 14 genes, including ulcer-healing genes (TFF1, TFF2, CDH1, and PPARG), were chosen from the CpG-island margins or non-island CpGs near the transcription start sites. The healthy individuals as well as the normal gastric mucosa of 23 ulcer, 21 non-invasive cancer, and 53 cancer patients were examined by semiquantitative methylation-specific polymerase chain reaction (PCR) analysis. The ulcer-healing genes were concurrently methylated with other genes depending on the presence or absence of CpG-islands in the normal mucosa of healthy individuals. Both the TFF2 and PPARG genes were frequently undermethylated in ulcer patients. The over- or intermediate-methylated TFF2 and undermethylated PPARG genes was more common in stage-1 cancer patients (71%) than in healthy individuals (10%; odds ratio [OR], 21.9) and non-invasive cancer patients (21%; OR, 8.9). The TFF2-PPARG methylation pattern of cancer patients was stronger in the older-age group (> or =55 yr; OR, 43.6). These results suggest that the combined methylation pattern of ulcer-healing genes serves as a sensitive marker for predicting cancer-prone gastric mucosa.Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy individuals and cancer patients was evaluated. The methylation-variable sites of 14 genes, including ulcer-healing genes (TFF1, TFF2, CDH1, and PPARG), were chosen from the CpG-island margins or non-island CpGs near the transcription start sites. The healthy individuals as well as the normal gastric mucosa of 23 ulcer, 21 non-invasive cancer, and 53 cancer patients were examined by semiquantitative methylation-specific polymerase chain reaction (PCR) analysis. The ulcer-healing genes were concurrently methylated with other genes depending on the presence or absence of CpG-islands in the normal mucosa of healthy individuals. Both the TFF2 and PPARG genes were frequently undermethylated in ulcer patients. The over- or intermediate-methylated TFF2 and undermethylated PPARG genes was more common in stage-1 cancer patients (71%) than in healthy individuals (10%; odds ratio [OR], 21.9) and non-invasive cancer patients (21%; OR, 8.9). The TFF2-PPARG methylation pattern of cancer patients was stronger in the older-age group (> or =55 yr; OR, 43.6). These results suggest that the combined methylation pattern of ulcer-healing genes serves as a sensitive marker for predicting cancer-prone gastric mucosa. Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy individuals and cancer patients was evaluated. The methylation-variable sites of 14 genes, including ulcer-healing genes ( TFF1 , TFF2 , CDH1 , and PPARG ), were chosen from the CpG-island margins or non-island CpGs near the transcription start sites. The healthy individuals as well as the normal gastric mucosa of 23 ulcer, 21 non-invasive cancer, and 53 cancer patients were examined by semiquantitative methylation-specific polymerase chain reaction (PCR) analysis. The ulcer-healing genes were concurrently methylated with other genes depending on the presence or absence of CpG-islands in the normal mucosa of healthy individuals. Both the TFF2 and PPARG genes were frequently undermethylated in ulcer patients. The over- or intermediate-methylated TFF2 and undermethylated PPARG genes was more common in stage-1 cancer patients (71%) than in healthy individuals (10%; odds ratio [OR], 21.9) and non-invasive cancer patients (21%; OR, 8.9). The TFF2-PPARG methylation pattern of cancer patients was stronger in the older-age group (≥55 yr; OR, 43.6). These results suggest that the combined methylation pattern of ulcer-healing genes serves as a sensitive marker for predicting cancer-prone gastric mucosa. Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy individuals and cancer patients was evaluated. The methylation-variable sites of 14 genes, including ulcer-healing genes (TFF1, TFF2, CDH1, and PPARG), were chosen from the CpG-island margins or non-island CpGs near the transcription start sites. The healthy individuals as well as the normal gastric mucosa of 23 ulcer, 21 non-invasive cancer, and 53 cancer patients were examined by semiquantitative methylation-specific polymerase chain reaction (PCR) analysis. The ulcer-healing genes were concurrently methylated with other genes depending on the presence or absence of CpG-islands in the normal mucosa of healthy individuals. Both the TFF2 and PPARG genes were frequently undermethylated in ulcer patients. The over- or intermediate-methylated TFF2 and undermethylated PPARG genes was more common in stage-1 cancer patients (71%) than in healthy individuals (10%; odds ratio [OR], 21.9) and non-invasive cancer patients (21%; OR, 8.9). The TFF2-PPARG methylation pattern of cancer patients was stronger in the older-age group (> or =55 yr; OR, 43.6). These results suggest that the combined methylation pattern of ulcer-healing genes serves as a sensitive marker for predicting cancer-prone gastric mucosa. Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy individuals and cancer patients was evaluated. The methylation-variable sites of 14 genes, including ulcer-healing genes (TFF1, TFF2, CDH1, and PPARG), were chosen from the CpG-island margins or non-island CpGs near the transcription start sites. The healthy individuals as well as the normal gastric mucosa of 23 ulcer, 21 non-invasive cancer, and 53 cancer patients were examined by semiquantitative methylation-specific polymerase chain reaction (PCR) analysis. The ulcer-healing genes were concurrently methylated with other genes depending on the presence or absence of CpG-islands in the normal mucosa of healthy individuals. Both the TFF2 and PPARG genes were frequently undermethylated in ulcer patients. The over- or intermediate-methylated TFF2 and undermethylated PPARG genes was more common in stage-1 cancer patients (71%)than in healthy individuals (10%; odds ratio [OR], 21.9) and non-invasive cancer patients (21%; OR, 8.9). The TFF2-PPARG methylation pattern of cancer patients was stronger in the older-age group (≥55 yr; OR, 43.6). These results suggest that the combined methylation pattern of ulcer-healing genes serves as a sensitive marker for predicting cancer-prone gastric mucosa. KCI Citation Count: 7 |
| Author | Kim, Young-Ho Choi, Sang-Wook Hong, Seung-Jin Kang, Seok-Jin Jung, Yu-Chae Kim, Sung-Ja Seo, Eun-Joo Rhyu, Mun-Gan Kang, Moo-Il Oh, Jung-Hwan |
| AuthorAffiliation | 1 Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea 3 Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea 2 Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea |
| AuthorAffiliation_xml | – name: 1 Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea – name: 2 Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea – name: 3 Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea |
| Author_xml | – sequence: 1 givenname: Seung-Jin surname: Hong fullname: Hong, Seung-Jin organization: Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea – sequence: 2 givenname: Jung-Hwan surname: Oh fullname: Oh, Jung-Hwan organization: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea – sequence: 3 givenname: Yu-Chae surname: Jung fullname: Jung, Yu-Chae organization: Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea – sequence: 4 givenname: Young-Ho surname: Kim fullname: Kim, Young-Ho organization: Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea – sequence: 5 givenname: Sung-Ja surname: Kim fullname: Kim, Sung-Ja organization: Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea – sequence: 6 givenname: Seok-Jin surname: Kang fullname: Kang, Seok-Jin organization: Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea – sequence: 7 givenname: Eun-Joo surname: Seo fullname: Seo, Eun-Joo organization: Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea – sequence: 8 givenname: Sang-Wook surname: Choi fullname: Choi, Sang-Wook organization: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea – sequence: 9 givenname: Moo-Il surname: Kang fullname: Kang, Moo-Il organization: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea., Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea – sequence: 10 givenname: Mun-Gan surname: Rhyu fullname: Rhyu, Mun-Gan organization: Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20191040$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001423331$$DAccess content in National Research Foundation of Korea (NRF) |
| BookMark | eNp9kUtvEzEUhS1URB_wB1gg72AzwePHjLNBigKkldqCULu2HM9148axi-2A-u_xJA0CFqyufX3OdyydU3QUYgCEXrdkwhjv3t-vN3lCSb1SMWETTsQzdNKKqWw6JvqjeiZt28gp48foNOd7QqgQlL1Ax9U0bQknJ8h_vJ7hKyirR6-LiwF_1aVAChlHi2-9gdScg_Yu3OEFBMh4lnM0ThcY8E9XVrisAF_HtNEeL3QuyRl8tTUx6xFw2Mx1qKT8Ej232md49TTP0O3nTzfz8-byy-JiPrtsDGe8NNLK-rdh2VMrqV4aaiwdeugNbzlZGst6S4TpjByo7uUgBYWBdcMAwljeSWBn6N2eG5JVa-NU1G4376JaJzX7dnOhRM8pnVbph730YbvcwGAglKS9ekhuo9Pjzvj3S3CrivmhqKRdz1kFvH0CpPh9C7mojcsGvNcB4jarnjHBWibHqDd_Rv3OOJRRBXIvMCnmnMAq48qulZrsvGqJGntXY--jiygqFFO192ql_1gP9P-YfgGBorNh |
| CitedBy_id | crossref_primary_10_1111_evj_13068 crossref_primary_10_1038_clpt_2012_152 crossref_primary_10_2217_epi_12_51 crossref_primary_10_2217_epi_13_17 crossref_primary_10_1002_hep_31039 crossref_primary_10_1371_journal_ppat_1003341 crossref_primary_10_1158_1940_6207_CAPR_13_0320 crossref_primary_10_1186_1471_230X_10_137 |
| Cites_doi | 10.1002/(SICI)1096-9896(199901)187:1<61::AID-PATH247>3.0.CO;2-I 10.1126/science.1099513 10.1158/1078-0432.CCR-05-2096 10.1016/j.ygeno.2006.01.002 10.3346/jkms.2009.24.5.918 10.3346/jkms.2005.20.5.790 10.1136/gut.47.2.251 10.1053/j.gastro.2007.06.026 10.1186/1471-2407-6-180 10.1111/j.1365-2362.2004.01401.x 10.1016/S0046-8177(03)00177-1 10.1016/j.biocel.2006.10.015 10.1007/978-1-4757-3656-4 10.1093/ajcp/114.3.364 10.1055/s-0028-1098086 10.1101/gad.947102 10.1038/sj.bjc.6600877 10.1002/path.1147 10.1002/jcb.21291 10.1038/ng1950 10.1091/mbc.e06-04-0322 10.1016/j.humpath.2005.12.019 10.3346/jkms.2008.23.6.1068 10.1038/sj.onc.1205599 10.1016/j.cell.2007.01.028 10.1073/pnas.191225998 10.4049/jimmunol.177.11.7497 10.1101/gr.140200 10.1038/ng1909 |
| ContentType | Journal Article |
| Copyright | 2010 The Korean Academy of Medical Sciences. 2010 |
| Copyright_xml | – notice: 2010 The Korean Academy of Medical Sciences. 2010 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM ACYCR |
| DOI | 10.3346/jkms.2010.25.3.405 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) Korean Citation Index |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1598-6357 |
| EndPage | 417 |
| ExternalDocumentID | oai_kci_go_kr_ARTI_574229 PMC2826743 20191040 10_3346_jkms_2010_25_3_405 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- 29K 2WC 3O- 5-W 53G 5GY 8JR 8XY 9ZL AAYXX ADBBV ADRAZ AENEX ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL CITATION CS3 D-I DIK DU5 E3Z EBS EF. EJD F5P FRP GROUPED_DOAJ GX1 HYE KQ8 M48 O5R O5S OK1 OVT PGMZT RNS RPM TR2 W2D XSB CGR CUY CVF ECM EIF NPM 7X8 5PM ACYCR |
| ID | FETCH-LOGICAL-c434t-8f8040db72f82abc2cf2d7e7c4140bcf37f05c6c8d2a78d852ed36dde5cf468e3 |
| IEDL.DBID | M48 |
| ISSN | 1011-8934 1598-6357 |
| IngestDate | Sun Mar 09 07:51:05 EDT 2025 Thu Aug 21 13:40:21 EDT 2025 Fri Jul 11 05:40:14 EDT 2025 Mon Jul 21 05:59:12 EDT 2025 Tue Jul 01 01:44:44 EDT 2025 Thu Apr 24 22:52:10 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Stomach Non-Invasive Cancer Ulcer DNA Methylation Neoplasms |
| Language | English |
| License | http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c434t-8f8040db72f82abc2cf2d7e7c4140bcf37f05c6c8d2a78d852ed36dde5cf468e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Seung-Jin Hong and Jung-Hwan Oh contributed equally to this work. http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0191120100250030405 G704-000345.2010.25.3.017 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3346/jkms.2010.25.3.405 |
| PMID | 20191040 |
| PQID | 733531389 |
| PQPubID | 23479 |
| PageCount | 13 |
| ParticipantIDs | nrf_kci_oai_kci_go_kr_ARTI_574229 pubmedcentral_primary_oai_pubmedcentral_nih_gov_2826743 proquest_miscellaneous_733531389 pubmed_primary_20191040 crossref_citationtrail_10_3346_jkms_2010_25_3_405 crossref_primary_10_3346_jkms_2010_25_3_405 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2010-03-01 |
| PublicationDateYYYYMMDD | 2010-03-01 |
| PublicationDate_xml | – month: 03 year: 2010 text: 2010-03-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Korea (South) |
| PublicationPlace_xml | – name: Korea (South) |
| PublicationTitle | Journal of Korean medical science |
| PublicationTitleAlternate | J Korean Med Sci |
| PublicationYear | 2010 |
| Publisher | The Korean Academy of Medical Sciences 대한의학회 |
| Publisher_xml | – name: The Korean Academy of Medical Sciences – name: 대한의학회 |
| References | Yatabe (10.3346/jkms.2010.25.3.405_ref5) 2001; 98 Broutet (10.3346/jkms.2010.25.3.405_ref15) 2003; 88 Jung (10.3346/jkms.2010.25.3.405_ref24) 2008; 23 Shimada (10.3346/jkms.2010.25.3.405_ref11) 2007; 39 Noer (10.3346/jkms.2010.25.3.405_ref27) 2006; 17 Camilo (10.3346/jkms.2010.25.3.405_ref21) 2006; 37 Leung (10.3346/jkms.2010.25.3.405_ref9) 2002; 197 Demetter (10.3346/jkms.2010.25.3.405_ref10) 2000; 114 Maekita (10.3346/jkms.2010.25.3.405_ref30) 2006; 12 Garcia (10.3346/jkms.2010.25.3.405_ref29) 1999; 187 Misteli (10.3346/jkms.2010.25.3.405_ref8) 2007; 128 Lang (10.3346/jkms.2010.25.3.405_ref20) 2006; 177 Schlemper (10.3346/jkms.2010.25.3.405_ref13) 2000; 47 Eckhardt (10.3346/jkms.2010.25.3.405_ref2) 2006; 38 Turker (10.3346/jkms.2010.25.3.405_ref6) 2002; 21 Correa (10.3346/jkms.2010.25.3.405_ref3) 2007; 133 Hong (10.3346/jkms.2010.25.3.405_ref26) 2009; 24 Zhang (10.3346/jkms.2010.25.3.405_ref22) 2000; 10 Kim (10.3346/jkms.2010.25.3.405_ref16) 2006; 6 Osaki (10.3346/jkms.2010.25.3.405_ref17) 2004; 34 Kang (10.3346/jkms.2010.25.3.405_ref7) 2006; 87 Schlesinger (10.3346/jkms.2010.25.3.405_ref28) 2007; 39 Yamamoto (10.3346/jkms.2010.25.3.405_ref19) 2001; 7 Kang (10.3346/jkms.2010.25.3.405_ref23) 2007; 102 Greene (10.3346/jkms.2010.25.3.405_ref14) 2002 Kimura (10.3346/jkms.2010.25.3.405_ref12) 1969; 3 Bird (10.3346/jkms.2010.25.3.405_ref1) 2002; 16 Houghton (10.3346/jkms.2010.25.3.405_ref4) 2004; 306 Frierson (10.3346/jkms.2010.25.3.405_ref18) 2003; 34 Hong (10.3346/jkms.2010.25.3.405_ref25) 2005; 20 12827615 - Hum Pathol. 2003 Jun;34(6):605-9 15567866 - Science. 2004 Nov 26;306(5701):1568-71 19119454 - J Korean Med Sci. 2008 Dec;23(6):1068-89 12154401 - Oncogene. 2002 Aug 12;21(35):5388-93 16488573 - Genomics. 2006 May;87(5):580-90 17200670 - Nat Genet. 2007 Feb;39(2):232-6 16467114 - Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):989-95 16827945 - BMC Cancer. 2006;6:180 17681184 - Gastroenterology. 2007 Aug;133(2):659-72 19794993 - J Korean Med Sci. 2009 Oct;24(5):918-29 10896917 - Gut. 2000 Aug;47(2):251-5 11234883 - Clin Cancer Res. 2001 Feb;7(2):297-303 10341707 - J Pathol. 1999 Jan;187(1):61-81 17114416 - J Immunol. 2006 Dec 1;177(11):7497-504 17352407 - J Cell Biochem. 2007 Sep 1;102(1):224-39 11042152 - Genome Res. 2000 Oct;10(10):1546-60 16647951 - Hum Pathol. 2006 May;37(5):542-6 11782440 - Genes Dev. 2002 Jan 1;16(1):6-21 11517339 - Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10839-44 17320514 - Cell. 2007 Feb 23;128(4):787-800 16224153 - J Korean Med Sci. 2005 Oct;20(5):790-805 17118693 - Int J Biochem Cell Biol. 2007;39(3):626-37 10989636 - Am J Clin Pathol. 2000 Sep;114(3):364-70 15379759 - Eur J Clin Invest. 2004 Sep;34(9):605-12 12698190 - Br J Cancer. 2003 Apr 22;88(8):1239-47 12210076 - J Pathol. 2002 Aug;197(5):582-8 17072317 - Nat Genet. 2006 Dec;38(12):1378-85 16760426 - Mol Biol Cell. 2006 Aug;17(8):3543-56 |
| References_xml | – volume: 187 start-page: 61 year: 1999 ident: 10.3346/jkms.2010.25.3.405_ref29 publication-title: J Pathol doi: 10.1002/(SICI)1096-9896(199901)187:1<61::AID-PATH247>3.0.CO;2-I – volume: 306 start-page: 1568 year: 2004 ident: 10.3346/jkms.2010.25.3.405_ref4 publication-title: Science doi: 10.1126/science.1099513 – volume: 12 start-page: 989 year: 2006 ident: 10.3346/jkms.2010.25.3.405_ref30 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-05-2096 – volume: 87 start-page: 580 year: 2006 ident: 10.3346/jkms.2010.25.3.405_ref7 publication-title: Genomics doi: 10.1016/j.ygeno.2006.01.002 – volume: 24 start-page: 918 year: 2009 ident: 10.3346/jkms.2010.25.3.405_ref26 publication-title: J Korean Med Sci doi: 10.3346/jkms.2009.24.5.918 – volume: 20 start-page: 790 year: 2005 ident: 10.3346/jkms.2010.25.3.405_ref25 publication-title: J Korean Med Sci doi: 10.3346/jkms.2005.20.5.790 – volume: 47 start-page: 251 year: 2000 ident: 10.3346/jkms.2010.25.3.405_ref13 publication-title: Gut doi: 10.1136/gut.47.2.251 – volume: 133 start-page: 659 year: 2007 ident: 10.3346/jkms.2010.25.3.405_ref3 publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.06.026 – volume: 6 start-page: 180 year: 2006 ident: 10.3346/jkms.2010.25.3.405_ref16 publication-title: BMC Cancer doi: 10.1186/1471-2407-6-180 – volume: 34 start-page: 605 year: 2004 ident: 10.3346/jkms.2010.25.3.405_ref17 publication-title: Eur J Clin Invest doi: 10.1111/j.1365-2362.2004.01401.x – volume: 34 start-page: 605 year: 2003 ident: 10.3346/jkms.2010.25.3.405_ref18 publication-title: Hum Pathol doi: 10.1016/S0046-8177(03)00177-1 – volume: 39 start-page: 626 year: 2007 ident: 10.3346/jkms.2010.25.3.405_ref11 publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2006.10.015 – volume-title: AJCC cancer staging manual year: 2002 ident: 10.3346/jkms.2010.25.3.405_ref14 doi: 10.1007/978-1-4757-3656-4 – volume: 114 start-page: 364 year: 2000 ident: 10.3346/jkms.2010.25.3.405_ref10 publication-title: Am J Clin Pathol doi: 10.1093/ajcp/114.3.364 – volume: 3 start-page: 87 year: 1969 ident: 10.3346/jkms.2010.25.3.405_ref12 publication-title: Endoscopy doi: 10.1055/s-0028-1098086 – volume: 16 start-page: 6 year: 2002 ident: 10.3346/jkms.2010.25.3.405_ref1 publication-title: Genes Dev doi: 10.1101/gad.947102 – volume: 88 start-page: 1239 year: 2003 ident: 10.3346/jkms.2010.25.3.405_ref15 publication-title: Br J Cancer doi: 10.1038/sj.bjc.6600877 – volume: 197 start-page: 582 year: 2002 ident: 10.3346/jkms.2010.25.3.405_ref9 publication-title: J Pathol doi: 10.1002/path.1147 – volume: 102 start-page: 224 year: 2007 ident: 10.3346/jkms.2010.25.3.405_ref23 publication-title: J Cell Biochem doi: 10.1002/jcb.21291 – volume: 39 start-page: 232 year: 2007 ident: 10.3346/jkms.2010.25.3.405_ref28 publication-title: Nat Genet doi: 10.1038/ng1950 – volume: 17 start-page: 3543 year: 2006 ident: 10.3346/jkms.2010.25.3.405_ref27 publication-title: Mol Biol Cell doi: 10.1091/mbc.e06-04-0322 – volume: 37 start-page: 542 year: 2006 ident: 10.3346/jkms.2010.25.3.405_ref21 publication-title: Hum Pathol doi: 10.1016/j.humpath.2005.12.019 – volume: 23 start-page: 1068 year: 2008 ident: 10.3346/jkms.2010.25.3.405_ref24 publication-title: J Korean Med Sci doi: 10.3346/jkms.2008.23.6.1068 – volume: 21 start-page: 5388 year: 2002 ident: 10.3346/jkms.2010.25.3.405_ref6 publication-title: Oncogene doi: 10.1038/sj.onc.1205599 – volume: 128 start-page: 787 year: 2007 ident: 10.3346/jkms.2010.25.3.405_ref8 publication-title: Cell doi: 10.1016/j.cell.2007.01.028 – volume: 7 start-page: 297 year: 2001 ident: 10.3346/jkms.2010.25.3.405_ref19 publication-title: Clin Cancer Res – volume: 98 start-page: 10839 year: 2001 ident: 10.3346/jkms.2010.25.3.405_ref5 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.191225998 – volume: 177 start-page: 7497 year: 2006 ident: 10.3346/jkms.2010.25.3.405_ref20 publication-title: J Immunol doi: 10.4049/jimmunol.177.11.7497 – volume: 10 start-page: 1546 year: 2000 ident: 10.3346/jkms.2010.25.3.405_ref22 publication-title: Genome Res doi: 10.1101/gr.140200 – volume: 38 start-page: 1378 year: 2006 ident: 10.3346/jkms.2010.25.3.405_ref2 publication-title: Nat Genet doi: 10.1038/ng1909 – reference: 17681184 - Gastroenterology. 2007 Aug;133(2):659-72 – reference: 10989636 - Am J Clin Pathol. 2000 Sep;114(3):364-70 – reference: 10896917 - Gut. 2000 Aug;47(2):251-5 – reference: 11517339 - Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10839-44 – reference: 16467114 - Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):989-95 – reference: 12210076 - J Pathol. 2002 Aug;197(5):582-8 – reference: 11782440 - Genes Dev. 2002 Jan 1;16(1):6-21 – reference: 17352407 - J Cell Biochem. 2007 Sep 1;102(1):224-39 – reference: 16224153 - J Korean Med Sci. 2005 Oct;20(5):790-805 – reference: 15379759 - Eur J Clin Invest. 2004 Sep;34(9):605-12 – reference: 19794993 - J Korean Med Sci. 2009 Oct;24(5):918-29 – reference: 10341707 - J Pathol. 1999 Jan;187(1):61-81 – reference: 15567866 - Science. 2004 Nov 26;306(5701):1568-71 – reference: 19119454 - J Korean Med Sci. 2008 Dec;23(6):1068-89 – reference: 16827945 - BMC Cancer. 2006;6:180 – reference: 12827615 - Hum Pathol. 2003 Jun;34(6):605-9 – reference: 17072317 - Nat Genet. 2006 Dec;38(12):1378-85 – reference: 17118693 - Int J Biochem Cell Biol. 2007;39(3):626-37 – reference: 16760426 - Mol Biol Cell. 2006 Aug;17(8):3543-56 – reference: 17320514 - Cell. 2007 Feb 23;128(4):787-800 – reference: 11042152 - Genome Res. 2000 Oct;10(10):1546-60 – reference: 16647951 - Hum Pathol. 2006 May;37(5):542-6 – reference: 16488573 - Genomics. 2006 May;87(5):580-90 – reference: 17114416 - J Immunol. 2006 Dec 1;177(11):7497-504 – reference: 11234883 - Clin Cancer Res. 2001 Feb;7(2):297-303 – reference: 12698190 - Br J Cancer. 2003 Apr 22;88(8):1239-47 – reference: 12154401 - Oncogene. 2002 Aug 12;21(35):5388-93 – reference: 17200670 - Nat Genet. 2007 Feb;39(2):232-6 |
| SSID | ssj0025523 |
| Score | 1.9453636 |
| Snippet | Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key... |
| SourceID | nrf pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 405 |
| SubjectTerms | Biomarkers - metabolism Cadherins - genetics CpG Islands DNA Methylation Female Gastric Mucosa - pathology Gastric Mucosa - physiology Gene Expression Regulation, Neoplastic Growth Substances - genetics Humans Male Middle Aged Neoplasm Invasiveness Original Peptides - genetics PPAR gamma - genetics Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach Ulcer - genetics Stomach Ulcer - pathology Trefoil Factor-1 Trefoil Factor-2 Tumor Suppressor Proteins - genetics Wound Healing - genetics 의학일반 |
| Title | DNA Methylation Patterns of Ulcer-Healing Genes Associated with the Normal Gastric Mucosa of Gastric Cancers |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/20191040 https://www.proquest.com/docview/733531389 https://pubmed.ncbi.nlm.nih.gov/PMC2826743 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001423331 |
| Volume | 25 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Journal of Korean Medical Science, 2010, 25(3), 136, pp.405-417 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3dT9swED-xTpr2gmDsI2xUnsTblKrzR-w-TKgaINgET1TizUocu0MNKUtaCf577pK0ohPbnhIlTk7yz_b9zne-Azg0Isk06o04T4yKZZAyzpTDO43aw6OK5Q3SF5fJ2UT-uFbXW7Aqd9R1YP2saUf1pCZVMbj__XCEE_4bWZyCPJSz27oN0uJqIAaSUpq-bPxFFMon114FZM9NuTfU4CamPGztIZq__GNDUb0oq_AcB_0zlPKJbjrdge2OVLJxOwp2YcuXb-DVRec234Pi-HLMqFb0Qxv5xu6arJplzeaBLQvnq5gII2oxNqW1j6UdaD5ntFHLkCWykthtwaYpVfpw7JZC3VP6weqJowFU1W9hcnpy9f0s7sosxE4KuYhNMDiT80zzYHiaOe4Cz7XXTqLxlbkgdBgqlziT81Sb3Cjuc5HgsqhckInx4h30ynnpPwDTIz8Knmsvg5KeEs-kw6F3PqdqSKnkEXxd9al1XQ5yKoVRWLRFCAdLOFjCwXJlhUUcIviy_uauzcDxz9afESo7czeWEmfTdTq3s8qieXBulZacjyJgKyAtTibykKSlny9rq4XANQk5XATvW1zXIlEKMis5jEBvIL5uQOI235Q3v5p83WjV0lGP_f-L_Qiv2-gEinH7BL1FtfQHSHoWWR_p_vnPfrNl0G9G9SOOBQJe |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=DNA+methylation+patterns+of+ulcer-healing+genes+associated+with+the+normal+gastric+mucosa+of+gastric+cancers&rft.jtitle=Journal+of+Korean+medical+science&rft.au=Hong%2C+Seung-Jin&rft.au=Oh%2C+Jung-Hwan&rft.au=Jung%2C+Yu-Chae&rft.au=Kim%2C+Young-Ho&rft.date=2010-03-01&rft.issn=1598-6357&rft.eissn=1598-6357&rft.volume=25&rft.issue=3&rft.spage=405&rft_id=info:doi/10.3346%2Fjkms.2010.25.3.405&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1011-8934&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1011-8934&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1011-8934&client=summon |