mTOR links oncogenic signaling to tumor cell metabolism

• Published in: Journal of molecular medicine (Berlin, Germany) Vol. 89; no. 3; pp. 221 - 228
• Main Authors: Yecies, Jessica L., Manning, Brendan D.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.03.2011; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Energy Metabolism - genetics; Energy Metabolism - physiology; Human Genetics; Humans; Internal Medicine; Mechanistic Target of Rapamycin Complex 1; Models, Biological; Molecular Medicine; Multiprotein Complexes; Neoplasms - genetics; Neoplasms - metabolism; Proteins - genetics; Proteins - metabolism; Review; Signal Transduction - genetics; Signal Transduction - physiology; TOR Serine-Threonine Kinases; Energy metabolism; Cell signaling; Cancer
• ISSN: 0946-2716; 1432-1440; 1432-1440
• DOI: 10.1007/s00109-011-0726-6

As a key regulator of cell growth and proliferation, the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) has been the subject of intense investigation for its role in tumor development and progression. This research has revealed a signaling network of oncogenes and tumor suppressors lying upstream of mTORC1, and oncogenic perturbations to this network result in the aberrant activation of this kinase complex in the majority of human cancers. However, the molecular events downstream of mTORC1 contributing to tumor cell growth and proliferation are just coming to light. In addition to its better-known functions in promoting protein synthesis and suppressing autophagy, mTORC1 has emerged as a key regulator of cellular metabolism. Recent studies have found that mTORC1 activation is sufficient to stimulate an increase in glucose uptake, glycolysis, and de novo lipid biosynthesis, which are considered metabolic hallmarks of cancer, as well as the pentose phosphate pathway. Here, we focus on the molecular mechanisms of metabolic regulation by mTORC1 and the potential consequences for anabolic tumor growth and therapeutic strategies.