Fibroblast Growth Factor 20 Attenuates Colitis by Restoring Impaired Intestinal Epithelial Barrier Integrity and Modulating Macrophage Polarization via S100A9 in an NF-κB-Dependent Manner - Zhen, Dong; Wang, Songxue; Liu, Zhen; Xi, Yiyuan; Du, Hanlin; Wang, Ningrui; Gao, Xiaotang; Lin, Zhuofeng; Wu, Fan (Cellular and molecular gastroenterology and hepatology, 2025)
Keywords: Animals; Calgranulin B - genetics; Calgranulin B - metabolism; Colitis - chemically induced; Colitis, Ulcerative - chemically induced; Colitis, Ulcerative - drug therapy; Colitis, Ulcerative - immunology; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - pathology; Dextran Sulfate - toxicity; Disease Models, Animal; FGF20; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Fibroblast Growth Factors - pharmacology; Gastroenterology and Hepatology; Humans; Intestinal Mucosa - drug effects; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Macrophage Polarization; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B - metabolism; Original Research; S100A9; Signal Transduction; Ulcerative Colitis; PBS; PAS; KO; DSS; IBD; DAI; LPS; UC; Macrophage Polarization; NF-κB; FITC; IL6; TNF-α; Ulcerative Colitis; AAV; FGF20; iNOS; S100A9; WT; PCR; fibroblast growth factor 20; nuclear factor kappa B; phosphate-buffered saline; interleukin-6; inducible nitric oxide synthase; tumor necrosis factor alpha; fluorescein isothiocyanate; polymerase chain reaction; knockout; dextran sulfate sodium; adenoassociated virus; periodic acid–Schiff; inflammatory bowel disease; disease activity index; lipopolysaccharide; wild-type