T-cell-receptor gene usage of Actinobacillus actinomycetemcomitans-reactive periodontal CD4+ T cells from localized juvenile periodontitis patients and human peripheral blood leukocyte-reconstituted NOD/SCID mice
We investigated the variable Vα and Vβ gene usage of Actinobacillus actinomycetemcomitans‐reactive periodontal CD4+ T cell receptors (TCR) from: (i) four A. actinomycetemcomitans‐infected localized juvenile periodontitis (LJP) patients, (ii) four groups of A. actinomycetemcomitans‐inoculated NOD/SCI...
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| Published in | Journal of periodontal research Vol. 37; no. 5; pp. 399 - 404 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Munksgaard International Publishers
01.10.2002
Blackwell |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-3484 1600-0765 |
| DOI | 10.1034/j.1600-0765.2002.01006.x |
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| Abstract | We investigated the variable Vα and Vβ gene usage of Actinobacillus actinomycetemcomitans‐reactive periodontal CD4+ T cell receptors (TCR) from: (i) four A. actinomycetemcomitans‐infected localized juvenile periodontitis (LJP) patients, (ii) four groups of A. actinomycetemcomitans‐inoculated NOD/SCID mice engrafted with individual LJP‐derived HuPBL and (iii) HuPBL samples of four LJP patients and two healthy control subjects, by quantitative PCR analyses. The results show that: (i) the majority of the TCR genes (82.5% of Vα and 91.1% of Vβ) used by periodontal CD4+ T cells in A. actinomycetemcomitans‐inoculated HuPBL‐engrafted NOD/SCID mice overlap with those used by local periodontal T cells in LJP patients, (ii) although A. actinomycetemcomitans‐reactive periodontal CD4+ TCR repertoire is relatively widespread, there are a few dominant genes shared by the LJP patients, suggesting a limited number of antigens or epitopes commonly recognized and (iii) A. actinomycetemcomitans likely lacks superantigenic characteristics. These results suggest A. actinomycetemcomitans‐associated human CD4+ T cell repertoire established in HuPBL‐NOD/SCID mice provides a useful approach to study specific aspects of immune–parasite interactions in the periodontium. |
|---|---|
| AbstractList | We investigated the variable Vα and Vβ gene usage of
Actinobacillus actinomycetemcomitans
‐reactive periodontal CD4
+
T cell receptors (TCR) from: (i) four
A. actinomycetemcomitan
s‐infected localized juvenile periodontitis (LJP) patients, (ii) four groups of
A. actinomycetemcomitans
‐inoculated NOD/SCID mice engrafted with individual LJP‐derived HuPBL and (iii) HuPBL samples of four LJP patients and two healthy control subjects, by quantitative PCR analyses. The results show that: (i) the majority of the TCR genes (82.5% of Vα and 91.1% of Vβ) used by periodontal CD4
+
T cells in
A. actinomycetemcomitans
‐inoculated HuPBL‐engrafted NOD/SCID mice overlap with those used by local periodontal T cells in LJP patients, (ii) although
A. actinomycetemcomitans
‐reactive periodontal CD4
+
TCR repertoire is relatively widespread, there are a few dominant genes shared by the LJP patients, suggesting a limited number of antigens or epitopes commonly recognized and (iii)
A. actinomycetemcomitans
likely lacks superantigenic characteristics. These results suggest
A. actinomycetemcomitans
‐associated human CD4
+
T cell repertoire established in HuPBL‐NOD/SCID mice provides a useful approach to study specific aspects of immune–parasite interactions in the periodontium. We investigated the variable Valpha and Vbeta gene usage of Actinobacillus actinomycetemcomitans-reactive periodontal CD4+ T cell receptors (TCR) from: (i) four A. actinomycetemcomitans-infected localized juvenile periodontitis (LJP) patients, (ii) four groups of A. actinomycetemcomitans-inoculated NOD/SCID mice engrafted with individual LJP-derived HuPBL and (iii) HuPBL samples of four LJP patients and two healthy control subjects, by quantitative PCR analyses. The results show that: (i) the majority of the TCR genes (82.5% of Valpha and 91.1% of Vbeta) used by periodontal CD4+ T cells in A. actinomycetemcomitans-inoculated HuPBL-engrafted NOD/SCID mice overlap with those used by local periodontal T cells in LJP patients, (ii) although A. actinomycetemcomitans-reactive periodontal CD4+ TCR repertoire is relatively widespread, there are a few dominant genes shared by the LJP patients, suggesting a limited number of antigens or epitopes commonly recognized and (iii) A. actinomycetemcomitans likely lacks superantigenic characteristics. These results suggest A. actinomycetemcomitans-associated human CD4+ T cell repertoire established in HuPBL-NOD/SCID mice provides a useful approach to study specific aspects of immune-parasite interactions in the periodontium.We investigated the variable Valpha and Vbeta gene usage of Actinobacillus actinomycetemcomitans-reactive periodontal CD4+ T cell receptors (TCR) from: (i) four A. actinomycetemcomitans-infected localized juvenile periodontitis (LJP) patients, (ii) four groups of A. actinomycetemcomitans-inoculated NOD/SCID mice engrafted with individual LJP-derived HuPBL and (iii) HuPBL samples of four LJP patients and two healthy control subjects, by quantitative PCR analyses. The results show that: (i) the majority of the TCR genes (82.5% of Valpha and 91.1% of Vbeta) used by periodontal CD4+ T cells in A. actinomycetemcomitans-inoculated HuPBL-engrafted NOD/SCID mice overlap with those used by local periodontal T cells in LJP patients, (ii) although A. actinomycetemcomitans-reactive periodontal CD4+ TCR repertoire is relatively widespread, there are a few dominant genes shared by the LJP patients, suggesting a limited number of antigens or epitopes commonly recognized and (iii) A. actinomycetemcomitans likely lacks superantigenic characteristics. These results suggest A. actinomycetemcomitans-associated human CD4+ T cell repertoire established in HuPBL-NOD/SCID mice provides a useful approach to study specific aspects of immune-parasite interactions in the periodontium. We investigated the variable Vα and Vβ gene usage of Actinobacillus actinomycetemcomitans‐reactive periodontal CD4+ T cell receptors (TCR) from: (i) four A. actinomycetemcomitans‐infected localized juvenile periodontitis (LJP) patients, (ii) four groups of A. actinomycetemcomitans‐inoculated NOD/SCID mice engrafted with individual LJP‐derived HuPBL and (iii) HuPBL samples of four LJP patients and two healthy control subjects, by quantitative PCR analyses. The results show that: (i) the majority of the TCR genes (82.5% of Vα and 91.1% of Vβ) used by periodontal CD4+ T cells in A. actinomycetemcomitans‐inoculated HuPBL‐engrafted NOD/SCID mice overlap with those used by local periodontal T cells in LJP patients, (ii) although A. actinomycetemcomitans‐reactive periodontal CD4+ TCR repertoire is relatively widespread, there are a few dominant genes shared by the LJP patients, suggesting a limited number of antigens or epitopes commonly recognized and (iii) A. actinomycetemcomitans likely lacks superantigenic characteristics. These results suggest A. actinomycetemcomitans‐associated human CD4+ T cell repertoire established in HuPBL‐NOD/SCID mice provides a useful approach to study specific aspects of immune–parasite interactions in the periodontium. We investigated the variable Valpha and Vbeta gene usage of Actinobacillus actinomycetemcomitans-reactive periodontal CD4+ T cell receptors (TCR) from: (i) four A. actinomycetemcomitans-infected localized juvenile periodontitis (LJP) patients, (ii) four groups of A. actinomycetemcomitans-inoculated NOD/SCID mice engrafted with individual LJP-derived HuPBL and (iii) HuPBL samples of four LJP patients and two healthy control subjects, by quantitative PCR analyses. The results show that: (i) the majority of the TCR genes (82.5% of Valpha and 91.1% of Vbeta) used by periodontal CD4+ T cells in A. actinomycetemcomitans-inoculated HuPBL-engrafted NOD/SCID mice overlap with those used by local periodontal T cells in LJP patients, (ii) although A. actinomycetemcomitans-reactive periodontal CD4+ TCR repertoire is relatively widespread, there are a few dominant genes shared by the LJP patients, suggesting a limited number of antigens or epitopes commonly recognized and (iii) A. actinomycetemcomitans likely lacks superantigenic characteristics. These results suggest A. actinomycetemcomitans-associated human CD4+ T cell repertoire established in HuPBL-NOD/SCID mice provides a useful approach to study specific aspects of immune-parasite interactions in the periodontium. |
| Author | Teng, Yen-Tung A. Gao, Xuijuan |
| Author_xml | – sequence: 1 givenname: Xuijuan surname: Gao fullname: Gao, Xuijuan organization: Division of Periodontics and Department of Microbiology & Immunology, Faculty of Medicine & Dentistry, the University of Western Ontario and – sequence: 2 givenname: Yen-Tung A. surname: Teng fullname: Teng, Yen-Tung A. organization: Division of Periodontics and Department of Microbiology & Immunology, Faculty of Medicine & Dentistry, the University of Western Ontario and |
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| Keywords | Immune response Pathophysiology Stomatology Leukocyte Rodentia Receiver Experimental study Pasteurellaceae Polymerase chain reaction Periodontal disease Vertebrata Mammalia Mouse Animal Actinobacillus actinomycetemcomitans T-Lymphocyte Juvenile periodontitis Bacteria Molecular biology |
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| Snippet | We investigated the variable Vα and Vβ gene usage of Actinobacillus actinomycetemcomitans‐reactive periodontal CD4+ T cell receptors (TCR) from: (i) four A.... We investigated the variable Vα and Vβ gene usage of Actinobacillus actinomycetemcomitans ‐reactive periodontal CD4 + T cell receptors (TCR) from: (i) four A.... We investigated the variable Valpha and Vbeta gene usage of Actinobacillus actinomycetemcomitans-reactive periodontal CD4+ T cell receptors (TCR) from: (i)... |
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| SubjectTerms | Actinobacillus actinomycetemcomitans Aggregatibacter actinomycetemcomitans - immunology Aggressive Periodontitis - genetics Aggressive Periodontitis - immunology Aggressive Periodontitis - microbiology Animals Antigens, Bacterial - genetics Antigens, Bacterial - immunology Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Epitopes - genetics Epitopes - immunology Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Genes, T-Cell Receptor alpha - genetics Genes, T-Cell Receptor beta - genetics Humans HuPBL-NOD/SCID mice immune repertoire Leukocytes - immunology Leukocytes - metabolism localized juvenile periodontitis Male Medical sciences Mice Mice, Inbred NOD Mice, SCID Non tumoral diseases Otorhinolaryngology. Stomatology Polymerase Chain Reaction Receptors, Antigen, T-Cell - genetics Superantigens - genetics T-cell-receptor genes |
| Title | T-cell-receptor gene usage of Actinobacillus actinomycetemcomitans-reactive periodontal CD4+ T cells from localized juvenile periodontitis patients and human peripheral blood leukocyte-reconstituted NOD/SCID mice |
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