The Correlation of Serum Osteoprotegerin with Non-Traditional Cardiovascular Risk Factors and Arterial Stiffness in Patients with Pre-Dialysis Chronic Kidney Disease: Results from the KNOW-CKD Study
Osteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased cardiovascular events in patients with chronic kidney disease (CKD). The present study aimed to find the non-traditional, kidney-related cardiovascular risk...
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| Published in | Journal of Korean medical science Vol. 33; no. 53; pp. e322 - 14 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Academy of Medical Sciences
31.12.2018
대한의학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1011-8934 1598-6357 1598-6357 |
| DOI | 10.3346/jkms.2018.33.e322 |
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| Abstract | Osteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased cardiovascular events in patients with chronic kidney disease (CKD). The present study aimed to find the non-traditional, kidney-related cardiovascular risk factors correlated to serum OPG and the effect of serum OPG on the arterial stiffness measured by brachial ankle pulse wave velocity (baPWV) in patients with the pre-dialysis CKD.
We cross-sectionally analyzed the data from the patients in whom baPWV and the serum OPG were measured at the time of enrollment in a prospective pre-dialysis CKD cohort study in Korea.
Along with traditional cardiovascular risk factors such as age, diabetes mellitus, pulse pressure, and baPWV, non-traditional, kidney-related factors such as albuminuria, plasma level of hemoglobin, total CO
content, alkaline phosphatase, and corrected calcium were independent variables for serum OPG in multivariate linear regression. Reciprocally, the serum OPG was positively associated with baPWV in multivariate linear regression. The baPWV in the 3rd and 4th quartile groups of serum OPG were higher than that in the 1st quartile group after adjustments by age, sex and other significant factors for baPWV in linear mixed model.
Non-traditional, kidney-related cardiovascular risk factors in addition to traditional cardiovascular risk factors were related to serum level of OPG in CKD. Serum OPG level was significantly related to baPWV. Our study suggests that kidney-related factors involved in CKD-specific pathways for VC play a role in the increased secretion of OPG into circulation in patients with CKD.
ClinicalTrials.gov Identifier: NCT01630486. |
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| AbstractList | Osteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased cardiovascular events in patients with chronic kidney disease (CKD). The present study aimed to find the non-traditional, kidney-related cardiovascular risk factors correlated to serum OPG and the effect of serum OPG on the arterial stiffness measured by brachial ankle pulse wave velocity (baPWV) in patients with the pre-dialysis CKD.BACKGROUNDOsteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased cardiovascular events in patients with chronic kidney disease (CKD). The present study aimed to find the non-traditional, kidney-related cardiovascular risk factors correlated to serum OPG and the effect of serum OPG on the arterial stiffness measured by brachial ankle pulse wave velocity (baPWV) in patients with the pre-dialysis CKD.We cross-sectionally analyzed the data from the patients in whom baPWV and the serum OPG were measured at the time of enrollment in a prospective pre-dialysis CKD cohort study in Korea.METHODSWe cross-sectionally analyzed the data from the patients in whom baPWV and the serum OPG were measured at the time of enrollment in a prospective pre-dialysis CKD cohort study in Korea.Along with traditional cardiovascular risk factors such as age, diabetes mellitus, pulse pressure, and baPWV, non-traditional, kidney-related factors such as albuminuria, plasma level of hemoglobin, total CO2 content, alkaline phosphatase, and corrected calcium were independent variables for serum OPG in multivariate linear regression. Reciprocally, the serum OPG was positively associated with baPWV in multivariate linear regression. The baPWV in the 3rd and 4th quartile groups of serum OPG were higher than that in the 1st quartile group after adjustments by age, sex and other significant factors for baPWV in linear mixed model.RESULTSAlong with traditional cardiovascular risk factors such as age, diabetes mellitus, pulse pressure, and baPWV, non-traditional, kidney-related factors such as albuminuria, plasma level of hemoglobin, total CO2 content, alkaline phosphatase, and corrected calcium were independent variables for serum OPG in multivariate linear regression. Reciprocally, the serum OPG was positively associated with baPWV in multivariate linear regression. The baPWV in the 3rd and 4th quartile groups of serum OPG were higher than that in the 1st quartile group after adjustments by age, sex and other significant factors for baPWV in linear mixed model.Non-traditional, kidney-related cardiovascular risk factors in addition to traditional cardiovascular risk factors were related to serum level of OPG in CKD. Serum OPG level was significantly related to baPWV. Our study suggests that kidney-related factors involved in CKD-specific pathways for VC play a role in the increased secretion of OPG into circulation in patients with CKD.CONCLUSIONNon-traditional, kidney-related cardiovascular risk factors in addition to traditional cardiovascular risk factors were related to serum level of OPG in CKD. Serum OPG level was significantly related to baPWV. Our study suggests that kidney-related factors involved in CKD-specific pathways for VC play a role in the increased secretion of OPG into circulation in patients with CKD.ClinicalTrials.gov Identifier: NCT01630486.TRIAL REGISTRATIONClinicalTrials.gov Identifier: NCT01630486. Background: Osteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased cardiovascular events in patients with chronic kidney disease (CKD). The present study aimed to find the non- traditional, kidney-related cardiovascular risk factors correlated to serum OPG and the effect of serum OPG on the arterial stiffness measured by brachial ankle pulse wave velocity (baPWV) in patients with the pre-dialysis CKD. Methods: We cross-sectionally analyzed the data from the patients in whom baPWV and the serum OPG were measured at the time of enrollment in a prospective pre-dialysis CKD cohort study in Korea. Results: Along with traditional cardiovascular risk factors such as age, diabetes mellitus, pulse pressure, and baPWV, non-traditional, kidney-related factors such as albuminuria, plasma level of hemoglobin, total CO2 content, alkaline phosphatase, and corrected calcium were independent variables for serum OPG in multivariate linear regression. Reciprocally, the serum OPG was positively associated with baPWV in multivariate linear regression. The baPWV in the 3rd and 4th quartile groups of serum OPG were higher than that in the 1st quartile group after adjustments by age, sex and other significant factors for baPWV in linear mixed model. Conclusion: Non-traditional, kidney-related cardiovascular risk factors in addition to traditional cardiovascular risk factors were related to serum level of OPG in CKD. Serum OPG level was significantly related to baPWV. Our study suggests that kidney-related factors involved in CKD-specific pathways for VC play a role in the increased secretion of OPG into circulation in patients with CKD. Trial Registration: ClinicalTrials.gov Identifier: NCT01630486 KCI Citation Count: 0 Osteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased cardiovascular events in patients with chronic kidney disease (CKD). The present study aimed to find the non-traditional, kidney-related cardiovascular risk factors correlated to serum OPG and the effect of serum OPG on the arterial stiffness measured by brachial ankle pulse wave velocity (baPWV) in patients with the pre-dialysis CKD. We cross-sectionally analyzed the data from the patients in whom baPWV and the serum OPG were measured at the time of enrollment in a prospective pre-dialysis CKD cohort study in Korea. Along with traditional cardiovascular risk factors such as age, diabetes mellitus, pulse pressure, and baPWV, non-traditional, kidney-related factors such as albuminuria, plasma level of hemoglobin, total CO content, alkaline phosphatase, and corrected calcium were independent variables for serum OPG in multivariate linear regression. Reciprocally, the serum OPG was positively associated with baPWV in multivariate linear regression. The baPWV in the 3rd and 4th quartile groups of serum OPG were higher than that in the 1st quartile group after adjustments by age, sex and other significant factors for baPWV in linear mixed model. Non-traditional, kidney-related cardiovascular risk factors in addition to traditional cardiovascular risk factors were related to serum level of OPG in CKD. Serum OPG level was significantly related to baPWV. Our study suggests that kidney-related factors involved in CKD-specific pathways for VC play a role in the increased secretion of OPG into circulation in patients with CKD. ClinicalTrials.gov Identifier: NCT01630486. |
| Author | Choi, Kyu Hun Lee, Joongyub Kim, Yeong Hoon Kim, Yong-Soo Ahn, Curie Chung, WooKyung Oh, Yun Kyu Chae, Seung Yun |
| AuthorAffiliation | 5 Department of Prevention and Management, Inha University School of Medicine, Incheon, Korea 2 Department of Internal Medicine, Gil Medical Center, Gachon University, Incheon, Korea 4 Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea 6 Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea 7 Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea 3 Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea 1 Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea |
| AuthorAffiliation_xml | – name: 1 Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea – name: 7 Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea – name: 4 Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea – name: 2 Department of Internal Medicine, Gil Medical Center, Gachon University, Incheon, Korea – name: 5 Department of Prevention and Management, Inha University School of Medicine, Incheon, Korea – name: 3 Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea – name: 6 Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea |
| Author_xml | – sequence: 1 givenname: Seung Yun orcidid: 0000-0002-1807-9461 surname: Chae fullname: Chae, Seung Yun organization: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea – sequence: 2 givenname: WooKyung orcidid: 0000-0001-7657-130X surname: Chung fullname: Chung, WooKyung organization: Department of Internal Medicine, Gil Medical Center, Gachon University, Incheon, Korea – sequence: 3 givenname: Yeong Hoon orcidid: 0000-0002-4101-9993 surname: Kim fullname: Kim, Yeong Hoon organization: Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea – sequence: 4 givenname: Yun Kyu orcidid: 0000-0001-8632-5743 surname: Oh fullname: Oh, Yun Kyu organization: Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea – sequence: 5 givenname: Joongyub orcidid: 0000-0003-2784-3772 surname: Lee fullname: Lee, Joongyub organization: Department of Prevention and Management, Inha University School of Medicine, Incheon, Korea – sequence: 6 givenname: Kyu Hun orcidid: 0000-0003-0095-9011 surname: Choi fullname: Choi, Kyu Hun organization: Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea – sequence: 7 givenname: Curie orcidid: 0000-0001-7033-1102 surname: Ahn fullname: Ahn, Curie organization: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea – sequence: 8 givenname: Yong-Soo orcidid: 0000-0003-2152-1289 surname: Kim fullname: Kim, Yong-Soo organization: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea |
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| Keywords | Chronic Kidney Disease Serum Osteoprotegerin Non-Traditional Cardiovascular Risk Factors Brachial-Ankle Pulse Wave Velocity |
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| Snippet | Osteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased cardiovascular... Background: Osteoprotegerin (OPG) plays protective roles against the development of vascular calcification (VC) which greatly contributes to the increased... |
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| SubjectTerms | Adult Aged Blood Pressure Cardiovascular Diseases - diagnosis Cardiovascular Diseases - etiology Creatinine - urine Cross-Sectional Studies Diabetes Mellitus - pathology Female Humans Linear Models Male Middle Aged Original Osteoprotegerin - blood Pulse Wave Analysis Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - diagnosis Risk Factors Vascular Stiffness - physiology 의학일반 |
| Title | The Correlation of Serum Osteoprotegerin with Non-Traditional Cardiovascular Risk Factors and Arterial Stiffness in Patients with Pre-Dialysis Chronic Kidney Disease: Results from the KNOW-CKD Study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/30595681 https://www.proquest.com/docview/2161924208 https://pubmed.ncbi.nlm.nih.gov/PMC6306329 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002420331 |
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