Nanotechnology approaches for personalized treatment of multidrug resistant cancers

The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffective doses of anticancer agents while other individ...

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Published inAdvanced drug delivery reviews Vol. 65; no. 13-14; pp. 1880 - 1895
Main Authors Minko, Tamara, Rodriguez-Rodriguez, Lorna, Pozharov, Vitaly
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.11.2013
Subjects
Animals
Antibody
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - therapeutic use
Antisense oligonucleotides
Cancer stem cells
CD44
Dose-Response Relationship, Drug
Drug delivery system
Drug Delivery Systems
Drug Resistance, Multiple - drug effects
Drug Resistance, Neoplasm - drug effects
Endocytosis - drug effects
Humans
LHRH
Molecular Targeted Therapy
Nanotechnology - methods
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Passive and active targeting
Peptides
Precision Medicine - methods
Pump and nonpump resistance
siRNA
ABC
NLC
Peptides
Antibody
CPT
EPR
DBD
Antisense oligonucleotides
siRNA
TMD
DOX
PAMAM
LHRH
NBD
Passive and active targeting
DDS
TPADDS
SNP
Pump and nonpump resistance
Cancer stem cells
ASO
Drug delivery system
CD44
IC50 dose
targeted proapoptotic drug delivery system
enhanced permeability and retention effect
small interfering RNA
IC dose
transmembrane domain
drug-binding domain
doxorubicin
single-nucleotide polymorphism
nucleotide-binding domain
luteinizing hormone-release hormone
a dose that kills 50% of cells
poly(amido amine)
camptothecin
adenosine triphosphate (ATP)-binding cassette
nanostructured lipid carriers
Online AccessGet full text
ISSN0169-409X
1872-8294
1872-8294
DOI10.1016/j.addr.2013.09.017

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Abstract The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffective doses of anticancer agents while other individuals obtain excessive amounts of drugs that induce severe adverse side effects on healthy tissues. The current review is focused on an individualized selection of drugs and targets to suppress multidrug resistance. Such selection is based on the molecular characteristics of a tumor from an individual patient that can potentially improve the treatment outcome and bring us closer to an era of personalized medicine. [Display omitted]
AbstractList The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffective doses of anticancer agents while other individuals obtain excessive amounts of drugs that induce severe adverse side effects on healthy tissues. The current review is focused on an individualized selection of drugs and targets to suppress multidrug resistance. Such selection is based on the molecular characteristics of a tumor from an individual patient that can potentially improve the treatment outcome and bring us closer to an era of personalized medicine.The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffective doses of anticancer agents while other individuals obtain excessive amounts of drugs that induce severe adverse side effects on healthy tissues. The current review is focused on an individualized selection of drugs and targets to suppress multidrug resistance. Such selection is based on the molecular characteristics of a tumor from an individual patient that can potentially improve the treatment outcome and bring us closer to an era of personalized medicine.
The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffective doses of anticancer agents while other individuals obtain excessive amounts of drugs that induce severe adverse side effects on healthy tissues. The current review is focused on an individualized selection of drugs and targets to suppress multidrug resistance. Such selection is based on the molecular characteristics of a tumor from an individual patient that can potentially improve the treatment outcome and bring us closer to an era of personalized medicine. [Display omitted]
The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffective doses of anticancer agents while other individuals obtain excessive amounts of drugs that induce severe adverse side effects on healthy tissues. The current review is focused on an individualized selection of drugs and targets to suppress multidrug resistance. Such selection is based on the molecular characteristics of a tumor from an individual patient that can potentially improve the treatment outcome and bring us closer to an era of personalized medicine.
Author Rodriguez-Rodriguez, Lorna
Minko, Tamara
Pozharov, Vitaly
Author_xml – sequence: 1
  givenname: Tamara
  surname: Minko
  fullname: Minko, Tamara
  email: minko@rci.rutgers.edu
  organization: Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA
– sequence: 2
  givenname: Lorna
  surname: Rodriguez-Rodriguez
  fullname: Rodriguez-Rodriguez, Lorna
  organization: Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA
– sequence: 3
  givenname: Vitaly
  surname: Pozharov
  fullname: Pozharov, Vitaly
  organization: Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24120655$$D View this record in MEDLINE/PubMed
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Issue 13-14
Keywords ABC
NLC
Peptides
Antibody
CPT
EPR
DBD
Antisense oligonucleotides
siRNA
TMD
DOX
PAMAM
LHRH
NBD
Passive and active targeting
DDS
TPADDS
SNP
Pump and nonpump resistance
Cancer stem cells
ASO
Drug delivery system
CD44
IC50 dose
targeted proapoptotic drug delivery system
enhanced permeability and retention effect
small interfering RNA
IC dose
transmembrane domain
drug-binding domain
doxorubicin
single-nucleotide polymorphism
nucleotide-binding domain
luteinizing hormone-release hormone
a dose that kills 50% of cells
poly(amido amine)
camptothecin
adenosine triphosphate (ATP)-binding cassette
nanostructured lipid carriers
Language English
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2013. Published by Elsevier B.V. All rights reserved.
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PublicationCentury 2000
PublicationDate 2013-Nov
PublicationDateYYYYMMDD 2013-11-01
PublicationDate_xml – month: 11
  year: 2013
  text: 2013-Nov
PublicationDecade 2010
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Advanced drug delivery reviews
PublicationTitleAlternate Adv Drug Deliv Rev
PublicationYear 2013
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
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Snippet The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different...
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SubjectTerms Animals
Antibody
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - therapeutic use
Antisense oligonucleotides
Cancer stem cells
CD44
Dose-Response Relationship, Drug
Drug delivery system
Drug Delivery Systems
Drug Resistance, Multiple - drug effects
Drug Resistance, Neoplasm - drug effects
Endocytosis - drug effects
Humans
LHRH
Molecular Targeted Therapy
Nanotechnology - methods
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Passive and active targeting
Peptides
Precision Medicine - methods
Pump and nonpump resistance
siRNA
Title Nanotechnology approaches for personalized treatment of multidrug resistant cancers
URI https://dx.doi.org/10.1016/j.addr.2013.09.017
https://www.ncbi.nlm.nih.gov/pubmed/24120655
https://www.proquest.com/docview/1461879477
https://www.proquest.com/docview/1516744718
Volume 65
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