Correlation of NPM1 Type A Mutation Burden With Clinical Status and Outcomes in Acute Myeloid Leukemia Patients With Mutated NPM1 Type A

Nucleophosmin gene (NPM1) mutation may be a good molecular marker for assessing the clinical status and predicting the outcomes in AML patients. We evaluated the applicability of NPM1 type A mutation (NPM1-mutA) quantitation for this purpose. Twenty-seven AML patients with normal karyotype but beari...

Full description

Saved in:
Bibliographic Details
Published inAnnals of laboratory medicine Vol. 36; no. 5; pp. 399 - 404
Main Authors Jo, Su Yeon, Park, Sang Hyuk, Kim, In-Suk, Yi, Jongyoun, Kim, Hyung-Hoi, Chang, Chulhun L., Lee, Eun Yup, Cho, Young-Uk, Jang, Seongsoo, Park, Chan-Jeoung, Chi, Hyun-Sook
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Society for Laboratory Medicine 01.09.2016
대한진단검사의학회
Subjects
Online AccessGet full text
ISSN2234-3806
2234-3814
2234-3814
DOI10.3343/alm.2016.36.5.399

Cover

Abstract Nucleophosmin gene (NPM1) mutation may be a good molecular marker for assessing the clinical status and predicting the outcomes in AML patients. We evaluated the applicability of NPM1 type A mutation (NPM1-mutA) quantitation for this purpose. Twenty-seven AML patients with normal karyotype but bearing the mutated NPM1 were enrolled in the study, and real-time quantitative PCR of NPM1-mutA was performed on 93 bone marrow (BM) samples (27 samples at diagnosis and 56 at follow-up). The NPM1-mutA allele burdens (represented as the NPM1-mutA/Abelson gene (ABL) ratio) at diagnosis and at follow-up were compared. The median NPM1-mutA/ABL ratio was 1.3287 at diagnosis and 0.092 at 28 days after chemotherapy, corresponding to a median log10 reduction of 1.7061. Significant correlations were observed between BM blast counts and NPM1-mutA quantitation results measured at diagnosis (γ=0.5885, P=0.0012) and after chemotherapy (γ=0.5106, P=0.0065). Total 16 patients achieved morphologic complete remission at 28 days after chemotherapy, and 14 (87.5%) patients showed a >3 log10 reduction of the NPM1-mutA/ABL ratio. The NPM1-mutA allele was detected in each of five patients who had relapsed, giving a median increase of 0.91-fold of the NPM1-mutA/ABL ratio at relapse over that at diagnosis. The NPM1-mutA quantitation results corresponded to BM assessment results with high stability at relapse, and could predict patient outcomes. Quantitation of the NPM1-mutA burden at follow-up would be useful in the management of AML patients harboring this gene mutation.
AbstractList Nucleophosmin gene (NPM1) mutation may be a good molecular marker for assessing the clinical status and predicting the outcomes in AML patients. We evaluated the applicability of NPM1 type A mutation (NPM1-mutA) quantitation for this purpose. Twenty-seven AML patients with normal karyotype but bearing the mutated NPM1 were enrolled in the study, and real-time quantitative PCR of NPM1-mutA was performed on 93 bone marrow (BM) samples (27 samples at diagnosis and 56 at follow-up). The NPM1-mutA allele burdens (represented as the NPM1-mutA/Abelson gene (ABL) ratio) at diagnosis and at follow-up were compared. The median NPM1-mutA/ABL ratio was 1.3287 at diagnosis and 0.092 at 28 days after chemotherapy, corresponding to a median log10 reduction of 1.7061. Significant correlations were observed between BM blast counts and NPM1-mutA quantitation results measured at diagnosis (γ=0.5885, P=0.0012) and after chemotherapy (γ=0.5106, P=0.0065). Total 16 patients achieved morphologic complete remission at 28 days after chemotherapy, and 14 (87.5%) patients showed a >3 log10 reduction of the NPM1-mutA/ABL ratio. The NPM1-mutA allele was detected in each of five patients who had relapsed, giving a median increase of 0.91-fold of the NPM1-mutA/ABL ratio at relapse over that at diagnosis. The NPM1-mutA quantitation results corresponded to BM assessment results with high stability at relapse, and could predict patient outcomes. Quantitation of the NPM1-mutA burden at follow-up would be useful in the management of AML patients harboring this gene mutation.
Background: Nucleophosmin gene (NPM1) mutation may be a good molecular marker for assessing the clinical status and predicting the outcomes in AML patients. We evaluated the applicability of NPM1 type A mutation (NPM1-mutA) quantitation for this purpose. Methods: Twenty-seven AML patients with normal karyotype but bearing the mutated NPM1 were enrolled in the study, and real-time quantitative PCR of NPM1-mutA was performed on 93 bone marrow (BM) samples (27 samples at diagnosis and 56 at follow-up). The NPM1-mutA allele burdens (represented as the NPM1-mutA/Abelson gene (ABL) ratio) at diagnosis and at follow-up were compared. Results: The median NPM1-mutA/ABL ratio was 1.3287 at diagnosis and 0.092 at 28 days after chemotherapy, corresponding to a median log10 reduction of 1.7061. Significant correlations were observed between BM blast counts and NPM1-mutA quantitation results measured at diagnosis (γ=0.5885, P=0.0012) and after chemotherapy (γ=0.5106, P=0.0065). Total 16 patients achieved morphologic complete remission at 28 days after chemotherapy, and 14 (87.5%) patients showed a >3 log10 reduction of the NPM1-mutA/ABL ratio. The NPM1-mutA allele was detected in each of five patients who had relapsed, giving a median increase of 0.91-fold of the NPM1-mutA/ABL ratio at relapse over that at diagnosis. Conclusions: The NPM1-mutA quantitation results corresponded to BM assessment results with high stability at relapse, and could predict patient outcomes. Quantitation of the NPM1-mutA burden at follow-up would be useful in the management of AML patients harboring this gene mutation. KCI Citation Count: 1
Author Yi, Jongyoun
Cho, Young-Uk
Jo, Su Yeon
Jang, Seongsoo
Kim, In-Suk
Park, Chan-Jeoung
Park, Sang Hyuk
Kim, Hyung-Hoi
Chang, Chulhun L.
Lee, Eun Yup
Chi, Hyun-Sook
AuthorAffiliation 4 Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
1 Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea
3 Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
2 Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea
AuthorAffiliation_xml – name: 1 Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea
– name: 2 Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea
– name: 4 Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
– name: 3 Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
Author_xml – sequence: 1
  givenname: Su Yeon
  surname: Jo
  fullname: Jo, Su Yeon
  organization: Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea
– sequence: 2
  givenname: Sang Hyuk
  surname: Park
  fullname: Park, Sang Hyuk
  organization: Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
– sequence: 3
  givenname: In-Suk
  surname: Kim
  fullname: Kim, In-Suk
  organization: Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea
– sequence: 4
  givenname: Jongyoun
  surname: Yi
  fullname: Yi, Jongyoun
  organization: Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
– sequence: 5
  givenname: Hyung-Hoi
  surname: Kim
  fullname: Kim, Hyung-Hoi
  organization: Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
– sequence: 6
  givenname: Chulhun L.
  surname: Chang
  fullname: Chang, Chulhun L.
  organization: Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea
– sequence: 7
  givenname: Eun Yup
  surname: Lee
  fullname: Lee, Eun Yup
  organization: Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
– sequence: 8
  givenname: Young-Uk
  surname: Cho
  fullname: Cho, Young-Uk
  organization: Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
– sequence: 9
  givenname: Seongsoo
  surname: Jang
  fullname: Jang, Seongsoo
  organization: Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
– sequence: 10
  givenname: Chan-Jeoung
  surname: Park
  fullname: Park, Chan-Jeoung
  organization: Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
– sequence: 11
  givenname: Hyun-Sook
  surname: Chi
  fullname: Chi, Hyun-Sook
  organization: Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27374703$$D View this record in MEDLINE/PubMed
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002139271$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNqNkc1uEzEUhS1UREvpA7BBXrLJ4L-xxxukEBWolLQVBLG0HP9QE48n8syA8gY8Nk4HSssC4c21fM937rXOU3CUuuQAeI5RRSmjr3RsK4Iwryiv6opK-QicEELZjDaYHd3dET8GZ33_FZXDESYSPQHHRFDBBKIn4Meiy9lFPYQuwc7Dy-sVhuv9zsE5XI3D9P5mzNYl-DkMN3ARQwpGR_ixNMce6mTh1TiYrnU9DAnOzTg4uNq72AULl27cujZoeF2cXBr6yeTW2dn7056Bx17H3p39qqfg09vz9eL9bHn17mIxX84Mo2SYWWR8bbVEbKMd9wRRpKVmDfeay5oaaYVhZKMb5oVvBBZ8IxpKKXe1sUJSegpeTr4pe7U1QXU63NYvndpmNf-wvlCYEYJQkZJJOqad3n_XMapdDq3Oe4WROoSgSgjqEIKiXNWqhFCg1xO0Gzets6Z8Ous_4GHaw04KN2X2N8UkQ6zBxeDFfYM78ndmRYAngcld32fn_2sr8RdjwhRu2SHEf5A_AZwIvYU
CitedBy_id crossref_primary_10_3892_ijmm_2019_4323
crossref_primary_10_1002_jcb_25971
crossref_primary_10_1016_j_heliyon_2017_e00277
crossref_primary_10_1098_rsif_2020_0091
crossref_primary_10_1080_16078454_2021_1990503
crossref_primary_10_3390_medicina58020264
Cites_doi 10.1182/blood-2013-06-506725
10.1182/blood-2009-03-213389
10.1056/NEJMoa1112304
10.3324/haematol.2009.017822
10.1056/NEJMoa041974
10.1200/JCO.2009.24.8997
10.1200/JCO.2009.22.4865
10.1182/blood-2009-07-235358
10.1053/beha.2001.0152
10.1182/blood-2012-06-435669
10.1056/NEJMoa1507471
10.1182/blood-2009-11-254441
10.1200/JCO.2011.35.0371
10.1200/JCO.2014.58.0571
10.1182/blood-2007-11-120535
10.1056/NEJM199909303411407
10.3324/haematol.11202
10.3324/haematol.2015.133819
10.1016/j.leukres.2013.08.014
10.1038/sj.leu.2404149
10.1182/asheducation.V2012.1.35.3797926
10.1182/blood-2012-10-461749
10.1002/ajh.21879
10.1002/cncr.23128
10.1016/S0268-960X(03)00040-7
10.1034/j.1600-0609.2001.00556.x
ContentType Journal Article
Copyright The Korean Society for Laboratory Medicine. 2016
Copyright_xml – notice: The Korean Society for Laboratory Medicine. 2016
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
5PM
ADTOC
UNPAY
ACYCR
DOI 10.3343/alm.2016.36.5.399
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
Korean Citation Index
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
DatabaseTitleList MEDLINE

Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2234-3814
EndPage 404
ExternalDocumentID oai_kci_go_kr_ARTI_142200
10.3343/alm.2016.36.5.399
PMC4940481
27374703
10_3343_alm_2016_36_5_399
Genre Journal Article
GrantInformation_xml – fundername: ;
GroupedDBID ---
5-W
53G
8JR
8XY
9ZL
AAYXX
ACYCR
ADBBV
ADRAZ
AENEX
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
CITATION
C~G
DIK
DYU
EF.
GX1
HYE
KQ8
M48
PGMZT
RPM
CGR
CUY
CVF
ECGQY
ECM
EIF
EMOBN
M~E
NPM
OK1
5PM
ADTOC
UNPAY
ID FETCH-LOGICAL-c432t-d0cf5da904bae6f2030a9a486fa6953c9d7c42ba84f7f87176b783336e5cd7933
IEDL.DBID M48
ISSN 2234-3806
2234-3814
IngestDate Sun Mar 09 07:51:25 EDT 2025
Wed Oct 01 16:37:00 EDT 2025
Thu Aug 21 18:26:51 EDT 2025
Thu Jan 02 22:25:02 EST 2025
Tue Jul 01 03:11:33 EDT 2025
Thu Apr 24 23:07:25 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords AML
Quantitation
Real-time PCR
Monitoring
NPM1 type A mutation
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c432t-d0cf5da904bae6f2030a9a486fa6953c9d7c42ba84f7f87176b783336e5cd7933
Notes G704-000327.2016.36.5.009
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3343/alm.2016.36.5.399
PMID 27374703
PageCount 6
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_142200
unpaywall_primary_10_3343_alm_2016_36_5_399
pubmedcentral_primary_oai_pubmedcentral_nih_gov_4940481
pubmed_primary_27374703
crossref_primary_10_3343_alm_2016_36_5_399
crossref_citationtrail_10_3343_alm_2016_36_5_399
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2016-09-01
PublicationDateYYYYMMDD 2016-09-01
PublicationDate_xml – month: 09
  year: 2016
  text: 2016-09-01
  day: 01
PublicationDecade 2010
PublicationPlace Korea (South)
PublicationPlace_xml – name: Korea (South)
PublicationTitle Annals of laboratory medicine
PublicationTitleAlternate Ann Lab Med
PublicationYear 2016
Publisher The Korean Society for Laboratory Medicine
대한진단검사의학회
Publisher_xml – name: The Korean Society for Laboratory Medicine
– name: 대한진단검사의학회
References Dvorakova (10.3343/alm.2016.36.5.399_ref27) 2010; 85
Grimwade (10.3343/alm.2016.36.5.399_ref13) 2001; 14
Craig (10.3343/alm.2016.36.5.399_ref10) 2008; 111
Palmisano (10.3343/alm.2016.36.5.399_ref28) 2007; 92
Falini (10.3343/alm.2016.36.5.399_ref17) 2010; 95
Shayegi (10.3343/alm.2016.36.5.399_ref7) 2013; 122
Grimwade (10.3343/alm.2016.36.5.399_ref18) 2010; 116
Falini (10.3343/alm.2016.36.5.399_ref22) 2005; 352
Patel (10.3343/alm.2016.36.5.399_ref20) 2012; 366
Schnittger (10.3343/alm.2016.36.5.399_ref4) 2009; 114
Stentoft (10.3343/alm.2016.36.5.399_ref2) 2001; 67
Sabattini (10.3343/alm.2016.36.5.399_ref9) 2010; 102
Walter (10.3343/alm.2016.36.5.399_ref3) 2013; 122
Cilloni (10.3343/alm.2016.36.5.399_ref5) 2009; 27
Döhner (10.3343/alm.2016.36.5.399_ref1) 2010; 115
Mrózek (10.3343/alm.2016.36.5.399_ref14) 2004; 18
Krönke (10.3343/alm.2016.36.5.399_ref6) 2011; 29
Paietta (10.3343/alm.2016.36.5.399_ref15) 2012; 2012
Harrison (10.3343/alm.2016.36.5.399_ref12) 2010; 28
Ivey (10.3343/alm.2016.36.5.399_ref25) 2016; 374
Löwenberg (10.3343/alm.2016.36.5.399_ref19) 1999; 341
Gorello (10.3343/alm.2016.36.5.399_ref23) 2006; 20
Park (10.3343/alm.2016.36.5.399_ref26) 2013; 37
Yin (10.3343/alm.2016.36.5.399_ref8) 2012; 120
Alpermann (10.3343/alm.2016.36.5.399_ref24) 2016; 101
Bene (10.3343/alm.2016.36.5.399_ref11) 1995; 9
Kern (10.3343/alm.2016.36.5.399_ref16) 2008; 112
Ostronoff (10.3343/alm.2016.36.5.399_ref21) 2015; 33
23233558 - Hematology Am Soc Hematol Educ Program. 2012;2012:35-42
16541144 - Leukemia. 2006 Jun;20(6):1103-8
15659725 - N Engl J Med. 2005 Jan 20;352(3):254-66
24054719 - Leuk Res. 2013 Nov;37(11):1488-94
22875911 - Blood. 2012 Oct 4;120(14):2826-35
22417203 - N Engl J Med. 2012 Mar 22;366(12):1079-89
26789727 - N Engl J Med. 2016 Feb 4;374(5):422-33
19752335 - J Clin Oncol. 2009 Nov 1;27(31):5195-201
21555683 - J Clin Oncol. 2011 Jul 1;29(19):2709-16
25713434 - J Clin Oncol. 2015 Apr 1;33(10 ):1157-64
23656730 - Blood. 2013 Jul 4;122(1):83-92
17768124 - Haematologica. 2007 Sep;92(9):1268-9
20981679 - Am J Hematol. 2010 Dec;85(12):926-9
7564526 - Leukemia. 1995 Oct;9(10):1783-6
26471486 - Haematologica. 2016 Feb;101(2):e55-8
20439644 - J Clin Oncol. 2010 Jun 1;28(16):2674-81
18198345 - Blood. 2008 Apr 15;111(8):3941-67
21171509 - Pathologica. 2010 Jun;102(3):83-7
19587375 - Blood. 2009 Sep 10;114(11):2220-31
19880497 - Blood. 2010 Jan 21;115(3):453-74
20378574 - Haematologica. 2010 Apr;95(4):529-34
20385793 - Blood. 2010 Jul 22;116(3):354-65
11872078 - Eur J Haematol. 2001 Nov-Dec;67(5-6):302-8
18000811 - Cancer. 2008 Jan 1;112(1):4-16
23847197 - Blood. 2013 Sep 5;122(10):1813-21
15010150 - Blood Rev. 2004 Jun;18(2):115-36
10502596 - N Engl J Med. 1999 Sep 30;341(14):1051-62
11640867 - Best Pract Res Clin Haematol. 2001 Sep;14(3):497-529
References_xml – volume: 122
  start-page: 1813
  year: 2013
  ident: 10.3343/alm.2016.36.5.399_ref3
  publication-title: Blood
  doi: 10.1182/blood-2013-06-506725
– volume: 114
  start-page: 2220
  year: 2009
  ident: 10.3343/alm.2016.36.5.399_ref4
  publication-title: Blood
  doi: 10.1182/blood-2009-03-213389
– volume: 366
  start-page: 1079
  year: 2012
  ident: 10.3343/alm.2016.36.5.399_ref20
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1112304
– volume: 95
  start-page: 529
  year: 2010
  ident: 10.3343/alm.2016.36.5.399_ref17
  publication-title: Haematologica
  doi: 10.3324/haematol.2009.017822
– volume: 352
  start-page: 254
  year: 2005
  ident: 10.3343/alm.2016.36.5.399_ref22
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa041974
– volume: 28
  start-page: 2674
  year: 2010
  ident: 10.3343/alm.2016.36.5.399_ref12
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2009.24.8997
– volume: 27
  start-page: 5195
  year: 2009
  ident: 10.3343/alm.2016.36.5.399_ref5
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2009.22.4865
– volume: 115
  start-page: 453
  year: 2010
  ident: 10.3343/alm.2016.36.5.399_ref1
  publication-title: Blood
  doi: 10.1182/blood-2009-07-235358
– volume: 14
  start-page: 497
  year: 2001
  ident: 10.3343/alm.2016.36.5.399_ref13
  publication-title: Best Pract Res Clin Haematol
  doi: 10.1053/beha.2001.0152
– volume: 120
  start-page: 2826
  year: 2012
  ident: 10.3343/alm.2016.36.5.399_ref8
  publication-title: Blood
  doi: 10.1182/blood-2012-06-435669
– volume: 374
  start-page: 422
  year: 2016
  ident: 10.3343/alm.2016.36.5.399_ref25
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1507471
– volume: 116
  start-page: 354
  year: 2010
  ident: 10.3343/alm.2016.36.5.399_ref18
  publication-title: Blood
  doi: 10.1182/blood-2009-11-254441
– volume: 29
  start-page: 2709
  year: 2011
  ident: 10.3343/alm.2016.36.5.399_ref6
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2011.35.0371
– volume: 33
  start-page: 1157
  year: 2015
  ident: 10.3343/alm.2016.36.5.399_ref21
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2014.58.0571
– volume: 111
  start-page: 3941
  year: 2008
  ident: 10.3343/alm.2016.36.5.399_ref10
  publication-title: Blood
  doi: 10.1182/blood-2007-11-120535
– volume: 341
  start-page: 1051
  year: 1999
  ident: 10.3343/alm.2016.36.5.399_ref19
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199909303411407
– volume: 92
  start-page: 1268
  year: 2007
  ident: 10.3343/alm.2016.36.5.399_ref28
  publication-title: Haematologica
  doi: 10.3324/haematol.11202
– volume: 101
  start-page: e55
  year: 2016
  ident: 10.3343/alm.2016.36.5.399_ref24
  publication-title: Haematologica
  doi: 10.3324/haematol.2015.133819
– volume: 37
  start-page: 1488
  year: 2013
  ident: 10.3343/alm.2016.36.5.399_ref26
  publication-title: Leuk Res
  doi: 10.1016/j.leukres.2013.08.014
– volume: 9
  start-page: 1783
  year: 1995
  ident: 10.3343/alm.2016.36.5.399_ref11
  publication-title: Leukemia
– volume: 20
  start-page: 1103
  year: 2006
  ident: 10.3343/alm.2016.36.5.399_ref23
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2404149
– volume: 2012
  start-page: 35
  year: 2012
  ident: 10.3343/alm.2016.36.5.399_ref15
  publication-title: Hematology Am Soc Hematol Educ Program
  doi: 10.1182/asheducation.V2012.1.35.3797926
– volume: 122
  start-page: 83
  year: 2013
  ident: 10.3343/alm.2016.36.5.399_ref7
  publication-title: Blood
  doi: 10.1182/blood-2012-10-461749
– volume: 85
  start-page: 926
  year: 2010
  ident: 10.3343/alm.2016.36.5.399_ref27
  publication-title: Am J Hematol
  doi: 10.1002/ajh.21879
– volume: 112
  start-page: 4
  year: 2008
  ident: 10.3343/alm.2016.36.5.399_ref16
  publication-title: Cancer
  doi: 10.1002/cncr.23128
– volume: 18
  start-page: 115
  year: 2004
  ident: 10.3343/alm.2016.36.5.399_ref14
  publication-title: Blood Rev
  doi: 10.1016/S0268-960X(03)00040-7
– volume: 102
  start-page: 83
  year: 2010
  ident: 10.3343/alm.2016.36.5.399_ref9
  publication-title: Pathologica
– volume: 67
  start-page: 302
  year: 2001
  ident: 10.3343/alm.2016.36.5.399_ref2
  publication-title: Eur J Haematol
  doi: 10.1034/j.1600-0609.2001.00556.x
– reference: 19752335 - J Clin Oncol. 2009 Nov 1;27(31):5195-201
– reference: 21171509 - Pathologica. 2010 Jun;102(3):83-7
– reference: 17768124 - Haematologica. 2007 Sep;92(9):1268-9
– reference: 11872078 - Eur J Haematol. 2001 Nov-Dec;67(5-6):302-8
– reference: 21555683 - J Clin Oncol. 2011 Jul 1;29(19):2709-16
– reference: 20439644 - J Clin Oncol. 2010 Jun 1;28(16):2674-81
– reference: 19880497 - Blood. 2010 Jan 21;115(3):453-74
– reference: 15010150 - Blood Rev. 2004 Jun;18(2):115-36
– reference: 23656730 - Blood. 2013 Jul 4;122(1):83-92
– reference: 19587375 - Blood. 2009 Sep 10;114(11):2220-31
– reference: 25713434 - J Clin Oncol. 2015 Apr 1;33(10 ):1157-64
– reference: 22417203 - N Engl J Med. 2012 Mar 22;366(12):1079-89
– reference: 26471486 - Haematologica. 2016 Feb;101(2):e55-8
– reference: 10502596 - N Engl J Med. 1999 Sep 30;341(14):1051-62
– reference: 11640867 - Best Pract Res Clin Haematol. 2001 Sep;14(3):497-529
– reference: 16541144 - Leukemia. 2006 Jun;20(6):1103-8
– reference: 22875911 - Blood. 2012 Oct 4;120(14):2826-35
– reference: 7564526 - Leukemia. 1995 Oct;9(10):1783-6
– reference: 23233558 - Hematology Am Soc Hematol Educ Program. 2012;2012:35-42
– reference: 18000811 - Cancer. 2008 Jan 1;112(1):4-16
– reference: 15659725 - N Engl J Med. 2005 Jan 20;352(3):254-66
– reference: 20385793 - Blood. 2010 Jul 22;116(3):354-65
– reference: 20378574 - Haematologica. 2010 Apr;95(4):529-34
– reference: 23847197 - Blood. 2013 Sep 5;122(10):1813-21
– reference: 24054719 - Leuk Res. 2013 Nov;37(11):1488-94
– reference: 18198345 - Blood. 2008 Apr 15;111(8):3941-67
– reference: 20981679 - Am J Hematol. 2010 Dec;85(12):926-9
– reference: 26789727 - N Engl J Med. 2016 Feb 4;374(5):422-33
SSID ssj0000601290
Score 2.0813375
Snippet Nucleophosmin gene (NPM1) mutation may be a good molecular marker for assessing the clinical status and predicting the outcomes in AML patients. We evaluated...
Background: Nucleophosmin gene (NPM1) mutation may be a good molecular marker for assessing the clinical status and predicting the outcomes in AML patients. We...
SourceID nrf
unpaywall
pubmedcentral
pubmed
crossref
SourceType Open Website
Open Access Repository
Index Database
Enrichment Source
StartPage 399
SubjectTerms Antineoplastic Agents - therapeutic use
Bone Marrow - metabolism
Bone Marrow - pathology
Cytarabine - therapeutic use
Daunorubicin
fms-Like Tyrosine Kinase 3 - genetics
Humans
Karyotype
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - pathology
Mutation
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Original
Real-Time Polymerase Chain Reaction
Recurrence
Remission Induction
Retrospective Studies
Sequence Analysis, DNA
병리학
SummonAdditionalLinks – databaseName: Unpaywall
  dbid: UNPAY
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELe2TgJe-B4LXzIST6B0bu04yQMP1cQ0EC19oGI8WY4_WNSQdG0iNP4C_mx8cVq1EwIh8ZREcS7x5Zy7y939DqGXJLGJVESGlkKYkRsbZprEoYycsqdUQagIsi0m_GzG3p9H53touq6FgbRKWZaOA04ZtJH8jqfHGsDjK6nFQtsWOcKt-TfgdFJGj2UBVeUD3qe8Hzk_Pt1HBxxCTj10MJtMR1-gx9yQspAmbbvNbn_AfKDz9zR2VNV-ubRbWup6BuXNplzIq--yKLbU0-kddLmemM9KmfebOuurH9cwH__nzO-i250ti0de-O6hPVPeRzfGXbT-Afp5Aq0_fLIdriyeTMcDDI4vHuFx43MAsK-jwJ_z-gJ3IKUFBhO4WWFZavyxqd2iMCucl3ikmtrg8ZUpqlzjD6aZm2-5xFOPDbvyRFrKRm_f7SGanb79dHIWdp0fQiccwzrURNlIy5SwTBpuh-5LJFPJEm4lTyOqUh0rNsxkwmxsncsX8yxOKKXcREq7Lw49RL2yKs0RwkxDcbDRGVGKJVQnxhinlHVmLbU8igJE1i9ZqA4WHbpzFMK5R8Bh4TgsgMOCchEJx-EAvdpcsvCYIH8a_MJJjpirXACSN2y_VmK-FM5feSfgDxwhAXrkxWlDzhmVzs8jNEDxjqBtBgCt3TNlftGig7OUAQZQgF5vRPLvT_n4n0Y_Qbfg2KfaPUW9etmYZ842q7Pn3XL7BaarNZY
  priority: 102
  providerName: Unpaywall
Title Correlation of NPM1 Type A Mutation Burden With Clinical Status and Outcomes in Acute Myeloid Leukemia Patients With Mutated NPM1 Type A
URI https://www.ncbi.nlm.nih.gov/pubmed/27374703
https://pubmed.ncbi.nlm.nih.gov/PMC4940481
https://www.annlabmed.org/journal/download_pdf.php?doi=10.3343/alm.2016.36.5.399
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002139271
UnpaywallVersion publishedVersion
Volume 36
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Annals of Laboratory Medicine, 2016, 36(5), , pp.399-404
journalDatabaseRights – providerCode: PRVCAB
  databaseName: Nutrition and Food Sciences Database
  customDbUrl:
  eissn: 2234-3814
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000601290
  issn: 2234-3806
  databaseCode: DYU
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://www.cabidigitallibrary.org/product/zd
  providerName: CAB International
– providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 2234-3814
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000601290
  issn: 2234-3806
  databaseCode: KQ8
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 2234-3814
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000601290
  issn: 2234-3806
  databaseCode: DIK
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVFQY
  databaseName: GFMER Free Medical Journals
  customDbUrl:
  eissn: 2234-3814
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000601290
  issn: 2234-3806
  databaseCode: GX1
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php
  providerName: Geneva Foundation for Medical Education and Research
– providerCode: PRVERR
  databaseName: KoreaMed Open Access
  customDbUrl:
  eissn: 2234-3814
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000601290
  issn: 2234-3806
  databaseCode: 5-W
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://koreamed.org/journals
  providerName: Korean Association of Medical Journal Editors
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 2234-3814
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000601290
  issn: 2234-3806
  databaseCode: RPM
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVFZP
  databaseName: Scholars Portal Journals: Open Access
  customDbUrl:
  eissn: 2234-3814
  dateEnd: 20250930
  omitProxy: true
  ssIdentifier: ssj0000601290
  issn: 2234-3806
  databaseCode: M48
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: http://journals.scholarsportal.info
  providerName: Scholars Portal
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lj9MwELb2IQEXxHMpj8pInEAp3tpxkgNC1YrVgmjpgYrdk-X4wUYN6dImgv4DfjYzdVq1aAWcckg8sfyNPfN57BlCXrDUp9owHXmOYUbpfJRblkQ6BmPPucFQEZ62GMmzifhwHp_vkXV5q3YAF9dSO6wnNZmXvZ_fl29hwr9BxskFf61LvFJ-LHtc9mIg8dk-OQTD1EclH7befliY17su0A0R8ZTJEOe8XsqOpdqv5n7LSP15gPJmU13p5Q9dllvW6fQOud26lXQQ9OAu2XPVPXJj2AbO75NfJ1iFI5x7ozNPR-PhMUUOSgd02IRwPA1XGuiXor6kbb7QkqI32iyoriz91NSgn25Bi4oOTFM7Oly6clZY-tE1U_et0HQc0rQugpCVZGe3__aATE7ffT45i9oiDBHg1K8jy4yPrc6YyLWTvg-Lgs60SKXXMou5yWxiRD_XqfCJB_aVyDxJOefSxcbC5OcPyUE1q9wjQoXFe7rO5swYkXKbOucAEZt7z72M4w5h6wFXps1QjoUySgVMBTFSgJFCjBSXKlaAUYe83DS5Cuk5_vbxc0BRTU2hMKk2Pr_O1HSugDq8V7gZxliHHAVoN-LAvwPKxXiHJDugbz5AWbtvquJylahbZALT8XTIq416_LuXj_-jl0_ILWwTzro9JQf1vHHPwDmq8y7QgotJd6X4XXI4GY0HF78Be3gNWg
linkProvider Scholars Portal
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELe2TgJe-B4LXzIST6B0bu04yQMP1cQ0EC19oGI8WY4_WNSQdG0iNP4C_mx8cVq1EwIh8ZREcS7x5Zy7y939DqGXJLGJVESGlkKYkRsbZprEoYycsqdUQagIsi0m_GzG3p9H53touq6FgbRKWZaOA04ZtJH8jqfHGsDjK6nFQtsWOcKt-TfgdFJGj2UBVeUD3qe8Hzk_Pt1HBxxCTj10MJtMR1-gx9yQspAmbbvNbn_AfKDz9zR2VNV-ubRbWup6BuXNplzIq--yKLbU0-kddLmemM9KmfebOuurH9cwH__nzO-i250ti0de-O6hPVPeRzfGXbT-Afp5Aq0_fLIdriyeTMcDDI4vHuFx43MAsK-jwJ_z-gJ3IKUFBhO4WWFZavyxqd2iMCucl3ikmtrg8ZUpqlzjD6aZm2-5xFOPDbvyRFrKRm_f7SGanb79dHIWdp0fQiccwzrURNlIy5SwTBpuh-5LJFPJEm4lTyOqUh0rNsxkwmxsncsX8yxOKKXcREq7Lw49RL2yKs0RwkxDcbDRGVGKJVQnxhinlHVmLbU8igJE1i9ZqA4WHbpzFMK5R8Bh4TgsgMOCchEJx-EAvdpcsvCYIH8a_MJJjpirXACSN2y_VmK-FM5feSfgDxwhAXrkxWlDzhmVzs8jNEDxjqBtBgCt3TNlftGig7OUAQZQgF5vRPLvT_n4n0Y_Qbfg2KfaPUW9etmYZ842q7Pn3XL7BaarNZY
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Correlation+of+NPM1+Type+A+Mutation+Burden+With+Clinical+Status+and+Outcomes+in+Acute+Myeloid+Leukemia+Patients+With+Mutated+NPM1+Type+A&rft.jtitle=Annals+of+laboratory+medicine&rft.au=%EC%A1%B0%EC%88%98%EC%97%B0&rft.au=%EB%B0%95%EC%83%81%ED%98%81&rft.au=%EA%B9%80%EC%9D%B8%EC%88%99&rft.au=%EC%9D%B4%EC%A2%85%EC%9C%A4&rft.date=2016-09-01&rft.pub=%EB%8C%80%ED%95%9C%EC%A7%84%EB%8B%A8%EA%B2%80%EC%82%AC%EC%9D%98%ED%95%99%ED%9A%8C&rft.issn=2234-3806&rft.eissn=2234-3814&rft.spage=399&rft.epage=404&rft_id=info:doi/10.3343%2Falm.2016.36.5.399&rft.externalDBID=n%2Fa&rft.externalDocID=oai_kci_go_kr_ARTI_142200
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2234-3806&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2234-3806&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2234-3806&client=summon