Results of the Seventh Scientific Workshop of ECCO: Precision Medicine in IBD—Disease Outcome and Response to Therapy

• Published in: Journal of Crohn's and colitis Vol. 15; no. 9; pp. 1431 - 1442
• Main Authors: Verstockt, Bram, Noor, Nurulamin M, Marigorta, Urko M, Pavlidis, Polychronis, Deepak, Parakkal, Ungaro, Ryan C
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 25.09.2021
• Subjects: Algorithms; Biomarkers - metabolism; ECCO Scientific Workshop Papers; Humans; Inflammatory Bowel Diseases - diagnosis; Inflammatory Bowel Diseases - etiology; Inflammatory Bowel Diseases - therapy; Outcome Assessment, Health Care; Precision Medicine; Prognosis; personalised medicine; disease outcome; Precision medicine; inflammatory bowel diseases; disease prognosis; response to therapy
• ISSN: 1873-9946; 1876-4479; 1876-4479
• DOI: 10.1093/ecco-jcc/jjab050

Abstract Inflammatory bowel diseases [IBD] are a heterogeneous spectrum with two extreme phenotypes, Crohn’s disease [CD] and ulcerative colitis [UC], which both represent numerous phenotypical variations. Hence, we should no longer approach all IBD patients similarly, but rather aim to rethink clinical classifications and modify treatment algorithms to usher in a new era of precision medicine in IBD. This scientific ECCO workshop aims to provide a state-of-the-art overview on prognostic and predictive markers, shed light on key questions in biomarker development, propose best practices in IBD biomarker development [including trial design], and discuss the potential for multi-omic data integration to help drive further advances to make precision medicine a reality in IBD.