Intellectual development in preschool children with early treated congenital hypothyroidism
Delayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual outcomes in preschool children with treated CH. We retrospectively reviewed the clinical records of 43 children (age range: 13 to 60 days of life; 22...
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| Published in | Annals of pediatric endocrinology & metabolism Vol. 22; no. 2; pp. 102 - 107 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Society of Pediatric Endocrinology
01.06.2017
Korean Society of Pediatric Endocrinology 대한소아내분비학회 |
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| Online Access | Get full text |
| ISSN | 2287-1012 2287-1292 |
| DOI | 10.6065/apem.2017.22.2.102 |
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| Abstract | Delayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual outcomes in preschool children with treated CH.
We retrospectively reviewed the clinical records of 43 children (age range: 13 to 60 days of life; 22 girls and 21 boys) diagnosed with CH. Children aged 5 to 7 years were examined using the Korean Wechsler Intelligence Scale for Children or the Korean Wechsler Preschool and Primary Scale of Intelligence.
The patients started treatment between 13 and 60 days of age. The mean intelligence quotient (IQ) of patients tested at age 5 to 7 years was 103.14±11.68 (IQ range: 76-126). None had intellectual disability (defined as an IQ <70). Twenty-one subjects were treated with a low dose (6.0-9.9 µg/kg/day) and 22 with a high dose of levothyroxine (10.0-16.0 µg/kg/day). There was no significant difference in the mean full-scale IQ (FSIQ), verbal IQ (VIQ), and performance IQ (PIQ) scores between the 2 groups. FSIQ, PIQ, and VIQ scores were not significantly correlated with initial dose of L-T4, initial fT4, age at treatment in multivariate analysis.
IQ scores of subjects with early treated CH diagnosed through a neonatal screening test were within normal range, regardless of etiology, thyroid function, initial dose of levothyroxine, and age at start of treatment. |
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| AbstractList | Delayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual outcomes in preschool children with treated CH.
We retrospectively reviewed the clinical records of 43 children (age range: 13 to 60 days of life; 22 girls and 21 boys) diagnosed with CH. Children aged 5 to 7 years were examined using the Korean Wechsler Intelligence Scale for Children or the Korean Wechsler Preschool and Primary Scale of Intelligence.
The patients started treatment between 13 and 60 days of age. The mean intelligence quotient (IQ) of patients tested at age 5 to 7 years was 103.14±11.68 (IQ range: 76-126). None had intellectual disability (defined as an IQ <70). Twenty-one subjects were treated with a low dose (6.0-9.9 µg/kg/day) and 22 with a high dose of levothyroxine (10.0-16.0 µg/kg/day). There was no significant difference in the mean full-scale IQ (FSIQ), verbal IQ (VIQ), and performance IQ (PIQ) scores between the 2 groups. FSIQ, PIQ, and VIQ scores were not significantly correlated with initial dose of L-T4, initial fT4, age at treatment in multivariate analysis.
IQ scores of subjects with early treated CH diagnosed through a neonatal screening test were within normal range, regardless of etiology, thyroid function, initial dose of levothyroxine, and age at start of treatment. PurposeDelayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual outcomes in preschool children with treated CH.MethodsWe retrospectively reviewed the clinical records of 43 children (age range: 13 to 60 days of life; 22 girls and 21 boys) diagnosed with CH. Children aged 5 to 7 years were examined using the Korean Wechsler Intelligence Scale for Children or the Korean Wechsler Preschool and Primary Scale of Intelligence.ResultsThe patients started treatment between 13 and 60 days of age. The mean intelligence quotient (IQ) of patients tested at age 5 to 7 years was 103.14±11.68 (IQ range: 76–126). None had intellectual disability (defined as an IQ <70). Twenty-one subjects were treated with a low dose (6.0–9.9 µg/kg/day) and 22 with a high dose of levothyroxine (10.0–16.0 µg/kg/day). There was no significant difference in the mean full-scale IQ (FSIQ), verbal IQ (VIQ), and performance IQ (PIQ) scores between the 2 groups. FSIQ, PIQ, and VIQ scores were not significantly correlated with initial dose of L-T4, initial fT4, age at treatment in multivariate analysis.ConclusionIQ scores of subjects with early treated CH diagnosed through a neonatal screening test were within normal range, regardless of etiology, thyroid function, initial dose of levothyroxine, and age at start of treatment. Delayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual outcomes in preschool children with treated CH.PURPOSEDelayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual outcomes in preschool children with treated CH.We retrospectively reviewed the clinical records of 43 children (age range: 13 to 60 days of life; 22 girls and 21 boys) diagnosed with CH. Children aged 5 to 7 years were examined using the Korean Wechsler Intelligence Scale for Children or the Korean Wechsler Preschool and Primary Scale of Intelligence.METHODSWe retrospectively reviewed the clinical records of 43 children (age range: 13 to 60 days of life; 22 girls and 21 boys) diagnosed with CH. Children aged 5 to 7 years were examined using the Korean Wechsler Intelligence Scale for Children or the Korean Wechsler Preschool and Primary Scale of Intelligence.The patients started treatment between 13 and 60 days of age. The mean intelligence quotient (IQ) of patients tested at age 5 to 7 years was 103.14±11.68 (IQ range: 76-126). None had intellectual disability (defined as an IQ <70). Twenty-one subjects were treated with a low dose (6.0-9.9 µg/kg/day) and 22 with a high dose of levothyroxine (10.0-16.0 µg/kg/day). There was no significant difference in the mean full-scale IQ (FSIQ), verbal IQ (VIQ), and performance IQ (PIQ) scores between the 2 groups. FSIQ, PIQ, and VIQ scores were not significantly correlated with initial dose of L-T4, initial fT4, age at treatment in multivariate analysis.RESULTSThe patients started treatment between 13 and 60 days of age. The mean intelligence quotient (IQ) of patients tested at age 5 to 7 years was 103.14±11.68 (IQ range: 76-126). None had intellectual disability (defined as an IQ <70). Twenty-one subjects were treated with a low dose (6.0-9.9 µg/kg/day) and 22 with a high dose of levothyroxine (10.0-16.0 µg/kg/day). There was no significant difference in the mean full-scale IQ (FSIQ), verbal IQ (VIQ), and performance IQ (PIQ) scores between the 2 groups. FSIQ, PIQ, and VIQ scores were not significantly correlated with initial dose of L-T4, initial fT4, age at treatment in multivariate analysis.IQ scores of subjects with early treated CH diagnosed through a neonatal screening test were within normal range, regardless of etiology, thyroid function, initial dose of levothyroxine, and age at start of treatment.CONCLUSIONIQ scores of subjects with early treated CH diagnosed through a neonatal screening test were within normal range, regardless of etiology, thyroid function, initial dose of levothyroxine, and age at start of treatment. Purpose: Delayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual outcomes in preschool children with treated CH. Methods: We retrospectively reviewed the clinical records of 43 children (age range: 13 to 60 days of life; 22 girls and 21 boys) diagnosed with CH. Children aged 5 to 7 years were examined using the Korean Wechsler Intelligence Scale for Children or the Korean Wechsler Preschool and Primary Scale of Intelligence. Results: The patients started treatment between 13 and 60 days of age. The mean intelligence quotient (IQ) of patients tested at age 5 to 7 years was 103.14±11.68 (IQ range: 76–126). None had intellectual disability (defined as an IQ <70). Twenty-one subjects were treated with a low dose (6.0–9.9 µg/kg/day) and 22 with a high dose of levothyroxine (10.0–16.0 µg/kg/day). There was no significant difference in the mean full-scale IQ (FSIQ), verbal IQ (VIQ), and performance IQ (PIQ) scores between the 2 groups. FSIQ, PIQ, and VIQ scores were not significantly correlated with initial dose of L-T4, initial fT4, age at treatment in multivariate analysis. Conclusion: IQ scores of subjects with early treated CH diagnosed through a neonatal screening test were within normal range, regardless of etiology, thyroid function, initial dose of levothyroxine, and age at start of treatment. KCI Citation Count: 0 |
| Author | Seo, Min Kyoung Yoon, Jong Seo Lee, Hae Sang So, Chul Hwan Hwang, Jin Soon |
| AuthorAffiliation | 1 Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea 2 Department of Pediatrics, Wonkwang University College of Medicine, Wonkwang University Hospital, Iksan, Korea |
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| CitedBy_id | crossref_primary_10_3389_fped_2022_788589 crossref_primary_10_1007_s11356_021_13083_6 crossref_primary_10_13181_mji_v28i4_3473 crossref_primary_10_1210_clinem_dgab412 crossref_primary_10_1080_09297049_2021_1876010 crossref_primary_10_1210_clinem_dgaa901 crossref_primary_10_6065_apem_2244260_130 crossref_primary_10_1007_s12519_019_00230_w crossref_primary_10_1186_s12913_025_12419_z crossref_primary_10_3390_jcm11123427 crossref_primary_10_1002_aur_2247 crossref_primary_10_1159_000492129 crossref_primary_10_1111_apa_17479 |
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| Keywords | Intellectual disability Congenital Hypothyroidism Synthyroid |
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| References | Wechsler (10.6065/apem.2017.22.2.102_ref11) 1989 Kwak (10.6065/apem.2017.22.2.102_ref9) 2002; 15 Léger (10.6065/apem.2017.22.2.102_ref16) 2014; 81 Hsiao (10.6065/apem.2017.22.2.102_ref22) 2001; 100 Dimitropoulos (10.6065/apem.2017.22.2.102_ref14) 2009; 65 Boileau (10.6065/apem.2017.22.2.102_ref4) 2004; 61 Salerno (10.6065/apem.2017.22.2.102_ref5) 2002; 12 Tillotson (10.6065/apem.2017.22.2.102_ref21) 1994; 309 Rovet (10.6065/apem.2017.22.2.102_ref2) 2014; 26 LaFranchi (10.6065/apem.2017.22.2.102_ref20) 2007; 20 MacFaul (10.6065/apem.2017.22.2.102_ref24) 1977; 52 Tuhan (10.6065/apem.2017.22.2.102_ref12) 2016; 29 Kreisner (10.6065/apem.2017.22.2.102_ref3) 2004; 60 Bongers-Schokking (10.6065/apem.2017.22.2.102_ref18) 2005; 147 Bongers-Schokking (10.6065/apem.2017.22.2.102_ref7) 2013; 98 Huo (10.6065/apem.2017.22.2.102_ref6) 2011; 58 Ng (10.6065/apem.2017.22.2.102_ref19) 2009 Kwak (10.6065/apem.2017.22.2.102_ref8) 2002 Rastogi (10.6065/apem.2017.22.2.102_ref13) 2010; 5 Park (10.6065/apem.2017.22.2.102_ref10) 1995 Rovet (10.6065/apem.2017.22.2.102_ref17) 1995; 126 American Academy of Pediatrics (10.6065/apem.2017.22.2.102_ref1) 2006; 117 Kim (10.6065/apem.2017.22.2.102_ref15) 2006; 11 Hulse (10.6065/apem.2017.22.2.102_ref23) 1984; 59 24662106 - Horm Res Paediatr. 2014;81(2):80-103 836070 - Arch Dis Child. 1977 Feb;52(2):87-8 11265259 - J Formos Med Assoc. 2001 Jan;100(1):40-4 14725688 - Clin Endocrinol (Oxf). 2004 Feb;60(2):250-5 15115051 - Horm Res. 2004;61(5):228-33 25231442 - Endocr Dev. 2014;26:26-43 17642417 - J Pediatr Endocrinol Metab. 2007 May;20(5):559-78 7920127 - BMJ. 1994 Aug 13;309(6952):440-5 16356429 - J Pediatr. 2005 Dec;147(6):768-74 11838730 - Thyroid. 2002 Jan;12(1):45-52 20537182 - Orphanet J Rare Dis. 2010 Jun 10;5:17 6198974 - Arch Dis Child. 1984 Jan;59(1):23-9 26244672 - J Pediatr Endocrinol Metab. 2016 Feb;29(2):133-8 18787501 - Pediatr Res. 2009 Feb;65(2):242-8 21467693 - Endocr J. 2011;58(5):355-61 7869196 - J Pediatr. 1995 Mar;126(3):380-6 23979950 - J Clin Endocrinol Metab. 2013 Nov;98(11):4499-506 19160309 - Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006972 16740880 - Pediatrics. 2006 Jun;117(6):2290-303 |
| References_xml | – volume: 60 start-page: 250 year: 2004 ident: 10.6065/apem.2017.22.2.102_ref3 publication-title: Clin Endocrinol (Oxf) doi: 10.1046/j.1365-2265.2004.01974.x – volume: 100 start-page: 40 year: 2001 ident: 10.6065/apem.2017.22.2.102_ref22 publication-title: J Formos Med Assoc – volume: 26 start-page: 26 year: 2014 ident: 10.6065/apem.2017.22.2.102_ref2 publication-title: Endocr Dev doi: 10.1159/000363153 – volume: 98 start-page: 4499 year: 2013 ident: 10.6065/apem.2017.22.2.102_ref7 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2013-2175 – volume-title: Korean-Wechsler preschool and primary scale of intelligence year: 1995 ident: 10.6065/apem.2017.22.2.102_ref10 – start-page: CD006972 issue: 1 year: 2009 ident: 10.6065/apem.2017.22.2.102_ref19 publication-title: Cochrane Database Syst Rev – volume: 65 start-page: 242 year: 2009 ident: 10.6065/apem.2017.22.2.102_ref14 publication-title: Pediatr Res doi: 10.1203/PDR.0b013e31818d2030 – volume: 5 start-page: 17 year: 2010 ident: 10.6065/apem.2017.22.2.102_ref13 publication-title: Orphanet J Rare Dis doi: 10.1186/1750-1172-5-17 – volume: 29 start-page: 133 year: 2016 ident: 10.6065/apem.2017.22.2.102_ref12 publication-title: J Pediatr Endocrinol Metab doi: 10.1515/jpem-2015-0047 – volume: 309 start-page: 440 year: 1994 ident: 10.6065/apem.2017.22.2.102_ref21 publication-title: BMJ doi: 10.1136/bmj.309.6952.440 – volume: 12 start-page: 45 year: 2002 ident: 10.6065/apem.2017.22.2.102_ref5 publication-title: Thyroid doi: 10.1089/105072502753451968 – volume: 11 start-page: 45 year: 2006 ident: 10.6065/apem.2017.22.2.102_ref15 publication-title: J Korean Soc Pediatr Endocrinol – volume: 15 start-page: 19 year: 2002 ident: 10.6065/apem.2017.22.2.102_ref9 publication-title: Korean J Dev Psychol – volume: 147 start-page: 768 year: 2005 ident: 10.6065/apem.2017.22.2.102_ref18 publication-title: J Pediatr doi: 10.1016/j.jpeds.2005.09.031 – volume-title: Wechsler preschool and primary scale of intelligence year: 1989 ident: 10.6065/apem.2017.22.2.102_ref11 – volume: 81 start-page: 80 year: 2014 ident: 10.6065/apem.2017.22.2.102_ref16 publication-title: Horm Res Paediatr doi: 10.1159/000358198 – volume: 61 start-page: 228 year: 2004 ident: 10.6065/apem.2017.22.2.102_ref4 publication-title: Horm Res – volume: 117 start-page: 2290 year: 2006 ident: 10.6065/apem.2017.22.2.102_ref1 publication-title: Pediatrics doi: 10.1542/peds.2006-0915 – volume-title: The manual for the Korean WISC-III year: 2002 ident: 10.6065/apem.2017.22.2.102_ref8 – volume: 126 start-page: 380 year: 1995 ident: 10.6065/apem.2017.22.2.102_ref17 publication-title: J Pediatr doi: 10.1016/S0022-3476(95)70452-3 – volume: 58 start-page: 355 year: 2011 ident: 10.6065/apem.2017.22.2.102_ref6 publication-title: Endocr J doi: 10.1507/endocrj.K10E-384 – volume: 52 start-page: 87 year: 1977 ident: 10.6065/apem.2017.22.2.102_ref24 publication-title: Arch Dis Child doi: 10.1136/adc.52.2.87 – volume: 20 start-page: 559 year: 2007 ident: 10.6065/apem.2017.22.2.102_ref20 publication-title: J Pediatr Endocrinol Metab doi: 10.1515/JPEM.2007.20.5.559 – volume: 59 start-page: 23 year: 1984 ident: 10.6065/apem.2017.22.2.102_ref23 publication-title: Arch Dis Child doi: 10.1136/adc.59.1.23 – reference: 836070 - Arch Dis Child. 1977 Feb;52(2):87-8 – reference: 15115051 - Horm Res. 2004;61(5):228-33 – reference: 11838730 - Thyroid. 2002 Jan;12(1):45-52 – reference: 7869196 - J Pediatr. 1995 Mar;126(3):380-6 – reference: 11265259 - J Formos Med Assoc. 2001 Jan;100(1):40-4 – reference: 25231442 - Endocr Dev. 2014;26:26-43 – reference: 20537182 - Orphanet J Rare Dis. 2010 Jun 10;5:17 – reference: 26244672 - J Pediatr Endocrinol Metab. 2016 Feb;29(2):133-8 – reference: 18787501 - Pediatr Res. 2009 Feb;65(2):242-8 – reference: 23979950 - J Clin Endocrinol Metab. 2013 Nov;98(11):4499-506 – reference: 17642417 - J Pediatr Endocrinol Metab. 2007 May;20(5):559-78 – reference: 19160309 - Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006972 – reference: 21467693 - Endocr J. 2011;58(5):355-61 – reference: 6198974 - Arch Dis Child. 1984 Jan;59(1):23-9 – reference: 16356429 - J Pediatr. 2005 Dec;147(6):768-74 – reference: 14725688 - Clin Endocrinol (Oxf). 2004 Feb;60(2):250-5 – reference: 24662106 - Horm Res Paediatr. 2014;81(2):80-103 – reference: 16740880 - Pediatrics. 2006 Jun;117(6):2290-303 – reference: 7920127 - BMJ. 1994 Aug 13;309(6952):440-5 |
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| Snippet | Delayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual outcomes... PurposeDelayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual... Purpose: Delayed treatment of congenital hypothyroidism (CH) is a common cause of mental retardation. The aim of the present study was to evaluate intellectual... |
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| SubjectTerms | Congenital Hypothyroidism Intellectual disability Original Synthyroid 소아과학 |
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| Title | Intellectual development in preschool children with early treated congenital hypothyroidism |
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| ispartofPNX | Annals of Pediatric Endocrinology & Metabolism, 2017, 22(2), , pp.102-107 |
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