Gene Profile of Adipose Tissue of Patients with Pheochromocytoma/Paraganglioma
Background: Brown adipose tissue (BAT) is a therapeutic target to combat obesity and related disorders. Pheochromocytoma and functional paraganglioma (PPGL) are associated with activated BAT due to catecholamine excess. Our aim was to evaluate BAT activity by gene profile and assess its relation to...
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| Published in | Biomedicines Vol. 10; no. 3; p. 586 |
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| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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02.03.2022
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| Online Access | Get full text |
| ISSN | 2227-9059 2227-9059 |
| DOI | 10.3390/biomedicines10030586 |
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| Abstract | Background: Brown adipose tissue (BAT) is a therapeutic target to combat obesity and related disorders. Pheochromocytoma and functional paraganglioma (PPGL) are associated with activated BAT due to catecholamine excess. Our aim was to evaluate BAT activity by gene profile and assess its relation to clinical characteristics and overproduced catecholamine. Methods: mRNA expression of 15 genes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was measured via RT-PCR in 25 patients with PPGL and 14 controls undergoing cholecystectomy. Results: We found in VAT of PPGL higher expression of UCP1 (p < 0.001), CEBPB, PPARGC1A (both p < 0.001), PRDM16 (p = 0.069) and DIO2 (p = 0.005). UCP1 expression correlated only with norepinephrine levels and its metabolite. UCP1 expression, among others, correlated negatively with BMI, age and positively with HDLc levels. Dominance of BAT or BeAT markers was not assessed in PPGL. In SAT of PPGL, we found higher expression of ADRB3, CIDEA (both p < 0.05), and PPARGC1A (p = 0.001), but not UCP1. Conclusion: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels. However, no direct relationship with increased basal energy metabolism measured by calorimetry was found. |
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| AbstractList | Background: Brown adipose tissue (BAT) is a therapeutic target to combat obesity and related disorders. Pheochromocytoma and functional paraganglioma (PPGL) are associated with activated BAT due to catecholamine excess. Our aim was to evaluate BAT activity by gene profile and assess its relation to clinical characteristics and overproduced catecholamine. Methods: mRNA expression of 15 genes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was measured via RT-PCR in 25 patients with PPGL and 14 controls undergoing cholecystectomy. Results: We found in VAT of PPGL higher expression of UCP1 (p < 0.001), CEBPB, PPARGC1A (both p < 0.001), PRDM16 (p = 0.069) and DIO2 (p = 0.005). UCP1 expression correlated only with norepinephrine levels and its metabolite. UCP1 expression, among others, correlated negatively with BMI, age and positively with HDLc levels. Dominance of BAT or BeAT markers was not assessed in PPGL. In SAT of PPGL, we found higher expression of ADRB3, CIDEA (both p < 0.05), and PPARGC1A (p = 0.001), but not UCP1. Conclusion: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels. However, no direct relationship with increased basal energy metabolism measured by calorimetry was found. Background: Brown adipose tissue (BAT) is a therapeutic target to combat obesity and related disorders. Pheochromocytoma and functional paraganglioma (PPGL) are associated with activated BAT due to catecholamine excess. Our aim was to evaluate BAT activity by gene profile and assess its relation to clinical characteristics and overproduced catecholamine. Methods: mRNA expression of 15 genes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was measured via RT-PCR in 25 patients with PPGL and 14 controls undergoing cholecystectomy. Results: We found in VAT of PPGL higher expression of UCP1 ( p < 0.001), CEBPB , PPARGC1A (both p < 0.001), PRDM16 ( p = 0.069) and DIO2 ( p = 0.005). UCP1 expression correlated only with norepinephrine levels and its metabolite. UCP1 expression, among others, correlated negatively with BMI, age and positively with HDLc levels. Dominance of BAT or BeAT markers was not assessed in PPGL. In SAT of PPGL, we found higher expression of ADRB3 , CIDEA (both p < 0.05), and PPARGC1A ( p = 0.001), but not UCP1 . Conclusion: We demonstrate signs of UCP1 -dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2 , PPARGC1A , CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels. However, no direct relationship with increased basal energy metabolism measured by calorimetry was found. Background: Brown adipose tissue (BAT) is a therapeutic target to combat obesity and related disorders. Pheochromocytoma and functional paraganglioma (PPGL) are associated with activated BAT due to catecholamine excess. Our aim was to evaluate BAT activity by gene profile and assess its relation to clinical characteristics and overproduced catecholamine. Methods: mRNA expression of 15 genes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was measured via RT-PCR in 25 patients with PPGL and 14 controls undergoing cholecystectomy. Results: We found in VAT of PPGL higher expression of UCP1 (p < 0.001), CEBPB, PPARGC1A (both p < 0.001), PRDM16 (p = 0.069) and DIO2 (p = 0.005). UCP1 expression correlated only with norepinephrine levels and its metabolite. UCP1 expression, among others, correlated negatively with BMI, age and positively with HDLc levels. Dominance of BAT or BeAT markers was not assessed in PPGL. In SAT of PPGL, we found higher expression of ADRB3, CIDEA (both p < 0.05), and PPARGC1A (p = 0.001), but not UCP1. Conclusion: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels. However, no direct relationship with increased basal energy metabolism measured by calorimetry was found.Background: Brown adipose tissue (BAT) is a therapeutic target to combat obesity and related disorders. Pheochromocytoma and functional paraganglioma (PPGL) are associated with activated BAT due to catecholamine excess. Our aim was to evaluate BAT activity by gene profile and assess its relation to clinical characteristics and overproduced catecholamine. Methods: mRNA expression of 15 genes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was measured via RT-PCR in 25 patients with PPGL and 14 controls undergoing cholecystectomy. Results: We found in VAT of PPGL higher expression of UCP1 (p < 0.001), CEBPB, PPARGC1A (both p < 0.001), PRDM16 (p = 0.069) and DIO2 (p = 0.005). UCP1 expression correlated only with norepinephrine levels and its metabolite. UCP1 expression, among others, correlated negatively with BMI, age and positively with HDLc levels. Dominance of BAT or BeAT markers was not assessed in PPGL. In SAT of PPGL, we found higher expression of ADRB3, CIDEA (both p < 0.05), and PPARGC1A (p = 0.001), but not UCP1. Conclusion: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels. However, no direct relationship with increased basal energy metabolism measured by calorimetry was found. |
| Author | Petrák, Ondřej Michalský, David Widimský, Jiří Kratochvílová, Helena Haluzíková, Denisa Zelinka, Tomáš Lacinová, Zdeňka Doležalová, Radka Petráková Novák, Květoslav Kvasnička, Jan Holaj, Robert Todorovová, Veronika Haluzík, Martin Klímová, Judita Mráz, Miloš Zítek, Matěj Krátká, Zuzana |
| AuthorAffiliation | 1 Center of Hypertension, 3rd Department of Medicine, First Faculty of Medicine and General Faculty Hospital, Charles University, 128 00 Prague, Czech Republic; judita.klimova@vfn.cz (J.K.); jan.kvasnicka3@vfn.cz (J.K.); robert.holaj@vfn.cz (R.H.); matej.zitek@vfn.cz (M.Z.); zuzana.kratka@vfn.cz (Z.K.); jwidi@lf1.cuni.cz (J.W.J.); tzeli@lf1.cuni.cz (T.Z.) 3 Institute for Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General Faculty Hospital, Charles University, 128 00 Prague, Czech Republic; krth@ikem.cz 4 Department of Urology, First Faculty of Medicine and General Faculty Hospital, Charles University, 128 00 Prague, Czech Republic; kvetoslav.novak@vfn.cz 6 Institute of Sport Medicine, First Faculty of Medicine and General Faculty Hospital, Charles University, 128 00 Prague, Czech Republic; denisa.haluzikova@lf1.cuni.cz (D.H.); radka.petrakovadolezalova@vfn.cz (R.P.D.) 7 Laboratory of Endocrinology and Metabolism, 3rd Department of Medicine, First Faculty |
| AuthorAffiliation_xml | – name: 1 Center of Hypertension, 3rd Department of Medicine, First Faculty of Medicine and General Faculty Hospital, Charles University, 128 00 Prague, Czech Republic; judita.klimova@vfn.cz (J.K.); jan.kvasnicka3@vfn.cz (J.K.); robert.holaj@vfn.cz (R.H.); matej.zitek@vfn.cz (M.Z.); zuzana.kratka@vfn.cz (Z.K.); jwidi@lf1.cuni.cz (J.W.J.); tzeli@lf1.cuni.cz (T.Z.) – name: 5 First Department of Surgery, First Faculty of Medicine and General Faculty Hospital, Charles University, 128 00 Prague, Czech Republic; david.michalsky@vfn.cz – name: 3 Institute for Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine and General Faculty Hospital, Charles University, 128 00 Prague, Czech Republic; krth@ikem.cz – name: 6 Institute of Sport Medicine, First Faculty of Medicine and General Faculty Hospital, Charles University, 128 00 Prague, Czech Republic; denisa.haluzikova@lf1.cuni.cz (D.H.); radka.petrakovadolezalova@vfn.cz (R.P.D.) – name: 2 Center for Experimental Medicine and Diabetes Center, Institute for Clinical and Experimental Medicine, 140 00 Prague, Czech Republic; milos_mraz@yahoo.co.uk (M.M.); lacz@ikem.cz (Z.L.); mhalu@lf1.cuni.cz (M.H.) – name: 4 Department of Urology, First Faculty of Medicine and General Faculty Hospital, Charles University, 128 00 Prague, Czech Republic; kvetoslav.novak@vfn.cz – name: 7 Laboratory of Endocrinology and Metabolism, 3rd Department of Medicine, First Faculty of Medicine and General Faculty Hospital, Charles University, 128 00 Prague, Czech Republic; veronika.todorovova@vfn.cz |
| Author_xml | – sequence: 1 givenname: Judita orcidid: 0000-0002-0088-0277 surname: Klímová fullname: Klímová, Judita – sequence: 2 givenname: Miloš surname: Mráz fullname: Mráz, Miloš – sequence: 3 givenname: Helena surname: Kratochvílová fullname: Kratochvílová, Helena – sequence: 4 givenname: Zdeňka surname: Lacinová fullname: Lacinová, Zdeňka – sequence: 5 givenname: Květoslav surname: Novák fullname: Novák, Květoslav – sequence: 6 givenname: David surname: Michalský fullname: Michalský, David – sequence: 7 givenname: Jan surname: Kvasnička fullname: Kvasnička, Jan – sequence: 8 givenname: Robert surname: Holaj fullname: Holaj, Robert – sequence: 9 givenname: Denisa surname: Haluzíková fullname: Haluzíková, Denisa – sequence: 10 givenname: Radka Petráková surname: Doležalová fullname: Doležalová, Radka Petráková – sequence: 11 givenname: Matěj surname: Zítek fullname: Zítek, Matěj – sequence: 12 givenname: Zuzana surname: Krátká fullname: Krátká, Zuzana – sequence: 13 givenname: Veronika surname: Todorovová fullname: Todorovová, Veronika – sequence: 14 givenname: Jiří surname: Widimský fullname: Widimský, Jiří – sequence: 15 givenname: Martin surname: Haluzík fullname: Haluzík, Martin – sequence: 16 givenname: Tomáš surname: Zelinka fullname: Zelinka, Tomáš – sequence: 17 givenname: Ondřej orcidid: 0000-0001-8992-3562 surname: Petrák fullname: Petrák, Ondřej |
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| CitedBy_id | crossref_primary_10_1016_j_isci_2023_106847 crossref_primary_10_3390_biomedicines10081980 crossref_primary_10_1097_MD_0000000000037916 |
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| Keywords | beige adipose tissue lipids brown adipose tissue pheochromocytoma metabolism energy metabolism functional paraganglioma gene expression |
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| Title | Gene Profile of Adipose Tissue of Patients with Pheochromocytoma/Paraganglioma |
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