First-in-Human Evaluation of Positron Emission Tomography/Computed Tomography With [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas - Fujimoto, Hiroyuki; Fujita, Naotaka; Hamamatsu, Keita; Murakami, Takaaki; Nakamoto, Yuji; Saga, Tsuneo; Ishimori, Takayoshi; Shimizu, Yoichi; Watanabe, Hiroyuki; Sano, Kohei; Harada, Norio; Nakamura, Hiroshi; et al. (Frontiers in endocrinology (Lausanne), 2021)
Keywords: Adult; Blood Glucose - analysis; Endocrinology; Exenatide - metabolism; exendin-4; first-in-human study; Fluorine Radioisotopes - pharmacokinetics; glucagon-like peptide-1 receptor (GLP-1R); Glucagon-Like Peptide-1 Receptor - metabolism; Healthy Volunteers; Humans; Male; Pancreas - diagnostic imaging; Pancreas - metabolism; PET; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals - pharmacokinetics; Tissue Distribution; Young Adult; β-cell imaging; β-cell imaging; glucagon-like peptide-1 receptor (GLP-1R); exendin-4; first-in-human study; PET