Individual electric field predicts functional connectivity changes after anodal transcranial direct-current stimulation in chronic stroke

• Published in: Neuroscience research Vol. 186; pp. 21 - 32
• Main Authors: Yuan, Kai, Ti, Chun-hang Eden, Wang, Xin, Chen, Cheng, Lau, Cathy Choi-yin, Chu, Winnie Chiu-wing, Tong, Raymond Kai-yu
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.01.2023
• Subjects: Electric field modeling; Functional connectivity; Functional magnetic resonance imaging; Humans; Motor Cortex - physiology; Stroke; Stroke - complications; Stroke - therapy; Stroke Rehabilitation; Transcranial direct current stimulation; Transcranial Direct Current Stimulation - methods; Functional connectivity; EF; Stroke; M1; GM; Electric field modeling; Transcranial direct current stimulation; FEM; fMRI; tDCS; WM; CSF; Functional magnetic resonance imaging; MEP; BOLD; FMA; TMS; VIP; FC; PLSR
• ISSN: 0168-0102; 1872-8111; 1872-8111
• DOI: 10.1016/j.neures.2022.10.003

The neuromodulation effect of anodal tDCS is not thoroughly studied, and the heterogeneous profile of stroke individuals with brain lesions would further complicate the stimulation outcomes. This study aimed to investigate the functional changes in sensorimotor areas induced by anodal tDCS and whether individual electric field could predict the functional outcomes. Twenty-five chronic stroke survivors were recruited and divided into tDCS group (n = 12) and sham group (n = 13). Increased functional connectivity (FC) within the surrounding areas of ipsilesional primary motor cortex (M1) was only observed after anodal tDCS. Averaged FC among the ipsilesional sensorimotor regions was observed to be increased after anodal tDCS (t(11) = 2.57, p = 0.026), but not after sham tDCS (t(12) = 0.69, p = 0.50). Partial least square analysis identified positive correlations between electric field (EF) strength normal to the ipsilesional M1 surface and individual FC changes in tDCS group (r = 0.84, p < 0.001) but not in sham group (r = 0.21, p = 0.5). Our results indicated anodal tDCS facilitates the FC within the ipsilesional sensorimotor network in chronic stroke subjects, and individual electric field predicts the functional outcomes. •tDCS facilitates intra-hemispheric functional reorganization in chronic stroke.•Individualized electric field model predicts tDCS-induced outcomes.•tDCS as a potential intervention for post-stroke motor rehabilitation.