Detection of SARS-CoV-2 in Human Retinal Biopsies of Deceased COVID-19 Patients

To report the presence of viral ribonucleic acid (RNA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human retina in deceased patients with confirmed novel coronavirus disease 2019 (COVID-19). Fourteen eyes of 14 deceased patients with confirmed COVID-19 disease were enucleated...

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Published inOcular immunology and inflammation Vol. 28; no. 5; pp. 721 - 725
Main Authors Casagrande, Maria, Fitzek, Antonia, Püschel, Klaus, Aleshcheva, Ganna, Schultheiss, Heinz-Peter, Berneking, Laura, Spitzer, Martin S., Schultheiss, Maximilian
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.07.2020
Subjects
ACE-2
Aged
Aged, 80 and over
Autopsy
Betacoronavirus - genetics
Betacoronavirus - isolation & purification
Biopsy
Clinical Laboratory Techniques
Coronavirus Infections - diagnosis
Coronavirus Infections - mortality
Coronavirus Infections - virology
COVID-19
COVID-19 Testing
COVID-19 Vaccines
Eye Enucleation
Eye Infections, Viral - mortality
Eye Infections, Viral - virology
Female
Humans
Male
Middle Aged
Pandemics
Pneumonia, Viral - mortality
Pneumonia, Viral - virology
Prospective Studies
Real-Time Polymerase Chain Reaction
retina
Retinal Diseases - mortality
Retinal Diseases - virology
RNA, Viral - genetics
RT-PCR
SARS-CoV-2
COVID-19
SARS-CoV-2
ACE-2
retina
autopsy
RT-PCR
Online AccessGet full text
ISSN0927-3948
1744-5078
1744-5078
DOI10.1080/09273948.2020.1770301

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Abstract To report the presence of viral ribonucleic acid (RNA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human retina in deceased patients with confirmed novel coronavirus disease 2019 (COVID-19). Fourteen eyes of 14 deceased patients with confirmed COVID-19 disease were enucleated during autopsy. A sample of human retina was secured and fixed in RNAlater™. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was performed to detect three different viral RNA sequences (RdRp-gene, E-gene and Orf1 gene) of SARS-CoV-2. In three out of 14 eyes SARS-CoV-2 viral RNA was detected in the retina of deceased COVID-19 patients. As analysis for three different sequences (RdRp-gene, E-gene and Orf1 gene) revealed positive results in RT-PCR, the existence of SARS-CoV-2 viral RNA in human retina is proven according to the standards of the World-Health-Organization. Viral RNA of SARS-CoV-2 is detectable in the retina of COVID-19 patients.
AbstractList To report the presence of viral ribonucleic acid (RNA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human retina in deceased patients with confirmed novel coronavirus disease 2019 (COVID-19).PURPOSETo report the presence of viral ribonucleic acid (RNA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human retina in deceased patients with confirmed novel coronavirus disease 2019 (COVID-19).Fourteen eyes of 14 deceased patients with confirmed COVID-19 disease were enucleated during autopsy. A sample of human retina was secured and fixed in RNAlater™. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was performed to detect three different viral RNA sequences (RdRp-gene, E-gene and Orf1 gene) of SARS-CoV-2.PATIENTS AND METHODSFourteen eyes of 14 deceased patients with confirmed COVID-19 disease were enucleated during autopsy. A sample of human retina was secured and fixed in RNAlater™. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was performed to detect three different viral RNA sequences (RdRp-gene, E-gene and Orf1 gene) of SARS-CoV-2.In three out of 14 eyes SARS-CoV-2 viral RNA was detected in the retina of deceased COVID-19 patients. As analysis for three different sequences (RdRp-gene, E-gene and Orf1 gene) revealed positive results in RT-PCR, the existence of SARS-CoV-2 viral RNA in human retina is proven according to the standards of the World-Health-Organization.RESULTSIn three out of 14 eyes SARS-CoV-2 viral RNA was detected in the retina of deceased COVID-19 patients. As analysis for three different sequences (RdRp-gene, E-gene and Orf1 gene) revealed positive results in RT-PCR, the existence of SARS-CoV-2 viral RNA in human retina is proven according to the standards of the World-Health-Organization.Viral RNA of SARS-CoV-2 is detectable in the retina of COVID-19 patients.CONCLUSIONViral RNA of SARS-CoV-2 is detectable in the retina of COVID-19 patients.
To report the presence of viral ribonucleic acid (RNA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human retina in deceased patients with confirmed novel coronavirus disease 2019 (COVID-19). Fourteen eyes of 14 deceased patients with confirmed COVID-19 disease were enucleated during autopsy. A sample of human retina was secured and fixed in RNAlater™. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was performed to detect three different viral RNA sequences (RdRp-gene, E-gene and Orf1 gene) of SARS-CoV-2. In three out of 14 eyes SARS-CoV-2 viral RNA was detected in the retina of deceased COVID-19 patients. As analysis for three different sequences (RdRp-gene, E-gene and Orf1 gene) revealed positive results in RT-PCR, the existence of SARS-CoV-2 viral RNA in human retina is proven according to the standards of the World-Health-Organization. Viral RNA of SARS-CoV-2 is detectable in the retina of COVID-19 patients.
Author Schultheiss, Maximilian
Casagrande, Maria
Aleshcheva, Ganna
Püschel, Klaus
Schultheiss, Heinz-Peter
Berneking, Laura
Spitzer, Martin S.
Fitzek, Antonia
Author_xml – sequence: 1
  givenname: Maria
  orcidid: 0000-0002-7529-2883
  surname: Casagrande
  fullname: Casagrande, Maria
  email: m.casagrande@uke.de
  organization: University Medical Center Hamburg-Eppendorf (UKE)
– sequence: 2
  givenname: Antonia
  surname: Fitzek
  fullname: Fitzek, Antonia
  organization: University Medical Center Hamburg-Eppendorf (UKE)
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  givenname: Klaus
  surname: Püschel
  fullname: Püschel, Klaus
  organization: University Medical Center Hamburg-Eppendorf (UKE)
– sequence: 4
  givenname: Ganna
  surname: Aleshcheva
  fullname: Aleshcheva, Ganna
  organization: Institute for Cardiac Diagnostics and Therapy
– sequence: 5
  givenname: Heinz-Peter
  surname: Schultheiss
  fullname: Schultheiss, Heinz-Peter
  organization: Institute for Cardiac Diagnostics and Therapy
– sequence: 6
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  surname: Berneking
  fullname: Berneking, Laura
  organization: Medical Center Hamburg-Eppendorf (UKE)
– sequence: 7
  givenname: Martin S.
  surname: Spitzer
  fullname: Spitzer, Martin S.
  organization: University Medical Center Hamburg-Eppendorf (UKE)
– sequence: 8
  givenname: Maximilian
  orcidid: 0000-0002-6537-3153
  surname: Schultheiss
  fullname: Schultheiss, Maximilian
  organization: University Medical Center Hamburg-Eppendorf (UKE)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32469258$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1167/iovs.06-1024
10.2807/1560-7917.ES.2020.25.9.2000152
10.1001/jamaophthalmol.2020.1294
10.1001/jamaophthalmol.2020.1291
10.1136/bjophthalmol-2020-316304
10.1080/02713680490517944
10.1080/09273948.2020.1738501
10.1161/01.RES.87.5.e1
10.1186/s12974-016-0489-7
10.1001/jama.2020.3786
10.1038/s41598-017-05882-0
10.1038/s41598-019-51379-3
10.1128/JVI.00127-20
10.1016/S0140-6736(20)30183-5
10.2174/1874364101509010028
10.1016/j.ijantimicag.2020.105924
10.1074/jbc.M002615200
10.1016/j.ophtha.2020.03.026
10.1038/nature02145
10.1038/s41564-020-0688-y
10.1089/jop.2008.0081
10.1001/jama.2020.3204
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Issue 5
Keywords COVID-19
SARS-CoV-2
ACE-2
retina
autopsy
RT-PCR
Language English
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PublicationTitle Ocular immunology and inflammation
PublicationTitleAlternate Ocul Immunol Inflamm
PublicationYear 2020
Publisher Taylor & Francis
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References cit0011
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Victor Corman TB (cit0015) 2020
Casto AM (cit0012) 2020; 221
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  doi: 10.1167/iovs.06-1024
– ident: cit0013
  doi: 10.2807/1560-7917.ES.2020.25.9.2000152
– ident: cit0007
  doi: 10.1001/jamaophthalmol.2020.1294
– ident: cit0005
  doi: 10.1001/jamaophthalmol.2020.1291
– ident: cit0006
  doi: 10.1136/bjophthalmol-2020-316304
– ident: cit0010
  doi: 10.1080/02713680490517944
– ident: cit0014
  doi: 10.1080/09273948.2020.1738501
– volume: 323
  start-page: 1843
  issue: 18
  year: 2020
  ident: cit0022
  publication-title: Jama
– ident: cit0019
  doi: 10.1161/01.RES.87.5.e1
– ident: cit0021
  doi: 10.1186/s12974-016-0489-7
– ident: cit0003
  doi: 10.1001/jama.2020.3786
– ident: cit0024
  doi: 10.1038/s41598-017-05882-0
– ident: cit0025
  doi: 10.1038/s41598-019-51379-3
– ident: cit0004
  doi: 10.1128/JVI.00127-20
– ident: cit0002
  doi: 10.1016/S0140-6736(20)30183-5
– ident: cit0020
  doi: 10.2174/1874364101509010028
– ident: cit0001
  doi: 10.1016/j.ijantimicag.2020.105924
– volume: 221
  start-page: 1271
  issue: 8
  year: 2020
  ident: cit0012
  publication-title: The Journal of infectious diseases
– ident: cit0018
  doi: 10.1074/jbc.M002615200
– ident: cit0008
  doi: 10.1016/j.ophtha.2020.03.026
– ident: cit0016
  doi: 10.1038/nature02145
– ident: cit0017
  doi: 10.1038/s41564-020-0688-y
– ident: cit0009
  doi: 10.1089/jop.2008.0081
– volume-title: Sebastian Brünink, Christian Drosten. Diagnostic detection of Wuhan coronavirus 2019 by real-time RTPCR -Protocol and preliminary evaluation as of Jan 13
  year: 2020
  ident: cit0015
– ident: cit0023
  doi: 10.1001/jama.2020.3204
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Snippet To report the presence of viral ribonucleic acid (RNA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human retina in deceased patients...
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SubjectTerms ACE-2
Aged
Aged, 80 and over
Autopsy
Betacoronavirus - genetics
Betacoronavirus - isolation & purification
Biopsy
Clinical Laboratory Techniques
Coronavirus Infections - diagnosis
Coronavirus Infections - mortality
Coronavirus Infections - virology
COVID-19
COVID-19 Testing
COVID-19 Vaccines
Eye Enucleation
Eye Infections, Viral - mortality
Eye Infections, Viral - virology
Female
Humans
Male
Middle Aged
Pandemics
Pneumonia, Viral - mortality
Pneumonia, Viral - virology
Prospective Studies
Real-Time Polymerase Chain Reaction
retina
Retinal Diseases - mortality
Retinal Diseases - virology
RNA, Viral - genetics
RT-PCR
SARS-CoV-2
Title Detection of SARS-CoV-2 in Human Retinal Biopsies of Deceased COVID-19 Patients
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