Large Field of View Corneal Epithelium and Bowman's Layer Thickness Maps in Keratoconic and Healthy Eyes
To assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes. Cross-sectional study. Setting: institutional. Study population: 47 patients (1 eye) with keratoconus (KC) and 20 healthy subjects (1 eye). Observation procedure...
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| Published in | American journal of ophthalmology Vol. 209; pp. 168 - 177 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.01.2020
Elsevier Limited |
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| Online Access | Get full text |
| ISSN | 0002-9394 1879-1891 1879-1891 |
| DOI | 10.1016/j.ajo.2019.05.025 |
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| Abstract | To assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes.
Cross-sectional study.
Setting: institutional. Study population: 47 patients (1 eye) with keratoconus (KC) and 20 healthy subjects (1 eye). Observation procedure: epithelium and Bowman's layer measurements were performed by using custom-designed polarization-sensitive optical coherence tomography (PS-OCT) with a conical scanning optics design. En face corneal ET and BLT maps with a diameter of 11 mm were computed. Main outcome measurements were mean ET and BLT of 25 sectors; the thinnest (minET, minBLT) and thickest sectors (maxET, maxBLT) were assessed. Ratios between thinnest/thickest sectors (R1) and between mean ET and BLT of the inferior temporal quadrant/superior nasal quadrant (R2) were calculated (R1ET, R1BLT; R2ET, R2BLT). Receiver operator characteristic (ROC) curve analysis was used to assess the diagnostic power of statistically different parameters.
In healthy eyes, smooth ET maps were observed. KC eyes showed a “doughnut pattern.” The BLT maps of healthy eyes had a smooth appearance, but highly irregular “moth”-like damage pattern could be observed in keratoconic eyes. Highest area under the curve values were found for the thinnest sector of the BLT map, the R1ET, and the thinnest sector of the ET map.
PS-OCT imaging enables the visualization of significant differences of the corneal epithelium and the Bowman's layer in en face maps covering almost the entire cornea. ET and BLT profiles could clearly show their diagnostic importance for the distinguishing of keratoconic eyes and healthy eyes. |
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| AbstractList | To assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes.
Cross-sectional study.
Setting: institutional. Study population: 47 patients (1 eye) with keratoconus (KC) and 20 healthy subjects (1 eye). Observation procedure: epithelium and Bowman's layer measurements were performed by using custom-designed polarization-sensitive optical coherence tomography (PS-OCT) with a conical scanning optics design. En face corneal ET and BLT maps with a diameter of 11 mm were computed. Main outcome measurements were mean ET and BLT of 25 sectors; the thinnest (minET, minBLT) and thickest sectors (maxET, maxBLT) were assessed. Ratios between thinnest/thickest sectors (R1) and between mean ET and BLT of the inferior temporal quadrant/superior nasal quadrant (R2) were calculated (R1ET, R1BLT; R2ET, R2BLT). Receiver operator characteristic (ROC) curve analysis was used to assess the diagnostic power of statistically different parameters.
In healthy eyes, smooth ET maps were observed. KC eyes showed a “doughnut pattern.” The BLT maps of healthy eyes had a smooth appearance, but highly irregular “moth”-like damage pattern could be observed in keratoconic eyes. Highest area under the curve values were found for the thinnest sector of the BLT map, the R1ET, and the thinnest sector of the ET map.
PS-OCT imaging enables the visualization of significant differences of the corneal epithelium and the Bowman's layer in en face maps covering almost the entire cornea. ET and BLT profiles could clearly show their diagnostic importance for the distinguishing of keratoconic eyes and healthy eyes. To assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes.PURPOSETo assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes.Cross-sectional study.DESIGNCross-sectional study.Setting: institutional.METHODSSetting: institutional.47 patients (1 eye) with keratoconus (KC) and 20 healthy subjects (1 eye).STUDY POPULATION47 patients (1 eye) with keratoconus (KC) and 20 healthy subjects (1 eye).epithelium and Bowman's layer measurements were performed by using custom-designed polarization-sensitive optical coherence tomography (PS-OCT) with a conical scanning optics design. En face corneal ET and BLT maps with a diameter of 11 mm were computed. Main outcome measurements were mean ET and BLT of 25 sectors; the thinnest (minET, minBLT) and thickest sectors (maxET, maxBLT) were assessed. Ratios between thinnest/thickest sectors (R1) and between mean ET and BLT of the inferior temporal quadrant/superior nasal quadrant (R2) were calculated (R1ET, R1BLT; R2ET, R2BLT). Receiver operator characteristic (ROC) curve analysis was used to assess the diagnostic power of statistically different parameters.OBSERVATION PROCEDUREepithelium and Bowman's layer measurements were performed by using custom-designed polarization-sensitive optical coherence tomography (PS-OCT) with a conical scanning optics design. En face corneal ET and BLT maps with a diameter of 11 mm were computed. Main outcome measurements were mean ET and BLT of 25 sectors; the thinnest (minET, minBLT) and thickest sectors (maxET, maxBLT) were assessed. Ratios between thinnest/thickest sectors (R1) and between mean ET and BLT of the inferior temporal quadrant/superior nasal quadrant (R2) were calculated (R1ET, R1BLT; R2ET, R2BLT). Receiver operator characteristic (ROC) curve analysis was used to assess the diagnostic power of statistically different parameters.In healthy eyes, smooth ET maps were observed. KC eyes showed a "doughnut pattern." The BLT maps of healthy eyes had a smooth appearance, but highly irregular "moth"-like damage pattern could be observed in keratoconic eyes. Highest area under the curve values were found for the thinnest sector of the BLT map, the R1ET, and the thinnest sector of the ET map.RESULTSIn healthy eyes, smooth ET maps were observed. KC eyes showed a "doughnut pattern." The BLT maps of healthy eyes had a smooth appearance, but highly irregular "moth"-like damage pattern could be observed in keratoconic eyes. Highest area under the curve values were found for the thinnest sector of the BLT map, the R1ET, and the thinnest sector of the ET map.PS-OCT imaging enables the visualization of significant differences of the corneal epithelium and the Bowman's layer in en face maps covering almost the entire cornea. ET and BLT profiles could clearly show their diagnostic importance for the distinguishing of keratoconic eyes and healthy eyes.CONCLUSIONSPS-OCT imaging enables the visualization of significant differences of the corneal epithelium and the Bowman's layer in en face maps covering almost the entire cornea. ET and BLT profiles could clearly show their diagnostic importance for the distinguishing of keratoconic eyes and healthy eyes. PurposeTo assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes.DesignCross-sectional study.MethodsSetting: institutional. Study population: 47 patients (1 eye) with keratoconus (KC) and 20 healthy subjects (1 eye). Observation procedure: epithelium and Bowman's layer measurements were performed by using custom-designed polarization-sensitive optical coherence tomography (PS-OCT) with a conical scanning optics design. En face corneal ET and BLT maps with a diameter of 11 mm were computed. Main outcome measurements were mean ET and BLT of 25 sectors; the thinnest (minET, minBLT) and thickest sectors (maxET, maxBLT) were assessed. Ratios between thinnest/thickest sectors (R1) and between mean ET and BLT of the inferior temporal quadrant/superior nasal quadrant (R2) were calculated (R1ET, R1BLT; R2ET, R2BLT). Receiver operator characteristic (ROC) curve analysis was used to assess the diagnostic power of statistically different parameters.ResultsIn healthy eyes, smooth ET maps were observed. KC eyes showed a “doughnut pattern.” The BLT maps of healthy eyes had a smooth appearance, but highly irregular “moth”-like damage pattern could be observed in keratoconic eyes. Highest area under the curve values were found for the thinnest sector of the BLT map, the R1ET, and the thinnest sector of the ET map.ConclusionsPS-OCT imaging enables the visualization of significant differences of the corneal epithelium and the Bowman's layer in en face maps covering almost the entire cornea. ET and BLT profiles could clearly show their diagnostic importance for the distinguishing of keratoconic eyes and healthy eyes. To assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes. Cross-sectional study. Setting: institutional. 47 patients (1 eye) with keratoconus (KC) and 20 healthy subjects (1 eye). epithelium and Bowman's layer measurements were performed by using custom-designed polarization-sensitive optical coherence tomography (PS-OCT) with a conical scanning optics design. En face corneal ET and BLT maps with a diameter of 11 mm were computed. Main outcome measurements were mean ET and BLT of 25 sectors; the thinnest (minET, minBLT) and thickest sectors (maxET, maxBLT) were assessed. Ratios between thinnest/thickest sectors (R1) and between mean ET and BLT of the inferior temporal quadrant/superior nasal quadrant (R2) were calculated (R1ET, R1BLT; R2ET, R2BLT). Receiver operator characteristic (ROC) curve analysis was used to assess the diagnostic power of statistically different parameters. In healthy eyes, smooth ET maps were observed. KC eyes showed a "doughnut pattern." The BLT maps of healthy eyes had a smooth appearance, but highly irregular "moth"-like damage pattern could be observed in keratoconic eyes. Highest area under the curve values were found for the thinnest sector of the BLT map, the R1ET, and the thinnest sector of the ET map. PS-OCT imaging enables the visualization of significant differences of the corneal epithelium and the Bowman's layer in en face maps covering almost the entire cornea. ET and BLT profiles could clearly show their diagnostic importance for the distinguishing of keratoconic eyes and healthy eyes. |
| Author | Schmidinger, Gerald Holzer, Stephan Pircher, Niklas Lammer, Jan Hitzenberger, Christoph K. Gschließer, Andreas Pircher, Michael Beer, Florian Donner, Ruth |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31170392$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3928/1081597X-20090610-06 10.1016/S0161-6420(02)01727-X 10.1016/j.ophtha.2013.11.034 10.1364/BOE.8.001221 10.1155/2016/5697343 10.1016/j.ajo.2018.02.006 10.1088/0031-9155/49/7/015 10.1016/j.jcrs.2015.09.021 10.1364/OE.17.017426 10.2147/OPTH.S67902 10.1016/S0886-3350(00)00434-X 10.1364/BOE.8.002906 10.1167/iovs.18-25311 10.1371/journal.pone.0097962 10.1016/j.ophtha.2012.06.023 10.1016/j.jcrs.2014.06.043 10.1001/archopht.116.1.62 10.1097/ICL.0b013e31829fae00 10.3928/1081-597X-19891101-10 10.1167/iovs.13-12578 10.1076/ceyr.16.8.792.8989 10.1016/j.jcrs.2015.07.038 10.1016/j.preteyeres.2011.06.003 |
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| References | Pircher, Schwarzhans, Holzer (bib8) 2018; 189 Amoils, Deist, Gous, Amoils (bib24) 2000; 26 Sawaguchi, Fukuchi, Abe, Kaiya, Sugar, Yue (bib7) 1998; 116 Li, Chamberlain, Tan, Brass, Weiss, Huang (bib21) 2016; 42 Rabinowitz, McDonnell (bib16) 1989; 5 Temstet, Sandali, Bouheraoua (bib1) 2015; 41 Beer, Wartak, Haindl (bib12) 2017; 8 Randleman, Russell, Ward, Thompson, Stulting (bib23) 2003; 110 Tao, Shao, Jiang (bib11) 2013; 39 Abou Shousha, Perez, Fraga Santini Canto (bib4) 2014; 121 Catalan, Cadarso, Esteves, Salgado-Borges, Lopez, Cadarso (bib2) 2016; 2016 Urs, Lloyd, Reinstein, Silverman (bib18) 2016; 42 Podoleanu, Charalambous, Plesea, Dogariu, Rosen (bib10) 2004; 49 Beer, Wartak, Pircher (bib15) 2018; 59 Li, Tan, Brass, Weiss, Huang (bib22) 2012; 119 Werkmeister, Sapeta, Schmidl (bib9) 2017; 8 Kalin, Maeda, Klyce, Hargrave, Wilson (bib17) 1996; 22 Reinstein, Archer, Gobbe (bib3) 2009; 25 Silverman, Urs, Roychoudhury, Archer, Gobbe, Reinstein (bib5) 2014; 55 Pircher, Hitzenberger, Schmidt-Erfurth (bib13) 2011; 30 Tuori, Virtanen, Aine, Kalluri, Miner, Uusitalo (bib6) 1997; 16 Wu, Tao, Jiang, Xu, Perez, Wang (bib19) 2014; 9 Kanellopoulos, Asimellis (bib20) 2014; 8 Miyazawa, Yamanari, Makita (bib14) 2009; 17 Reinstein (10.1016/j.ajo.2019.05.025_bib3) 2009; 25 Werkmeister (10.1016/j.ajo.2019.05.025_bib9) 2017; 8 Kanellopoulos (10.1016/j.ajo.2019.05.025_bib20) 2014; 8 Pircher (10.1016/j.ajo.2019.05.025_bib13) 2011; 30 Randleman (10.1016/j.ajo.2019.05.025_bib23) 2003; 110 Catalan (10.1016/j.ajo.2019.05.025_bib2) 2016; 2016 Kalin (10.1016/j.ajo.2019.05.025_bib17) 1996; 22 Pircher (10.1016/j.ajo.2019.05.025_bib8) 2018; 189 Li (10.1016/j.ajo.2019.05.025_bib21) 2016; 42 Tuori (10.1016/j.ajo.2019.05.025_bib6) 1997; 16 Beer (10.1016/j.ajo.2019.05.025_bib12) 2017; 8 Li (10.1016/j.ajo.2019.05.025_bib22) 2012; 119 Silverman (10.1016/j.ajo.2019.05.025_bib5) 2014; 55 Wu (10.1016/j.ajo.2019.05.025_bib19) 2014; 9 Tao (10.1016/j.ajo.2019.05.025_bib11) 2013; 39 Beer (10.1016/j.ajo.2019.05.025_bib15) 2018; 59 Rabinowitz (10.1016/j.ajo.2019.05.025_bib16) 1989; 5 Abou Shousha (10.1016/j.ajo.2019.05.025_bib4) 2014; 121 Sawaguchi (10.1016/j.ajo.2019.05.025_bib7) 1998; 116 Podoleanu (10.1016/j.ajo.2019.05.025_bib10) 2004; 49 Urs (10.1016/j.ajo.2019.05.025_bib18) 2016; 42 Amoils (10.1016/j.ajo.2019.05.025_bib24) 2000; 26 Temstet (10.1016/j.ajo.2019.05.025_bib1) 2015; 41 Miyazawa (10.1016/j.ajo.2019.05.025_bib14) 2009; 17 |
| References_xml | – volume: 59 start-page: 5579 year: 2018 ident: bib15 article-title: Mapping of corneal layer thicknesses with polarization-sensitive optical coherence tomography using a conical scan pattern publication-title: Investig Opthalmology Vis Sci – volume: 41 start-page: 812 year: 2015 end-page: 820 ident: bib1 article-title: Corneal epithelial thickness mapping using Fourier-domain optical coherence tomography for detection of form fruste keratoconus publication-title: J Cataract Refract Surg – volume: 39 start-page: 329 year: 2013 end-page: 334 ident: bib11 article-title: Entire thickness profiles of the epithelium and contact lens in vivo imaged with high-speed and high-resolution optical coherence tomography publication-title: Eye Contact Lens Sci Clin Pract – volume: 42 start-page: 95 year: 2016 end-page: 101 ident: bib18 article-title: Comparison of very-high-frequency ultrasound and spectral-domain optical coherence tomography corneal and epithelial thickness maps publication-title: J Cataract Refract Surg – volume: 55 start-page: 1580 year: 2014 end-page: 1587 ident: bib5 article-title: Epithelial remodeling as basis for machine-based identification of keratoconus publication-title: Investig Ophthalmol Vis Sci – volume: 189 start-page: 47 year: 2018 end-page: 54 ident: bib8 article-title: Distinguishing keratoconic eyes and healthy eyes using ultrahigh-resolution (UHR)-OCT based corneal epithelium thickness mapping publication-title: Am J Ophthalmol – volume: 17 start-page: 17426 year: 2009 end-page: 17440 ident: bib14 article-title: Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography publication-title: Opt Express – volume: 25 start-page: 604 year: 2009 end-page: 610 ident: bib3 article-title: Corneal epithelial thickness profile in the diagnosis of keratoconus publication-title: J Refract Surg – volume: 9 start-page: e97962 year: 2014 ident: bib19 article-title: Vertical and horizontal corneal epithelial thickness profile using ultra-high resolution and long scan depth optical coherence tomography publication-title: PLoS One – volume: 26 start-page: 967 year: 2000 end-page: 977 ident: bib24 article-title: Iatrogenic keratectasia after laser in situ keratomileusis for less than −4.0 to −7.0 diopters of myopia publication-title: J Cataract Refract Surg – volume: 121 start-page: 988 year: 2014 end-page: 993 ident: bib4 article-title: The use of Bowman’s layer vertical topographic thickness map in the diagnosis of keratoconus publication-title: Ophthalmology – volume: 30 start-page: 431 year: 2011 end-page: 451 ident: bib13 article-title: Polarization sensitive optical coherence tomography in the human eye publication-title: Prog Retin Eye Res – volume: 8 start-page: 2277 year: 2014 end-page: 2287 ident: bib20 article-title: OCT corneal epithelial topographic asymmetry as a sensitive diagnostic tool for early and advancing keratoconus publication-title: Clin Ophthalmol – volume: 42 start-page: 284 year: 2016 end-page: 295 ident: bib21 article-title: Subclinical keratoconus detection by pattern analysis of corneal and epithelial thickness maps with optical coherence tomography publication-title: J Cataract Refract Surg – volume: 16 start-page: 792 year: 1997 end-page: 801 ident: bib6 article-title: The immunohistochemical composition of corneal basement membrane in keratoconus publication-title: Curr Eye Res – volume: 116 start-page: 62 year: 1998 end-page: 68 ident: bib7 article-title: Three-dimensional scanning electron microscopic study of keratoconus corneas publication-title: Arch Ophthalmol – volume: 2016 start-page: 5697343 year: 2016 ident: bib2 article-title: Assessment of corneal epithelial thickness in asymmetric keratoconic eyes and normal eyes using fourier domain optical coherence tomography publication-title: J Ophthalmol – volume: 8 start-page: 1221 year: 2017 end-page: 1239 ident: bib9 article-title: Ultrahigh-resolution OCT imaging of the human cornea publication-title: Biomed Opt Express – volume: 22 start-page: 164 year: 1996 end-page: 167 ident: bib17 article-title: Automated topographic screening for keratoconus in refractive surgery candidates publication-title: CLAO J – volume: 119 start-page: 2425 year: 2012 end-page: 2433 ident: bib22 article-title: Corneal epithelial thickness mapping by fourier-domain optical coherence tomography in normal and keratoconic eyes publication-title: Ophthalmology – volume: 5 start-page: 400 year: 1989 end-page: 408 ident: bib16 article-title: Computer-assisted corneal topography in keratoconus publication-title: Refract Corneal Surg – volume: 110 start-page: 267 year: 2003 end-page: 275 ident: bib23 article-title: Risk factors and prognosis for corneal ectasia after LASIK publication-title: Ophthalmology – volume: 8 start-page: 2906 year: 2017 ident: bib12 article-title: Conical scan pattern for enhanced visualization of the human cornea using polarization-sensitive OCT publication-title: Biomed Opt Express – volume: 49 start-page: 1277 year: 2004 end-page: 1294 ident: bib10 article-title: Correction of distortions in optical coherence tomography imaging of the eye publication-title: Phys Med Biol – volume: 25 start-page: 604 issue: 7 year: 2009 ident: 10.1016/j.ajo.2019.05.025_bib3 article-title: Corneal epithelial thickness profile in the diagnosis of keratoconus publication-title: J Refract Surg doi: 10.3928/1081597X-20090610-06 – volume: 110 start-page: 267 issue: 2 year: 2003 ident: 10.1016/j.ajo.2019.05.025_bib23 article-title: Risk factors and prognosis for corneal ectasia after LASIK publication-title: Ophthalmology doi: 10.1016/S0161-6420(02)01727-X – volume: 121 start-page: 988 issue: 5 year: 2014 ident: 10.1016/j.ajo.2019.05.025_bib4 article-title: The use of Bowman’s layer vertical topographic thickness map in the diagnosis of keratoconus publication-title: Ophthalmology doi: 10.1016/j.ophtha.2013.11.034 – volume: 8 start-page: 1221 issue: 2 year: 2017 ident: 10.1016/j.ajo.2019.05.025_bib9 article-title: Ultrahigh-resolution OCT imaging of the human cornea publication-title: Biomed Opt Express doi: 10.1364/BOE.8.001221 – volume: 2016 start-page: 5697343 year: 2016 ident: 10.1016/j.ajo.2019.05.025_bib2 article-title: Assessment of corneal epithelial thickness in asymmetric keratoconic eyes and normal eyes using fourier domain optical coherence tomography publication-title: J Ophthalmol doi: 10.1155/2016/5697343 – volume: 189 start-page: 47 year: 2018 ident: 10.1016/j.ajo.2019.05.025_bib8 article-title: Distinguishing keratoconic eyes and healthy eyes using ultrahigh-resolution (UHR)-OCT based corneal epithelium thickness mapping publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2018.02.006 – volume: 49 start-page: 1277 issue: 7 year: 2004 ident: 10.1016/j.ajo.2019.05.025_bib10 article-title: Correction of distortions in optical coherence tomography imaging of the eye publication-title: Phys Med Biol doi: 10.1088/0031-9155/49/7/015 – volume: 22 start-page: 164 issue: 3 year: 1996 ident: 10.1016/j.ajo.2019.05.025_bib17 article-title: Automated topographic screening for keratoconus in refractive surgery candidates publication-title: CLAO J – volume: 42 start-page: 284 issue: 2 year: 2016 ident: 10.1016/j.ajo.2019.05.025_bib21 article-title: Subclinical keratoconus detection by pattern analysis of corneal and epithelial thickness maps with optical coherence tomography publication-title: J Cataract Refract Surg doi: 10.1016/j.jcrs.2015.09.021 – volume: 17 start-page: 17426 issue: 20 year: 2009 ident: 10.1016/j.ajo.2019.05.025_bib14 article-title: Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography publication-title: Opt Express doi: 10.1364/OE.17.017426 – volume: 8 start-page: 2277 year: 2014 ident: 10.1016/j.ajo.2019.05.025_bib20 article-title: OCT corneal epithelial topographic asymmetry as a sensitive diagnostic tool for early and advancing keratoconus publication-title: Clin Ophthalmol doi: 10.2147/OPTH.S67902 – volume: 26 start-page: 967 issue: 7 year: 2000 ident: 10.1016/j.ajo.2019.05.025_bib24 article-title: Iatrogenic keratectasia after laser in situ keratomileusis for less than −4.0 to −7.0 diopters of myopia publication-title: J Cataract Refract Surg doi: 10.1016/S0886-3350(00)00434-X – volume: 8 start-page: 2906 issue: 6 year: 2017 ident: 10.1016/j.ajo.2019.05.025_bib12 article-title: Conical scan pattern for enhanced visualization of the human cornea using polarization-sensitive OCT publication-title: Biomed Opt Express doi: 10.1364/BOE.8.002906 – volume: 59 start-page: 5579 issue: 13 year: 2018 ident: 10.1016/j.ajo.2019.05.025_bib15 article-title: Mapping of corneal layer thicknesses with polarization-sensitive optical coherence tomography using a conical scan pattern publication-title: Investig Opthalmology Vis Sci doi: 10.1167/iovs.18-25311 – volume: 9 start-page: e97962 issue: 5 year: 2014 ident: 10.1016/j.ajo.2019.05.025_bib19 article-title: Vertical and horizontal corneal epithelial thickness profile using ultra-high resolution and long scan depth optical coherence tomography publication-title: PLoS One doi: 10.1371/journal.pone.0097962 – volume: 119 start-page: 2425 issue: 12 year: 2012 ident: 10.1016/j.ajo.2019.05.025_bib22 article-title: Corneal epithelial thickness mapping by fourier-domain optical coherence tomography in normal and keratoconic eyes publication-title: Ophthalmology doi: 10.1016/j.ophtha.2012.06.023 – volume: 41 start-page: 812 issue: 4 year: 2015 ident: 10.1016/j.ajo.2019.05.025_bib1 article-title: Corneal epithelial thickness mapping using Fourier-domain optical coherence tomography for detection of form fruste keratoconus publication-title: J Cataract Refract Surg doi: 10.1016/j.jcrs.2014.06.043 – volume: 116 start-page: 62 issue: 1 year: 1998 ident: 10.1016/j.ajo.2019.05.025_bib7 article-title: Three-dimensional scanning electron microscopic study of keratoconus corneas publication-title: Arch Ophthalmol doi: 10.1001/archopht.116.1.62 – volume: 39 start-page: 329 issue: 5 year: 2013 ident: 10.1016/j.ajo.2019.05.025_bib11 article-title: Entire thickness profiles of the epithelium and contact lens in vivo imaged with high-speed and high-resolution optical coherence tomography publication-title: Eye Contact Lens Sci Clin Pract doi: 10.1097/ICL.0b013e31829fae00 – volume: 5 start-page: 400 issue: 6 year: 1989 ident: 10.1016/j.ajo.2019.05.025_bib16 article-title: Computer-assisted corneal topography in keratoconus publication-title: Refract Corneal Surg doi: 10.3928/1081-597X-19891101-10 – volume: 55 start-page: 1580 issue: 3 year: 2014 ident: 10.1016/j.ajo.2019.05.025_bib5 article-title: Epithelial remodeling as basis for machine-based identification of keratoconus publication-title: Investig Ophthalmol Vis Sci doi: 10.1167/iovs.13-12578 – volume: 16 start-page: 792 issue: 8 year: 1997 ident: 10.1016/j.ajo.2019.05.025_bib6 article-title: The immunohistochemical composition of corneal basement membrane in keratoconus publication-title: Curr Eye Res doi: 10.1076/ceyr.16.8.792.8989 – volume: 42 start-page: 95 issue: 1 year: 2016 ident: 10.1016/j.ajo.2019.05.025_bib18 article-title: Comparison of very-high-frequency ultrasound and spectral-domain optical coherence tomography corneal and epithelial thickness maps publication-title: J Cataract Refract Surg doi: 10.1016/j.jcrs.2015.07.038 – volume: 30 start-page: 431 issue: 6 year: 2011 ident: 10.1016/j.ajo.2019.05.025_bib13 article-title: Polarization sensitive optical coherence tomography in the human eye publication-title: Prog Retin Eye Res doi: 10.1016/j.preteyeres.2011.06.003 |
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| Snippet | To assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes.
Cross-sectional study.... PurposeTo assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy... To assess differences between epithelium thickness (ET) and Bowman's layer thickness (BLT) maps in keratoconic eyes and healthy eyes.PURPOSETo assess... |
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| SubjectTerms | Adult Bowman Membrane - pathology Cornea Corneal Topography Cross-Sectional Studies Design Epithelium, Corneal - pathology Female Healthy Volunteers Humans Keratoconus - diagnosis Light Male Ophthalmology Organ Size Population ROC Curve Tomography, Optical Coherence Topography |
| Title | Large Field of View Corneal Epithelium and Bowman's Layer Thickness Maps in Keratoconic and Healthy Eyes |
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