Balancing Protein Stability and Activity in Cancer: A New Approach for Identifying Driver Mutations Affecting CBL Ubiquitin Ligase Activation - Li, Minghui; Kales, Stephen C.; Ma, Ke; Shoemaker, Benjamin A.; Crespo-Barreto, Juan; Cangelosi, Andrew L.; Lipkowitz, Stanley; Panchenko, Anna R. (Cancer research (Chicago, Ill.), 2016)
Keywords: Carcinoma, Non-Small-Cell Lung - enzymology; Carcinoma, Non-Small-Cell Lung - genetics; Enzyme Activation; ErbB Receptors - chemistry; ErbB Receptors - metabolism; Female; HEK293 Cells; HeLa Cells; Humans; Lung Neoplasms - enzymology; Lung Neoplasms - genetics; Models, Molecular; Mutation, Missense; Phosphorylation; Protein Stability; Proto-Oncogene Proteins c-cbl - chemistry; Proto-Oncogene Proteins c-cbl - genetics; Proto-Oncogene Proteins c-cbl - metabolism; Signal Transduction; Thermodynamics; Transfection; Ubiquitination; Uterine Cervical Neoplasms - enzymology; Uterine Cervical Neoplasms - genetics