Cerebral amyloid deposition predicts long‐term cognitive decline in hemorrhagic small vessel disease
To investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and survivors of intracerebral hemorrhage (ICH). Patients experiencing an ICH without overt dementia were prospectively recruited (n = 68) for b...
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| Published in | Brain and behavior Vol. 13; no. 10; pp. e3189 - n/a |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
John Wiley & Sons, Inc
01.10.2023
John Wiley and Sons Inc Wiley |
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| Online Access | Get full text |
| ISSN | 2162-3279 2162-3279 |
| DOI | 10.1002/brb3.3189 |
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| Abstract | To investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and survivors of intracerebral hemorrhage (ICH).
Patients experiencing an ICH without overt dementia were prospectively recruited (n = 68) for brain MRI and Pittsburgh compound B (PiB) positron emission tomography scans at baseline. Cognitive function was assessed using the mini-mental status examination (MMSE) and clinical dementia rating after an overall median follow-up of 3.8 years. A positive amyloid scan was defined as a global PiB standardized uptake value ratio >1.2. Associations between follow-up cognitive outcomes and neuroimaging markers were explored using multivariable Cox regression models.
PiB(+) patients were older (72.1 ± 7.8 vs. 59.9 ± 11.7, p = .002) and more frequently had cerebral amyloid angiopathy (CAA) (63.6% vs. 15.8%, p = .002) than PiB(-) patients. PiB(+) was associated with a higher risk of dementia conversion (32.9 vs. 4.0 per 100-person-years, hazard ratio [HR] = 15.7 [3.0-80.7], p = .001) and MMSE score decline (58.8 vs. 9.9 per 100-person-years, HR = 6.2 [1.9-20.0], p = .002). In the non-CAA subgroup (n = 52), PiB(+) remained an independent predictor of dementia conversion, p = .04). In the Cox models, PiB(+) was an independent predictor of dementia conversion (HR = 15.8 [2.6-95.4], p = .003) and MMSE score decline (HR = 5.7 [1.6-20.3], p = .008) after adjusting for confounders.
Cerebral amyloid deposition potentially contributes to long-term cognitive decline in SVD-related ICH. |
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| AbstractList | To investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and survivors of intracerebral hemorrhage (ICH).
Patients experiencing an ICH without overt dementia were prospectively recruited (n = 68) for brain MRI and Pittsburgh compound B (PiB) positron emission tomography scans at baseline. Cognitive function was assessed using the mini-mental status examination (MMSE) and clinical dementia rating after an overall median follow-up of 3.8 years. A positive amyloid scan was defined as a global PiB standardized uptake value ratio >1.2. Associations between follow-up cognitive outcomes and neuroimaging markers were explored using multivariable Cox regression models.
PiB(+) patients were older (72.1 ± 7.8 vs. 59.9 ± 11.7, p = .002) and more frequently had cerebral amyloid angiopathy (CAA) (63.6% vs. 15.8%, p = .002) than PiB(-) patients. PiB(+) was associated with a higher risk of dementia conversion (32.9 vs. 4.0 per 100-person-years, hazard ratio [HR] = 15.7 [3.0-80.7], p = .001) and MMSE score decline (58.8 vs. 9.9 per 100-person-years, HR = 6.2 [1.9-20.0], p = .002). In the non-CAA subgroup (n = 52), PiB(+) remained an independent predictor of dementia conversion, p = .04). In the Cox models, PiB(+) was an independent predictor of dementia conversion (HR = 15.8 [2.6-95.4], p = .003) and MMSE score decline (HR = 5.7 [1.6-20.3], p = .008) after adjusting for confounders.
Cerebral amyloid deposition potentially contributes to long-term cognitive decline in SVD-related ICH. This study with 68 dementia‐free small vessel disease‐related intracerebral hemorrhage survivors investigated the association between cerebral amyloid deposition and long‐term cognitive outcomes.We found cerebral amyloid depositions are strong indicators of long‐term cognitive decline in both patients with cerebral amyloid angiopathy and hypertensive arteriosclerosis. Abstract Background To investigate the association between cerebral amyloid deposition and long‐term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and survivors of intracerebral hemorrhage (ICH). Methods Patients experiencing an ICH without overt dementia were prospectively recruited (n = 68) for brain MRI and Pittsburgh compound B (PiB) positron emission tomography scans at baseline. Cognitive function was assessed using the mini‐mental status examination (MMSE) and clinical dementia rating after an overall median follow‐up of 3.8 years. A positive amyloid scan was defined as a global PiB standardized uptake value ratio >1.2. Associations between follow‐up cognitive outcomes and neuroimaging markers were explored using multivariable Cox regression models. Results PiB(+) patients were older (72.1 ± 7.8 vs. 59.9 ± 11.7, p = .002) and more frequently had cerebral amyloid angiopathy (CAA) (63.6% vs. 15.8%, p = .002) than PiB(−) patients. PiB(+) was associated with a higher risk of dementia conversion (32.9 vs. 4.0 per 100‐person‐years, hazard ratio [HR] = 15.7 [3.0–80.7], p = .001) and MMSE score decline (58.8 vs. 9.9 per 100‐person‐years, HR = 6.2 [1.9–20.0], p = .002). In the non‐CAA subgroup (n = 52), PiB(+) remained an independent predictor of dementia conversion, p = .04). In the Cox models, PiB(+) was an independent predictor of dementia conversion (HR = 15.8 [2.6–95.4], p = .003) and MMSE score decline (HR = 5.7 [1.6–20.3], p = .008) after adjusting for confounders. Conclusions Cerebral amyloid deposition potentially contributes to long‐term cognitive decline in SVD‐related ICH. BackgroundTo investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and survivors of intracerebral hemorrhage (ICH).MethodsPatients experiencing an ICH without overt dementia were prospectively recruited (n = 68) for brain MRI and Pittsburgh compound B (PiB) positron emission tomography scans at baseline. Cognitive function was assessed using the mini-mental status examination (MMSE) and clinical dementia rating after an overall median follow-up of 3.8 years. A positive amyloid scan was defined as a global PiB standardized uptake value ratio >1.2. Associations between follow-up cognitive outcomes and neuroimaging markers were explored using multivariable Cox regression models.ResultsPiB(+) patients were older (72.1 ± 7.8 vs. 59.9 ± 11.7, p = .002) and more frequently had cerebral amyloid angiopathy (CAA) (63.6% vs. 15.8%, p = .002) than PiB(−) patients. PiB(+) was associated with a higher risk of dementia conversion (32.9 vs. 4.0 per 100-person-years, hazard ratio [HR] = 15.7 [3.0–80.7], p = .001) and MMSE score decline (58.8 vs. 9.9 per 100-person-years, HR = 6.2 [1.9–20.0], p = .002). In the non-CAA subgroup (n = 52), PiB(+) remained an independent predictor of dementia conversion, p = .04). In the Cox models, PiB(+) was an independent predictor of dementia conversion (HR = 15.8 [2.6–95.4], p = .003) and MMSE score decline (HR = 5.7 [1.6–20.3], p = .008) after adjusting for confounders.ConclusionsCerebral amyloid deposition potentially contributes to long-term cognitive decline in SVD-related ICH. To investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and survivors of intracerebral hemorrhage (ICH).BACKGROUNDTo investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and survivors of intracerebral hemorrhage (ICH).Patients experiencing an ICH without overt dementia were prospectively recruited (n = 68) for brain MRI and Pittsburgh compound B (PiB) positron emission tomography scans at baseline. Cognitive function was assessed using the mini-mental status examination (MMSE) and clinical dementia rating after an overall median follow-up of 3.8 years. A positive amyloid scan was defined as a global PiB standardized uptake value ratio >1.2. Associations between follow-up cognitive outcomes and neuroimaging markers were explored using multivariable Cox regression models.METHODSPatients experiencing an ICH without overt dementia were prospectively recruited (n = 68) for brain MRI and Pittsburgh compound B (PiB) positron emission tomography scans at baseline. Cognitive function was assessed using the mini-mental status examination (MMSE) and clinical dementia rating after an overall median follow-up of 3.8 years. A positive amyloid scan was defined as a global PiB standardized uptake value ratio >1.2. Associations between follow-up cognitive outcomes and neuroimaging markers were explored using multivariable Cox regression models.PiB(+) patients were older (72.1 ± 7.8 vs. 59.9 ± 11.7, p = .002) and more frequently had cerebral amyloid angiopathy (CAA) (63.6% vs. 15.8%, p = .002) than PiB(-) patients. PiB(+) was associated with a higher risk of dementia conversion (32.9 vs. 4.0 per 100-person-years, hazard ratio [HR] = 15.7 [3.0-80.7], p = .001) and MMSE score decline (58.8 vs. 9.9 per 100-person-years, HR = 6.2 [1.9-20.0], p = .002). In the non-CAA subgroup (n = 52), PiB(+) remained an independent predictor of dementia conversion, p = .04). In the Cox models, PiB(+) was an independent predictor of dementia conversion (HR = 15.8 [2.6-95.4], p = .003) and MMSE score decline (HR = 5.7 [1.6-20.3], p = .008) after adjusting for confounders.RESULTSPiB(+) patients were older (72.1 ± 7.8 vs. 59.9 ± 11.7, p = .002) and more frequently had cerebral amyloid angiopathy (CAA) (63.6% vs. 15.8%, p = .002) than PiB(-) patients. PiB(+) was associated with a higher risk of dementia conversion (32.9 vs. 4.0 per 100-person-years, hazard ratio [HR] = 15.7 [3.0-80.7], p = .001) and MMSE score decline (58.8 vs. 9.9 per 100-person-years, HR = 6.2 [1.9-20.0], p = .002). In the non-CAA subgroup (n = 52), PiB(+) remained an independent predictor of dementia conversion, p = .04). In the Cox models, PiB(+) was an independent predictor of dementia conversion (HR = 15.8 [2.6-95.4], p = .003) and MMSE score decline (HR = 5.7 [1.6-20.3], p = .008) after adjusting for confounders.Cerebral amyloid deposition potentially contributes to long-term cognitive decline in SVD-related ICH.CONCLUSIONSCerebral amyloid deposition potentially contributes to long-term cognitive decline in SVD-related ICH. |
| Author | Yen, Ruoh‐Fang Chen, Ya‐Fang Tsai, Hsin‐Hsi Jeng, Jiann‐Shing Tsai, Li‐Kai Tsai, Ya‐Chin Liu, Chia‐Ju Lin, Sheng‐Sian |
| AuthorAffiliation | 3 Department of Neurology National Taiwan University Hospital Taipei Taiwan 4 Department of Nuclear Medicine National Taiwan University Hospital Taipei Taiwan 6 Department of Neurology National Taiwan University Hospital Hsin‐Chu Branch Hsinchu Taiwan 5 Department of Medical Imaging National Taiwan University Hospital Taipei Taiwan 1 Department of Nuclear Medicine National Taiwan University Hospital Hsin‐Chu Branch Hsinchu Taiwan 2 Department of Neurology National Taiwan University Hospital Bei‐Hu Branch Taipei Taiwan |
| AuthorAffiliation_xml | – name: 6 Department of Neurology National Taiwan University Hospital Hsin‐Chu Branch Hsinchu Taiwan – name: 2 Department of Neurology National Taiwan University Hospital Bei‐Hu Branch Taipei Taiwan – name: 3 Department of Neurology National Taiwan University Hospital Taipei Taiwan – name: 5 Department of Medical Imaging National Taiwan University Hospital Taipei Taiwan – name: 1 Department of Nuclear Medicine National Taiwan University Hospital Hsin‐Chu Branch Hsinchu Taiwan – name: 4 Department of Nuclear Medicine National Taiwan University Hospital Taipei Taiwan |
| Author_xml | – sequence: 1 givenname: Ya‐Chin surname: Tsai fullname: Tsai, Ya‐Chin organization: Department of Nuclear Medicine National Taiwan University Hospital Hsin‐Chu Branch Hsinchu Taiwan – sequence: 2 givenname: Hsin‐Hsi orcidid: 0000-0002-4721-1468 surname: Tsai fullname: Tsai, Hsin‐Hsi organization: Department of Neurology National Taiwan University Hospital Bei‐Hu Branch Taipei Taiwan, Department of Neurology National Taiwan University Hospital Taipei Taiwan – sequence: 3 givenname: Chia‐Ju surname: Liu fullname: Liu, Chia‐Ju organization: Department of Nuclear Medicine National Taiwan University Hospital Taipei Taiwan – sequence: 4 givenname: Sheng‐Sian surname: Lin fullname: Lin, Sheng‐Sian organization: Department of Neurology National Taiwan University Hospital Bei‐Hu Branch Taipei Taiwan – sequence: 5 givenname: Ya‐Fang surname: Chen fullname: Chen, Ya‐Fang organization: Department of Medical Imaging National Taiwan University Hospital Taipei Taiwan – sequence: 6 givenname: Jiann‐Shing surname: Jeng fullname: Jeng, Jiann‐Shing organization: Department of Neurology National Taiwan University Hospital Bei‐Hu Branch Taipei Taiwan – sequence: 7 givenname: Li‐Kai surname: Tsai fullname: Tsai, Li‐Kai organization: Department of Neurology National Taiwan University Hospital Bei‐Hu Branch Taipei Taiwan, Department of Neurology National Taiwan University Hospital Hsin‐Chu Branch Hsinchu Taiwan – sequence: 8 givenname: Ruoh‐Fang surname: Yen fullname: Yen, Ruoh‐Fang organization: Department of Nuclear Medicine National Taiwan University Hospital Taipei Taiwan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37533346$$D View this record in MEDLINE/PubMed |
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| Keywords | intracerebral hemorrhage small vessel disease dementia cognitive impairment Pittsburgh compound B |
| Language | English |
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| Snippet | To investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and... BackgroundTo investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease... This study with 68 dementia‐free small vessel disease‐related intracerebral hemorrhage survivors investigated the association between cerebral amyloid... Abstract Background To investigate the association between cerebral amyloid deposition and long‐term cognitive outcomes in patients with hemorrhagic small... |
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| SubjectTerms | Cognitive ability cognitive impairment Cohort analysis Dementia intracerebral hemorrhage Ischemia Medical imaging Neuroimaging Original Patients Pittsburgh compound B small vessel disease |
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| Title | Cerebral amyloid deposition predicts long‐term cognitive decline in hemorrhagic small vessel disease |
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