Treadmill exercise activates ATF3 and ERK1/2 downstream molecules to facilitate axonal regrowth after sciatic nerve injury

The purpose of this study was to investigate the effect of treadmill exer-cise on activating transcription factors such as activating transcription factor 3 (ATF3) and extracellular signal-regulated kinase (ERK1/2) sig-naling pathway to facilitate axonal regrowth after sciatic nerve injury (SNI). Th...

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Bibliographic Details
Published inJournal of exercise rehabilitation Vol. 16; no. 2; pp. 141 - 147
Main Authors Kim, Ji-Eun, Cho, Yeong-Hyun, Seo, Tae-Beom
Format Journal Article
LanguageEnglish
Published Korean Society of Exercise Rehabilitation 01.04.2020
한국운동재활학회
Subjects
Original
심리과학
Treadmill exercise
Mitogen-activated protein kinase
Regeneration
Axonal regrowth
Activating transcription factor 3
Sciatic nerve
Online AccessGet full text
ISSN2288-176X
2288-1778
2288-1778
DOI10.12965/jer.2040188.094

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Table of Contents:
  • Abstract INTRODUCTION MATERIALS AND METHODS Experimental animals Sciatic nerve injury Treadmill exercise Western blot analysis Immunofluorescence staining RESULTS Treadmill exercise increases GAP-43 and axonal elongation in the distal area of the injured sciatic nerve at 7 and 14 dpc Treadmill exercise upregulates activation of ERK1/2 and CREB signaling pathway at early stage of sciatic nerve regeneration Treadmill exercise increases phosphorylation ofATF3-mediated c-Jun at early stage of sciatic nerve regeneration DISCUSSION CONFLICT OF INTEREST ACKNOWLEDGMENTS REFERENCES