Evaluation of the regenerative capacity of stem cells combined with bone graft material and collagen matrix using a rabbit calvarial defect model
The purpose of this study was to evaluate the regenerative capacity of stem cells combined with bone graft material and a collagen matrix in rabbit calvarial defect models according to the type and form of the scaffolds, which included type I collagen matrix and synthetic bone. Mesenchymal stem cell...
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| Published in | Journal of periodontal & implant science Vol. 53; no. 6; pp. 467 - 477 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Academy of Periodontology
01.12.2023
대한치주과학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2093-2278 2093-2286 2093-2286 |
| DOI | 10.5051/jpis.2204880244 |
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| Abstract | The purpose of this study was to evaluate the regenerative capacity of stem cells combined with bone graft material and a collagen matrix in rabbit calvarial defect models according to the type and form of the scaffolds, which included type I collagen matrix and synthetic bone.
Mesenchymal stem cells (MSCs) were obtained from the periosteum of participants. Four symmetrical 6-mm-diameter circular defects were made in New Zealand white rabbits using a trephine drill. The defects were grafted with (1) group 1: synthetic bone (β-tricalcium phosphate/hydroxyapatite [β-TCP/HA]) and 1×10
MSCs; (2) group 2: collagen matrix and 1×10
MSCs; (3) group 3: β-TCP/HA, collagen matrix covering β-TCP/HA, and 1×10
MSCs; or (4) group 4: β-TCP/HA, chipped collagen matrix mixed with β-TCP/HA, and 1×10
MSCs. Cellular viability and cell migration rates were analyzed.
Uneventful healing was achieved in all areas where the defects were made at 4 weeks, and no signs of infection were identified during the healing period or at the time of retrieval. New bone formation was more evident in groups 3 and 4 than in the other groups. A densitometric analysis of the calvarium at 8 weeks post-surgery showed the highest values in group 3.
This study showed that the highest regeneration was found when the stem cells were applied to synthetic bone along with a collagen matrix. |
|---|---|
| AbstractList | Purpose: The purpose of this study was to evaluate the regenerative capacity of stem cells combined with bone graft material and a collagen matrix in rabbit calvarial defect models according to the type and form of the scaffolds, which included type I collagen matrix and synthetic bone.
Methods: Mesenchymal stem cells (MSCs) were obtained from the periosteum of participants. Four symmetrical 6-mm-diameter circular defects were made in New Zealand white rabbits using a trephine drill. The defects were grafted with (1) group 1: synthetic bone (β-tricalcium phosphate/hydroxyapatite [β-TCP/HA]) and 1×105 MSCs; (2) group 2: collagen matrix and 1×105 MSCs; (3) group 3: β-TCP/HA, collagen matrix covering β-TCP/HA, and 1×105 MSCs; or (4) group 4: β-TCP/HA, chipped collagen matrix mixed with β-TCP/HA, and 1×105 MSCs. Cellular viability and cell migration rates were analyzed.
Results: Uneventful healing was achieved in all areas where the defects were made at 4 weeks, and no signs of infection were identified during the healing period or at the time of retrieval. New bone formation was more evident in groups 3 and 4 than in the other groups.
A densitometric analysis of the calvarium at 8 weeks post-surgery showed the highest values in group 3.
Conclusions: This study showed that the highest regeneration was found when the stem cells were applied to synthetic bone along with a collagen matrix. KCI Citation Count: 0 The purpose of this study was to evaluate the regenerative capacity of stem cells combined with bone graft material and a collagen matrix in rabbit calvarial defect models according to the type and form of the scaffolds, which included type I collagen matrix and synthetic bone.PURPOSEThe purpose of this study was to evaluate the regenerative capacity of stem cells combined with bone graft material and a collagen matrix in rabbit calvarial defect models according to the type and form of the scaffolds, which included type I collagen matrix and synthetic bone.Mesenchymal stem cells (MSCs) were obtained from the periosteum of participants. Four symmetrical 6-mm-diameter circular defects were made in New Zealand white rabbits using a trephine drill. The defects were grafted with (1) group 1: synthetic bone (β-tricalcium phosphate/hydroxyapatite [β-TCP/HA]) and 1×105 MSCs; (2) group 2: collagen matrix and 1×105 MSCs; (3) group 3: β-TCP/HA, collagen matrix covering β-TCP/HA, and 1×105 MSCs; or (4) group 4: β-TCP/HA, chipped collagen matrix mixed with β-TCP/HA, and 1×105 MSCs. Cellular viability and cell migration rates were analyzed.METHODSMesenchymal stem cells (MSCs) were obtained from the periosteum of participants. Four symmetrical 6-mm-diameter circular defects were made in New Zealand white rabbits using a trephine drill. The defects were grafted with (1) group 1: synthetic bone (β-tricalcium phosphate/hydroxyapatite [β-TCP/HA]) and 1×105 MSCs; (2) group 2: collagen matrix and 1×105 MSCs; (3) group 3: β-TCP/HA, collagen matrix covering β-TCP/HA, and 1×105 MSCs; or (4) group 4: β-TCP/HA, chipped collagen matrix mixed with β-TCP/HA, and 1×105 MSCs. Cellular viability and cell migration rates were analyzed.Uneventful healing was achieved in all areas where the defects were made at 4 weeks, and no signs of infection were identified during the healing period or at the time of retrieval. New bone formation was more evident in groups 3 and 4 than in the other groups. A densitometric analysis of the calvarium at 8 weeks post-surgery showed the highest values in group 3.RESULTSUneventful healing was achieved in all areas where the defects were made at 4 weeks, and no signs of infection were identified during the healing period or at the time of retrieval. New bone formation was more evident in groups 3 and 4 than in the other groups. A densitometric analysis of the calvarium at 8 weeks post-surgery showed the highest values in group 3.This study showed that the highest regeneration was found when the stem cells were applied to synthetic bone along with a collagen matrix.CONCLUSIONSThis study showed that the highest regeneration was found when the stem cells were applied to synthetic bone along with a collagen matrix. The purpose of this study was to evaluate the regenerative capacity of stem cells combined with bone graft material and a collagen matrix in rabbit calvarial defect models according to the type and form of the scaffolds, which included type I collagen matrix and synthetic bone. Mesenchymal stem cells (MSCs) were obtained from the periosteum of participants. Four symmetrical 6-mm-diameter circular defects were made in New Zealand white rabbits using a trephine drill. The defects were grafted with (1) group 1: synthetic bone (β-tricalcium phosphate/hydroxyapatite [β-TCP/HA]) and 1×10 MSCs; (2) group 2: collagen matrix and 1×10 MSCs; (3) group 3: β-TCP/HA, collagen matrix covering β-TCP/HA, and 1×10 MSCs; or (4) group 4: β-TCP/HA, chipped collagen matrix mixed with β-TCP/HA, and 1×10 MSCs. Cellular viability and cell migration rates were analyzed. Uneventful healing was achieved in all areas where the defects were made at 4 weeks, and no signs of infection were identified during the healing period or at the time of retrieval. New bone formation was more evident in groups 3 and 4 than in the other groups. A densitometric analysis of the calvarium at 8 weeks post-surgery showed the highest values in group 3. This study showed that the highest regeneration was found when the stem cells were applied to synthetic bone along with a collagen matrix. |
| Author | Kim, InSoo Lee, Won Park, Jun-Beom Kim, Heesung |
| AuthorAffiliation | 1 Department of Periodontics, College of Medicine, The Catholic University of Korea, Seoul, Korea 5 The Faculty of Liberal Arts, Eulji University, Seongnam, Korea 4 Division of Oral and Maxillofacial Surgery, Department of Dentistry, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea 2 Dental Implantology, Graduate School of Clinical Dental Science, The Catholic University of Korea, Seoul, Korea 3 Department of Oral and Maxillofacial Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea |
| AuthorAffiliation_xml | – name: 1 Department of Periodontics, College of Medicine, The Catholic University of Korea, Seoul, Korea – name: 2 Dental Implantology, Graduate School of Clinical Dental Science, The Catholic University of Korea, Seoul, Korea – name: 5 The Faculty of Liberal Arts, Eulji University, Seongnam, Korea – name: 3 Department of Oral and Maxillofacial Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea – name: 4 Division of Oral and Maxillofacial Surgery, Department of Dentistry, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea |
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| Cites_doi | 10.1016/j.jcms.2011.05.004 10.1016/j.jormas.2021.12.001 10.1242/bio.20122162 10.1016/j.archoralbio.2015.10.011 10.1016/j.biomaterials.2017.10.046 10.1016/j.biomaterials.2018.07.017 10.5051/jpis.2019.49.4.258 10.2217/rme-2015-0045 10.3390/ph14111133 10.1097/PRS.0b013e31826d100e 10.1038/s41467-018-03124-z 10.1016/j.tripleo.2007.12.001 10.2217/rme-2021-0178 10.1155/2015/108571 10.4252/wjsc.v6.i3.266 10.1016/j.tripleo.2008.01.010 10.1002/jbm.b.34169 10.1155/2012/980353 10.1186/s40729-021-00317-y 10.1007/s10856-021-06600-z 10.1007/s10029-012-0941-2 10.3390/ijms21176425 10.1016/j.mtbio.2022.100267 10.4055/cios.2018.10.3.271 |
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| Keywords | Bone transplantation Cell differentiation Collagen Osteogenesis Stem cells |
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| Title | Evaluation of the regenerative capacity of stem cells combined with bone graft material and collagen matrix using a rabbit calvarial defect model |
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