Prognosis versus Actual Outcomes in Stereotactic Radiosurgery of Brain Metastases: Reliability of Common Prognostic Parameters and Indices

This study aims to evaluate the clinical outcome of stereotactic radiosurgery as the sole treatment for brain metastases and to assess prognostic factors influencing survival. A total of 108 consecutive patients with 213 metastases were retrospectively analyzed. Treatment was determined with close-m...

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Published in	Current oncology (Toronto) Vol. 31; no. 4; pp. 1739 - 1751
Main Authors	Mangesius, Julian, Seppi, Thomas, Arnold, Christoph Reinhold, Mangesius, Stephanie, Kerschbaumer, Johannes, Demetz, Matthias, Minasch, Danijela, Vorbach, Samuel Moritz, Sarcletti, Manuel, Lukas, Peter, Nevinny-Stickel, Meinhard, Ganswindt, Ute
Format	Journal Article
Language	English
Published	Switzerland MDPI AG 01.04.2024
Subjects	Adult Aged Aged, 80 and over brain metastases Brain Neoplasms - mortality Brain Neoplasms - secondary Brain Neoplasms - surgery Development and progression Female Health aspects Humans Magnetic Resonance Imaging - methods Male Metastasis Middle Aged outcome Patient outcomes Prognosis prognostic scores Radiosurgery Radiosurgery - methods Retrospective Studies Risk factors sex differences Surgery Treatment Outcome Women radiosurgery prognostic scores prognosis brain metastases outcome sex differences
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ISSN	1718-7729 1198-0052 1718-7729
DOI	10.3390/curroncol31040132

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Abstract	This study aims to evaluate the clinical outcome of stereotactic radiosurgery as the sole treatment for brain metastases and to assess prognostic factors influencing survival. A total of 108 consecutive patients with 213 metastases were retrospectively analyzed. Treatment was determined with close-meshed MRI follow-up. Various prognostic factors were assessed, and several prognostic indices were compared regarding their reliability to estimate overall survival. Median overall survival was 15 months; one-year overall survival was 50.5%. Both one- and two-year local controls were 90.9%. The rate of new metastases after SRS was 49.1%. Multivariate analysis of prognostic factors revealed that the presence of extracranial metastases, male sex, lower KPI, and progressive extracranial disease were significant risk factors for decreased survival. Of all evaluated prognostic indices, the Basic Score for Brain Metastases (BSBMs) showed the best correlation with overall survival. A substantial survival advantage was found for female patients after SRS when compared to male patients (18 versus 9 months, p = 0.003). SRS of brain metastasis is a safe and effective treatment option when frequent monitoring for new metastases with MRI is performed. Common prognostic scores lack reliable estimation of survival times. Female sex should be considered as an additional independent positive prognostic factor influencing survival.
AbstractList	This study aims to evaluate the clinical outcome of stereotactic radiosurgery as the sole treatment for brain metastases and to assess prognostic factors influencing survival. A total of 108 consecutive patients with 213 metastases were retrospectively analyzed. Treatment was determined with close-meshed MRI follow-up. Various prognostic factors were assessed, and several prognostic indices were compared regarding their reliability to estimate overall survival. Median overall survival was 15 months; one-year overall survival was 50.5%. Both one- and two-year local controls were 90.9%. The rate of new metastases after SRS was 49.1%. Multivariate analysis of prognostic factors revealed that the presence of extracranial metastases, male sex, lower KPI, and progressive extracranial disease were significant risk factors for decreased survival. Of all evaluated prognostic indices, the Basic Score for Brain Metastases (BSBMs) showed the best correlation with overall survival. A substantial survival advantage was found for female patients after SRS when compared to male patients (18 versus 9 months, p = 0.003). SRS of brain metastasis is a safe and effective treatment option when frequent monitoring for new metastases with MRI is performed. Common prognostic scores lack reliable estimation of survival times. Female sex should be considered as an additional independent positive prognostic factor influencing survival. This study aims to evaluate the clinical outcome of stereotactic radiosurgery as the sole treatment for brain metastases and to assess prognostic factors influencing survival. A total of 108 consecutive patients with 213 metastases were retrospectively analyzed. Treatment was determined with close-meshed MRI follow-up. Various prognostic factors were assessed, and several prognostic indices were compared regarding their reliability to estimate overall survival. Median overall survival was 15 months; one-year overall survival was 50.5%. Both one- and two-year local controls were 90.9%. The rate of new metastases after SRS was 49.1%. Multivariate analysis of prognostic factors revealed that the presence of extracranial metastases, male sex, lower KPI, and progressive extracranial disease were significant risk factors for decreased survival. Of all evaluated prognostic indices, the Basic Score for Brain Metastases (BSBMs) showed the best correlation with overall survival. A substantial survival advantage was found for female patients after SRS when compared to male patients (18 versus 9 months, p = 0.003). SRS of brain metastasis is a safe and effective treatment option when frequent monitoring for new metastases with MRI is performed. Common prognostic scores lack reliable estimation of survival times. Female sex should be considered as an additional independent positive prognostic factor influencing survival.This study aims to evaluate the clinical outcome of stereotactic radiosurgery as the sole treatment for brain metastases and to assess prognostic factors influencing survival. A total of 108 consecutive patients with 213 metastases were retrospectively analyzed. Treatment was determined with close-meshed MRI follow-up. Various prognostic factors were assessed, and several prognostic indices were compared regarding their reliability to estimate overall survival. Median overall survival was 15 months; one-year overall survival was 50.5%. Both one- and two-year local controls were 90.9%. The rate of new metastases after SRS was 49.1%. Multivariate analysis of prognostic factors revealed that the presence of extracranial metastases, male sex, lower KPI, and progressive extracranial disease were significant risk factors for decreased survival. Of all evaluated prognostic indices, the Basic Score for Brain Metastases (BSBMs) showed the best correlation with overall survival. A substantial survival advantage was found for female patients after SRS when compared to male patients (18 versus 9 months, p = 0.003). SRS of brain metastasis is a safe and effective treatment option when frequent monitoring for new metastases with MRI is performed. Common prognostic scores lack reliable estimation of survival times. Female sex should be considered as an additional independent positive prognostic factor influencing survival. This study aims to evaluate the clinical outcome of stereotactic radiosurgery as the sole treatment for brain metastases and to assess prognostic factors influencing survival. A total of 108 consecutive patients with 213 metastases were retrospectively analyzed. Treatment was determined with close-meshed MRI follow-up. Various prognostic factors were assessed, and several prognostic indices were compared regarding their reliability to estimate overall survival. Median overall survival was 15 months; one-year overall survival was 50.5%. Both one- and two-year local controls were 90.9%. The rate of new metastases after SRS was 49.1%. Multivariate analysis of prognostic factors revealed that the presence of extracranial metastases, male sex, lower KPI, and progressive extracranial disease were significant risk factors for decreased survival. Of all evaluated prognostic indices, the Basic Score for Brain Metastases (BSBMs) showed the best correlation with overall survival. A substantial survival advantage was found for female patients after SRS when compared to male patients (18 versus 9 months, = 0.003). SRS of brain metastasis is a safe and effective treatment option when frequent monitoring for new metastases with MRI is performed. Common prognostic scores lack reliable estimation of survival times. Female sex should be considered as an additional independent positive prognostic factor influencing survival.
Audience	Academic
Author	Sarcletti, Manuel Mangesius, Julian Arnold, Christoph Reinhold Ganswindt, Ute Minasch, Danijela Vorbach, Samuel Moritz Lukas, Peter Kerschbaumer, Johannes Demetz, Matthias Seppi, Thomas Mangesius, Stephanie Nevinny-Stickel, Meinhard
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Cites_doi	10.1001/jama.2016.9839 10.3171/2013.9.JNS13788 10.1016/S0360-3016(99)00549-0 10.1016/j.radonc.2011.01.011 10.3389/fonc.2022.866542 10.4103/sni.sni_303_18 10.1007/s00066-016-1073-x 10.1007/s00066-012-0118-z 10.1002/(SICI)1097-0215(20000220)90:1<37::AID-IJC5>3.0.CO;2-7 10.1038/s41598-021-88070-5 10.1007/s00066-008-1908-1 10.1016/j.ijrobp.2007.06.074 10.1200/JCO.2010.30.1655 10.1007/s00066-012-0122-3 10.1016/j.ijrobp.2009.02.091 10.1016/j.radonc.2016.05.001 10.1159/000068015 10.1200/JCO.20.01255 10.3389/fonc.2018.00395 10.1371/journal.pone.0052457 10.1007/s00066-008-1946-8 10.1007/s00066-008-1831-5 10.1016/j.wneu.2022.05.036 10.1200/JCO.22.00333 10.1007/s11060-009-0073-4 10.1016/S1470-2045(14)70061-0 10.1016/0360-3016(95)02106-X 10.3390/ijms17122132 10.1016/j.radonc.2017.02.006 10.1200/JCO.1998.16.11.3563 10.21037/cco-22-15 10.1186/1748-717X-6-48 10.1001/jama.295.21.2483 10.1200/JCO.2011.41.0639 10.1016/j.ijrobp.2022.06.064 10.1001/jamaoncol.2016.3834 10.1158/1055-9965.EPI-11-0246 10.1016/j.ijrobp.2004.02.017 10.1227/01.neu.0000316281.07124.ea 10.1007/s00066-014-0625-1 10.1016/S0360-3016(96)00619-0 10.1002/cncr.23037 10.1016/S1470-2045(09)70263-3 10.1007/s11060-004-8093-6
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References	Soffietti (ref_4) 2013; 31 Willmann (ref_38) 2022; 114 Brown (ref_23) 2016; 316 Minniti (ref_9) 2011; 6 Rades (ref_36) 2008; 184 Chang (ref_22) 2009; 10 ref_34 Wang (ref_19) 2002; 78 Wiggenraad (ref_12) 2012; 188 Gavrilovic (ref_2) 2005; 75 Xu (ref_37) 2022; 164 Mangesius (ref_44) 2021; 11 Rades (ref_18) 2007; 110 Zindler (ref_43) 2017; 123 Lawrence (ref_27) 2010; 76 Vellayappan (ref_11) 2018; 8 Rades (ref_31) 2008; 184 Rades (ref_26) 2014; 190 Yamamoto (ref_5) 2014; 15 Shaw (ref_29) 1996; 34 Juthani (ref_7) 2022; 11 Wiggenraad (ref_30) 2011; 98 Kondziolka (ref_35) 2014; 120 Roengvoraphoj (ref_39) 2017; 193 Gani (ref_40) 2012; 188 Weltman (ref_15) 2000; 46 Schiff (ref_3) 2022; 40 Sperduto (ref_32) 2017; 3 Rogers (ref_6) 2022; 12 Li (ref_20) 2000; 90 Sperduto (ref_33) 2020; 38 Lorenzoni (ref_16) 2004; 60 Bohoudi (ref_28) 2016; 120 Rades (ref_17) 2008; 184 Aoyama (ref_21) 2006; 295 Lutterbach (ref_24) 2008; 62 ref_41 Kocher (ref_8) 2011; 29 Cook (ref_42) 2011; 20 Linskey (ref_1) 2010; 96 Peng (ref_10) 2019; 10 Gaspar (ref_13) 1997; 37 Sperduto (ref_14) 2008; 70 Pirzkall (ref_25) 1998; 16
References_xml	– volume: 316 start-page: 401 year: 2016 ident: ref_23 article-title: Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial publication-title: JAMA doi: 10.1001/jama.2016.9839 – volume: 120 start-page: 24 year: 2014 ident: ref_35 article-title: The accuracy of predicting survival in individual patients with cancer publication-title: J. Neurosurg. doi: 10.3171/2013.9.JNS13788 – volume: 46 start-page: 1155 year: 2000 ident: ref_15 article-title: Radiosurgery for brain metastases: A score index for predicting prognosis publication-title: Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/S0360-3016(99)00549-0 – volume: 98 start-page: 292 year: 2011 ident: ref_30 article-title: Dose-effect relation in stereotactic radiotherapy for brain metastases. A systematic review publication-title: Radiother. Oncol. doi: 10.1016/j.radonc.2011.01.011 – volume: 12 start-page: 866542 year: 2022 ident: ref_6 article-title: Radiosurgery for Five to Fifteen Brain Metastases: A Single Centre Experience and a Review of the Literature publication-title: Front. Oncol. doi: 10.3389/fonc.2022.866542 – volume: 10 start-page: 32 year: 2019 ident: ref_10 article-title: Updated risk models demonstrate low risk of symptomatic radionecrosis following stereotactic radiosurgery for brain metastases publication-title: Surg. Neurol. Int. doi: 10.4103/sni.sni_303_18 – volume: 193 start-page: 150 year: 2017 ident: ref_39 article-title: Prognostic role of patient gender in limited-disease small-cell lung cancer treated with chemoradiotherapy publication-title: Strahlenther. Onkol. doi: 10.1007/s00066-016-1073-x – volume: 188 start-page: 782 year: 2012 ident: ref_40 article-title: Are there biologic differences between male and female breast cancer explaining inferior outcome of men despite equal stage and treatment?! publication-title: Strahlenther. Onkol. doi: 10.1007/s00066-012-0118-z – volume: 90 start-page: 37 year: 2000 ident: ref_20 article-title: Comparison of three treatment options for single brain metastasis from lung cancer publication-title: Int. J. Cancer doi: 10.1002/(SICI)1097-0215(20000220)90:1<37::AID-IJC5>3.0.CO;2-7 – volume: 11 start-page: 8639 year: 2021 ident: ref_44 article-title: Hypofractionated and single-fraction radiosurgery for brain metastases with sex as a key predictor of overall survival publication-title: Sci. Rep. doi: 10.1038/s41598-021-88070-5 – volume: 184 start-page: 565 year: 2008 ident: ref_36 article-title: Comparison of different treatment approaches for one to two brain metastases in elderly patients publication-title: Strahlenther. Onkol. doi: 10.1007/s00066-008-1908-1 – volume: 70 start-page: 510 year: 2008 ident: ref_14 article-title: A new prognostic index and comparison to three other indices for patients with brain metastases: An analysis of 1,960 patients in the RTOG database publication-title: Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/j.ijrobp.2007.06.074 – volume: 29 start-page: 134 year: 2011 ident: ref_8 article-title: Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the EORTC 22952-26001 study publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2010.30.1655 – volume: 188 start-page: 696 year: 2012 ident: ref_12 article-title: Local progression and pseudo progression after single fraction or fractionated stereotactic radiotherapy for large brain metastases publication-title: Strahlenther. Onkol. doi: 10.1007/s00066-012-0122-3 – volume: 76 start-page: S20 year: 2010 ident: ref_27 article-title: Radiation dose-volume effects in the brain publication-title: Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/j.ijrobp.2009.02.091 – volume: 120 start-page: 253 year: 2016 ident: ref_28 article-title: Isotoxic radiosurgery planning for brain metastases publication-title: Radiother. Oncol. doi: 10.1016/j.radonc.2016.05.001 – volume: 78 start-page: 70 year: 2002 ident: ref_19 article-title: Brain metastasis: Experience of the Xi-Jing hospital publication-title: Ster. Funct. Neurosurg. doi: 10.1159/000068015 – volume: 38 start-page: 3773 year: 2020 ident: ref_33 article-title: Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient publication-title: J. Clin. Oncol. doi: 10.1200/JCO.20.01255 – volume: 8 start-page: 395 year: 2018 ident: ref_11 article-title: Diagnosis and Management of Radiation Necrosis in Patients With Brain Metastases publication-title: Front. Oncol. doi: 10.3389/fonc.2018.00395 – ident: ref_41 doi: 10.1371/journal.pone.0052457 – volume: 184 start-page: 655 year: 2008 ident: ref_31 article-title: Comparison of stereotactic radiosurgery (SRS) alone and whole brain radiotherapy (WBRT) plus a stereotactic boost (WBRT + SRS) for one to three brain metastases publication-title: Strahlenther. Onkol. doi: 10.1007/s00066-008-1946-8 – volume: 184 start-page: 251 year: 2008 ident: ref_17 article-title: A new scoring system to predicting the survival of patients treated with whole-brain radiotherapy for brain metastases publication-title: Strahlenther. Onkol. doi: 10.1007/s00066-008-1831-5 – volume: 164 start-page: e671 year: 2022 ident: ref_37 article-title: Prognostic and Predictive Markers of Limited (1-4) Brain Metastases in Patients with Lung Adenocarcinoma After Stereotactic Radiosurgery: A Retrospective Analysis publication-title: World Neurosurg. doi: 10.1016/j.wneu.2022.05.036 – volume: 40 start-page: JCO2200333 year: 2022 ident: ref_3 article-title: Radiation Therapy for Brain Metastases: ASCO Guideline Endorsement of ASTRO Guideline publication-title: J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. doi: 10.1200/JCO.22.00333 – volume: 96 start-page: 45 year: 2010 ident: ref_1 article-title: The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline publication-title: J. Neurooncol. doi: 10.1007/s11060-009-0073-4 – volume: 15 start-page: 387 year: 2014 ident: ref_5 article-title: Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): A multi-institutional prospective observational study publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(14)70061-0 – volume: 34 start-page: 647 year: 1996 ident: ref_29 article-title: Radiosurgery for the treatment of previously irradiated recurrent primary brain tumors and brain metastases: Initial report of radiation therapy oncology group protocol (90-05) publication-title: Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/0360-3016(95)02106-X – ident: ref_34 doi: 10.3390/ijms17122132 – volume: 123 start-page: 189 year: 2017 ident: ref_43 article-title: Individualized early death and long-term survival prediction after stereotactic radiosurgery for brain metastases of non-small cell lung cancer: Two externally validated nomograms publication-title: Radiother. Oncol. doi: 10.1016/j.radonc.2017.02.006 – volume: 16 start-page: 3563 year: 1998 ident: ref_25 article-title: Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases publication-title: J. Clin. Oncol. doi: 10.1200/JCO.1998.16.11.3563 – volume: 11 start-page: 17 year: 2022 ident: ref_7 article-title: Novel approaches to the management of patients with 5-15 brain metastases: A narrative review publication-title: Chin. Clin. Oncol. doi: 10.21037/cco-22-15 – volume: 6 start-page: 48 year: 2011 ident: ref_9 article-title: Stereotactic radiosurgery for brain metastases: Analysis of outcome and risk of brain radionecrosis publication-title: Radiat. Oncol. doi: 10.1186/1748-717X-6-48 – volume: 295 start-page: 2483 year: 2006 ident: ref_21 article-title: Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: A randomized controlled trial publication-title: JAMA doi: 10.1001/jama.295.21.2483 – volume: 31 start-page: 65 year: 2013 ident: ref_4 article-title: A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: Quality-of-life results publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2011.41.0639 – volume: 114 start-page: 871 year: 2022 ident: ref_38 article-title: Distant metastasis velocity as a novel prognostic score for overall survival after disease progression following stereotactic body radiotherapy for oligometastatic disease publication-title: Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/j.ijrobp.2022.06.064 – volume: 3 start-page: 827 year: 2017 ident: ref_32 article-title: Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA) publication-title: JAMA Oncol. doi: 10.1001/jamaoncol.2016.3834 – volume: 20 start-page: 1629 year: 2011 ident: ref_42 article-title: Sex disparities in cancer mortality and survival publication-title: Cancer Epidemiol. Biomark. Prev. doi: 10.1158/1055-9965.EPI-11-0246 – volume: 60 start-page: 218 year: 2004 ident: ref_16 article-title: Radiosurgery for treatment of brain metastases: Estimation of patient eligibility using three stratification systems publication-title: Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/j.ijrobp.2004.02.017 – volume: 62 start-page: 776 year: 2008 ident: ref_24 article-title: Radiosurgery followed by planned observation in patients with one to three brain metastases publication-title: Neurosurgery doi: 10.1227/01.neu.0000316281.07124.ea – volume: 190 start-page: 786 year: 2014 ident: ref_26 article-title: Stereotactic radiosurgery for newly diagnosed brain metastases publication-title: Strahlenther. Onkol. doi: 10.1007/s00066-014-0625-1 – volume: 37 start-page: 745 year: 1997 ident: ref_13 article-title: Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials publication-title: Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/S0360-3016(96)00619-0 – volume: 110 start-page: 2285 year: 2007 ident: ref_18 article-title: Whole-brain radiotherapy versus stereotactic radiosurgery for patients in recursive partitioning analysis classes 1 and 2 with 1 to 3 brain metastases publication-title: Cancer doi: 10.1002/cncr.23037 – volume: 10 start-page: 1037 year: 2009 ident: ref_22 article-title: Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: A randomised controlled trial publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(09)70263-3 – volume: 75 start-page: 5 year: 2005 ident: ref_2 article-title: Brain metastases: Epidemiology and pathophysiology publication-title: J. Neurooncol. doi: 10.1007/s11060-004-8093-6
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SubjectTerms	Adult Aged Aged, 80 and over brain metastases Brain Neoplasms - mortality Brain Neoplasms - secondary Brain Neoplasms - surgery Development and progression Female Health aspects Humans Magnetic Resonance Imaging - methods Male Metastasis Middle Aged outcome Patient outcomes Prognosis prognostic scores Radiosurgery Radiosurgery - methods Retrospective Studies Risk factors sex differences Surgery Treatment Outcome Women
Title	Prognosis versus Actual Outcomes in Stereotactic Radiosurgery of Brain Metastases: Reliability of Common Prognostic Parameters and Indices
URI	https://www.ncbi.nlm.nih.gov/pubmed/38668035 https://www.proquest.com/docview/3047939285 https://doaj.org/article/680c2955c3aa4fffa2d63250fbe0da40
Volume	31
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