Bioactive compounds from Ocimum tenuiflorum and Poria cocos: A novel natural Compound for insomnia treatment based on A computational approach - Ranteh, Onggan; Tedasen, Aman; Rahman, Md. Atiar; Ibrahim, Mohammed Auwal; Sama-ae, Imran (Computers in biology and medicine, 2024)
Keywords: Amino acids; Benzodiazepines; Bioactive compounds; Bioavailability; Biocompatibility; Biological activity; Blood-brain barrier; Carboxylic acids; Cardiovascular diseases; Computational drug discovery; Computer applications; Drug dosages; Drug therapy; Drugs; Genetic algorithms; Herbal medicine; Humans; Insomnia; Internal Medicine; Libraries; Ligands; Medicinal plants; Molecular docking; Molecular Docking Simulation; Molecular dynamic simulations; Molecular dynamics; Molecular Dynamics Simulation; Neuropeptides; Ocimum - chemistry; Ocimum tenuiflorum; Orexin receptors; Orexins; Other; Pharmacokinetics; Pharmacology; Phenanthrene; Plant Extracts - chemistry; Plant Extracts - therapeutic use; Poria cocos; Proteins; Public health; Receptors; Simulation; Sleep deprivation; Sleep disorders; Sleep Initiation and Maintenance Disorders - drug therapy; Toxicity; Molecular dynamic simulations; Medicinal plants; Insomnia; Orexin receptors; Bioactive compounds; Computational drug discovery; Molecular docking; orexin receptors; molecular docking; molecular dynamic simulations; computational drug discovery; bioactive compounds; medicinal plants