Synergic effect in the reduction of serum uric acid level between ethanol extract of Aster glehni and vitamin B6
In this study, synergistic hypoudpricemic activities between ethanol extract of Aster glehni (AG) and vitamin B 6 were investigated in vitro and in vivo. Xanthine oxidase inhibitory activities in the different parts, leaf, stem, and flower, during spring and autumn were compared. In addition, to imp...
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| Published in | Food science and biotechnology Vol. 27; no. 5; pp. 1439 - 1444 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Singapore
Springer Singapore
01.10.2018
Springer Nature B.V 한국식품과학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-7708 2092-6456 2092-6456 |
| DOI | 10.1007/s10068-018-0394-1 |
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| Abstract | In this study, synergistic hypoudpricemic activities between ethanol extract of
Aster glehni
(AG) and vitamin B
6
were investigated in vitro and in vivo. Xanthine oxidase inhibitory activities in the different parts, leaf, stem, and flower, during spring and autumn were compared. In addition, to improve hypouricemic activity, two chemicals (AG extract and vitamins) were mixed and measured inhibitory activity of xanthine oxidase. As a result, autumn leaf AG extracts showed the most effective xanthine oxidase inhibitory activity and we named autumn leaf AG extracts as AG-D006. In synergistic study, AG-D006 with vitamin B
6
showed significantly increased inhibitory activity on xanthine oxidase. AG-D006 with vitamin B
6
also showed significantly reduced uric acid level in hyperuricemic rats in vivo. In conclusion, AG-D006 with vitamin B
6
might be used functional foods in reducing serum uric acid level in gout. |
|---|---|
| AbstractList | In this study, synergistic hypoudpricemic activities between ethanol extract of Aster glehni (AG) and vitamin B₆ were investigated in vitro and in vivo. Xanthine oxidase inhibitory activities in the different parts, leaf, stem, and flower, during spring and autumn were compared. In addition, to improve hypouricemic activity, two chemicals (AG extract and vitamins) were mixed and measured inhibitory activity of xanthine oxidase. As a result, autumn leaf AG extracts showed the most effective xanthine oxidase inhibitory activity and we named autumn leaf AG extracts as AG-D006. In synergistic study, AG-D006 with vitamin B₆ showed significantly increased inhibitory activity on xanthine oxidase. AG-D006 with vitamin B₆ also showed significantly reduced uric acid level in hyperuricemic rats in vivo. In conclusion, AG-D006 with vitamin B₆ might be used functional foods in reducing serum uric acid level in gout. In this study, synergistic hypoudpricemic activities between ethanol extract of Aster glehni (AG) and vitamin B6 were investigated in vitro and in vivo. Xanthine oxidase inhibitory activities in the different parts, leaf, stem, and flower, during spring and autumn were compared. In addition, to improve hypouricemic activity, two chemicals (AG extract and vitamins) were mixed and measured inhibitory activity of xanthine oxidase. As a result, autumn leaf AG extracts showed the most effective xanthine oxidase inhibitory activity and we named autumn leaf AG extracts as AG-D006. In synergistic study, AG-D006 with vitamin B6 showed significantly increased inhibitory activity on xanthine oxidase. AG-D006 with vitamin B6 also showed significantly reduced uric acid level in hyperuricemic rats in vivo. In conclusion, AG-D006 with vitamin B6 might be used functional foods in reducing serum uric acid level in gout. In this study, synergistic hypoudpricemic activities between ethanol extract of Aster glehni (AG) and vitamin B 6 were investigated in vitro and in vivo. Xanthine oxidase inhibitory activities in the different parts, leaf, stem, and flower, during spring and autumn were compared. In addition, to improve hypouricemic activity, two chemicals (AG extract and vitamins) were mixed and measured inhibitory activity of xanthine oxidase. As a result, autumn leaf AG extracts showed the most effective xanthine oxidase inhibitory activity and we named autumn leaf AG extracts as AG-D006. In synergistic study, AG-D006 with vitamin B 6 showed significantly increased inhibitory activity on xanthine oxidase. AG-D006 with vitamin B 6 also showed significantly reduced uric acid level in hyperuricemic rats in vivo. In conclusion, AG-D006 with vitamin B 6 might be used functional foods in reducing serum uric acid level in gout. In this study, synergistic hypoudpricemic activities between ethanol extract of Aster glehni (AG) and vitamin B6 were investigated in vitro and in vivo. Xanthine oxidase inhibitory activities in the different parts, leaf, stem, and flower, during spring and autumn were compared. In addition, to improve hypouricemic activity, two chemicals (AG extract and vitamins) were mixed and measured inhibitory activity of xanthine oxidase. As a result, autumn leaf AG extracts showed the most effective xanthine oxidase inhibitory activity and we named autumn leaf AG extracts as AG-D006. In synergistic study, AGD006 with vitamin B6 showed significantly increased inhibitory activity on xanthine oxidase. AG-D006 with vitamin B6 also showed significantly reduced uric acid level in hyperuricemic rats in vivo. In conclusion, AGD006 with vitamin B6 might be used functional foods in reducing serum uric acid level in gout. KCI Citation Count: 3 In this study, synergistic hypoudpricemic activities between ethanol extract of Aster glehni (AG) and vitamin B6 were investigated in vitro and in vivo. Xanthine oxidase inhibitory activities in the different parts, leaf, stem, and flower, during spring and autumn were compared. In addition, to improve hypouricemic activity, two chemicals (AG extract and vitamins) were mixed and measured inhibitory activity of xanthine oxidase. As a result, autumn leaf AG extracts showed the most effective xanthine oxidase inhibitory activity and we named autumn leaf AG extracts as AG-D006. In synergistic study, AG-D006 with vitamin B6 showed significantly increased inhibitory activity on xanthine oxidase. AG-D006 with vitamin B6 also showed significantly reduced uric acid level in hyperuricemic rats in vivo. In conclusion, AG-D006 with vitamin B6 might be used functional foods in reducing serum uric acid level in gout.In this study, synergistic hypoudpricemic activities between ethanol extract of Aster glehni (AG) and vitamin B6 were investigated in vitro and in vivo. Xanthine oxidase inhibitory activities in the different parts, leaf, stem, and flower, during spring and autumn were compared. In addition, to improve hypouricemic activity, two chemicals (AG extract and vitamins) were mixed and measured inhibitory activity of xanthine oxidase. As a result, autumn leaf AG extracts showed the most effective xanthine oxidase inhibitory activity and we named autumn leaf AG extracts as AG-D006. In synergistic study, AG-D006 with vitamin B6 showed significantly increased inhibitory activity on xanthine oxidase. AG-D006 with vitamin B6 also showed significantly reduced uric acid level in hyperuricemic rats in vivo. In conclusion, AG-D006 with vitamin B6 might be used functional foods in reducing serum uric acid level in gout. |
| Author | Han, Eun Hye Kim, Hyoung Ja Lee, Sang Ho Lim, Mi Kyung Hwang, Dahyun |
| Author_xml | – sequence: 1 givenname: Eun Hye surname: Han fullname: Han, Eun Hye organization: R&D Center, Koreaeundan – sequence: 2 givenname: Mi Kyung surname: Lim fullname: Lim, Mi Kyung organization: R&D Center, Koreaeundan – sequence: 3 givenname: Sang Ho surname: Lee fullname: Lee, Sang Ho organization: R&D Center, Koreaeundan – sequence: 4 givenname: Hyoung Ja surname: Kim fullname: Kim, Hyoung Ja organization: Molecular Recognition Research Center, Korea Institute of Science and Technology – sequence: 5 givenname: Dahyun surname: Hwang fullname: Hwang, Dahyun email: hdh@hoseo.edu organization: Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, The Research Institute for Basic Sciences, Hoseo University |
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| Cites_doi | 10.2147/IJGM.S24953 10.1016/j.ijcard.2015.08.109 10.1002/art.24164 10.1038/ncprheum0556 10.4078/jrd.2011.18.2.94 10.4078/jrd.2011.18.3.187 10.1001/archinternmed.2008.606 10.1016/S0140-6736(99)92381-4 10.1002/bkcs.10021 10.3390/ijms12096077 10.1038/nrrheum.2015.91 10.1002/art.21105 10.3109/15563657808988228 10.1016/j.nut.2004.04.001 10.1002/art.1780290111 |
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| Snippet | In this study, synergistic hypoudpricemic activities between ethanol extract of
Aster glehni
(AG) and vitamin B
6
were investigated in vitro and in vivo.... In this study, synergistic hypoudpricemic activities between ethanol extract of Aster glehni (AG) and vitamin B6 were investigated in vitro and in vivo.... In this study, synergistic hypoudpricemic activities between ethanol extract of Aster glehni (AG) and vitamin B₆ were investigated in vitro and in vivo.... |
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| SubjectTerms | Aster glehnii Autumn blood serum Chemical activity Chemistry Chemistry and Materials Science enzyme inhibition Ethanol flowers Food Science functional foods Functional foods & nutraceuticals Gout In vivo methods and tests Kidney stones Leaves Nutrition Organic chemistry pyridoxine rats spring synergism Uric acid Vitamin B6 Vitamins Xanthine oxidase 식품과학 |
| Title | Synergic effect in the reduction of serum uric acid level between ethanol extract of Aster glehni and vitamin B6 |
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