Aberrant Adiposity and Ectopic Lipid Deposition Characterize the Adult Phenotype of the Preterm Infant

Our investigation addresses the hypothesis that disruption of third trimester development by preterm birth alters multiple biological pathways affecting metabolic health in adult life. We compared healthy adult volunteers aged 18–27 y born at ≤33 wk gestation or at term. We used whole-body MRI, 1 H...

Full description

Saved in:

Bibliographic Details
Published in	Pediatric research Vol. 70; no. 5; pp. 507 - 512
Main Authors	Thomas, E Louise, Parkinson, James R, Hyde, Matthew J, Yap, Ivan K S, Holmes, Elaine, Doré, Caroline J, Bell, Jimmy D, Modi, Neena
Format	Journal Article
Language	English
Published	New York Nature Publishing Group US 01.11.2011 Lippincott Williams & Wilkins
Subjects	692/53 692/700/1720 Adiposity - physiology Adult Biological and medical sciences Biomarkers - metabolism Blood Pressure clinical-investigation Female General aspects Glycoproteins - urine Hippurates - urine Humans Infant, Newborn Infant, Premature - physiology Lipids - analysis Liver - metabolism Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Medical sciences Medicine Medicine & Public Health Metabolome Methylamines - urine Muscles - metabolism Pediatric Surgery Pediatrics Sex Factors Human Premature Pediatrics Adipose tissue Lipids Infant Newborn diseases Phenotype Adiposity Prematurity Adult Anomaly Ectopia Deposition
Online Access	Get full text
ISSN	0031-3998 1530-0447 1530-0447
DOI	10.1203/PDR.0b013e31822d7860

Cover

Abstract	Our investigation addresses the hypothesis that disruption of third trimester development by preterm birth alters multiple biological pathways affecting metabolic health in adult life. We compared healthy adult volunteers aged 18–27 y born at ≤33 wk gestation or at term. We used whole-body MRI, 1 H magnetic resonance spectroscopy (MRS) of liver and muscle, metabonomic profiling of blood and urine, and anthropometric and blood pressure measurements. Preterm subjects had greater (mean difference (95% CI)) total [2.21 L (0.3, 4.1), p = 0.03] and abdominal adipose tissue [internal 0.51 (0.1, 0.9), p = 0.007]; blood pressure [systolic 6.5 mm Hg (2.2, 10.8), p = 0.004; diastolic 5.9 (1.8, 10.1), p = 0.006]; and ectopic lipid (ratio (95% CI)), intrahepatocellular lipid (IHCL) 3.01 (1.78, 5.28) p < 0.001, and tibialis-intramyocellular lipid (T-IMCL) [1.31 (1.02, 1.69) p = 0.04]. In preterm, compared with term men, there was greater internal adipose tissue [mean (SD); men: preterm 4.0 (1.6), term 2.7 (1.1) liters; women: preterm 2.6 (0.9); term 2.6 (0.5); gender-gestation interaction p = 0.048] and significant differences in the urinary metabolome (elevated methylamines and acetyl-glycoproteins, lower hippurate). We have identified multiple premorbid biomarkers in ex-preterm young adults, which are most marked in men and indicative of risks to later wellbeing. These data offer insight into biological trajectories affected by preterm birth and/or neonatal care.
AbstractList	Our investigation addresses the hypothesis that disruption of third trimester development by preterm birth alters multiple biological pathways affecting metabolic health in adult life. We compared healthy adult volunteers aged 18–27 y born at ≤33 wk gestation or at term. We used whole-body MRI, 1 H magnetic resonance spectroscopy (MRS) of liver and muscle, metabonomic profiling of blood and urine, and anthropometric and blood pressure measurements. Preterm subjects had greater (mean difference (95% CI)) total [2.21 L (0.3, 4.1), p = 0.03] and abdominal adipose tissue [internal 0.51 (0.1, 0.9), p = 0.007]; blood pressure [systolic 6.5 mm Hg (2.2, 10.8), p = 0.004; diastolic 5.9 (1.8, 10.1), p = 0.006]; and ectopic lipid (ratio (95% CI)), intrahepatocellular lipid (IHCL) 3.01 (1.78, 5.28) p < 0.001, and tibialis-intramyocellular lipid (T-IMCL) [1.31 (1.02, 1.69) p = 0.04]. In preterm, compared with term men, there was greater internal adipose tissue [mean (SD); men: preterm 4.0 (1.6), term 2.7 (1.1) liters; women: preterm 2.6 (0.9); term 2.6 (0.5); gender-gestation interaction p = 0.048] and significant differences in the urinary metabolome (elevated methylamines and acetyl-glycoproteins, lower hippurate). We have identified multiple premorbid biomarkers in ex-preterm young adults, which are most marked in men and indicative of risks to later wellbeing. These data offer insight into biological trajectories affected by preterm birth and/or neonatal care. Our investigation addresses the hypothesis that disruption of third trimester development by preterm birth alters multiple biological pathways affecting metabolic health in adult life. We compared healthy adult volunteers aged 18-27 y born at ≤ 33 wk gestation or at term. We used whole-body MRI, (1)H magnetic resonance spectroscopy (MRS) of liver and muscle, metabonomic profiling of blood and urine, and anthropometric and blood pressure measurements. Preterm subjects had greater (mean difference (95% CI)) total [2.21 L (0.3, 4.1), p = 0.03] and abdominal adipose tissue [internal 0.51 (0.1, 0.9), p = 0.007]; blood pressure [systolic 6.5 mm Hg (2.2, 10.8), p = 0.004; diastolic 5.9 (1.8, 10.1), p = 0.006]; and ectopic lipid (ratio (95% CI)), intrahepatocellular lipid (IHCL) 3.01 (1.78, 5.28) p < 0.001, and tibialis-intramyocellular lipid (T-IMCL) [1.31 (1.02, 1.69) p = 0.04]. In preterm, compared with term men, there was greater internal adipose tissue [mean (SD); men: preterm 4.0 (1.6), term 2.7 (1.1) liters; women: preterm 2.6 (0.9); term 2.6 (0.5); gender-gestation interaction p = 0.048] and significant differences in the urinary metabolome (elevated methylamines and acetyl-glycoproteins, lower hippurate). We have identified multiple premorbid biomarkers in ex-preterm young adults, which are most marked in men and indicative of risks to later wellbeing. These data offer insight into biological trajectories affected by preterm birth and/or neonatal care.Our investigation addresses the hypothesis that disruption of third trimester development by preterm birth alters multiple biological pathways affecting metabolic health in adult life. We compared healthy adult volunteers aged 18-27 y born at ≤ 33 wk gestation or at term. We used whole-body MRI, (1)H magnetic resonance spectroscopy (MRS) of liver and muscle, metabonomic profiling of blood and urine, and anthropometric and blood pressure measurements. Preterm subjects had greater (mean difference (95% CI)) total [2.21 L (0.3, 4.1), p = 0.03] and abdominal adipose tissue [internal 0.51 (0.1, 0.9), p = 0.007]; blood pressure [systolic 6.5 mm Hg (2.2, 10.8), p = 0.004; diastolic 5.9 (1.8, 10.1), p = 0.006]; and ectopic lipid (ratio (95% CI)), intrahepatocellular lipid (IHCL) 3.01 (1.78, 5.28) p < 0.001, and tibialis-intramyocellular lipid (T-IMCL) [1.31 (1.02, 1.69) p = 0.04]. In preterm, compared with term men, there was greater internal adipose tissue [mean (SD); men: preterm 4.0 (1.6), term 2.7 (1.1) liters; women: preterm 2.6 (0.9); term 2.6 (0.5); gender-gestation interaction p = 0.048] and significant differences in the urinary metabolome (elevated methylamines and acetyl-glycoproteins, lower hippurate). We have identified multiple premorbid biomarkers in ex-preterm young adults, which are most marked in men and indicative of risks to later wellbeing. These data offer insight into biological trajectories affected by preterm birth and/or neonatal care. Our investigation addresses the hypothesis that disruption of third trimester development by preterm birth alters multiple biological pathways affecting metabolic health in adult life. We compared healthy adult volunteers aged 18-27 y born at ≤ 33 wk gestation or at term. We used whole-body MRI, (1)H magnetic resonance spectroscopy (MRS) of liver and muscle, metabonomic profiling of blood and urine, and anthropometric and blood pressure measurements. Preterm subjects had greater (mean difference (95% CI)) total [2.21 L (0.3, 4.1), p = 0.03] and abdominal adipose tissue [internal 0.51 (0.1, 0.9), p = 0.007]; blood pressure [systolic 6.5 mm Hg (2.2, 10.8), p = 0.004; diastolic 5.9 (1.8, 10.1), p = 0.006]; and ectopic lipid (ratio (95% CI)), intrahepatocellular lipid (IHCL) 3.01 (1.78, 5.28) p < 0.001, and tibialis-intramyocellular lipid (T-IMCL) [1.31 (1.02, 1.69) p = 0.04]. In preterm, compared with term men, there was greater internal adipose tissue [mean (SD); men: preterm 4.0 (1.6), term 2.7 (1.1) liters; women: preterm 2.6 (0.9); term 2.6 (0.5); gender-gestation interaction p = 0.048] and significant differences in the urinary metabolome (elevated methylamines and acetyl-glycoproteins, lower hippurate). We have identified multiple premorbid biomarkers in ex-preterm young adults, which are most marked in men and indicative of risks to later wellbeing. These data offer insight into biological trajectories affected by preterm birth and/or neonatal care.
Author	Holmes, Elaine Doré, Caroline J Thomas, E Louise Yap, Ivan K S Modi, Neena Hyde, Matthew J Parkinson, James R Bell, Jimmy D
Author_xml	– sequence: 1 givenname: E Louise surname: Thomas fullname: Thomas, E Louise organization: Metabolic and Molecular Imaging Group, Imperial College London – sequence: 2 givenname: James R surname: Parkinson fullname: Parkinson, James R organization: Department of Medicine, Imperial College London – sequence: 3 givenname: Matthew J surname: Hyde fullname: Hyde, Matthew J organization: Department of Medicine, Imperial College London – sequence: 4 givenname: Ivan K S surname: Yap fullname: Yap, Ivan K S organization: Department of Surgery and Cancer, Imperial College London – sequence: 5 givenname: Elaine surname: Holmes fullname: Holmes, Elaine organization: Department of Surgery and Cancer, Imperial College London – sequence: 6 givenname: Caroline J surname: Doré fullname: Doré, Caroline J organization: Clinical Trials Unit, Medical Research Council – sequence: 7 givenname: Jimmy D surname: Bell fullname: Bell, Jimmy D organization: Metabolic and Molecular Imaging Group, Imperial College London – sequence: 8 givenname: Neena surname: Modi fullname: Modi, Neena email: n.modi@imperial.ac.uk organization: Department of Medicine, Imperial College London
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24724035$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21772225$$D View this record in MEDLINE/PubMed
BookMark	eNqFkc1uEzEURi1URNPAGyDkDWI1xX8z9rCL0gKVIhGh7i2P5w5xNbEH27NInx6nSYXUBax85XvOXXzfFbrwwQNC7ym5pozwz9ubn9ekI5QDp4qxXqqGvEILWnNSESHkBVoQwmnF21ZdoquUHgiholbiDbpkVErGWL1Aw6qDGI3PeNW7KSSXD9j4Ht_aHCZn8cZNrsc38LRyweP1zkRjM0T3CDjvoHjzmPF2Bz7kwwQ4DE_f2wgF2uM7P5Trb9HrwYwJ3p3fJbr_enu__l5tfny7W682lRVM5QoaWRtOJO862QLhXU-6Msq-jI0g3SDUYIZCNFQyYhrWdFaZhrY97UEJvkSfTmenGH7PkLLeu2RhHI2HMCetWqko5SWXJfpwJuduD72eotubeNDPyRTg4xkwyZpxKBlZl_5yQjJB-JH7cuJsDClFGLR12RyjytG4UVOij3XpUpd-WVeRxQv5-f5_tPqkpYL7XxD1Q5ijL8H-2_sD3dupVg
CODEN	PEREBL
CitedBy_id	crossref_primary_10_1016_j_cgh_2021_04_014 crossref_primary_10_1016_j_ajog_2017_07_015 crossref_primary_10_1007_s11936_019_0712_9 crossref_primary_10_1161_HYPERTENSIONAHA_120_15786 crossref_primary_10_1371_journal_pone_0232659 crossref_primary_10_1016_j_pnmrs_2013_04_001 crossref_primary_10_1038_ijo_2012_213 crossref_primary_10_1017_S2040174418000302 crossref_primary_10_1542_peds_2012_2177 crossref_primary_10_1111_ppe_13147 crossref_primary_10_1016_j_jpeds_2012_10_044 crossref_primary_10_1038_srep31560 crossref_primary_10_1136_archdischild_2014_306742 crossref_primary_10_7554_eLife_65554 crossref_primary_10_1001_jamapediatrics_2023_0083 crossref_primary_10_1159_000456040 crossref_primary_10_1159_000443734 crossref_primary_10_2217_bmm_14_13 crossref_primary_10_3945_ajcn_115_125138 crossref_primary_10_3390_metabo11100697 crossref_primary_10_1111_cen_13733 crossref_primary_10_3310_eme03020 crossref_primary_10_3233_NPM_221156 crossref_primary_10_1038_s41390_019_0709_9 crossref_primary_10_2217_clp_12_32 crossref_primary_10_1371_journal_pone_0180082 crossref_primary_10_1159_000517951 crossref_primary_10_1016_j_jpeds_2016_10_015 crossref_primary_10_1038_ijo_2014_48 crossref_primary_10_3389_fphys_2018_00326 crossref_primary_10_1089_chi_2020_0186 crossref_primary_10_1093_ije_dyw155 crossref_primary_10_1152_ajpregu_00271_2017 crossref_primary_10_1016_j_prrv_2017_12_001 crossref_primary_10_3389_fpubh_2020_605149 crossref_primary_10_1177_0148607112444756 crossref_primary_10_1016_j_ynpm_2012_05_020 crossref_primary_10_1038_s41390_023_02896_5 crossref_primary_10_3389_fendo_2021_612888 crossref_primary_10_1007_s00431_018_3090_5 crossref_primary_10_1136_archdischild_2012_303536 crossref_primary_10_1186_s12889_021_10368_w crossref_primary_10_1038_pr_2014_4 crossref_primary_10_3390_nu14235045 crossref_primary_10_1016_j_earlhumdev_2012_12_005 crossref_primary_10_1016_j_rchipe_2015_11_004 crossref_primary_10_1053_j_nainr_2012_09_009 crossref_primary_10_1038_s41598_020_58827_5 crossref_primary_10_1038_pr_2017_301 crossref_primary_10_1038_s41390_020_01190_y crossref_primary_10_1038_s41598_022_13936_1 crossref_primary_10_1002_oby_21267 crossref_primary_10_1515_jpem_2017_0547 crossref_primary_10_1038_pr_2013_204 crossref_primary_10_1210_jc_2012_1716 crossref_primary_10_1038_s41598_021_88465_4 crossref_primary_10_1080_07853890_2022_2067895 crossref_primary_10_1017_S2040174420000914 crossref_primary_10_1515_cclm_2019_0789 crossref_primary_10_1111_j_1753_4887_2012_00501_x crossref_primary_10_3389_fped_2020_00417 crossref_primary_10_1136_archdischild_2022_324920 crossref_primary_10_3390_children10101683 crossref_primary_10_1038_nature11708 crossref_primary_10_1111_apa_13958 crossref_primary_10_1016_j_jogn_2017_09_005 crossref_primary_10_1016_j_jpeds_2019_02_041 crossref_primary_10_1016_j_numecd_2019_08_012 crossref_primary_10_1038_s41390_020_01252_1 crossref_primary_10_1371_journal_pone_0081840 crossref_primary_10_1136_bmjpo_2017_000192 crossref_primary_10_1136_postgradmedj_2020_137707 crossref_primary_10_1016_j_appet_2016_01_007 crossref_primary_10_1016_S0378_3782_14_50007_2 crossref_primary_10_1111_apa_13880
Cites_doi	10.1203/01.PDR.0000180551.93470.56 10.1203/01.PDR.0000148284.58934.1C 10.1038/nature06882 10.1007/s00125-004-1637-7 10.1136/fn.84.1.F18 10.1152/jappl.1999.87.6.2068 10.1016/S0140-6736(00)02384-9 10.1542/peds.2005-0309 10.1038/nprot.2007.376 10.1210/jc.2008-1585 10.1038/ijo.2010.44 10.1001/jama.299.12.1429 10.1152/ajpendo.00229.2009 10.1038/nature05488 10.1007/s00467-004-1717-4 10.1038/ijo.2008.182 10.1021/ac048803i 10.1136/gut.2003.036566 10.1542/peds.111.2.252 10.1002/iub.142 10.1210/jcem.85.7.6661 10.1161/CIRCULATIONAHA.105.540906 10.1159/000047114 10.1007/BF00280883 10.1038/nrendo.2009.264 10.2337/diabetes.48.8.1600 10.1093/ajcn/81.1.256S 10.2466/pr0.94.1.189-194 10.1056/NEJMoa067187 10.1038/nrmicro1152 10.1111/j.1463-1326.2006.00590.x 10.1210/jc.85.7.2402
ContentType	Journal Article
Copyright	International Pediatrics Research Foundation, Inc. 2011 2015 INIST-CNRS
Copyright_xml	– notice: International Pediatrics Research Foundation, Inc. 2011 – notice: 2015 INIST-CNRS
DBID	AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1203/PDR.0b013e31822d7860
DatabaseName	CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1530-0447
EndPage	512
ExternalDocumentID	21772225 24724035 10_1203_PDR_0b013e31822d7860
Genre	Journal Article Comparative Study
GrantInformation_xml	– fundername: Medical Research Council grantid: MC_U120061305
GroupedDBID	--- -Q- .-D .55 .GJ 08G 0R~ 123 2WC 3V. 406 4Q1 4Q2 4Q3 53G 5RE 5VS 70F 77Y 7X7 88E 8C1 8FI 8FJ AACDK AAKAS AANZL AASML AATNV AAWTL AAYEP AAYZH AAZLF ABAKF ABAWZ ABJNI ABLJU ABOCM ABPPZ ABUWG ABZZP ACAOD ACGFO ACGFS ACKTT ACMJI ACRQY ACZOJ ADBBV ADBIZ ADFPA ADHDB ADZCM AE3 AE6 AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFKRA AFSHS AFTRI AFUWQ AGAYW AGHAI AGQEE AHRYX AHSBF AHVBC AIGIU AILAN AIZYK AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF AWKKM AXYYD BAWUL BENPR BKKNO BPHCQ BS7 BVXVI CCPQU CS3 DIK DNIVK DPUIP DU5 EBLON EBS EE. EIOEI EJD EX3 F2K F2L F2M F2N F5P FDQFY FERAY FIGPU FIZPM FRP FSGXE FYUFA H0~ HMCUK IWAJR JF9 JG8 JK3 JSO JZLTJ K8S KD2 KMI L7B M18 M1P N9A NAO NQJWS NXXTH N~M OAG OAH ODA OK1 OL1 OLG OLH OLU OLV OLY OLZ OVD OWU OWV OWW OWX OWY OWZ P-K P2P PQQKQ PROAC PSQYO R58 RNT RNTTT ROL S4R SJN SNX SNYQT SOHCF SOJ SRMVM SWTZT T8P TAOOD TBHMF TDRGL TEORI TR2 UKHRP VVN W2D W3M WOQ WOW X7M XXN XYM YFH YOC ZFV ZXP AAYXX ABBRH ABDBE ABFSG ACMFV ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT ABRTQ IQODW PJZUB PPXIY CGR CUY CVF ECM EIF NPM PMFND 7X8
ID	FETCH-LOGICAL-c428t-e675a3073bb79e03bd0bbb77d03b640bf48fafa3061720a626bc8a619d1de843
ISSN	0031-3998 1530-0447
IngestDate	Sun Sep 28 09:43:00 EDT 2025 Sat May 31 02:05:24 EDT 2025 Mon Jul 21 09:15:12 EDT 2025 Tue Jul 01 03:13:38 EDT 2025 Thu Apr 24 22:50:30 EDT 2025 Fri Feb 21 02:38:42 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	5
Keywords	Human Premature Pediatrics Adipose tissue Lipids Infant Newborn diseases Phenotype Adiposity Prematurity Adult Anomaly Ectopia Deposition
Language	English
License	CC BY 4.0
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c428t-e675a3073bb79e03bd0bbb77d03b640bf48fafa3061720a626bc8a619d1de843
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
OpenAccessLink	https://www.nature.com/articles/pr2011217.pdf
PMID	21772225
PQID	897811300
PQPubID	23479
PageCount	6
ParticipantIDs	proquest_miscellaneous_897811300 pubmed_primary_21772225 pascalfrancis_primary_24724035 crossref_citationtrail_10_1203_PDR_0b013e31822d7860 crossref_primary_10_1203_PDR_0b013e31822d7860 springer_journals_10_1203_PDR_0b013e31822d7860
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2011-11-01
PublicationDateYYYYMMDD	2011-11-01
PublicationDate_xml	– month: 11 year: 2011 text: 2011-11-01 day: 01
PublicationDecade	2010
PublicationPlace	New York
PublicationPlace_xml	– name: New York – name: Hagerstown, MD – name: United States
PublicationSubtitle	Official publication of the American Pediatric Society, the European Society for Paediatric Research and the Society for Pediatric Research
PublicationTitle	Pediatric research
PublicationTitleAbbrev	Pediatr Res
PublicationTitleAlternate	Pediatr Res
PublicationYear	2011
Publisher	Nature Publishing Group US Lippincott Williams & Wilkins
Publisher_xml	– name: Nature Publishing Group US – name: Lippincott Williams & Wilkins
References	Uthaya, Thomas, Hamilton, Dore, Bell, Modi (CR10) 2005; 57 Calvani, Miccheli, Capuani, Tomassini Miccheli, Puccetti, Delfini, Iaconelli, Nanni, Mingrone (CR31) 2010; 34 Hovi, Andersson, Eriksson, Jarvenpaa, Strang-Karlsson, Makitie, Kajantie (CR8) 2007; 356 Matthews, Hosker, Rudenski, Naylor, Treacher, Turner (CR15) 1985; 28 Hagströmer, Bergman, De Bourdeaudhuij, Ortega, Ruiz, Manios, Rey-López, Phillipp, Sjöström (CR14) 2008; 32 Mulder, Rietveld, van Amelsvoort (CR29) 2005; 81 Lucas (CR33) 1991; 156 Cloarec, Dumas, Trygg, Craig, Barton, Lindon, Nicholson, Holmes (CR20) 2005; 77 Després, Lemieux (CR12) 2006; 444 Kistner, Celsi, Vanpee, Jacobson (CR3) 2005; 20 Beckonert, Keun, Ebbels, Bundy, Holmes, Lindon, Nicholson (CR19) 2007; 2 Perseghin, Scifo, De Cobelli, Pagliato, Battezzati, Arcelloni, Vanzulli, Testolin, Pozza, Del, Maschio, Luzi (CR25) 1999; 48 Rasouli, Molavi, Elbein, Kern (CR23) 2007; 9 Vettor, Milan, Franzin, Sanna, De Coppi, Rizzuto, Federspil (CR24) 2009; 297 Iyer, Fairlie, Prins, Hammock, Brown (CR27) 2010; 6 Thomas, Uthaya, Vasu, McCarthy, McEwan, Hamilton, Bell, Modi (CR11) 2008; 93 Snijder, Visser, Dekker, Goodpaster, Harris, Kritchevsky, De Rekeneire, Kanaya, Newman, Tylavsky, Seidell (CR26) 2005; 48 Hack, Schluchter, Cartar, Rahman (CR5) 2005; 58 Holmes, Loo, Stamler, Bictash, Yap, Chan, Ebbels, De Iorio, Brown, Veselkov, Daviglus, Kesteloot, Ueshima, Zhao, Nicholson, Elliott (CR28) 2008; 453 Yamato, Kimura, Inoue, Kurosawa, Kato (CR32) 2001; 80 Jensen (CR22) 2008; 93 Doyle, Faber, Callanan, Morley (CR4) 2003; 111 Neuhäuser, Manly (CR21) 2004; 94 Thomas, Hamilton, Patel, O'Dwyer, Doré, Goldin, Bell, Taylor-Robinson (CR17) 2005; 54 Stevenson, West, Pharoah (CR1) 2001; 84 Johansson, Iliadou, Bergvall, Tuvemo, Norman, Cnattingius (CR6) 2005; 112 Nicholson, Holmes, Wilson (CR30) 2005; 3 Swamy, Ostbye, Skjaerven (CR9) 2008; 299 Katz, Nambi, Mather, Baron, Follmann, Sullivan, Quon (CR16) 2000; 85 Consitt, Bell, Houmard (CR13) 2009; 61 Irving, Belton, Elton, Walker (CR2) 2000; 355 Keijzer-Veen, Finken, Nauta, Dekker, Hille, Frolich, Wit, van der Heijden (CR7) 2005; 116 Rico-Sanz, Thomas, Jenkinson, Mierisova, Iles, Bell (CR18) 1999; 87 Uthaya S (pr2011217-bib10) 2005; 57 Stevenson CJ (pr2011217-bib1) 2001; 84 Irving RJ (pr2011217-bib2) 2000; 355 Yamato Y (pr2011217-bib32) 2001; 80 Neuhäuser M (pr2011217-bib21) 2004; 94 Katz A (pr2011217-bib16) 2000; 85 Kistner A (pr2011217-bib3) 2005; 20 Swamy GK (pr2011217-bib9) 2008; 299 Jensen MD (pr2011217-bib22) 2008; 93 Hovi P (pr2011217-bib8) 2007; 356 Thomas EL (pr2011217-bib11) 2008; 93 Hagströmer M (pr2011217-bib14) 2008; 32 Rasouli N (pr2011217-bib23) 2007; 9 Thomas EL (pr2011217-bib17) 2005; 54 Iyer A (pr2011217-bib27) 2010; 6 Doyle LW (pr2011217-bib4) 2003; 111 Cloarec O (pr2011217-bib20) 2005; 77 Consitt LA (pr2011217-bib13) 2009; 61 Holmes E (pr2011217-bib28) 2008; 453 Lucas A (pr2011217-bib33) 1991; 156 Després JP (pr2011217-bib12) 2006; 444 Beckonert O (pr2011217-bib19) 2007; 2 Calvani R (pr2011217-bib31) 2010; 34 Hack M (pr2011217-bib5) 2005; 58 Rico-Sanz J (pr2011217-bib18) 1999; 87 Vettor R (pr2011217-bib24) 2009; 297 Perseghin G (pr2011217-bib25) 1999; 48 Snijder MB (pr2011217-bib26) 2005; 48 Nicholson JK (pr2011217-bib30) 2005; 3 Johansson S (pr2011217-bib6) 2005; 112 Mulder TP (pr2011217-bib29) 2005; 81 Keijzer-Veen MG (pr2011217-bib7) 2005; 116 Matthews DR (pr2011217-bib15) 1985; 28
References_xml	– volume: 58 start-page: 677 year: 2005 end-page: 684 ident: CR5 article-title: Blood pressure among very low birth weight (<1.5 kg) young adults publication-title: Pediatr Res doi: 10.1203/01.PDR.0000180551.93470.56 – volume: 57 start-page: 211 year: 2005 end-page: 215 ident: CR10 article-title: Altered adiposity after extremely preterm birth publication-title: Pediatr Res doi: 10.1203/01.PDR.0000148284.58934.1C – volume: 453 start-page: 396 year: 2008 end-page: 400 ident: CR28 article-title: Human metabolic phenotype diversity and its association with diet and blood pressure publication-title: Nature doi: 10.1038/nature06882 – volume: 48 start-page: 301 year: 2005 end-page: 308 ident: CR26 article-title: Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study publication-title: Diabetologia doi: 10.1007/s00125-004-1637-7 – volume: 84 start-page: F18 year: 2001 end-page: F22 ident: CR1 article-title: Dermatoglyphic patterns, very low birth weight, and blood pressure in adolescence publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/fn.84.1.F18 – volume: 87 start-page: 2068 year: 1999 end-page: 2072 ident: CR18 article-title: Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by (1)H-MRS publication-title: J Appl Physiol doi: 10.1152/jappl.1999.87.6.2068 – volume: 355 start-page: 2135 year: 2000 end-page: 2136 ident: CR2 article-title: Adult cardiovascular risk factors in premature babies publication-title: Lancet doi: 10.1016/S0140-6736(00)02384-9 – volume: 116 start-page: 725 year: 2005 end-page: 731 ident: CR7 article-title: Is blood pressure increased 19 years after intrauterine growth restriction and preterm birth? A prospective follow-up study in The Netherlands publication-title: Pediatrics doi: 10.1542/peds.2005-0309 – volume: 2 start-page: 2692 year: 2007 end-page: 2703 ident: CR19 article-title: Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts publication-title: Nat Protoc doi: 10.1038/nprot.2007.376 – volume: 93 start-page: S57 year: 2008 end-page: S63 ident: CR22 article-title: Role of body fat distribution and the metabolic complications of obesity publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-1585 – volume: 34 start-page: 1095 year: 2010 end-page: 1098 ident: CR31 article-title: Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype publication-title: Int J Obes (Lond) doi: 10.1038/ijo.2010.44 – volume: 299 start-page: 1429 year: 2008 end-page: 1436 ident: CR9 article-title: Association of preterm birth with long-term survival, reproduction, and next-generation preterm birth publication-title: JAMA doi: 10.1001/jama.299.12.1429 – volume: 297 start-page: E987 year: 2009 end-page: E998 ident: CR24 article-title: The origin of intermuscular adipose tissue and its pathophysiological implications publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00229.2009 – volume: 444 start-page: 881 year: 2006 end-page: 887 ident: CR12 article-title: Abdominal obesity and metabolic syndrome publication-title: Nature doi: 10.1038/nature05488 – volume: 20 start-page: 232 year: 2005 end-page: 233 ident: CR3 article-title: Increased systolic daily ambulatory blood pressure in adult women born preterm publication-title: Pediatr Nephrol doi: 10.1007/s00467-004-1717-4 – volume: 32 start-page: S42 year: 2008 end-page: S48 ident: CR14 article-title: Concurrent validity of a modified version of the International Physical Activity Questionnaire (IPAQ-A) in European adolescents: the HELENA Study publication-title: Int J Obes (Lond) doi: 10.1038/ijo.2008.182 – volume: 77 start-page: 517 year: 2005 end-page: 526 ident: CR20 article-title: Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies publication-title: Anal Chem doi: 10.1021/ac048803i – volume: 54 start-page: 122 year: 2005 end-page: 127 ident: CR17 article-title: Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study publication-title: Gut doi: 10.1136/gut.2003.036566 – volume: 111 start-page: 252 year: 2003 end-page: 257 ident: CR4 article-title: Blood pressure in late adolescence and very low birth weight publication-title: Pediatrics doi: 10.1542/peds.111.2.252 – volume: 61 start-page: 47 year: 2009 end-page: 55 ident: CR13 article-title: Intramuscular lipid metabolism, insulin action, and obesity publication-title: IUBMB Life doi: 10.1002/iub.142 – volume: 85 start-page: 2402 year: 2000 end-page: 2410 ident: CR16 article-title: Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.85.7.6661 – volume: 112 start-page: 3430 year: 2005 end-page: 3436 ident: CR6 article-title: Risk of high blood pressure among young men increases with the degree of immaturity at birth publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.540906 – volume: 80 start-page: 19 year: 2001 end-page: 25 ident: CR32 article-title: Fetal bile acid metabolism: analysis of urinary 3 beta-monohydroxy-delta(5) bile acid in preterm infants publication-title: Biol Neonate doi: 10.1159/000047114 – volume: 156 start-page: 38 year: 1991 end-page: 50 ident: CR33 article-title: Programming by early nutrition in man publication-title: Ciba Found Symp – volume: 28 start-page: 412 year: 1985 end-page: 419 ident: CR15 article-title: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man publication-title: Diabetologia doi: 10.1007/BF00280883 – volume: 6 start-page: 71 year: 2010 end-page: 82 ident: CR27 article-title: Inflammatory lipid mediators in adipocyte function and obesity publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2009.264 – volume: 48 start-page: 1600 year: 1999 end-page: 1606 ident: CR25 article-title: Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H–13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents publication-title: Diabetes doi: 10.2337/diabetes.48.8.1600 – volume: 81 start-page: 256S year: 2005 end-page: 260S ident: CR29 article-title: Consumption of both black tea and green tea results in an increase in the excretion of hippuric acid into urine publication-title: Am J Clin Nutr doi: 10.1093/ajcn/81.1.256S – volume: 94 start-page: 189 year: 2004 end-page: 194 ident: CR21 article-title: The Fisher-Pitman permutation test when testing for differences in mean and variance publication-title: Psychol Rep doi: 10.2466/pr0.94.1.189-194 – volume: 356 start-page: 2053 year: 2007 end-page: 2063 ident: CR8 article-title: Glucose regulation in young adults with very low birth weight publication-title: N Engl J Med doi: 10.1056/NEJMoa067187 – volume: 3 start-page: 431 year: 2005 end-page: 438 ident: CR30 article-title: Gut microorganisms, mammalian metabolism and personalized health care publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro1152 – volume: 93 start-page: F382 year: 2008 end-page: F383 ident: CR11 article-title: Neonatal intrahepatocellular lipid publication-title: Arch Dis Child Fetal Neonatal Ed – volume: 9 start-page: 1 year: 2007 end-page: 10 ident: CR23 article-title: Ectopic fat accumulation and metabolic syndrome publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2006.00590.x – volume: 112 start-page: 3430 year: 2005 ident: pr2011217-bib6 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.540906 – volume: 356 start-page: 2053 year: 2007 ident: pr2011217-bib8 publication-title: N Engl J Med doi: 10.1056/NEJMoa067187 – volume: 453 start-page: 396 year: 2008 ident: pr2011217-bib28 publication-title: Nature doi: 10.1038/nature06882 – volume: 2 start-page: 2692 year: 2007 ident: pr2011217-bib19 publication-title: Nat Protoc doi: 10.1038/nprot.2007.376 – volume: 28 start-page: 412 year: 1985 ident: pr2011217-bib15 publication-title: Diabetologia doi: 10.1007/BF00280883 – volume: 93 start-page: S57 year: 2008 ident: pr2011217-bib22 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-1585 – volume: 297 start-page: E987 year: 2009 ident: pr2011217-bib24 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00229.2009 – volume: 20 start-page: 232 year: 2005 ident: pr2011217-bib3 publication-title: Pediatr Nephrol doi: 10.1007/s00467-004-1717-4 – volume: 58 start-page: 677 year: 2005 ident: pr2011217-bib5 publication-title: Pediatr Res doi: 10.1203/01.PDR.0000180551.93470.56 – volume: 93 start-page: F382 year: 2008 ident: pr2011217-bib11 publication-title: Arch Dis Child Fetal Neonatal Ed – volume: 48 start-page: 301 year: 2005 ident: pr2011217-bib26 publication-title: Diabetologia doi: 10.1007/s00125-004-1637-7 – volume: 6 start-page: 71 year: 2010 ident: pr2011217-bib27 publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2009.264 – volume: 32 start-page: S42 year: 2008 ident: pr2011217-bib14 publication-title: Int J Obes (Lond) doi: 10.1038/ijo.2008.182 – volume: 116 start-page: 725 year: 2005 ident: pr2011217-bib7 publication-title: Pediatrics doi: 10.1542/peds.2005-0309 – volume: 85 start-page: 2402 year: 2000 ident: pr2011217-bib16 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.85.7.2402 – volume: 80 start-page: 19 year: 2001 ident: pr2011217-bib32 publication-title: Biol Neonate doi: 10.1159/000047114 – volume: 444 start-page: 881 year: 2006 ident: pr2011217-bib12 publication-title: Nature doi: 10.1038/nature05488 – volume: 61 start-page: 47 year: 2009 ident: pr2011217-bib13 publication-title: IUBMB Life doi: 10.1002/iub.142 – volume: 54 start-page: 122 year: 2005 ident: pr2011217-bib17 publication-title: Gut doi: 10.1136/gut.2003.036566 – volume: 156 start-page: 38 year: 1991 ident: pr2011217-bib33 publication-title: Ciba Found Symp – volume: 94 start-page: 189 year: 2004 ident: pr2011217-bib21 publication-title: Psychol Rep doi: 10.2466/pr0.94.1.189-194 – volume: 3 start-page: 431 year: 2005 ident: pr2011217-bib30 publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro1152 – volume: 57 start-page: 211 year: 2005 ident: pr2011217-bib10 publication-title: Pediatr Res doi: 10.1203/01.PDR.0000148284.58934.1C – volume: 299 start-page: 1429 year: 2008 ident: pr2011217-bib9 publication-title: JAMA doi: 10.1001/jama.299.12.1429 – volume: 48 start-page: 1600 year: 1999 ident: pr2011217-bib25 publication-title: Diabetes doi: 10.2337/diabetes.48.8.1600 – volume: 84 start-page: F18 year: 2001 ident: pr2011217-bib1 publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/fn.84.1.F18 – volume: 111 start-page: 252 year: 2003 ident: pr2011217-bib4 publication-title: Pediatrics doi: 10.1542/peds.111.2.252 – volume: 87 start-page: 2068 year: 1999 ident: pr2011217-bib18 publication-title: J Appl Physiol doi: 10.1152/jappl.1999.87.6.2068 – volume: 355 start-page: 2135 year: 2000 ident: pr2011217-bib2 publication-title: Lancet doi: 10.1016/S0140-6736(00)02384-9 – volume: 81 start-page: 256S year: 2005 ident: pr2011217-bib29 publication-title: Am J Clin Nutr doi: 10.1093/ajcn/81.1.256S – volume: 77 start-page: 517 year: 2005 ident: pr2011217-bib20 publication-title: Anal Chem doi: 10.1021/ac048803i – volume: 34 start-page: 1095 year: 2010 ident: pr2011217-bib31 publication-title: Int J Obes (Lond) doi: 10.1038/ijo.2010.44 – volume: 9 start-page: 1 year: 2007 ident: pr2011217-bib23 publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2006.00590.x
SSID	ssj0014584
Score	2.3411117
Snippet	Our investigation addresses the hypothesis that disruption of third trimester development by preterm birth alters multiple biological pathways affecting...
SourceID	proquest pubmed pascalfrancis crossref springer
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	507
SubjectTerms	692/53 692/700/1720 Adiposity - physiology Adult Biological and medical sciences Biomarkers - metabolism Blood Pressure clinical-investigation Female General aspects Glycoproteins - urine Hippurates - urine Humans Infant, Newborn Infant, Premature - physiology Lipids - analysis Liver - metabolism Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Medical sciences Medicine Medicine & Public Health Metabolome Methylamines - urine Muscles - metabolism Pediatric Surgery Pediatrics Sex Factors
Title	Aberrant Adiposity and Ectopic Lipid Deposition Characterize the Adult Phenotype of the Preterm Infant
URI	https://link.springer.com/article/10.1203/PDR.0b013e31822d7860 https://www.ncbi.nlm.nih.gov/pubmed/21772225 https://www.proquest.com/docview/897811300
Volume	70
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Ja9tAFB5cB0qhlO5VlzCH3oxcWRpJ46PSOJi2dkxwITmJGWlEDEEyXi75N_2nfbNoJCWmaXsRQkjW4O_Te_N2hD7zQkQBY76bCUJcEnljl4HmcSkNGAEDOg6JLE6ezaPpT_LtMrzs9X61spb2Oz7Mbg_WlfwPqnANcJVVsv-ArP1RuADngC8cAWE4_hXGCRcb0DWyBe5KZV_pZkqTbFetV9lAzqWWecZ1YpaKrevuzLdC15TI7huDxbUoK-WLNQkDi41KkgHhUbCy47y3kz0GpkuQ9SYvp-ezROUBToaDH9V-1UR9FsmFdBKcz21abpOmOL06neiaITV3vIlSXSULJb9kfdX3ofHQ5tbfOuq6Jw60mVDuidWNzAFqi-Zg5MJuibZFs54pYigYtuRsqEflGpUd6kzse9rA92RXisXpRePu9f08pnqCQbf59h2laFMVfRLLloXhI3Tkx7A966Oj5OzkZG5DVTLQrHt_6vWb-kx495dDb-7sf56u2RY-xULPUDlk5NwL0Kt9z_I5emYMFpxo9r1APVG-RI9nJiXjFSpqEmJLQgwkxIaEWJEQNyTEbRJiwBwrEmJLQlwV6rIhIdYkfI2WZ5Pl16lrhne4GVi0O1eAJcqkAuE8Hgsv4LnH4TTO4TQiHi8ILVgBd8gttMfAruYZZWDO56NcUBK8Qf2yKsU7hD3hE5qzgI_igkR5RoOIjcMQRAoR1COBg4L6H00z09hezle5SaWBCzikgEN6FwcHufaptW7s8sD9xx2w7EM1QRyEa_RSENEy7sZKUe23KZV95WTY2EFvNarNwyOwbkGlOmhYw5waAbP943LeP7ScD-hJ8zl-RP3dZi8-wf55x48Ng38DG77A5A
linkProvider	Library Specific Holdings
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Aberrant+Adiposity+and+Ectopic+Lipid+Deposition+Characterize+the+Adult+Phenotype+of+the+Preterm+Infant&rft.jtitle=Pediatric+research&rft.au=THOMAS%2C+E.+Louise&rft.au=PARKINSON%2C+James+R&rft.au=HYDE%2C+Matthew+J&rft.au=YAP%2C+Ivan+K.+S&rft.date=2011-11-01&rft.pub=Lippincott+Williams+%26+Wilkins&rft.issn=0031-3998&rft.volume=70&rft.issue=5&rft.spage=507&rft.epage=512&rft_id=info:doi/10.1203%2FPDR.0b013e31822d7860&rft.externalDBID=n%2Fa&rft.externalDocID=24724035
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0031-3998&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0031-3998&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0031-3998&client=summon