High-Temporal-Resolution Kinetic Modeling of Lung Tumors with Dual-Blood Input Function Using Total-Body Dynamic PET

• Published in: Journal of Nuclear Medicine Vol. 65; no. 5; pp. 714 - 721
• Main Authors: Wang, Yiran, Abdelhafez, Yasser G., Spencer, Benjamin A., Verma, Rashmi, Parikh, Mamta, Stollenwerk, Nicholas, Nardo, Lorenzo, Jones, Terry, Badawi, Ramsey D., Cherry, Simon R., Wang, Guobao
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.05.2024
• Subjects: Adult; Aged; Arteries; Blood; Clinical Investigation; Computed tomography; Criteria; Curve fitting; Deoxygenation; Electrons; Female; Fluorine isotopes; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Kinetics; Lung cancer; Lung diseases; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - metabolism; Lungs; Male; Medical imaging; Middle Aged; Modelling; Models, Biological; Positron emission; Positron emission tomography; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography - methods; Pulmonary arteries; Pulmonary artery; Radiopharmaceuticals - pharmacokinetics; Regional analysis; Temporal resolution; Time Factors; Time lag; Tumors; Ventricle; Whole Body Imaging; lung cancer; total-body dynamic PET; dual-blood input function; high temporal resolution; kinetic modeling
• ISSN: 0161-5505; 1535-5667; 2159-662X; 1535-5667
• DOI: 10.2967/jnumed.123.267036

The lungs are supplied by both the pulmonary arteries carrying deoxygenated blood originating from the right ventricle and the bronchial arteries carrying oxygenated blood downstream from the left ventricle. However, this effect of dual blood supply has never been investigated using PET, partially because the temporal resolution of conventional dynamic PET scans is limited. The advent of PET scanners with a long axial field of view, such as the uEXPLORER total-body PET/CT system, permits dynamic imaging with high temporal resolution (HTR). In this work, we modeled the dual-blood input function (DBIF) and studied its impact on the kinetic quantification of normal lung tissue and lung tumors using HTR dynamic PET imaging. Thirteen healthy subjects and 6 cancer subjects with lung tumors underwent a dynamic F-FDG scan with the uEXPLORER for 1 h. Data were reconstructed into dynamic frames of 1 s in the early phase. Regional time-activity curves of lung tissue and tumors were analyzed using a 2-tissue compartmental model with 3 different input functions: the right ventricle input function, left ventricle input function, and proposed DBIF, all with time delay and dispersion corrections. These models were compared for time-activity curve fitting quality using the corrected Akaike information criterion and for differentiating lung tumors from lung tissue using the Mann-Whitney test. Voxelwise multiparametric images by the DBIF model were further generated to verify the regional kinetic analysis. The effect of dual blood supply was pronounced in the high-temporal-resolution time-activity curves of lung tumors. The DBIF model achieved better time-activity curve fitting than the other 2 single-input models according to the corrected Akaike information criterion. The estimated fraction of left ventricle input was low in normal lung tissue of healthy subjects but much higher in lung tumors (∼0.04 vs. ∼0.3, < 0.0003). The DBIF model also showed better robustness in the difference in F-FDG net influx rate [Formula: see text] and delivery rate [Formula: see text] between lung tumors and normal lung tissue. Multiparametric imaging with the DBIF model further confirmed the differences in tracer kinetics between normal lung tissue and lung tumors. The effect of dual blood supply in the lungs was demonstrated using HTR dynamic imaging and compartmental modeling with the proposed DBIF model. The effect was small in lung tissue but nonnegligible in lung tumors. HTR dynamic imaging with total-body PET can offer a sensitive tool for investigating lung diseases.