The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver - Hörbelt, Tina; Knebel, Birgit; Fahlbusch, Pia; Barbosa, David; de Wiza, Daniella Herzfeld; Van de Velde, Frederique; Van Nieuwenhove, Yves; Lapauw, Bruno; Thoresen, G. Hege; Al-Hasani, Hadi; Müller-Wieland, Dirk; Ouwens, D. Margriet; et al. (Biochimica et biophysica acta. Molecular basis of disease, 2019)
Keywords: Adipokines; Adipokines - metabolism; Adipose Tissue, White; Adult; Animals; Diabetes Mellitus, Type 2 - metabolism; Disease Models, Animal; Fatty Acids - metabolism; Female; Forkhead Box Protein O1 - metabolism; FoxO1; Gene Expression Regulation; Gluconeogenesis; Hepatic insulin resistance; Hepatocytes - metabolism; Humans; Insulin - metabolism; Insulin action; Insulin Receptor Substrate Proteins - metabolism; Insulin resistance; Insulin Resistance - physiology; Lipogenesis - physiology; Liver - metabolism; Male; Mice; Mice, Inbred C57BL; Middle Aged; Muscle Fibers, Skeletal - metabolism; NAFLD; Non-alcoholic Fatty Liver Disease - metabolism; Obesity - metabolism; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; sFRP4; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Triglycerides - metabolism; HOMA2-%B; NAFLD; DNL; SAT; VAT; ALT; Adipokines; SREBP-1c; Insulin action; HOMA-IR; GGT; sFRP4; BZ; Insulin resistance; Hepatic insulin resistance; BMI; FoxO1