The therapeutic potential of curcumin: A review of clinical trials
Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventi...
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| Published in | European journal of medicinal chemistry Vol. 163; pp. 527 - 545 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
France
Elsevier Masson SAS
01.02.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0223-5234 1768-3254 1768-3254 |
| DOI | 10.1016/j.ejmech.2018.12.016 |
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| Abstract | Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases.
[Display omitted]
•Curcuma longa L., and its main bioactive constituent, curcumin, have a wide spectrum of biological potentialities.•Promising in vitro and in vivo therapeutic effects have been markedly reported.•Curcumin therapeutic effects in human subjects are carefully discussed here.•Curcumin anti-inflammatory and cardioprotective effects are the most often investigated.•Renowned benefits on malignant diseases, gastrointestinal and central nervous system have also been demonstrated. |
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| AbstractList | Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases.Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases. Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases. [Display omitted] •Curcuma longa L., and its main bioactive constituent, curcumin, have a wide spectrum of biological potentialities.•Promising in vitro and in vivo therapeutic effects have been markedly reported.•Curcumin therapeutic effects in human subjects are carefully discussed here.•Curcumin anti-inflammatory and cardioprotective effects are the most often investigated.•Renowned benefits on malignant diseases, gastrointestinal and central nervous system have also been demonstrated. Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases. |
| Author | Salehi, Bahare Anil Kumar, Nanjangud V. Stojanović-Radić, Zorica Sharifi-Rad, Mehdi Martins, Natália Sharifi-Rad, Javad Matejić, Jelena |
| Author_xml | – sequence: 1 givenname: Bahare surname: Salehi fullname: Salehi, Bahare email: bahar.salehi007@gmail.com organization: Bam University of Medical Sciences, Bam, Iran – sequence: 2 givenname: Zorica surname: Stojanović-Radić fullname: Stojanović-Radić, Zorica email: zstojanovicradic@yahoo.com organization: Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000, Niš, Serbia – sequence: 3 givenname: Jelena surname: Matejić fullname: Matejić, Jelena email: jekamatejic@gmail.com organization: Department of Pharmacy, Faculty of Medicine, University of Niš, Boulevard Dr Zorana Đinđića 81, 18000, Niš, Serbia – sequence: 4 givenname: Mehdi surname: Sharifi-Rad fullname: Sharifi-Rad, Mehdi email: mehdi_sharifirad@yahoo.com organization: Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol, 61663-335, Iran – sequence: 5 givenname: Nanjangud V. orcidid: 0000-0002-8016-8991 surname: Anil Kumar fullname: Anil Kumar, Nanjangud V. email: nv.anil@manipal.edu organization: Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India – sequence: 6 givenname: Natália orcidid: 0000-0002-5934-5201 surname: Martins fullname: Martins, Natália email: ncmartins@med.up.pt organization: Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto, 4200-319, Portugal – sequence: 7 givenname: Javad surname: Sharifi-Rad fullname: Sharifi-Rad, Javad email: javad.sharifirad@gmail.com, javad.sharifirad@sbmu.ac.ir organization: Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30553144$$D View this record in MEDLINE/PubMed |
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