Origin of Life: The Point of No Return
Origin of life research is one of the greatest scientific frontiers of mankind. Many hypotheses have been proposed to explain how life began. Although different hypotheses emphasize different initial phenomena, all of them agree around one important concept: at some point, along with the chain of ev...
Saved in:
Published in | Life (Basel, Switzerland) Vol. 10; no. 11; p. 269 |
---|---|
Main Author | |
Format | Journal Article |
Language | English |
Published |
MDPI
03.11.2020
MDPI AG |
Subjects | |
Online Access | Get full text |
ISSN | 2075-1729 2075-1729 |
DOI | 10.3390/life10110269 |
Cover
Abstract | Origin of life research is one of the greatest scientific frontiers of mankind. Many hypotheses have been proposed to explain how life began. Although different hypotheses emphasize different initial phenomena, all of them agree around one important concept: at some point, along with the chain of events toward life, Darwinian evolution emerged. There is no consensus, however, how this occurred. Frequently, the mechanism leading to Darwinian evolution is not addressed and it is assumed that this problem could be solved later, with experimental proof of the hypothesis. Here, the author first defines the minimum components required for Darwinian evolution and then from this standpoint, analyzes some of the hypotheses for the origin of life. Distinctive features of Darwinian evolution and life rooted in the interaction between information and its corresponding structure/function are then reviewed. Due to the obligatory dependency of the information and structure subject to Darwinian evolution, these components must be locked in their origin. One of the most distinctive characteristics of Darwinian evolution in comparison with all other processes is the establishment of a fundamentally new level of matter capable of evolving and adapting. Therefore, the initiation of Darwinian evolution is the “point of no return” after which life begins. In summary: a definition and a mechanism for Darwinian evolution are provided together with a critical analysis of some of the hypotheses for the origin of life. |
---|---|
AbstractList | Origin of life research is one of the greatest scientific frontiers of mankind. Many hypotheses have been proposed to explain how life began. Although different hypotheses emphasize different initial phenomena, all of them agree around one important concept: at some point, along with the chain of events toward life, Darwinian evolution emerged. There is no consensus, however, how this occurred. Frequently, the mechanism leading to Darwinian evolution is not addressed and it is assumed that this problem could be solved later, with experimental proof of the hypothesis. Here, the author first defines the minimum components required for Darwinian evolution and then from this standpoint, analyzes some of the hypotheses for the origin of life. Distinctive features of Darwinian evolution and life rooted in the interaction between information and its corresponding structure/function are then reviewed. Due to the obligatory dependency of the information and structure subject to Darwinian evolution, these components must be locked in their origin. One of the most distinctive characteristics of Darwinian evolution in comparison with all other processes is the establishment of a fundamentally new level of matter capable of evolving and adapting. Therefore, the initiation of Darwinian evolution is the “point of no return” after which life begins. In summary: a definition and a mechanism for Darwinian evolution are provided together with a critical analysis of some of the hypotheses for the origin of life. Origin of life research is one of the greatest scientific frontiers of mankind. Many hypotheses have been proposed to explain how life began. Although different hypotheses emphasize different initial phenomena, all of them agree around one important concept: at some point, along with the chain of events toward life, Darwinian evolution emerged. There is no consensus, however, how this occurred. Frequently, the mechanism leading to Darwinian evolution is not addressed and it is assumed that this problem could be solved later, with experimental proof of the hypothesis. Here, the author first defines the minimum components required for Darwinian evolution and then from this standpoint, analyzes some of the hypotheses for the origin of life. Distinctive features of Darwinian evolution and life rooted in the interaction between information and its corresponding structure/function are then reviewed. Due to the obligatory dependency of the information and structure subject to Darwinian evolution, these components must be locked in their origin. One of the most distinctive characteristics of Darwinian evolution in comparison with all other processes is the establishment of a fundamentally new level of matter capable of evolving and adapting. Therefore, the initiation of Darwinian evolution is the "point of no return" after which life begins. In summary: a definition and a mechanism for Darwinian evolution are provided together with a critical analysis of some of the hypotheses for the origin of life.Origin of life research is one of the greatest scientific frontiers of mankind. Many hypotheses have been proposed to explain how life began. Although different hypotheses emphasize different initial phenomena, all of them agree around one important concept: at some point, along with the chain of events toward life, Darwinian evolution emerged. There is no consensus, however, how this occurred. Frequently, the mechanism leading to Darwinian evolution is not addressed and it is assumed that this problem could be solved later, with experimental proof of the hypothesis. Here, the author first defines the minimum components required for Darwinian evolution and then from this standpoint, analyzes some of the hypotheses for the origin of life. Distinctive features of Darwinian evolution and life rooted in the interaction between information and its corresponding structure/function are then reviewed. Due to the obligatory dependency of the information and structure subject to Darwinian evolution, these components must be locked in their origin. One of the most distinctive characteristics of Darwinian evolution in comparison with all other processes is the establishment of a fundamentally new level of matter capable of evolving and adapting. Therefore, the initiation of Darwinian evolution is the "point of no return" after which life begins. In summary: a definition and a mechanism for Darwinian evolution are provided together with a critical analysis of some of the hypotheses for the origin of life. |
Author | Kunnev, Dimiter |
AuthorAffiliation | Department of Oral Biology, University at Buffalo, Buffalo, NY 14263, USA; dkunnev@buffalo.edu |
AuthorAffiliation_xml | – name: Department of Oral Biology, University at Buffalo, Buffalo, NY 14263, USA; dkunnev@buffalo.edu |
Author_xml | – sequence: 1 givenname: Dimiter orcidid: 0000-0002-8134-7545 surname: Kunnev fullname: Kunnev, Dimiter |
BookMark | eNptkU1LBDEMhosoft_8AXMSD64m_Zx6EGTxCxYV0XPpdNq1MjvVzqzgv3fWFVExl4Q3b54EskVW29R6QvYQjhjTcNzE4BEQgUq9QjYpKDFCRfXqj3qD7HbdMwwhBcqSr5MNxlAwKNUm2b_NcRrbIoViMrBOiocnX9yl2PYL6SYV976f53aHrAXbdH73K2-Tx4vzh_HVaHJ7eT0-m4wcp6ofoUSQulaIJSgJYCtwLHhZyxJAy1ABWq1RhIopAEFLhjUtUfvKIZMQ2Da5XnLrZJ_NS44zm99NstF8CilPjc19dI03tai487IKygbuqLeKK8GVFaVi1gU5sE6XrJd5NfO1822fbfML-rvTxiczTW9GSc24FAPg4AuQ0-vcd72Zxc75prGtT_POUC5KYILDwnq4tLqcui778L0GwSw-ZX5-arDTP3YXe9vHtDgkNv8PfQAppJRd |
CitedBy_id | crossref_primary_10_1042_ETLS20220081 crossref_primary_10_1089_ast_2021_0161 crossref_primary_10_30683_1929_2279_2023_12_8 crossref_primary_10_1002_syst_202100002 crossref_primary_10_1007_s00239_021_10014_4 crossref_primary_10_5812_jjcmb_136216 crossref_primary_10_1039_D4SC03384A crossref_primary_10_3390_life12060834 crossref_primary_10_1002_adfm_202406210 crossref_primary_10_3390_biom13050782 crossref_primary_10_3390_life14050564 crossref_primary_10_3389_fgene_2021_672780 |
Cites_doi | 10.1101/cshperspect.a034801 10.3390/ijms20010040 10.1089/ast.2017.1674 10.1023/A:1016523207700 10.3390/life9030065 10.3390/life9020051 10.3390/life6040043 10.1021/jacs.9b06453 10.1016/j.peptides.2005.01.007 10.1016/j.jtbi.2014.11.025 10.1038/433581a 10.1016/j.biosystems.2017.09.006 10.1098/rsob.130156 10.3390/life10050052 10.1093/oxfordjournals.jbchem.a124715 10.1038/nature24019 10.3390/life5010294 10.1007/s00726-009-0249-4 10.1002/bies.20208 10.3390/life5010230 10.1016/0273-1177(84)90559-3 10.1186/1745-6150-7-1 10.1038/s41467-018-07220-y 10.1128/MMBR.69.4.585-607.2005 10.1098/rsif.2018.0159 10.1098/rstb.2011.0137 10.1261/rna.072074.119 10.1038/71225 10.3390/life5041629 10.1021/ja00047a001 10.3390/life9030066 10.1002/jmr.690 10.1007/s00239-017-9799-3 10.1186/s12862-014-0265-1 10.1038/319618a0 10.1080/21541264.2018.1429837 10.3390/life9040080 10.1016/j.jtbi.2014.05.005 10.1016/0006-291X(70)90006-9 10.1007/s00239-015-9669-9 10.1016/j.sbi.2017.11.006 10.1186/1745-6150-2-14 10.1080/073911011010524992 10.3390/life10030021 10.1101/cshperspect.a003590 10.1073/pnas.1900275116 10.1021/ja900597d 10.1186/1745-6150-4-16 10.1002/anie.201902050 10.1098/rsfs.2019.0057 10.1016/j.jtbi.2020.110316 10.3390/life9010025 10.3390/life10020007 10.1016/j.cell.2015.06.038 10.1093/molbev/msx265 10.3184/003685018X15379391431599 10.20944/preprints201705.0121.v1 10.1038/nrg3841 10.1042/bst0301162 10.3390/life6010006 10.1098/rsif.2012.0869 10.7554/eLife.17756 10.1080/073911012010524998 10.1002/iub.146 10.1006/jtbi.1995.0054 10.1006/jtbi.1997.0476 10.1111/nyas.12695 10.3390/life9020037 10.3390/life10060081 10.3390/life8040044 10.1146/annurev-genet-120116-024713 10.1007/s00285-017-1190-x 10.1016/j.jtbi.2009.09.004 10.1007/s12064-008-0043-y 10.1186/1745-6150-6-14 10.1186/s13062-018-0216-7 10.1101/cshperspect.a002204 10.1016/j.biosystems.2009.02.004 10.1371/journal.pone.0032776 10.3390/life6020021 10.1098/rsob.170050 10.1006/jtbi.1997.0580 10.1371/journal.pgen.1007518 10.1089/ast.2008.0280 10.1038/nchem.1086 10.1007/s00239-017-9804-x 10.1021/ar200209k 10.1007/PL00006280 10.1002/bies.20389 10.1038/s41467-020-16891-5 10.1017/S1355838299991264 10.1080/21541264.2017.1318811 10.1186/1745-6150-7-4 10.1016/0022-2836(82)90169-3 10.1007/BF00623322 10.1098/rstb.2016.0419 |
ContentType | Journal Article |
Copyright | 2020 by the author. 2020 |
Copyright_xml | – notice: 2020 by the author. 2020 |
DBID | AAYXX CITATION 7X8 5PM DOA |
DOI | 10.3390/life10110269 |
DatabaseName | CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | CrossRef MEDLINE - Academic |
DatabaseTitleList | CrossRef MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 2075-1729 |
ExternalDocumentID | oai_doaj_org_article_d5b4ce6bf7af4c2ea747547a5873acf6 PMC7693465 10_3390_life10110269 |
GroupedDBID | 53G 5VS 7XC 8FE 8FH AADQD AAFWJ AAYXX ABDBF ACUHS ADBBV AEUYN AFKRA AFPKN AFZYC ALMA_UNASSIGNED_HOLDINGS AOIJS ATCPS BAWUL BBNVY BCNDV BENPR BHPHI CCPQU CITATION DIK ESX GROUPED_DOAJ HCIFZ HYE IAO IEP ISR ITC KQ8 LK8 M48 M7P MODMG M~E OK1 PATMY PGMZT PHGZM PHGZT PIMPY PQGLB PROAC PUEGO PYCSY RPM 7X8 5PM |
ID | FETCH-LOGICAL-c427t-161069d711807600ab0c3fe6d680096fb01a9915fb370052831d2819ebc1360f3 |
IEDL.DBID | M48 |
ISSN | 2075-1729 |
IngestDate | Wed Aug 27 01:27:40 EDT 2025 Tue Sep 30 15:39:57 EDT 2025 Wed Oct 01 13:17:10 EDT 2025 Wed Oct 01 04:45:02 EDT 2025 Thu Apr 24 22:59:56 EDT 2025 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 11 |
Language | English |
License | https://creativecommons.org/licenses/by/4.0 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c427t-161069d711807600ab0c3fe6d680096fb01a9915fb370052831d2819ebc1360f3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-8134-7545 |
OpenAccessLink | https://doaj.org/article/d5b4ce6bf7af4c2ea747547a5873acf6 |
PMID | 33153087 |
PQID | 2458035405 |
PQPubID | 23479 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_d5b4ce6bf7af4c2ea747547a5873acf6 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7693465 proquest_miscellaneous_2458035405 crossref_primary_10_3390_life10110269 crossref_citationtrail_10_3390_life10110269 |
ProviderPackageCode | CITATION AAYXX |
PublicationCentury | 2000 |
PublicationDate | 20201103 |
PublicationDateYYYYMMDD | 2020-11-03 |
PublicationDate_xml | – month: 11 year: 2020 text: 20201103 day: 3 |
PublicationDecade | 2020 |
PublicationTitle | Life (Basel, Switzerland) |
PublicationYear | 2020 |
Publisher | MDPI MDPI AG |
Publisher_xml | – name: MDPI – name: MDPI AG |
References | (ref_62) 2005; 18 Higgs (ref_48) 2009; 9 Dillon (ref_60) 1997; 188 (ref_39) 1998; 191 (ref_97) 2015; 367 (ref_8) 2005; 433 ref_13 Thomas (ref_38) 1970; 40 ref_11 Harrison (ref_21) 2018; 9 ref_18 Wu (ref_75) 1992; 114 ref_16 Cornell (ref_91) 2019; 116 Walker (ref_17) 2013; 10 Rodin (ref_42) 2011; 6 Cheng (ref_68) 2010; 2 ref_23 ref_22 Walton (ref_74) 2019; 58 Pak (ref_50) 2018; 9 Carter (ref_86) 2018; 35 Pearce (ref_55) 2018; 18 Suga (ref_27) 2011; 366 Higgs (ref_49) 2009; 4 ref_28 Muller (ref_26) 2015; 1341 Higgs (ref_77) 2015; 16 Illangasekare (ref_96) 1999; 5 Basener (ref_12) 2018; 76 Lanier (ref_87) 2017; 85 ref_70 Tessera (ref_10) 2018; 13 Bernhardt (ref_66) 2012; 7 Baross (ref_98) 2015; 162 ref_79 Moreira (ref_41) 2008; 127 ref_78 ref_73 Vasas (ref_58) 2012; 7 (ref_29) 2019; 9 Koonin (ref_44) 2017; 51 Tashiro (ref_56) 2017; 549 Wong (ref_52) 2005; 27 Trifonov (ref_5) 2011; 29 Riquelme (ref_15) 2020; 499 ref_80 Speijer (ref_31) 2015; 5 Shimizu (ref_94) 1995; 33 ref_88 ref_84 Carter (ref_82) 2015; 5 Shimizu (ref_93) 1995; 117 (ref_61) 2012; 45 Gulik (ref_34) 2015; 5 Hunding (ref_59) 2006; 28 Pak (ref_51) 2017; 8 Eigen (ref_6) 1971; 58 ref_57 ref_54 ref_53 Zhang (ref_76) 2019; 141 Bowman (ref_81) 2015; 80 Li (ref_35) 2010; 38 Oro (ref_1) 1984; 4 Pulselli (ref_20) 2009; 96 Higgs (ref_9) 2017; 84 Markovitch (ref_19) 2014; 357 ref_64 ref_63 Koonin (ref_40) 2009; 61 Carter (ref_83) 2016; 125 Goto (ref_24) 2009; 131 Wills (ref_7) 2018; 164 (ref_90) 2018; 101 Alva (ref_85) 2018; 48 ref_32 Gilbert (ref_65) 1986; 319 Pascal (ref_14) 2013; 3 Cech (ref_67) 2002; 30 Wolf (ref_47) 2007; 2 Deck (ref_72) 2011; 3 Jeffares (ref_69) 1998; 46 Massar (ref_30) 2009; 261 Lee (ref_25) 2000; 7 Haynes (ref_95) 2020; 11 Plankensteiner (ref_37) 2002; 32 ref_46 Dila (ref_89) 2019; 25 ref_45 ref_43 ref_3 ref_2 Inoue (ref_71) 1982; 162 Gordon (ref_92) 1995; 173 Szostak (ref_4) 2012; 29 Scheffers (ref_33) 2005; 69 Plankensteiner (ref_36) 2005; 26 |
References_xml | – ident: ref_70 doi: 10.1101/cshperspect.a034801 – ident: ref_53 doi: 10.3390/ijms20010040 – volume: 18 start-page: 343 year: 2018 ident: ref_55 article-title: Constraining the Time Interval for the Origin of Life on Earth publication-title: Astrobiology doi: 10.1089/ast.2017.1674 – volume: 32 start-page: 225 year: 2002 ident: ref_37 article-title: Glycine and diglycine as possible catalytic factors in the prebiotic evolution of peptides publication-title: Orig. Life Evol. Biosph. doi: 10.1023/A:1016523207700 – ident: ref_79 doi: 10.3390/life9030065 – ident: ref_78 doi: 10.3390/life9020051 – ident: ref_13 doi: 10.3390/life6040043 – volume: 141 start-page: 12159 year: 2019 ident: ref_76 article-title: Template-Directed Nonenzymatic Primer Extension Using 2-Methylimidazole-Activated Morpholino Derivatives of Guanosine and Cytidine publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b06453 – volume: 26 start-page: 1109 year: 2005 ident: ref_36 article-title: Catalytic effects of glycine on prebiotic divaline and diproline formation publication-title: Peptides doi: 10.1016/j.peptides.2005.01.007 – volume: 367 start-page: 130 year: 2015 ident: ref_97 article-title: The ribosome as a missing link in the evolution of life publication-title: J. Theor. Biol. doi: 10.1016/j.jtbi.2014.11.025 – volume: 433 start-page: 581 year: 2005 ident: ref_8 article-title: The onset of selection publication-title: Nature doi: 10.1038/433581a – volume: 164 start-page: 155 year: 2018 ident: ref_7 article-title: Insuperable problems of the genetic code initially emerging in an RNA world publication-title: Biosystems doi: 10.1016/j.biosystems.2017.09.006 – volume: 3 start-page: 130156 year: 2013 ident: ref_14 article-title: Towards an evolutionary theory of the origin of life based on kinetics and thermodynamics publication-title: Open Biol. doi: 10.1098/rsob.130156 – ident: ref_2 doi: 10.3390/life10050052 – volume: 117 start-page: 23 year: 1995 ident: ref_93 article-title: Specific aminoacylation of C4N hairpin RNAs with the cognate aminoacyl-adenylates in the presence of a dipeptide: Origin of the genetic code publication-title: J. Biochem. doi: 10.1093/oxfordjournals.jbchem.a124715 – volume: 549 start-page: 516 year: 2017 ident: ref_56 article-title: Early trace of life from 3.95 Ga sedimentary rocks in Labrador, Canada publication-title: Nature doi: 10.1038/nature24019 – volume: 5 start-page: 294 year: 2015 ident: ref_82 article-title: What RNA World? Why a Peptide/RNA Partnership Merits Renewed Experimental Attention publication-title: Life doi: 10.3390/life5010294 – volume: 38 start-page: 287 year: 2010 ident: ref_35 article-title: Catalytic effects of histidine enantiomers and glycine on the formation of dileucine and dimethionine in the salt-induced peptide formation reaction publication-title: Amino Acids doi: 10.1007/s00726-009-0249-4 – volume: 27 start-page: 416 year: 2005 ident: ref_52 article-title: Coevolution theory of the genetic code at age thirty publication-title: Bioessays doi: 10.1002/bies.20208 – volume: 5 start-page: 230 year: 2015 ident: ref_31 article-title: How amino acids and peptides shaped the RNA world publication-title: Life doi: 10.3390/life5010230 – volume: 4 start-page: 167 year: 1984 ident: ref_1 article-title: A minimal living system and the origin of a protocell publication-title: Adv. Space Res. doi: 10.1016/0273-1177(84)90559-3 – volume: 7 start-page: 1 year: 2012 ident: ref_58 article-title: Evolution before genes publication-title: Biol. Direct doi: 10.1186/1745-6150-7-1 – volume: 9 start-page: 5176 year: 2018 ident: ref_21 article-title: Life as a guide to prebiotic nucleotide synthesis publication-title: Nat. Commun. doi: 10.1038/s41467-018-07220-y – volume: 69 start-page: 585 year: 2005 ident: ref_33 article-title: Bacterial cell wall synthesis: New insights from localization studies publication-title: Microbiol. Mol. Biol. Rev. doi: 10.1128/MMBR.69.4.585-607.2005 – ident: ref_18 doi: 10.1098/rsif.2018.0159 – volume: 366 start-page: 2959 year: 2011 ident: ref_27 article-title: The RNA origin of transfer RNA aminoacylation and beyond publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2011.0137 – volume: 33 start-page: 179 year: 1995 ident: ref_94 article-title: Oligomer biology and polymer biology: Primitive RNA-protein interactions publication-title: Nucleic Acids Symp. Ser. – volume: 25 start-page: 1714 year: 2019 ident: ref_89 article-title: Circular code motifs in the ribosome: A missing link in the evolution of translation? publication-title: RNA doi: 10.1261/rna.072074.119 – volume: 7 start-page: 28 year: 2000 ident: ref_25 article-title: Ribozyme-catalyzed tRNA aminoacylation publication-title: Nat. Struct. Biol. doi: 10.1038/71225 – volume: 5 start-page: 1629 year: 2015 ident: ref_34 article-title: On the Origin of Sequence publication-title: Life doi: 10.3390/life5041629 – volume: 114 start-page: 7963 year: 1992 ident: ref_75 article-title: Nonenzymatic template-directed synthesis on hairpin oligonucleotides. 3. Incorporation of adenosine and uridine residues publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00047a001 – ident: ref_63 doi: 10.3390/life9030066 – volume: 18 start-page: 40 year: 2005 ident: ref_62 article-title: Peptide self-aggregation and peptide complementarity as bases for the evolution of peptide receptors: A review publication-title: J. Mol. Recognit. doi: 10.1002/jmr.690 – volume: 84 start-page: 225 year: 2017 ident: ref_9 article-title: Chemical Evolution and the Evolutionary Definition of Life publication-title: J. Mol. Evol. doi: 10.1007/s00239-017-9799-3 – ident: ref_16 doi: 10.1186/s12862-014-0265-1 – volume: 319 start-page: 618 year: 1986 ident: ref_65 article-title: Origin of life: The RNA world publication-title: Nature doi: 10.1038/319618a0 – volume: 9 start-page: 205 year: 2018 ident: ref_50 article-title: Aminoacyl-tRNA synthetase evolution and sectoring of the genetic code publication-title: Transcription doi: 10.1080/21541264.2018.1429837 – ident: ref_64 doi: 10.3390/life9040080 – volume: 357 start-page: 26 year: 2014 ident: ref_19 article-title: Multispecies population dynamics of prebiotic compositional assemblies publication-title: J. Theor. Biol. doi: 10.1016/j.jtbi.2014.05.005 – volume: 40 start-page: 1289 year: 1970 ident: ref_38 article-title: The origin of the genetic code publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(70)90006-9 – volume: 80 start-page: 143 year: 2015 ident: ref_81 article-title: The ribosome challenge to the RNA world publication-title: J. Mol. Evol. doi: 10.1007/s00239-015-9669-9 – volume: 48 start-page: 103 year: 2018 ident: ref_85 article-title: From ancestral peptides to designed proteins publication-title: Curr. Opin. Struct. Biol. doi: 10.1016/j.sbi.2017.11.006 – volume: 2 start-page: 14 year: 2007 ident: ref_47 article-title: On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalization publication-title: Biol. Direct doi: 10.1186/1745-6150-2-14 – volume: 29 start-page: 259 year: 2011 ident: ref_5 article-title: Vocabulary of definitions of life suggests a definition publication-title: J. Biomol. Struct. Dyn. doi: 10.1080/073911011010524992 – ident: ref_45 doi: 10.3390/life10030021 – ident: ref_80 doi: 10.1101/cshperspect.a003590 – volume: 116 start-page: 17239 year: 2019 ident: ref_91 article-title: Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1900275116 – volume: 131 start-page: 5040 year: 2009 ident: ref_24 article-title: Translation initiation with initiator tRNA charged with exotic peptides publication-title: J. Am. Chem. Soc. doi: 10.1021/ja900597d – volume: 4 start-page: 16 year: 2009 ident: ref_49 article-title: A four-column theory for the origin of the genetic code: Tracing the evolutionary pathways that gave rise to an optimized code publication-title: Biol. Direct doi: 10.1186/1745-6150-4-16 – volume: 58 start-page: 10812 year: 2019 ident: ref_74 article-title: The Mechanism of Nonenzymatic Template Copying with Imidazole-Activated Nucleotides publication-title: Angew. Chem. Int. Ed. Engl. doi: 10.1002/anie.201902050 – volume: 9 start-page: 20190057 year: 2019 ident: ref_29 article-title: Protein three-dimensional structures at the origin of life publication-title: Interface Focus doi: 10.1098/rsfs.2019.0057 – volume: 499 start-page: 110316 year: 2020 ident: ref_15 article-title: Molecular shape as a key source of prebiotic information publication-title: J. Theor. Biol. doi: 10.1016/j.jtbi.2020.110316 – ident: ref_88 doi: 10.3390/life9010025 – ident: ref_11 doi: 10.3390/life10020007 – volume: 162 start-page: 13 year: 2015 ident: ref_98 article-title: The Ribofilm as a Concept for Life’s Origins publication-title: Cell doi: 10.1016/j.cell.2015.06.038 – volume: 35 start-page: 269 year: 2018 ident: ref_86 article-title: Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msx265 – volume: 101 start-page: 360 year: 2018 ident: ref_90 article-title: Evolution of macromolecular structure: A ‘double tale’ of biological accretion and diversification publication-title: Sci. Prog. doi: 10.3184/003685018X15379391431599 – ident: ref_43 doi: 10.20944/preprints201705.0121.v1 – volume: 16 start-page: 7 year: 2015 ident: ref_77 article-title: The RNA World: Molecular cooperation at the origins of life publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3841 – volume: 30 start-page: 1162 year: 2002 ident: ref_67 article-title: Ribozymes, the first 20 years publication-title: Biochem. Soc. Trans. doi: 10.1042/bst0301162 – ident: ref_28 doi: 10.3390/life6010006 – volume: 10 start-page: 20120869 year: 2013 ident: ref_17 article-title: The algorithmic origins of life publication-title: J. R. Soc. Interface doi: 10.1098/rsif.2012.0869 – ident: ref_73 doi: 10.7554/eLife.17756 – volume: 29 start-page: 599 year: 2012 ident: ref_4 article-title: Attempts to define life do not help to understand the origin of life publication-title: J. Biomol. Struct. Dyn. doi: 10.1080/073911012010524998 – volume: 61 start-page: 99 year: 2009 ident: ref_40 article-title: Origin and evolution of the genetic code: The universal enigma publication-title: IUBMB Life doi: 10.1002/iub.146 – volume: 173 start-page: 179 year: 1995 ident: ref_92 article-title: Were RNA replication and translation directly coupled in the RNA (+protein?) world? publication-title: J. Theor. Biol. doi: 10.1006/jtbi.1995.0054 – volume: 188 start-page: 447 year: 1997 ident: ref_60 article-title: Molecular complementarity I: The complementarity theory of the origin and evolution of life publication-title: J. Theor. Biol. doi: 10.1006/jtbi.1997.0476 – volume: 1341 start-page: 54 year: 2015 ident: ref_26 article-title: Engineering of ribozymes with useful activities in the ancient RNA world publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/nyas.12695 – ident: ref_32 doi: 10.3390/life9020037 – ident: ref_46 doi: 10.3390/life10060081 – ident: ref_84 doi: 10.3390/life8040044 – volume: 51 start-page: 45 year: 2017 ident: ref_44 article-title: Origin and Evolution of the Universal Genetic Code publication-title: Annu. Rev. Genet. doi: 10.1146/annurev-genet-120116-024713 – volume: 76 start-page: 1589 year: 2018 ident: ref_12 article-title: The fundamental theorem of natural selection with mutations publication-title: J. Math. Biol. doi: 10.1007/s00285-017-1190-x – volume: 261 start-page: 531 year: 2009 ident: ref_30 article-title: The first peptides: The evolutionary transition between prebiotic amino acids and early proteins publication-title: J. Theor. Biol. doi: 10.1016/j.jtbi.2009.09.004 – volume: 127 start-page: 249 year: 2008 ident: ref_41 article-title: A self-referential model for the formation of the genetic code publication-title: Theory BioSci. doi: 10.1007/s12064-008-0043-y – volume: 6 start-page: 14 year: 2011 ident: ref_42 article-title: On origin of genetic code and tRNA before translation publication-title: Biol. Direct doi: 10.1186/1745-6150-6-14 – volume: 13 start-page: 18 year: 2018 ident: ref_10 article-title: Is pre-Darwinian evolution plausible? publication-title: Biol. Direct doi: 10.1186/s13062-018-0216-7 – volume: 2 start-page: a002204 year: 2010 ident: ref_68 article-title: Closing the circle: Replicating RNA with RNA publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a002204 – volume: 96 start-page: 237 year: 2009 ident: ref_20 article-title: Self-organization in dissipative structures: A thermodynamic theory for the emergence of prebiotic cells and their epigenetic evolution publication-title: Biosystems doi: 10.1016/j.biosystems.2009.02.004 – ident: ref_54 doi: 10.1371/journal.pone.0032776 – volume: 125 start-page: 28 year: 2016 ident: ref_83 article-title: An Alternative to the RNA World publication-title: Nat. Hist – ident: ref_23 doi: 10.3390/life6020021 – ident: ref_57 doi: 10.1098/rsob.170050 – volume: 191 start-page: 191 year: 1998 ident: ref_39 article-title: Reflections on the origin of the genetic code: A hypothesis publication-title: J. Theor. Biol. doi: 10.1006/jtbi.1997.0580 – ident: ref_3 doi: 10.1371/journal.pgen.1007518 – volume: 9 start-page: 483 year: 2009 ident: ref_48 article-title: A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code publication-title: Astrobiology doi: 10.1089/ast.2008.0280 – volume: 3 start-page: 603 year: 2011 ident: ref_72 article-title: Efficient enzyme-free copying of all four nucleobases templated by immobilized RNA publication-title: Nat. Chem. doi: 10.1038/nchem.1086 – volume: 85 start-page: 8 year: 2017 ident: ref_87 article-title: The Central Symbiosis of Molecular Biology: Molecules in Mutualism publication-title: J. Mol. Evol. doi: 10.1007/s00239-017-9804-x – volume: 45 start-page: 2169 year: 2012 ident: ref_61 article-title: A modular hierarchy-based theory of the chemical origins of life based on molecular complementarity publication-title: Acc. Chem. Res. doi: 10.1021/ar200209k – volume: 46 start-page: 18 year: 1998 ident: ref_69 article-title: Relics from the RNA world publication-title: J. Mol. Evol. doi: 10.1007/PL00006280 – volume: 28 start-page: 399 year: 2006 ident: ref_59 article-title: Compositional complementarity and prebiotic ecology in the origin of life publication-title: Bioessays doi: 10.1002/bies.20389 – volume: 11 start-page: 3137 year: 2020 ident: ref_95 article-title: Mutually stabilizing interactions between proto-peptides and RNA publication-title: Nat. Commun. doi: 10.1038/s41467-020-16891-5 – volume: 5 start-page: 1482 year: 1999 ident: ref_96 article-title: A tiny RNA that catalyzes both aminoacyl-RNA and peptidyl-RNA synthesis publication-title: Rna doi: 10.1017/S1355838299991264 – volume: 8 start-page: 205 year: 2017 ident: ref_51 article-title: tRNA structure and evolution and standardization to the three nucleotide genetic code publication-title: Transcription doi: 10.1080/21541264.2017.1318811 – volume: 7 start-page: 4 year: 2012 ident: ref_66 article-title: Primordial soup or vinaigrette: Did the RNA world evolve at acidic pH? publication-title: Biol. Direct doi: 10.1186/1745-6150-7-4 – volume: 162 start-page: 201 year: 1982 ident: ref_71 article-title: Oligomerization of (guanosine 5’-phosphor)-2-methylimidazolide on poly(C). An RNA polymerase model publication-title: J. Mol. Biol. doi: 10.1016/0022-2836(82)90169-3 – volume: 58 start-page: 465 year: 1971 ident: ref_6 article-title: Selforganization of matter and the evolution of biological macromolecules publication-title: Naturwissenschaften doi: 10.1007/BF00623322 – ident: ref_22 doi: 10.1098/rstb.2016.0419 |
SSID | ssj0000651684 |
Score | 2.2332642 |
Snippet | Origin of life research is one of the greatest scientific frontiers of mankind. Many hypotheses have been proposed to explain how life began. Although... |
SourceID | doaj pubmedcentral proquest crossref |
SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database |
StartPage | 269 |
SubjectTerms | biological evolution chemical evolution Concept Paper Darwinian evolution definition of life origin of life prebiotic evolution |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8NAEF6kIHgRnxhfRFAvEppkX6k3FUsRrSIWegu7m1kslEQ0Pfjv3UnSkhzEi9fNsLvMLJlvHnxDyDkDYBlkLlIFLDNKqoJBAjYItQWlo1CxqqL7NBajCXuY8mlr1Bf2hNX0wLXi-hnXzIDQVirLTAzK4V_OpOKJ29fYimzbubFWMFX_g3kkElZ3ulMX1_fnMwsROrsYe5tbPqii6u_gy253ZMvdDLfIZoMT_Zv6fttkDfIdsl5PjvzeJZfP1UArv7D-ozvy2nfm9l-KWV7i0rjwX8H5knyPTIb3b3ejoBl5EBgWyzJw-CsUg0wiMRuWzJQODbUgMpFgsGF1GCmH6LjVVGJGN6FRhqUw0CaiIrR0n_TyIocD4gPEVnMupaIJczBIAVPGUOU0F2uWgEeulkpITcMHjmMp5qmLC1BlaVtlHrlYSX_UPBi_yN2iPlcyyF5dLTibpo1N079s6pGzpTVS99qxhKFyKBZfacx4EmKqintEdszUObH7JZ-9V7zZOPaRCX74H1c8IhsxRt6YYKbHpFd-LuDEwZNSn1Yv8QfP2eOF priority: 102 providerName: Directory of Open Access Journals |
Title | Origin of Life: The Point of No Return |
URI | https://www.proquest.com/docview/2458035405 https://pubmed.ncbi.nlm.nih.gov/PMC7693465 https://doaj.org/article/d5b4ce6bf7af4c2ea747547a5873acf6 |
Volume | 10 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2075-1729 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: KQ8 dateStart: 20110101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2075-1729 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: Academic Search Ultimate | Ebsco customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 2075-1729 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: ABDBF dateStart: 20120901 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 2075-1729 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: DIK dateStart: 20110101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2075-1729 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 2075-1729 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: RPM dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 2075-1729 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: BENPR dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 2075-1729 dateEnd: 20250831 omitProxy: true ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: M48 dateStart: 20111101 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1ta9RAEB5qi-AXsb7g-XJE0H6RaLKvOUFKKy1F7FmKB_0WdjezenAk7fUK9t87k-RKQxX8ull2w-zszvPsLPMAvFWIqsKKmCpymtFKl04KjGnmIzqfZ061Gd3jqTmaqa9n-mwD1u_newNe_pXasZ7UbLn48Pviepc2_GdmnETZPy7mEXOOY8JMds4vUpaU4tRrr69xD7YoTAl2-eMe-3fHtM5Nq0gsKGymFMgn3cP4O2MOQlZb2X8AR4ePKW9Fp8NH8LCHlcle5wfbsIH1Y7jfCU1eP4Gd763-VdLE5BtN-Skh70hOmnm94qZpk5wihZ76KcwOD358OUp7hYQ0KGFXKcG1zEwqy3XcOMPmfBZkRFOZgrlJ9FnuCADq6KXlC-BC5hVnztCHXJosymewWTc1PocEUUSvtbVOFopQk0PlQpDO6UJ4VeAI3q-NUIa-fDirWCxKohFssvK2yUbw7qb3eVc24x_99tmeN3242HXb0Cx_lv3eKSvtVUDjo3VRBYGOKJBWlv6MXCtEM4I369UoaXNwxsPV2FxdlkLpIuObLT0CO1imwYzDL_X8V1tmm1UildEv_mP0l_BAMA_n62b5CjZXyyt8TWBl5cewtX8wPTkdt2R_3LrgH06u6kY |
linkProvider | Scholars Portal |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Origin+of+Life%3A+The+Point+of+No+Return&rft.jtitle=Life+%28Basel%2C+Switzerland%29&rft.au=Kunnev%2C+Dimiter&rft.date=2020-11-03&rft.issn=2075-1729&rft.eissn=2075-1729&rft.volume=10&rft.issue=11&rft_id=info:doi/10.3390%2Flife10110269&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2075-1729&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2075-1729&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2075-1729&client=summon |