MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity - Yang, Mi; Li, Chang-Jun; Sun, Xi; Guo, Qi; Xiao, Ye; Su, Tian; Tu, Man-Li; Peng, Hui; Lu, Qiong; Liu, Qing; He, Hong-Bo; Jiang, Tie-Jian; et al. (Nature communications, 2017)
Keywords: 13/109; 13/31; 14/19; 38; 38/61; 692/4019/592/16; Aging; Angiogenesis; Animals; Antagomirs - genetics; Antagomirs - metabolism; Aptamers; Aptamers, Nucleotide - genetics; Aptamers, Nucleotide - metabolism; Bone and Bones - blood supply; Bone and Bones - metabolism; Bone and Bones - pathology; Bone Density; Bone growth; Bone loss; Bone mass; Cdc4 protein; Clusters; Coupling; Endothelial cells; Endothelium; F-Box-WD Repeat-Containing Protein 7 - genetics; F-Box-WD Repeat-Containing Protein 7 - metabolism; Gene Expression Regulation, Developmental; Humanities and Social Sciences; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factor 1a; Mice; Mice, Knockout; MicroRNAs - agonists; MicroRNAs - antagonists & inhibitors; MicroRNAs - genetics; MicroRNAs - metabolism; Molecular Targeted Therapy; multidisciplinary; Neovascularization, Physiologic - genetics; Osteogenesis; Osteogenesis - genetics; Osteoporosis; Osteoporosis - genetics; Osteoporosis - metabolism; Osteoporosis - pathology; Osteoporosis - therapy; Platelet Endothelial Cell Adhesion Molecule-1 - agonists; Platelet Endothelial Cell Adhesion Molecule-1 - genetics; Platelet Endothelial Cell Adhesion Molecule-1 - metabolism; Procollagen-proline dioxygenase; Prolyl Hydroxylases - genetics; Prolyl Hydroxylases - metabolism; Receptor, Notch1 - genetics; Receptor, Notch1 - metabolism; Science; Science (multidisciplinary); Sialoglycoproteins - agonists; Sialoglycoproteins - genetics; Sialoglycoproteins - metabolism; Signal Transduction; Therapeutic targets; Transmembrane domains