Apoptotic Potential of Iloneoside from Gongronema latifolium Benth against Prostate Cancer Cells Using In Vitro and In Silico Approach - Gyebi, Gideon A.; Afolabi, Saheed O.; Ogunyemi, Oludare M.; Ibrahim, Ibrahim M.; Olorundare, Olufunke E.; Adebayo, Joseph O.; Koketsu, Mamoru (Cell biochemistry and biophysics, 2025)
Keywords: Antiproliferatives; Apoptosis; Apoptosis - drug effects; Bcl-2 protein; Bcl-x protein; bcl-X Protein - chemistry; bcl-X Protein - metabolism; Binding energy; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Biotechnology; Cell Biology; Cell cycle; Cell Cycle - drug effects; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Chemical fingerprinting; Cluster analysis; Clustering; Fingerprinting; Flow cytometry; Free energy; Gongronema latifolium; Humans; Leaves; Life Sciences; Male; Mcl-1 protein; Molecular docking; Molecular Docking Simulation; Molecular dynamics; Molecular Dynamics Simulation; Myeloid Cell Leukemia Sequence 1 Protein - chemistry; Myeloid Cell Leukemia Sequence 1 Protein - metabolism; Original Paper; Pharmacology/Toxicology; Plant extracts; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Leaves - chemistry; Plant Leaves - metabolism; Pregnanes - chemistry; Pregnanes - isolation & purification; Pregnanes - metabolism; Pregnanes - pharmacology; Prostate cancer; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Proteins; Proto-Oncogene Proteins c-bcl-2 - chemistry; Proto-Oncogene Proteins c-bcl-2 - metabolism; Tumor cell lines; Pregnanes; Iloneoside; Prostate cancer; Molecular docking; Apoptosis; Gongronema latilolium