Toxoplasma gondii: The severity of toxoplasmic encephalitis in C57BL/6 mice is associated with increased ALCAM and VCAM-1 expression in the central nervous system and higher blood–brain barrier permeability
In order to investigate the differential ALCAM, ICAM-1 and VCAM-1 adhesion molecules mRNA expression and the blood–brain barrier (BBB) permeability in C57BL/6 and BALB/c mice in Toxoplasma gondii infection, animals were infected with ME-49 strain. It was observed higher ALCAM on day 9 and VCAM-1 exp...
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| Published in | Experimental parasitology Vol. 126; no. 2; pp. 167 - 177 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier Inc
01.10.2010
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0014-4894 1090-2449 1090-2449 |
| DOI | 10.1016/j.exppara.2010.04.019 |
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| Abstract | In order to investigate the differential ALCAM, ICAM-1 and VCAM-1 adhesion molecules mRNA expression and the blood–brain barrier (BBB) permeability in C57BL/6 and BALB/c mice in
Toxoplasma gondii infection, animals were infected with ME-49 strain. It was observed higher ALCAM on day 9 and VCAM-1 expression on days 9 and 14 of infection in the central nervous system (CNS) of C57BL/6 compared to BALB/c mice. The expression of ICAM-1 was high and similar in the CNS of both lineages of infected mice. In addition, C57BL/6 presented higher BBB permeability and higher IFN-γ and iNOS expression in the CNS compared to BALB/c mice. The CNS of C57BL/6 mice presented elevated tissue pathology and parasitism. In conclusion, our data suggest that the higher adhesion molecules expression and higher BBB permeability contributed to the major inflammatory cell infiltration into the CNS of C57BL/6 mice that was not efficient to control the parasite. |
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| AbstractList | In order to investigate the differential ALCAM, ICAM-1 and VCAM-1 adhesion molecules mRNA expression and the blood-brain barrier (BBB) permeability in C57BL/6 and BALB/c mice in Toxoplasma gondii infection, animals were infected with ME-49 strain. It was observed higher ALCAM on day 9 and VCAM-1 expression on days 9 and 14 of infection in the central nervous system (CNS) of C57BL/6 compared to BALB/c mice. The expression of ICAM-1 was high and similar in the CNS of both lineages of infected mice. In addition, C57BL/6 presented higher BBB permeability and higher IFN-I[sup3 and iNOS expression in the CNS compared to BALB/c mice. The CNS of C57BL/6 mice presented elevated tissue pathology and parasitism. In conclusion, our data suggest that the higher adhesion molecules expression and higher BBB permeability contributed to the major inflammatory cell infiltration into the CNS of C57BL/6 mice that was not efficient to control the parasite. In order to investigate the differential ALCAM, ICAM-1 and VCAM-1 adhesion molecules mRNA expression and the blood-brain barrier (BBB) permeability in C57BL/6 and BALB/c mice in Toxoplasma gondii infection, animals were infected with ME-49 strain. It was observed higher ALCAM on day 9 and VCAM-1 expression on days 9 and 14 of infection in the central nervous system (CNS) of C57BL/6 compared to BALB/c mice. The expression of ICAM-1 was high and similar in the CNS of both lineages of infected mice. In addition, C57BL/6 presented higher BBB permeability and higher IFN-gamma and iNOS expression in the CNS compared to BALB/c mice. The CNS of C57BL/6 mice presented elevated tissue pathology and parasitism. In conclusion, our data suggest that the higher adhesion molecules expression and higher BBB permeability contributed to the major inflammatory cell infiltration into the CNS of C57BL/6 mice that was not efficient to control the parasite. In order to investigate the differential ALCAM, ICAM-1 and VCAM-1 adhesion molecules mRNA expression and the blood–brain barrier (BBB) permeability in C57BL/6 and BALB/c mice in Toxoplasma gondii infection, animals were infected with ME-49 strain. It was observed higher ALCAM on day 9 and VCAM-1 expression on days 9 and 14 of infection in the central nervous system (CNS) of C57BL/6 compared to BALB/c mice. The expression of ICAM-1 was high and similar in the CNS of both lineages of infected mice. In addition, C57BL/6 presented higher BBB permeability and higher IFN-γ and iNOS expression in the CNS compared to BALB/c mice. The CNS of C57BL/6 mice presented elevated tissue pathology and parasitism. In conclusion, our data suggest that the higher adhesion molecules expression and higher BBB permeability contributed to the major inflammatory cell infiltration into the CNS of C57BL/6 mice that was not efficient to control the parasite. In order to investigate the differential ALCAM, ICAM-1 and VCAM-1 adhesion molecules mRNA expression and the blood-brain barrier (BBB) permeability in C57BL/6 and BALB/c mice in Toxoplasma gondii infection, animals were infected with ME-49 strain. It was observed higher ALCAM on day 9 and VCAM-1 expression on days 9 and 14 of infection in the central nervous system (CNS) of C57BL/6 compared to BALB/c mice. The expression of ICAM-1 was high and similar in the CNS of both lineages of infected mice. In addition, C57BL/6 presented higher BBB permeability and higher IFN-gamma and iNOS expression in the CNS compared to BALB/c mice. The CNS of C57BL/6 mice presented elevated tissue pathology and parasitism. In conclusion, our data suggest that the higher adhesion molecules expression and higher BBB permeability contributed to the major inflammatory cell infiltration into the CNS of C57BL/6 mice that was not efficient to control the parasite.In order to investigate the differential ALCAM, ICAM-1 and VCAM-1 adhesion molecules mRNA expression and the blood-brain barrier (BBB) permeability in C57BL/6 and BALB/c mice in Toxoplasma gondii infection, animals were infected with ME-49 strain. It was observed higher ALCAM on day 9 and VCAM-1 expression on days 9 and 14 of infection in the central nervous system (CNS) of C57BL/6 compared to BALB/c mice. The expression of ICAM-1 was high and similar in the CNS of both lineages of infected mice. In addition, C57BL/6 presented higher BBB permeability and higher IFN-gamma and iNOS expression in the CNS compared to BALB/c mice. The CNS of C57BL/6 mice presented elevated tissue pathology and parasitism. In conclusion, our data suggest that the higher adhesion molecules expression and higher BBB permeability contributed to the major inflammatory cell infiltration into the CNS of C57BL/6 mice that was not efficient to control the parasite. |
| Author | Silva, Neide Maria Milanezi, Cristiane Maria Silva, João Santana Mineo, José Roberto Manzan, Renato Martins Ferro, Eloísa Amália Vieira Carneiro, Wesley Pereira |
| Author_xml | – sequence: 1 givenname: Neide Maria surname: Silva fullname: Silva, Neide Maria email: nmsilva@icbim.ufu.br organization: Laboratory of Immunopathology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, MG 38400-902, Brazil – sequence: 2 givenname: Renato Martins surname: Manzan fullname: Manzan, Renato Martins organization: Laboratory of Immunopathology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, MG 38400-902, Brazil – sequence: 3 givenname: Wesley Pereira surname: Carneiro fullname: Carneiro, Wesley Pereira organization: Laboratory of Immunopathology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, MG 38400-902, Brazil – sequence: 4 givenname: Cristiane Maria surname: Milanezi fullname: Milanezi, Cristiane Maria organization: Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil – sequence: 5 givenname: João Santana surname: Silva fullname: Silva, João Santana organization: Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil – sequence: 6 givenname: Eloísa Amália Vieira surname: Ferro fullname: Ferro, Eloísa Amália Vieira organization: Laboratory of Immunopathology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, MG 38400-902, Brazil – sequence: 7 givenname: José Roberto surname: Mineo fullname: Mineo, José Roberto organization: Laboratory of Immunoparasitology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, MG 38400-902, Brazil |
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| Keywords | BALB/c mice VCAM-1 ALCAM Toxoplasma gondii C57BL/6 mice ICAM-1 Blood–brain barrier Protozoa Brain Encephalitis Apicomplexa Rodentia Central nervous system Parasite Barrier Permeability Blood Vertebrata Mammalia Mouse Blood-brain barrier |
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| Snippet | In order to investigate the differential ALCAM, ICAM-1 and VCAM-1 adhesion molecules mRNA expression and the blood–brain barrier (BBB) permeability in C57BL/6... In order to investigate the differential ALCAM, ICAM-1 and VCAM-1 adhesion molecules mRNA expression and the blood-brain barrier (BBB) permeability in C57BL/6... |
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| SubjectTerms | Activated-Leukocyte Cell Adhesion Molecule - biosynthesis Activated-Leukocyte Cell Adhesion Molecule - genetics ALCAM Animals BALB/c mice Biological and medical sciences Blood-brain barrier Blood-Brain Barrier - metabolism Blood-Brain Barrier - parasitology C57BL/6 mice Central Nervous System - immunology Central Nervous System - parasitology Central Nervous System - pathology Encephalitis - immunology Encephalitis - metabolism Encephalitis - parasitology Female Fundamental and applied biological sciences. Psychology Heart - parasitology ICAM-1 Immunohistochemistry Interferon-gamma - biosynthesis Interferon-gamma - genetics Life cycle. Host-agent relationship. Pathogenesis Liver - parasitology Liver - pathology Lung - immunology Lung - parasitology Lung - pathology Mice Mice, Inbred BALB C Mice, Inbred C57BL Myocardium - pathology Nitric Oxide Synthase Type II - biosynthesis Nitric Oxide Synthase Type II - genetics Permeability Protozoa RNA, Messenger - metabolism Spleen - parasitology Spleen - pathology Toxoplasma - immunology Toxoplasma - pathogenicity Toxoplasma gondii Toxoplasmosis, Cerebral - immunology Toxoplasmosis, Cerebral - metabolism Toxoplasmosis, Cerebral - parasitology Vascular Cell Adhesion Molecule-1 - biosynthesis Vascular Cell Adhesion Molecule-1 - genetics VCAM-1 |
| Title | Toxoplasma gondii: The severity of toxoplasmic encephalitis in C57BL/6 mice is associated with increased ALCAM and VCAM-1 expression in the central nervous system and higher blood–brain barrier permeability |
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