Association and haplotype analysis of TCF7L2 gene variants with development of obesity in type 2 diabetic patients among Northern Iranians
Introduction The current study aimed to investigate the possible association of TCF7L2 well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372 with obesity occurrence among northern Iranians with Type 2 Diabetes Mellitus (T2DM). Materials and methods DNA extraction from whole blood of...
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| Published in | Journal of diabetes and metabolic disorders Vol. 24; no. 2; p. 177 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Cham
Springer International Publishing
28.07.2025
BioMed Central Ltd Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2251-6581 2251-6581 |
| DOI | 10.1007/s40200-025-01658-w |
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| Abstract | Introduction
The current study aimed to investigate the possible association of
TCF7L2
well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372 with obesity occurrence among northern Iranians with Type 2 Diabetes Mellitus (T2DM).
Materials and methods
DNA extraction from whole blood of all subjects was done by salting-out technique. A total of 483 T2DM patients (307 T2DM individuals without Obesity and 176 T2DM individuals with Obesity) were genotyped through TaqMan assay technology. Statistical analyses were computed by ASSOTEST, Haploview (ver. 4.2), SPSS (ver. 27), and Python (ver. 3.13).
Results
Clinical characteristics assessments between the study groups showed that there was significant association for the gender type of T2DM individuals for being obese (
P
< 0.001, males were at higher risk). Importantly, the genetic association analysis uncovered that rs7903146 was associated with the susceptibility of Obesity among T2DM people (
P
= 0.021, OR = 0.60[0.38–0.93]) in a recessive model of inheritance. Genotype-Phenotype association analysis indicated no significant associations. Finally, using Python programming and based on libraries including Pandas, NumPy, SciPy, and statsmodels, 6 haplotypes with frequency higher than 0.05 found. One significant haplotype including TT-GG-GT (
P
= 0.03) found, however, following p-value adjustment, it was not significant.
Conclusion
In conclusion, this study indicated various significant results highlighting on the association of rs7903146 with susceptibility to obesity among northern Iranians with T2DM. Importantly, this study showed that females are more at risk of getting obesity than males. |
|---|---|
| AbstractList | Introduction The current study aimed to investigate the possible association of TCF7L2 well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372 with obesity occurrence among northern Iranians with Type 2 Diabetes Mellitus (T2DM). Materials and methods DNA extraction from whole blood of all subjects was done by salting-out technique. A total of 483 T2DM patients (307 T2DM individuals without Obesity and 176 T2DM individuals with Obesity) were genotyped through TaqMan assay technology. Statistical analyses were computed by ASSOTEST, Haploview (ver. 4.2), SPSS (ver. 27), and Python (ver. 3.13). Results Clinical characteristics assessments between the study groups showed that there was significant association for the gender type of T2DM individuals for being obese (P < 0.001, males were at higher risk). Importantly, the genetic association analysis uncovered that rs7903146 was associated with the susceptibility of Obesity among T2DM people (P = 0.021, OR = 0.60[0.38-0.93]) in a recessive model of inheritance. Genotype-Phenotype association analysis indicated no significant associations. Finally, using Python programming and based on libraries including Pandas, NumPy, SciPy, and statsmodels, 6 haplotypes with frequency higher than 0.05 found. One significant haplotype including TT-GG-GT (P = 0.03) found, however, following p-value adjustment, it was not significant. Conclusion In conclusion, this study indicated various significant results highlighting on the association of rs7903146 with susceptibility to obesity among northern Iranians with T2DM. Importantly, this study showed that females are more at risk of getting obesity than males. Keywords: Obesity, Type 2 diabetes, TCF7L2 gene, Variant, rs7903146 The current study aimed to investigate the possible association of well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372 with obesity occurrence among northern Iranians with Type 2 Diabetes Mellitus (T2DM). DNA extraction from whole blood of all subjects was done by salting-out technique. A total of 483 T2DM patients (307 T2DM individuals without Obesity and 176 T2DM individuals with Obesity) were genotyped through TaqMan assay technology. Statistical analyses were computed by ASSOTEST, Haploview (ver. 4.2), SPSS (ver. 27), and Python (ver. 3.13). Clinical characteristics assessments between the study groups showed that there was significant association for the gender type of T2DM individuals for being obese ( < 0.001, males were at higher risk). Importantly, the genetic association analysis uncovered that rs7903146 was associated with the susceptibility of Obesity among T2DM people ( = 0.021, OR = 0.60[0.38-0.93]) in a recessive model of inheritance. Genotype-Phenotype association analysis indicated no significant associations. Finally, using Python programming and based on libraries including Pandas, NumPy, SciPy, and statsmodels, 6 haplotypes with frequency higher than 0.05 found. One significant haplotype including TT-GG-GT ( = 0.03) found, however, following p-value adjustment, it was not significant. In conclusion, this study indicated various significant results highlighting on the association of rs7903146 with susceptibility to obesity among northern Iranians with T2DM. Importantly, this study showed that females are more at risk of getting obesity than males. The online version contains supplementary material available at 10.1007/s40200-025-01658-w. Introduction The current study aimed to investigate the possible association of TCF7L2 well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372 with obesity occurrence among northern Iranians with Type 2 Diabetes Mellitus (T2DM). Materials and methods DNA extraction from whole blood of all subjects was done by salting-out technique. A total of 483 T2DM patients (307 T2DM individuals without Obesity and 176 T2DM individuals with Obesity) were genotyped through TaqMan assay technology. Statistical analyses were computed by ASSOTEST, Haploview (ver. 4.2), SPSS (ver. 27), and Python (ver. 3.13). Results Clinical characteristics assessments between the study groups showed that there was significant association for the gender type of T2DM individuals for being obese ( P < 0.001, males were at higher risk). Importantly, the genetic association analysis uncovered that rs7903146 was associated with the susceptibility of Obesity among T2DM people ( P = 0.021, OR = 0.60[0.38–0.93]) in a recessive model of inheritance. Genotype-Phenotype association analysis indicated no significant associations. Finally, using Python programming and based on libraries including Pandas, NumPy, SciPy, and statsmodels, 6 haplotypes with frequency higher than 0.05 found. One significant haplotype including TT-GG-GT ( P = 0.03) found, however, following p-value adjustment, it was not significant. Conclusion In conclusion, this study indicated various significant results highlighting on the association of rs7903146 with susceptibility to obesity among northern Iranians with T2DM. Importantly, this study showed that females are more at risk of getting obesity than males. The current study aimed to investigate the possible association of TCF7L2 well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372 with obesity occurrence among northern Iranians with Type 2 Diabetes Mellitus (T2DM). DNA extraction from whole blood of all subjects was done by salting-out technique. A total of 483 T2DM patients (307 T2DM individuals without Obesity and 176 T2DM individuals with Obesity) were genotyped through TaqMan assay technology. Statistical analyses were computed by ASSOTEST, Haploview (ver. 4.2), SPSS (ver. 27), and Python (ver. 3.13). Clinical characteristics assessments between the study groups showed that there was significant association for the gender type of T2DM individuals for being obese (P < 0.001, males were at higher risk). Importantly, the genetic association analysis uncovered that rs7903146 was associated with the susceptibility of Obesity among T2DM people (P = 0.021, OR = 0.60[0.38-0.93]) in a recessive model of inheritance. Genotype-Phenotype association analysis indicated no significant associations. Finally, using Python programming and based on libraries including Pandas, NumPy, SciPy, and statsmodels, 6 haplotypes with frequency higher than 0.05 found. One significant haplotype including TT-GG-GT (P = 0.03) found, however, following p-value adjustment, it was not significant. In conclusion, this study indicated various significant results highlighting on the association of rs7903146 with susceptibility to obesity among northern Iranians with T2DM. Importantly, this study showed that females are more at risk of getting obesity than males. The current study aimed to investigate the possible association of TCF7L2 well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372 with obesity occurrence among northern Iranians with Type 2 Diabetes Mellitus (T2DM).IntroductionThe current study aimed to investigate the possible association of TCF7L2 well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372 with obesity occurrence among northern Iranians with Type 2 Diabetes Mellitus (T2DM).DNA extraction from whole blood of all subjects was done by salting-out technique. A total of 483 T2DM patients (307 T2DM individuals without Obesity and 176 T2DM individuals with Obesity) were genotyped through TaqMan assay technology. Statistical analyses were computed by ASSOTEST, Haploview (ver. 4.2), SPSS (ver. 27), and Python (ver. 3.13).Materials and methodsDNA extraction from whole blood of all subjects was done by salting-out technique. A total of 483 T2DM patients (307 T2DM individuals without Obesity and 176 T2DM individuals with Obesity) were genotyped through TaqMan assay technology. Statistical analyses were computed by ASSOTEST, Haploview (ver. 4.2), SPSS (ver. 27), and Python (ver. 3.13).Clinical characteristics assessments between the study groups showed that there was significant association for the gender type of T2DM individuals for being obese (P < 0.001, males were at higher risk). Importantly, the genetic association analysis uncovered that rs7903146 was associated with the susceptibility of Obesity among T2DM people (P = 0.021, OR = 0.60[0.38-0.93]) in a recessive model of inheritance. Genotype-Phenotype association analysis indicated no significant associations. Finally, using Python programming and based on libraries including Pandas, NumPy, SciPy, and statsmodels, 6 haplotypes with frequency higher than 0.05 found. One significant haplotype including TT-GG-GT (P = 0.03) found, however, following p-value adjustment, it was not significant.ResultsClinical characteristics assessments between the study groups showed that there was significant association for the gender type of T2DM individuals for being obese (P < 0.001, males were at higher risk). Importantly, the genetic association analysis uncovered that rs7903146 was associated with the susceptibility of Obesity among T2DM people (P = 0.021, OR = 0.60[0.38-0.93]) in a recessive model of inheritance. Genotype-Phenotype association analysis indicated no significant associations. Finally, using Python programming and based on libraries including Pandas, NumPy, SciPy, and statsmodels, 6 haplotypes with frequency higher than 0.05 found. One significant haplotype including TT-GG-GT (P = 0.03) found, however, following p-value adjustment, it was not significant.In conclusion, this study indicated various significant results highlighting on the association of rs7903146 with susceptibility to obesity among northern Iranians with T2DM. Importantly, this study showed that females are more at risk of getting obesity than males.ConclusionIn conclusion, this study indicated various significant results highlighting on the association of rs7903146 with susceptibility to obesity among northern Iranians with T2DM. Importantly, this study showed that females are more at risk of getting obesity than males.The online version contains supplementary material available at 10.1007/s40200-025-01658-w.Supplementary InformationThe online version contains supplementary material available at 10.1007/s40200-025-01658-w. IntroductionThe current study aimed to investigate the possible association of TCF7L2 well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372 with obesity occurrence among northern Iranians with Type 2 Diabetes Mellitus (T2DM).Materials and methodsDNA extraction from whole blood of all subjects was done by salting-out technique. A total of 483 T2DM patients (307 T2DM individuals without Obesity and 176 T2DM individuals with Obesity) were genotyped through TaqMan assay technology. Statistical analyses were computed by ASSOTEST, Haploview (ver. 4.2), SPSS (ver. 27), and Python (ver. 3.13).ResultsClinical characteristics assessments between the study groups showed that there was significant association for the gender type of T2DM individuals for being obese (P < 0.001, males were at higher risk). Importantly, the genetic association analysis uncovered that rs7903146 was associated with the susceptibility of Obesity among T2DM people (P = 0.021, OR = 0.60[0.38–0.93]) in a recessive model of inheritance. Genotype-Phenotype association analysis indicated no significant associations. Finally, using Python programming and based on libraries including Pandas, NumPy, SciPy, and statsmodels, 6 haplotypes with frequency higher than 0.05 found. One significant haplotype including TT-GG-GT (P = 0.03) found, however, following p-value adjustment, it was not significant.ConclusionIn conclusion, this study indicated various significant results highlighting on the association of rs7903146 with susceptibility to obesity among northern Iranians with T2DM. Importantly, this study showed that females are more at risk of getting obesity than males. |
| ArticleNumber | 177 |
| Audience | General |
| Author | Abbaspour, Saima Keshavarz, Parvaneh Sharafshah, Alireza |
| Author_xml | – sequence: 1 givenname: Saima surname: Abbaspour fullname: Abbaspour, Saima organization: School of Medicine, Guilan University of Medical Sciences – sequence: 2 givenname: Parvaneh surname: Keshavarz fullname: Keshavarz, Parvaneh email: keshavarz@gums.ac.ir, keshavarz909@gmail.com organization: Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Department of Genetics, School of Medicine, Guilan University of Medical Sciences – sequence: 3 givenname: Alireza surname: Sharafshah fullname: Sharafshah, Alireza organization: Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40741526$$D View this record in MEDLINE/PubMed |
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| Keywords | Type 2 diabetes Variant Obesity rs7903146 TCF7L2 gene |
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| PublicationTitle | Journal of diabetes and metabolic disorders |
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| Snippet | Introduction
The current study aimed to investigate the possible association of
TCF7L2
well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372... The current study aimed to investigate the possible association of well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372 with obesity... Introduction The current study aimed to investigate the possible association of TCF7L2 well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372... The current study aimed to investigate the possible association of TCF7L2 well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372 with obesity... IntroductionThe current study aimed to investigate the possible association of TCF7L2 well-acknowledged SNPs including rs7903146, rs11196205, and rs12255372... |
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| SubjectTerms | Analysis Body fat Chi-square test Diabetes Diabetics Endocrinology Genes Genetic aspects Genetic engineering Genotype & phenotype Haplotypes Medicine Medicine & Public Health Metabolic Diseases Metabolism Obesity Polymorphism Research Article Software Statistical analysis Transcription factors Type 2 diabetes Variance analysis |
| Title | Association and haplotype analysis of TCF7L2 gene variants with development of obesity in type 2 diabetic patients among Northern Iranians |
| URI | https://link.springer.com/article/10.1007/s40200-025-01658-w https://www.ncbi.nlm.nih.gov/pubmed/40741526 https://www.proquest.com/docview/3255740606 https://www.proquest.com/docview/3235028603 |
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