Bronchoarterial ratio in never‐smokers adults: Implications for bronchial dilation definition

ABSTRACT Background and objective Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasi...

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Published inRespirology (Carlton, Vic.) Vol. 22; no. 1; pp. 108 - 113
Main Authors Diaz, Alejandro A., Young, Thomas P., Maselli, Diego J., Martinez, Carlos H., Maclean, Erick S., Yen, Andrew, Dass, Chandra, Simpson, Scott A., Lynch, David A., Kinney, Gregory L., Hokanson, John E., Washko, George R., San José Estépar, Raul
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.01.2017
Wiley Subscription Services, Inc
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Online AccessGet full text
ISSN1323-7799
1440-1843
1440-1843
DOI10.1111/resp.12875

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Abstract ABSTRACT Background and objective Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never‐smokers without pulmonary disease and its associations with lung function. Methods Objective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never‐smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1 s (FEV1 ) was assessed using regression analysis. Results The BA ratio was 0.79 ± 0.16 and was smaller in more peripheral RB1 bronchi (P < 0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus ≤1 had smaller artery diameters (P < 0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV1 (P = 0.0007). Conclusion In never‐smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate. In 106 never‐smokers adults, the mean ratio of the diameters of the bronchial lumen and adjacent pulmonary artery, a defining radiological feature of bronchiectasis, was 0.79, varied by airway generation and in 8.5% of them was >1. This metric was directly related with expiratory airflow regardless of body size.
AbstractList In 106 never‐smokers adults, the mean ratio of the diameters of the bronchial lumen and adjacent pulmonary artery, a defining radiological feature of bronchiectasis, was 0.79, varied by airway generation and in 8.5% of them was >1. This metric was directly related with expiratory airflow regardless of body size.
Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never-smokers without pulmonary disease and its associations with lung function. Objective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never-smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1 s (FEV ) was assessed using regression analysis. The BA ratio was 0.79 ± 0.16 and was smaller in more peripheral RB1 bronchi (P < 0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus ≤1 had smaller artery diameters (P < 0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV (P = 0.0007). In never-smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate.
Background and objective Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never-smokers without pulmonary disease and its associations with lung function. Methods Objective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never-smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1s (FEV sub(1) ) was assessed using regression analysis. Results The BA ratio was 0.79 plus or minus 0.16 and was smaller in more peripheral RB1 bronchi ( P <0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus less than or equal to 1 had smaller artery diameters ( P <0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV sub(1) ( P =0.0007). Conclusion In never-smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate. In 106 never-smokers adults, the mean ratio of the diameters of the bronchial lumen and adjacent pulmonary artery, a defining radiological feature of bronchiectasis, was 0.79, varied by airway generation and in 8.5% of them was >1. This metric was directly related with expiratory airflow regardless of body size.
ABSTRACTBackground and objectiveBronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never‐smokers without pulmonary disease and its associations with lung function.MethodsObjective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never‐smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1 s (FEV1) was assessed using regression analysis.ResultsThe BA ratio was 0.79 ± 0.16 and was smaller in more peripheral RB1 bronchi (P < 0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus ≤1 had smaller artery diameters (P < 0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV1 (P = 0.0007).ConclusionIn never‐smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate.
BACKGROUND AND OBJECTIVEBronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never-smokers without pulmonary disease and its associations with lung function.METHODSObjective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never-smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1 s (FEV1 ) was assessed using regression analysis.RESULTSThe BA ratio was 0.79 ± 0.16 and was smaller in more peripheral RB1 bronchi (P < 0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus ≤1 had smaller artery diameters (P < 0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV1 (P = 0.0007).CONCLUSIONIn never-smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate.
ABSTRACT Background and objective Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never‐smokers without pulmonary disease and its associations with lung function. Methods Objective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never‐smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1 s (FEV1 ) was assessed using regression analysis. Results The BA ratio was 0.79 ± 0.16 and was smaller in more peripheral RB1 bronchi (P < 0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus ≤1 had smaller artery diameters (P < 0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV1 (P = 0.0007). Conclusion In never‐smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate. In 106 never‐smokers adults, the mean ratio of the diameters of the bronchial lumen and adjacent pulmonary artery, a defining radiological feature of bronchiectasis, was 0.79, varied by airway generation and in 8.5% of them was >1. This metric was directly related with expiratory airflow regardless of body size.
Author Maclean, Erick S.
Maselli, Diego J.
Martinez, Carlos H.
Yen, Andrew
Simpson, Scott A.
Young, Thomas P.
Hokanson, John E.
Dass, Chandra
Lynch, David A.
San José Estépar, Raul
Kinney, Gregory L.
Washko, George R.
Diaz, Alejandro A.
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  surname: San José Estépar
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Keywords non-smoking
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bronchoarterial ratio
bronchiectasis
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Snippet ABSTRACT Background and objective Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as...
In 106 never‐smokers adults, the mean ratio of the diameters of the bronchial lumen and adjacent pulmonary artery, a defining radiological feature of...
Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the...
ABSTRACTBackground and objectiveBronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as...
BACKGROUND AND OBJECTIVEBronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio...
Background and objective Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the...
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SubjectTerms Aged
Body size
Bronchi - diagnostic imaging
Bronchi - pathology
Bronchi - physiopathology
Bronchiectasis
Bronchiectasis - diagnosis
Bronchiectasis - physiopathology
bronchoarterial ratio
Bronchus
Computed tomography
Female
Forced Expiratory Volume - physiology
Humans
Lung diseases
Male
Middle Aged
non‐smoking
normal
Organ Size
Pulmonary arteries
Pulmonary artery
Pulmonary Artery - diagnostic imaging
Pulmonary Artery - pathology
Regression Analysis
Reproducibility of Results
Respiratory function
Respiratory Function Tests - methods
Respiratory tract
Severity of Illness Index
Tomography, X-Ray Computed - methods
Veins & arteries
volumetric computed tomography
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Title Bronchoarterial ratio in never‐smokers adults: Implications for bronchial dilation definition
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