Bronchoarterial ratio in never‐smokers adults: Implications for bronchial dilation definition
ABSTRACT Background and objective Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasi...
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Published in | Respirology (Carlton, Vic.) Vol. 22; no. 1; pp. 108 - 113 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.01.2017
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
ISSN | 1323-7799 1440-1843 1440-1843 |
DOI | 10.1111/resp.12875 |
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Abstract | ABSTRACT
Background and objective
Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never‐smokers without pulmonary disease and its associations with lung function.
Methods
Objective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never‐smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1 s (FEV1
) was assessed using regression analysis.
Results
The BA ratio was 0.79 ± 0.16 and was smaller in more peripheral RB1 bronchi (P < 0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus ≤1 had smaller artery diameters (P < 0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV1
(P = 0.0007).
Conclusion
In never‐smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate.
In 106 never‐smokers adults, the mean ratio of the diameters of the bronchial lumen and adjacent pulmonary artery, a defining radiological feature of bronchiectasis, was 0.79, varied by airway generation and in 8.5% of them was >1. This metric was directly related with expiratory airflow regardless of body size. |
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AbstractList | In 106 never‐smokers adults, the mean ratio of the diameters of the bronchial lumen and adjacent pulmonary artery, a defining radiological feature of bronchiectasis, was 0.79, varied by airway generation and in 8.5% of them was >1. This metric was directly related with expiratory airflow regardless of body size. Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never-smokers without pulmonary disease and its associations with lung function. Objective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never-smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1 s (FEV ) was assessed using regression analysis. The BA ratio was 0.79 ± 0.16 and was smaller in more peripheral RB1 bronchi (P < 0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus ≤1 had smaller artery diameters (P < 0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV (P = 0.0007). In never-smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate. Background and objective Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never-smokers without pulmonary disease and its associations with lung function. Methods Objective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never-smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1s (FEV sub(1) ) was assessed using regression analysis. Results The BA ratio was 0.79 plus or minus 0.16 and was smaller in more peripheral RB1 bronchi ( P <0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus less than or equal to 1 had smaller artery diameters ( P <0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV sub(1) ( P =0.0007). Conclusion In never-smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate. In 106 never-smokers adults, the mean ratio of the diameters of the bronchial lumen and adjacent pulmonary artery, a defining radiological feature of bronchiectasis, was 0.79, varied by airway generation and in 8.5% of them was >1. This metric was directly related with expiratory airflow regardless of body size. ABSTRACTBackground and objectiveBronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never‐smokers without pulmonary disease and its associations with lung function.MethodsObjective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never‐smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1 s (FEV1) was assessed using regression analysis.ResultsThe BA ratio was 0.79 ± 0.16 and was smaller in more peripheral RB1 bronchi (P < 0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus ≤1 had smaller artery diameters (P < 0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV1 (P = 0.0007).ConclusionIn never‐smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate. BACKGROUND AND OBJECTIVEBronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never-smokers without pulmonary disease and its associations with lung function.METHODSObjective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never-smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1 s (FEV1 ) was assessed using regression analysis.RESULTSThe BA ratio was 0.79 ± 0.16 and was smaller in more peripheral RB1 bronchi (P < 0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus ≤1 had smaller artery diameters (P < 0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV1 (P = 0.0007).CONCLUSIONIn never-smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate. ABSTRACT Background and objective Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the bronchial lumen (B) and adjacent pulmonary artery (A), is a defining radiological feature of bronchiectasis. A challenge to equating the bronchoarterial (BA) ratio to disease severity is that the diameters of airway and vessel in health are not established. We sought to explore the variability of BA ratio in never‐smokers without pulmonary disease and its associations with lung function. Methods Objective measurements of the BA ratio on volumetric computed tomography (CT) scans and pulmonary function data were collected in 106 never‐smokers. The BA ratio was measured in the right upper lobe apical bronchus (RB1) and the right lower lobe basal posterior bronchus. The association between the BA ratio and forced expiratory volume in 1 s (FEV1 ) was assessed using regression analysis. Results The BA ratio was 0.79 ± 0.16 and was smaller in more peripheral RB1 bronchi (P < 0.0001). The BA ratio was >1, a typical threshold for bronchiectasis, in 10 (8.5%) subjects. Subjects with a BA ratio >1 versus ≤1 had smaller artery diameters (P < 0.0001) but not significantly larger bronchial lumens. After adjusting for age, gender, race and height, the BA ratio was directly related to FEV1 (P = 0.0007). Conclusion In never‐smokers, the BA ratio varies by airway generation and is associated with lung function. A BA ratio >1 is driven by small arteries. Using artery diameter as reference to define bronchial dilation seems inappropriate. In 106 never‐smokers adults, the mean ratio of the diameters of the bronchial lumen and adjacent pulmonary artery, a defining radiological feature of bronchiectasis, was 0.79, varied by airway generation and in 8.5% of them was >1. This metric was directly related with expiratory airflow regardless of body size. |
Author | Maclean, Erick S. Maselli, Diego J. Martinez, Carlos H. Yen, Andrew Simpson, Scott A. Young, Thomas P. Hokanson, John E. Dass, Chandra Lynch, David A. San José Estépar, Raul Kinney, Gregory L. Washko, George R. Diaz, Alejandro A. |
Author_xml | – sequence: 1 givenname: Alejandro A. surname: Diaz fullname: Diaz, Alejandro A. email: ADiaz6@Partners.org organization: Brigham and Women's Hospital, Harvard Medical School – sequence: 2 givenname: Thomas P. surname: Young fullname: Young, Thomas P. organization: Brigham and Women's Hospital, Harvard Medical School – sequence: 3 givenname: Diego J. surname: Maselli fullname: Maselli, Diego J. organization: University of Texas Health Science Center – sequence: 4 givenname: Carlos H. surname: Martinez fullname: Martinez, Carlos H. organization: University of Michigan Health System – sequence: 5 givenname: Erick S. surname: Maclean fullname: Maclean, Erick S. organization: Brigham and Women's Hospital, Harvard Medical School – sequence: 6 givenname: Andrew surname: Yen fullname: Yen, Andrew organization: University of California – sequence: 7 givenname: Chandra surname: Dass fullname: Dass, Chandra organization: Temple University Hospital – sequence: 8 givenname: Scott A. surname: Simpson fullname: Simpson, Scott A. organization: Temple University Hospital – sequence: 9 givenname: David A. surname: Lynch fullname: Lynch, David A. organization: National Jewish Health – sequence: 10 givenname: Gregory L. surname: Kinney fullname: Kinney, Gregory L. organization: University of Colorado Denver – sequence: 11 givenname: John E. surname: Hokanson fullname: Hokanson, John E. organization: University of Colorado Denver – sequence: 12 givenname: George R. surname: Washko fullname: Washko, George R. organization: Brigham and Women's Hospital, Harvard Medical School – sequence: 13 givenname: Raul surname: San José Estépar fullname: San José Estépar, Raul organization: Brigham and Women's Hospital, Harvard Medical School |
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Keywords | non-smoking normal volumetric computed tomography bronchoarterial ratio bronchiectasis |
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Snippet | ABSTRACT
Background and objective
Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as... In 106 never‐smokers adults, the mean ratio of the diameters of the bronchial lumen and adjacent pulmonary artery, a defining radiological feature of... Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio of the diameters of the... ABSTRACTBackground and objectiveBronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as... BACKGROUND AND OBJECTIVEBronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the ratio... Background and objective Bronchiectasis manifests as recurrent respiratory infections and reduced lung function. Airway dilation, which is measured as the... |
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SubjectTerms | Aged Body size Bronchi - diagnostic imaging Bronchi - pathology Bronchi - physiopathology Bronchiectasis Bronchiectasis - diagnosis Bronchiectasis - physiopathology bronchoarterial ratio Bronchus Computed tomography Female Forced Expiratory Volume - physiology Humans Lung diseases Male Middle Aged non‐smoking normal Organ Size Pulmonary arteries Pulmonary artery Pulmonary Artery - diagnostic imaging Pulmonary Artery - pathology Regression Analysis Reproducibility of Results Respiratory function Respiratory Function Tests - methods Respiratory tract Severity of Illness Index Tomography, X-Ray Computed - methods Veins & arteries volumetric computed tomography |
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Title | Bronchoarterial ratio in never‐smokers adults: Implications for bronchial dilation definition |
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