In Vivo Expression of Reprogramming Factor OCT4 Ameliorates Myelination Deficits and Induces Striatal Neuroprotection in Huntington’s Disease

White matter atrophy has been shown to precede the massive loss of striatal GABAergic neurons in Huntington’s disease (HD). This study investigated the effects of in vivo expression of reprogramming factor octamer-binding transcription factor 4 (OCT4) on neural stem cell (NSC) niche activation in th...

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Published inGenes Vol. 12; no. 5; p. 712
Main Authors Yu, Ji-Hea, Nam, Bae-Geun, Kim, Min-Gi, Pyo, Soonil, Seo, Jung-Hwa, Cho, Sung-Rae
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 10.05.2021
MDPI
Subjects
Age
Atrophy
Cell activation
Cell fate
Corpus callosum
Dependoparvovirus
Disease
Electron microscopy
Glial cell line-derived neurotrophic factor
Glial stem cells
Huntington's disease
Huntingtons disease
Hypotheses
Laboratory animals
Magnetic resonance imaging
magnetism
Microenvironments
Myelination
Neostriatum
Neural stem cells
Neuronal-glial interactions
Neuroprotection
neuroprotective effect
Oct-4 protein
oligodendroglia
Progenitor cells
Substantia alba
Subventricular zone
transcription factors
Ventricle (lateral)
γ-Aminobutyric acid
United States > US
Germany
Online AccessGet full text
ISSN2073-4425
2073-4425
DOI10.3390/genes12050712

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Abstract White matter atrophy has been shown to precede the massive loss of striatal GABAergic neurons in Huntington’s disease (HD). This study investigated the effects of in vivo expression of reprogramming factor octamer-binding transcription factor 4 (OCT4) on neural stem cell (NSC) niche activation in the subventricular zone (SVZ) and induction of cell fate specific to the microenvironment of HD. R6/2 mice randomly received adeno-associated virus 9 (AAV9)-OCT4, AAV9-Null, or phosphate-buffered saline into both lateral ventricles at 4 weeks of age. The AAV9-OCT4 group displayed significantly improved behavioral performance compared to the control groups. Following AAV9-OCT4 treatment, the number of newly generated NSCs and oligodendrocyte progenitor cells (OPCs) significantly increased in the SVZ, and the expression of OPC-related genes and glial cell-derived neurotrophic factor (GDNF) significantly increased. Further, amelioration of myelination deficits in the corpus callosum was observed through electron microscopy and magnetic resonance imaging, and striatal DARPP32+ GABAergic neurons significantly increased in the AAV9-OCT4 group. These results suggest that in situ expression of the reprogramming factor OCT4 in the SVZ induces OPC proliferation, thereby attenuating myelination deficits. Particularly, GDNF released by OPCs seems to induce striatal neuroprotection in HD, which explains the behavioral improvement in R6/2 mice overexpressing OCT4.
AbstractList White matter atrophy has been shown to precede the massive loss of striatal GABAergic neurons in Huntington’s disease (HD). This study investigated the effects of in vivo expression of reprogramming factor octamer-binding transcription factor 4 (OCT4) on neural stem cell (NSC) niche activation in the subventricular zone (SVZ) and induction of cell fate specific to the microenvironment of HD. R6/2 mice randomly received adeno-associated virus 9 (AAV9)-OCT4, AAV9-Null, or phosphate-buffered saline into both lateral ventricles at 4 weeks of age. The AAV9-OCT4 group displayed significantly improved behavioral performance compared to the control groups. Following AAV9-OCT4 treatment, the number of newly generated NSCs and oligodendrocyte progenitor cells (OPCs) significantly increased in the SVZ, and the expression of OPC-related genes and glial cell-derived neurotrophic factor (GDNF) significantly increased. Further, amelioration of myelination deficits in the corpus callosum was observed through electron microscopy and magnetic resonance imaging, and striatal DARPP32+ GABAergic neurons significantly increased in the AAV9-OCT4 group. These results suggest that in situ expression of the reprogramming factor OCT4 in the SVZ induces OPC proliferation, thereby attenuating myelination deficits. Particularly, GDNF released by OPCs seems to induce striatal neuroprotection in HD, which explains the behavioral improvement in R6/2 mice overexpressing OCT4.
White matter atrophy has been shown to precede the massive loss of striatal GABAergic neurons in Huntington's disease (HD). This study investigated the effects of in vivo expression of reprogramming factor octamer-binding transcription factor 4 (OCT4) on neural stem cell (NSC) niche activation in the subventricular zone (SVZ) and induction of cell fate specific to the microenvironment of HD. R6/2 mice randomly received adeno-associated virus 9 (AAV9)-OCT4, AAV9-Null, or phosphate-buffered saline into both lateral ventricles at 4 weeks of age. The AAV9-OCT4 group displayed significantly improved behavioral performance compared to the control groups. Following AAV9-OCT4 treatment, the number of newly generated NSCs and oligodendrocyte progenitor cells (OPCs) significantly increased in the SVZ, and the expression of OPC-related genes and glial cell-derived neurotrophic factor (GDNF) significantly increased. Further, amelioration of myelination deficits in the corpus callosum was observed through electron microscopy and magnetic resonance imaging, and striatal DARPP32+ GABAergic neurons significantly increased in the AAV9-OCT4 group. These results suggest that in situ expression of the reprogramming factor OCT4 in the SVZ induces OPC proliferation, thereby attenuating myelination deficits. Particularly, GDNF released by OPCs seems to induce striatal neuroprotection in HD, which explains the behavioral improvement in R6/2 mice overexpressing OCT4.White matter atrophy has been shown to precede the massive loss of striatal GABAergic neurons in Huntington's disease (HD). This study investigated the effects of in vivo expression of reprogramming factor octamer-binding transcription factor 4 (OCT4) on neural stem cell (NSC) niche activation in the subventricular zone (SVZ) and induction of cell fate specific to the microenvironment of HD. R6/2 mice randomly received adeno-associated virus 9 (AAV9)-OCT4, AAV9-Null, or phosphate-buffered saline into both lateral ventricles at 4 weeks of age. The AAV9-OCT4 group displayed significantly improved behavioral performance compared to the control groups. Following AAV9-OCT4 treatment, the number of newly generated NSCs and oligodendrocyte progenitor cells (OPCs) significantly increased in the SVZ, and the expression of OPC-related genes and glial cell-derived neurotrophic factor (GDNF) significantly increased. Further, amelioration of myelination deficits in the corpus callosum was observed through electron microscopy and magnetic resonance imaging, and striatal DARPP32+ GABAergic neurons significantly increased in the AAV9-OCT4 group. These results suggest that in situ expression of the reprogramming factor OCT4 in the SVZ induces OPC proliferation, thereby attenuating myelination deficits. Particularly, GDNF released by OPCs seems to induce striatal neuroprotection in HD, which explains the behavioral improvement in R6/2 mice overexpressing OCT4.
White matter atrophy has been shown to precede the massive loss of striatal GABAergic neurons in Huntington’s disease (HD). This study investigated the effects of in vivo expression of reprogramming factor octamer-binding transcription factor 4 (OCT4) on neural stem cell (NSC) niche activation in the subventricular zone (SVZ) and induction of cell fate specific to the microenvironment of HD. R6/2 mice randomly received adeno-associated virus 9 (AAV9)-OCT4, AAV9-Null, or phosphate-buffered saline into both lateral ventricles at 4 weeks of age. The AAV9-OCT4 group displayed significantly improved behavioral performance compared to the control groups. Following AAV9-OCT4 treatment, the number of newly generated NSCs and oligodendrocyte progenitor cells (OPCs) significantly increased in the SVZ, and the expression of OPC-related genes and glial cell-derived neurotrophic factor (GDNF) significantly increased. Further, amelioration of myelination deficits in the corpus callosum was observed through electron microscopy and magnetic resonance imaging, and striatal DARPP32⁺ GABAergic neurons significantly increased in the AAV9-OCT4 group. These results suggest that in situ expression of the reprogramming factor OCT4 in the SVZ induces OPC proliferation, thereby attenuating myelination deficits. Particularly, GDNF released by OPCs seems to induce striatal neuroprotection in HD, which explains the behavioral improvement in R6/2 mice overexpressing OCT4.
Author Pyo, Soonil
Yu, Ji-Hea
Nam, Bae-Geun
Seo, Jung-Hwa
Kim, Min-Gi
Cho, Sung-Rae
AuthorAffiliation 1 Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea; onlyjin112@yuhs.ac (J.-H.Y.); nbg6824@naver.com (B.-G.N.); neuro94@naver.com (S.P.); zugula@naver.com (J.-H.S.)
2 Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul 03722, Korea; mg0521k@naver.com
3 Graduate Program of Nano Science and Technology, Yonsei University College of Medicine, Seoul 03722, Korea
4 Rehabilitation Institute of Neuromuscular Disease, Yonsei University College of Medicine, Seoul 03722, Korea
AuthorAffiliation_xml – name: 3 Graduate Program of Nano Science and Technology, Yonsei University College of Medicine, Seoul 03722, Korea
– name: 4 Rehabilitation Institute of Neuromuscular Disease, Yonsei University College of Medicine, Seoul 03722, Korea
– name: 1 Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea; onlyjin112@yuhs.ac (J.-H.Y.); nbg6824@naver.com (B.-G.N.); neuro94@naver.com (S.P.); zugula@naver.com (J.-H.S.)
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CitedBy_id crossref_primary_10_3389_fnagi_2024_1306312
crossref_primary_10_3389_fnins_2022_884667
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Cites_doi 10.3390/cells8101204
10.1016/j.biopsych.2017.10.019
10.1016/j.brainresrev.2011.01.001
10.1371/journal.pone.0076310
10.1093/cercor/bhr360
10.1073/pnas.1818042116
10.1038/nature08436
10.1523/JNEUROSCI.22-05-01592.2002
10.1002/hipo.23087
10.1002/hbm.22055
10.1038/nrneurol.2014.24
10.3389/fncel.2013.00275
10.4049/jimmunol.133.4.1710
10.1002/hbm.21205
10.1016/S0165-6147(00)01884-8
10.1523/JNEUROSCI.1291-11.2011
10.1007/s12035-015-9205-3
10.1152/physiolgenomics.00021.2002
10.1186/1471-2202-11-114
10.1093/hmg/ddv016
10.1016/j.nicl.2016.02.014
10.1038/sj.gt.3301529
10.1146/annurev.pharmtox.44.101802.121631
10.3402/pba.v6.32981
10.1007/s11682-011-9121-8
10.1038/s41593-020-0637-3
10.1111/j.1469-7580.2005.00454.x
10.1155/2016/1431349
10.1038/nrm.2016.8
10.1038/nature09553
10.1016/j.omtm.2018.07.006
10.1523/JNEUROSCI.3491-13.2014
10.1016/j.neuroscience.2016.01.028
10.1016/j.brainres.2013.04.030
10.1038/nrn917
10.1038/nature09820
10.3390/ijms17091550
10.1523/JNEUROSCI.23-07-02557.2003
10.1016/S1474-4422(10)70276-3
10.1016/j.neuroimage.2009.10.015
10.1371/journal.pone.0019926
10.1097/00005072-199505000-00002
10.1101/cshperspect.a021287
10.1371/journal.pone.0116069
10.5483/BMBRep.2011.44.12.793
10.1038/mt.2016.124
10.1097/00005072-199111000-00005
10.1097/01.wnn.0000152205.79033.73
10.1016/j.stem.2010.04.002
10.1523/JNEUROSCI.23-12-04967.2003
10.1038/nature11039
10.1021/cb500724t
10.1258/la.2008.007147
10.1523/JNEUROSCI.4527-08.2009
10.3233/JHD-150173
10.1155/2015/794632
10.1016/S0092-8674(02)00678-5
10.1016/j.neuron.2015.02.026
10.1038/cddis.2017.504
10.1002/1531-8249(200101)49:1<29::AID-ANA7>3.0.CO;2-B
10.1002/mds.28109
10.15252/embj.201592652
10.1016/j.celrep.2018.06.110
10.1016/j.nicl.2018.01.029
10.1523/JNEUROSCI.3883-04.2004
10.1016/j.neuron.2011.05.004
10.1002/cpmo.58
10.1016/j.cell.2009.01.023
10.1007/978-1-4939-7825-0_6
10.1006/nimg.2001.0765
10.1007/s10334-019-00742-6
10.1046/j.1471-4159.2003.01706.x
10.1146/annurev.pharmtox.43.100901.140257
10.1089/hgtb.2013.076
10.1523/JNEUROSCI.23-28-09418.2003
10.1016/j.stemcr.2016.12.010
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J.-H.Y. and B.-G.N. equally contributed to this study.
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References Xing (ref_21) 2014; 34
Polito (ref_18) 2005; 207
Lu (ref_75) 2002; 109
Yang (ref_46) 2003; 23
Dumas (ref_3) 2012; 33
Gregory (ref_8) 2015; 4
Tang (ref_49) 2017; 8
Pierpaoli (ref_79) 2001; 13
McCollum (ref_11) 2013; 1518
Dehghan (ref_23) 2016; 318
Caron (ref_15) 2019; 116
Akamatsu (ref_35) 2009; 29
Khoueiry (ref_76) 2017; 8
Xu (ref_42) 2001; 8
Winner (ref_48) 2015; 7
ref_17
Lie (ref_31) 2004; 44
Chen (ref_59) 2018; 8
Delmaire (ref_82) 2013; 34
Magavi (ref_47) 2002; 198
(ref_68) 2011; 67
Kuan (ref_45) 2004; 24
Gholizadeh (ref_67) 2013; 24
Gao (ref_52) 2016; 2016
Ross (ref_6) 2014; 10
Wilkins (ref_50) 2003; 23
Gatto (ref_7) 2019; 32
Macchi (ref_74) 2014; 8
Imitola (ref_20) 2003; 14
Huang (ref_78) 2015; 85
Xiang (ref_55) 2011; 31
ref_22
McColgan (ref_1) 2018; 83
Tabrizi (ref_2) 2011; 10
Schoenfeld (ref_43) 2019; 29
ref_65
Myers (ref_9) 1991; 50
Maki (ref_71) 2013; 7
Li (ref_36) 2005; 2
Bacmeister (ref_54) 2020; 23
Gerdes (ref_72) 1984; 133
Miller (ref_73) 2018; 24
Ferrante (ref_57) 2003; 23
Hudry (ref_66) 2018; 10
Olsson (ref_41) 2008; 42
Tye (ref_62) 2011; 471
Marques (ref_70) 2012; 6
Rosas (ref_14) 2018; 20
Beglinger (ref_53) 2005; 18
ref_32
Smith (ref_44) 1995; 54
ref_30
Sim (ref_34) 2011; 44
Kim (ref_28) 2009; 461
Casella (ref_16) 2020; 35
MacDonald (ref_10) 2001; 49
Takahashi (ref_25) 2016; 17
ref_39
Zawadzka (ref_77) 2010; 6
Jin (ref_12) 2015; 24
Huber (ref_63) 2012; 484
Franklin (ref_19) 2002; 3
Seo (ref_24) 2016; 24
Rosas (ref_80) 2010; 49
Bohanna (ref_81) 2011; 5
Haubensak (ref_64) 2010; 468
Luders (ref_4) 2012; 22
Collins (ref_61) 2017; 67
Lin (ref_27) 2015; 2015
Faria (ref_5) 2016; 11
Farshim (ref_38) 2018; 1780
Ettle (ref_51) 2016; 53
Ferrante (ref_56) 2002; 22
ref_40
Kim (ref_33) 2015; 34
Menalled (ref_37) 2002; 23
Dedeoglu (ref_58) 2003; 85
Kootstra (ref_60) 2003; 43
Ihrie (ref_69) 2011; 70
Kim (ref_29) 2009; 136
Teo (ref_13) 2016; 25
Pandian (ref_26) 2014; 9
References_xml – ident: ref_22
  doi: 10.3390/cells8101204
– volume: 83
  start-page: 456
  year: 2018
  ident: ref_1
  article-title: Brain regions showing white matter loss in huntington’s disease are enriched for synaptic and metabolic genes
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2017.10.019
– volume: 67
  start-page: 147
  year: 2011
  ident: ref_68
  article-title: Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor
  publication-title: Brain Res. Rev.
  doi: 10.1016/j.brainresrev.2011.01.001
– ident: ref_65
  doi: 10.1371/journal.pone.0076310
– volume: 22
  start-page: 2858
  year: 2012
  ident: ref_4
  article-title: Multimodal mri analysis of the corpus callosum reveals white matter differences in presymptomatic and early huntington’s disease
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/bhr360
– volume: 116
  start-page: 9622
  year: 2019
  ident: ref_15
  article-title: Intrinsic mutant htt-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in huntington disease
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1818042116
– volume: 461
  start-page: 649
  year: 2009
  ident: ref_28
  article-title: Direct reprogramming of human neural stem cells by oct4
  publication-title: Nature
  doi: 10.1038/nature08436
– volume: 22
  start-page: 1592
  year: 2002
  ident: ref_56
  article-title: Therapeutic effects of coenzyme q10 and remacemide in transgenic mouse models of huntington’s disease
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.22-05-01592.2002
– volume: 6
  start-page: 34
  year: 2012
  ident: ref_70
  article-title: The path from the choroid plexus to the subventricular zone: Go with the flow!
  publication-title: Front. Cell. Neurosci.
– volume: 29
  start-page: 848
  year: 2019
  ident: ref_43
  article-title: New neurons restore structural and behavioral abnormalities in a rat model of ptsd
  publication-title: Hippocampus
  doi: 10.1002/hipo.23087
– volume: 34
  start-page: 2141
  year: 2013
  ident: ref_82
  article-title: The structural correlates of functional deficits in early huntington’s disease
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.22055
– volume: 10
  start-page: 204
  year: 2014
  ident: ref_6
  article-title: Huntington disease: Natural history, biomarkers and prospects for therapeutics
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/nrneurol.2014.24
– volume: 7
  start-page: 275
  year: 2013
  ident: ref_71
  article-title: Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2013.00275
– volume: 133
  start-page: 1710
  year: 1984
  ident: ref_72
  article-title: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody ki-67
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.133.4.1710
– volume: 33
  start-page: 203
  year: 2012
  ident: ref_3
  article-title: Early changes in white matter pathways of the sensorimotor cortex in premanifest huntington’s disease
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.21205
– volume: 23
  start-page: 32
  year: 2002
  ident: ref_37
  article-title: Mouse models of huntington’s disease
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/S0165-6147(00)01884-8
– volume: 31
  start-page: 9544
  year: 2011
  ident: ref_55
  article-title: Peroxisome-proliferator-activated receptor γ coactivator 1 α contributes to dysmyelination in experimental models of huntington’s disease
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1291-11.2011
– volume: 53
  start-page: 3046
  year: 2016
  ident: ref_51
  article-title: Oligodendroglia and myelin in neurodegenerative diseases: More than just bystanders?
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-015-9205-3
– volume: 14
  start-page: 171
  year: 2003
  ident: ref_20
  article-title: Genetic programs and responses of neural stem/progenitor cells during demyelination: Potential insights into repair mechanisms in multiple sclerosis
  publication-title: Physiol. Genom.
  doi: 10.1152/physiolgenomics.00021.2002
– ident: ref_32
  doi: 10.1186/1471-2202-11-114
– volume: 24
  start-page: 2508
  year: 2015
  ident: ref_12
  article-title: Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of huntington’s disease
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddv016
– volume: 11
  start-page: 450
  year: 2016
  ident: ref_5
  article-title: Linking white matter and deep gray matter alterations in premanifest huntington disease
  publication-title: Neurolimage Clin.
  doi: 10.1016/j.nicl.2016.02.014
– volume: 8
  start-page: 1323
  year: 2001
  ident: ref_42
  article-title: Quantitative comparison of expression with adeno-associated virus (aav-2) brain-specific gene cassettes
  publication-title: Gene Ther.
  doi: 10.1038/sj.gt.3301529
– volume: 44
  start-page: 399
  year: 2004
  ident: ref_31
  article-title: Neurogenesis in the adult brain: New strategies for central nervous system diseases
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev.pharmtox.44.101802.121631
– ident: ref_40
  doi: 10.3402/pba.v6.32981
– volume: 5
  start-page: 171
  year: 2011
  ident: ref_81
  article-title: Diffusion tensor imaging in huntington’s disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits
  publication-title: Brain Imaging Behav.
  doi: 10.1007/s11682-011-9121-8
– volume: 23
  start-page: 819
  year: 2020
  ident: ref_54
  article-title: Motor learning promotes remyelination via new and surviving oligodendrocytes
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-0637-3
– volume: 207
  start-page: 707
  year: 2005
  ident: ref_18
  article-title: Ng2-expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system
  publication-title: J. Anat.
  doi: 10.1111/j.1469-7580.2005.00454.x
– volume: 2016
  start-page: 1431349
  year: 2016
  ident: ref_52
  article-title: Gdnf enhances therapeutic efficiency of neural stem cells-based therapy in chronic experimental allergic encephalomyelitis in rat
  publication-title: Stem Cells Int.
  doi: 10.1155/2016/1431349
– volume: 17
  start-page: 183
  year: 2016
  ident: ref_25
  article-title: A decade of transcription factor-mediated reprogramming to pluripotency
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm.2016.8
– volume: 468
  start-page: 270
  year: 2010
  ident: ref_64
  article-title: Genetic dissection of an amygdala microcircuit that gates conditioned fear
  publication-title: Nature
  doi: 10.1038/nature09553
– volume: 10
  start-page: 197
  year: 2018
  ident: ref_66
  article-title: Efficient gene transfer to the central nervous system by single-stranded anc80l65
  publication-title: Mol. Therapy. Methods Clin. Dev.
  doi: 10.1016/j.omtm.2018.07.006
– volume: 34
  start-page: 14128
  year: 2014
  ident: ref_21
  article-title: Adult neural precursor cells from the subventricular zone contribute significantly to oligodendrocyte regeneration and remyelination
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3491-13.2014
– volume: 318
  start-page: 178
  year: 2016
  ident: ref_23
  article-title: Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2016.01.028
– volume: 25
  start-page: 2621
  year: 2016
  ident: ref_13
  article-title: Structural and molecular myelination deficits occur prior to neuronal loss in the yac128 and bachd models of huntington disease
  publication-title: Hum. Mol. Genet.
– volume: 1518
  start-page: 91
  year: 2013
  ident: ref_11
  article-title: Striatal oligodendrogliogenesis and neuroblast recruitment are increased in the r6/2 mouse model of huntington’s disease
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2013.04.030
– volume: 3
  start-page: 705
  year: 2002
  ident: ref_19
  article-title: Why does remyelination fail in multiple sclerosis?
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn917
– volume: 471
  start-page: 358
  year: 2011
  ident: ref_62
  article-title: Amygdala circuitry mediating reversible and bidirectional control of anxiety
  publication-title: Nature
  doi: 10.1038/nature09820
– ident: ref_39
  doi: 10.3390/ijms17091550
– volume: 23
  start-page: 2557
  year: 2003
  ident: ref_46
  article-title: Neuronal cell death is preceded by cell cycle events at all stages of alzheimer’s disease
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.23-07-02557.2003
– volume: 10
  start-page: 31
  year: 2011
  ident: ref_2
  article-title: Biological and clinical changes in premanifest and early stage huntington’s disease in the track-hd study: The 12-month longitudinal analysis
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(10)70276-3
– volume: 49
  start-page: 2995
  year: 2010
  ident: ref_80
  article-title: Altered white matter microstructure in the corpus callosum in huntington’s disease: Implications for cortical “disconnection”
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2009.10.015
– ident: ref_30
  doi: 10.1371/journal.pone.0019926
– volume: 54
  start-page: 297
  year: 1995
  ident: ref_44
  article-title: Ki-67 immunoreactivity in alzheimer’s disease and other neurodegenerative disorders
  publication-title: J. Neuropathol. Exp. Neurol.
  doi: 10.1097/00005072-199505000-00002
– volume: 2
  start-page: 447
  year: 2005
  ident: ref_36
  article-title: The use of the r6 transgenic mouse models of huntington’s disease in attempts to develop novel therapeutic strategies
  publication-title: NeuroRx J. Am. Soc. Exp. Neurother.
– volume: 7
  start-page: a021287
  year: 2015
  ident: ref_48
  article-title: Adult neurogenesis in neurodegenerative diseases
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a021287
– ident: ref_17
  doi: 10.1371/journal.pone.0116069
– volume: 44
  start-page: 793
  year: 2011
  ident: ref_34
  article-title: Assessment of the effects of virus-mediated limited oct4 overexpression on the structure of the hippocampus and behavior in mice
  publication-title: BMB Rep.
  doi: 10.5483/BMBRep.2011.44.12.793
– volume: 24
  start-page: 1538
  year: 2016
  ident: ref_24
  article-title: In situ pluripotency factor expression promotes functional recovery from cerebral ischemia
  publication-title: Mol. Ther. J. Am. Soc. Gene Ther.
  doi: 10.1038/mt.2016.124
– volume: 50
  start-page: 729
  year: 1991
  ident: ref_9
  article-title: Decreased neuronal and increased oligodendroglial densities in huntington’s disease caudate nucleus
  publication-title: J. Neuropathol. Exp. Neurol.
  doi: 10.1097/00005072-199111000-00005
– volume: 18
  start-page: 102
  year: 2005
  ident: ref_53
  article-title: White matter volume and cognitive dysfunction in early huntington’s disease
  publication-title: Cogn. Behav. Neurol. Off. J. Soc. Behav. Cogn. Neurol.
  doi: 10.1097/01.wnn.0000152205.79033.73
– volume: 6
  start-page: 578
  year: 2010
  ident: ref_77
  article-title: Cns-resident glial progenitor/stem cells produce schwann cells as well as oligodendrocytes during repair of cns demyelination
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2010.04.002
– volume: 23
  start-page: 4967
  year: 2003
  ident: ref_50
  article-title: Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: A novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.23-12-04967.2003
– volume: 484
  start-page: 473
  year: 2012
  ident: ref_63
  article-title: Multiple dynamic representations in the motor cortex during sensorimotor learning
  publication-title: Nature
  doi: 10.1038/nature11039
– volume: 8
  start-page: 145
  year: 2014
  ident: ref_74
  article-title: Oligodendrogenesis in the normal and pathological central nervous system
  publication-title: Front. Neurosci.
– volume: 67
  start-page: 215
  year: 2017
  ident: ref_61
  article-title: Viral vector biosafety in laboratory animal research
  publication-title: Comp. Med.
– volume: 9
  start-page: 2729
  year: 2014
  ident: ref_26
  article-title: Identification of a small molecule that turns on the pluripotency gene circuitry in human fibroblasts
  publication-title: ACS Chem. Biol.
  doi: 10.1021/cb500724t
– volume: 42
  start-page: 277
  year: 2008
  ident: ref_41
  article-title: Animal welfare and the refinement of neuroscience research methods—A case study of huntington’s disease models
  publication-title: Lab. Anim.
  doi: 10.1258/la.2008.007147
– volume: 29
  start-page: 2113
  year: 2009
  ident: ref_35
  article-title: Suppression of oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4527-08.2009
– volume: 4
  start-page: 333
  year: 2015
  ident: ref_8
  article-title: Longitudinal diffusion tensor imaging shows progressive changes in white matter in huntington’s disease
  publication-title: J. Huntingt. Dis.
  doi: 10.3233/JHD-150173
– volume: 198
  start-page: 283
  year: 2002
  ident: ref_47
  article-title: Identification of newborn cells by brdu labeling and immunocytochemistry in vivo
  publication-title: Methods Mol. Biol
– volume: 2015
  start-page: 794632
  year: 2015
  ident: ref_27
  article-title: Reprogramming with small molecules instead of exogenous transcription factors
  publication-title: Stem Cells Int.
  doi: 10.1155/2015/794632
– volume: 109
  start-page: 75
  year: 2002
  ident: ref_75
  article-title: Common developmental requirement for olig function indicates a motor neuron/oligodendrocyte connection
  publication-title: Cell
  doi: 10.1016/S0092-8674(02)00678-5
– volume: 85
  start-page: 1212
  year: 2015
  ident: ref_78
  article-title: Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.02.026
– volume: 8
  start-page: e3108
  year: 2017
  ident: ref_49
  article-title: Current progress in the derivation and therapeutic application of neural stem cells
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2017.504
– volume: 49
  start-page: 29
  year: 2001
  ident: ref_10
  article-title: Quantitative neuropathological changes in presymptomatic huntington’s disease
  publication-title: Ann. Neurol.
  doi: 10.1002/1531-8249(200101)49:1<29::AID-ANA7>3.0.CO;2-B
– volume: 35
  start-page: 1302
  year: 2020
  ident: ref_16
  article-title: A critical review of white matter changes in huntington’s disease
  publication-title: Mov. Disord. Off. J. Mov. Disord. Soc.
  doi: 10.1002/mds.28109
– volume: 34
  start-page: 2971
  year: 2015
  ident: ref_33
  article-title: Oct4-induced oligodendrocyte progenitor cells enhance functional recovery in spinal cord injury model
  publication-title: EMBO J.
  doi: 10.15252/embj.201592652
– volume: 24
  start-page: 1105
  year: 2018
  ident: ref_73
  article-title: Ki67 is a graded rather than a binary marker of proliferation versus quiescence
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.06.110
– volume: 20
  start-page: 236
  year: 2018
  ident: ref_14
  article-title: Complex spatial and temporally defined myelin and axonal degeneration in huntington disease
  publication-title: Neurolimage Clin.
  doi: 10.1016/j.nicl.2018.01.029
– volume: 24
  start-page: 10763
  year: 2004
  ident: ref_45
  article-title: Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3883-04.2004
– volume: 70
  start-page: 674
  year: 2011
  ident: ref_69
  article-title: Lake-front property: A unique germinal niche by the lateral ventricles of the adult brain
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.05.004
– volume: 8
  start-page: e58
  year: 2018
  ident: ref_59
  article-title: Viral vectors for gene transfer
  publication-title: Curr. Protoc. Mouse Biol.
  doi: 10.1002/cpmo.58
– volume: 136
  start-page: 411
  year: 2009
  ident: ref_29
  article-title: Oct4-induced pluripotency in adult neural stem cells
  publication-title: Cell
  doi: 10.1016/j.cell.2009.01.023
– volume: 1780
  start-page: 97
  year: 2018
  ident: ref_38
  article-title: Mouse models of huntington’s disease
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-7825-0_6
– volume: 13
  start-page: 1174
  year: 2001
  ident: ref_79
  article-title: Water diffusion changes in wallerian degeneration and their dependence on white matter architecture
  publication-title: NeuroImage
  doi: 10.1006/nimg.2001.0765
– volume: 32
  start-page: 461
  year: 2019
  ident: ref_7
  article-title: Detection of axonal degeneration in a mouse model of huntington’s disease: Comparison between diffusion tensor imaging and anomalous diffusion metrics
  publication-title: Magma
  doi: 10.1007/s10334-019-00742-6
– volume: 85
  start-page: 1359
  year: 2003
  ident: ref_58
  article-title: Creatine therapy provides neuroprotection after onset of clinical symptoms in huntington’s disease transgenic mice
  publication-title: J. Neurochem.
  doi: 10.1046/j.1471-4159.2003.01706.x
– volume: 43
  start-page: 413
  year: 2003
  ident: ref_60
  article-title: Gene therapy with viral vectors
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev.pharmtox.43.100901.140257
– volume: 24
  start-page: 205
  year: 2013
  ident: ref_67
  article-title: Transduction of the central nervous system after intracerebroventricular injection of adeno-associated viral vectors in neonatal and juvenile mice
  publication-title: Hum. Gene Ther. Methods
  doi: 10.1089/hgtb.2013.076
– volume: 23
  start-page: 9418
  year: 2003
  ident: ref_57
  article-title: Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in huntington’s disease mice
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.23-28-09418.2003
– volume: 8
  start-page: 318
  year: 2017
  ident: ref_76
  article-title: Pdgfrα(+) cells in embryonic stem cell cultures represent the in vitro equivalent of the pre-implantation primitive endoderm precursors
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2016.12.010
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Snippet White matter atrophy has been shown to precede the massive loss of striatal GABAergic neurons in Huntington’s disease (HD). This study investigated the effects...
White matter atrophy has been shown to precede the massive loss of striatal GABAergic neurons in Huntington's disease (HD). This study investigated the effects...
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pubmedcentral
proquest
crossref
SourceType Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage 712
SubjectTerms Age
Atrophy
Cell activation
Cell fate
Corpus callosum
Dependoparvovirus
Disease
Electron microscopy
Glial cell line-derived neurotrophic factor
Glial stem cells
Huntington's disease
Huntingtons disease
Hypotheses
Laboratory animals
Magnetic resonance imaging
magnetism
Microenvironments
Myelination
Neostriatum
Neural stem cells
Neuronal-glial interactions
Neuroprotection
neuroprotective effect
Oct-4 protein
oligodendroglia
Progenitor cells
Substantia alba
Subventricular zone
transcription factors
Ventricle (lateral)
γ-Aminobutyric acid
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Title In Vivo Expression of Reprogramming Factor OCT4 Ameliorates Myelination Deficits and Induces Striatal Neuroprotection in Huntington’s Disease
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