DNA adducts in skin biopsies and 1-hydroxypyrene in urine of psoriasis patients and healthy volunteers following treatment with coal tar - Roelofzen, J.H.J.; van der Valk, P.G.M.; Godschalk, R.; Dettbarn, G.; Seidel, A.; Golsteijn, L.; Anzion, R.; Aben, K.K.H.; van Schooten, F.J.; Kiemeney, L.A.L.M.; Scheepers, P.T.J. (Toxicology letters, 2012)
Keywords: 1-Hydroxypyrene; absorption; Adolescent; Adult; Aged; bioavailability; Biological and medical sciences; Biomarkers; Biopsy; Carcinogenesis, carcinogens and anticarcinogens; Carcinogenic effect; carcinogenicity; Case-Control Studies; Chemical agents; coal; Coal tar; Coal Tar - adverse effects; Coal Tar - pharmacokinetics; Coal Tar - therapeutic use; Dermatology; DNA adducts; DNA Adducts - analysis; Drug toxicity and drugs side effects treatment; eczema; excretion; exposure duration; Humans; Male; males; Medical sciences; metabolism; Middle Aged; nucleotides; ointments; PAH-DNA adducts; patients; Pharmacology. Drug treatments; polycyclic aromatic hydrocarbons; psoriasis; Psoriasis - drug therapy; Psoriasis - metabolism; Psoriasis. Parapsoriasis. Lichen; Pyrenes - analysis; risk; Skin - chemistry; Toxicity: skin, dermoskeleton; Tumors; urine; volunteers; Young Adult; Biomarkers; PAH-DNA adducts; Coal tar; 1-Hydroxypyrene; Carcinogenic effect; Human; Urine; Biological fluid; Skin disease; Healthy subject; Psoriasis; Biological marker; Polycyclic aromatic compound; Carcinogen; Anatomic pathology; Treatment; Biopsy; DNA; Skin; Molecular adduct