Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element - Cho, Seung Woo; Xu, Jin; Sun, Ruping; Mumbach, Maxwell R.; Carter, Ava C.; Chen, Y. Grace; Yost, Kathryn E.; Kim, Jeewon; He, Jing; Nevins, Stephanie A.; Chin, Suet-Feung; Caldas, Carlos; et al. (Cell, 2018)
Keywords: Animals; breast neoplasms; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Carcinogenesis - genetics; cell growth; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chromatin; CRISPR-Cas Systems; CRISPRi; DNA; DNA, Neoplasm - genetics; enhancer; Enhancer Elements, Genetic; Female; gene editing; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; lncRNA; loci; Mice; Mice, Inbred NOD; Mutation; MYC; neoplasm cells; Neoplasm Transplantation; oncogenes; promoter; Promoter Regions, Genetic; PVT1; regulatory sequences; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; topological domains; transcription (genetics); Transcription, Genetic; transcriptional regulation; tumor suppressor; enhancer; lncRNA; CRISPRi; PVT1; MYC; transcriptional regulation; tumor suppressor; promoter; topological domains