Meteorology and ethnicity as critical factors in HRIPT: Comparing responses between Chinese and Indian ethnicities

• Published in: Regulatory toxicology and pharmacology Vol. 66; no. 1; pp. 59 - 65
• Main Authors: Yuan, Chao, Wang, Xue-Min, Galzote, Carlos, Tan, Yi-Mei, Bhagat, Kamlesh V., Yuan, Zhi-Kang, Du, Jian-Fei, Tan, Yuan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.06.2013
• Subjects: Adolescent; Adult; China; cities; Climate; cosmetics; Cosmetics - administration & dosage; Cosmetics - adverse effects; Ethnic Groups; Ethnicity; Female; HRIPT; Human repeated insult patch test; Humans; India; Irritants - administration & dosage; Irritants - toxicity; Male; Meteorology; Middle Aged; nationalities and ethnic groups; patch test; Patch Tests - methods; Skin - drug effects; Skin - pathology; Skin Irritancy Tests - methods; sodium dodecyl sulfate; Sodium Dodecyl Sulfate - administration & dosage; Sodium Dodecyl Sulfate - adverse effects; Young Adult; China; India; ISW, India, Maharashtra, Greater Mumbai Dist., Mumbai; INW, China, People's Rep., Shanghai; Ethnicity; Human repeated insult patch test; HRIPT; Meteorology
• ISSN: 0273-2300; 1096-0295; 1096-0295
• DOI: 10.1016/j.yrtph.2013.02.009

Two human repeated insult patch tests were carried out in Shanghai and Mumbai in 2011. Even using the same protocol in two cities, thete was still some difference between them. What was the key point in HRIPT? [Display omitted] ► Two HRIPTs in same protocol were carried out in Shanghai and Mumbai. ► There remains to be clear distinction between the results of the two cities. ► Greater attention should be paid to factors that influence the results of HRIPT. ► Those factors are the meteorological impact and the ethnicity of the subject. Human repeated insult patch test (HRIPT) is regarded as one of the confirmatory test in determining the safety of skin sensitizers. A number of important factors should be considered when conducting and interpreting the results of the HRIPT. To investigate for probable critical factors that influence the results of HRIPT with the same protocol in Shanghai and Mumbai. Two HRIPTs were carried out in Shanghai and Mumbai in 2011. Six identical products and 1% sodium lauryl sulfate were tested. Two Chinese dermatologists performed the grading in the two cities. Climate conditions of Shanghai and Mumbai were also recorded. For four lower reaction ratio products, cumulative irritation scores in the induction phase were higher in individuals whose ethnicity was Indian rather than Chinese. Reaction ratio of the same four products was highly correlated to the climatic parameters. The other two higher reaction ratio products and the positive control had no difference between the two ethnicities. Greater attention ought to be paid to the impact of climate on the results of HRIPT, especially for the mild irritation cosmetics when giving the interpretation. Greater emphasis also needs to be placed on the ethnicity of the subjects.