IL-10 Expression-Inducing Gut Bacteria Alleviate High-Fat Diet-Induced Obesity and Hyperlipidemia in Mice

• Published in: Journal of microbiology and biotechnology Vol. 30; no. 4; pp. 599 - 603
• Main Authors: Kim, Hye-In, Yun, Soo-Won, Han, Myung Joo, Jang, Se-Eun, Kim, Dong Hyun
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society for Microbiology and Biotechnology 28.04.2020; 한국미생물·생명공학회
• Subjects: Animals; Bifidobacterium adolescentis - physiology; Colitis - drug therapy; Colitis - etiology; Colitis - metabolism; Diet, High-Fat - adverse effects; Fatty Liver - drug therapy; Fatty Liver - etiology; Fatty Liver - metabolism; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - physiology; Hyperlipidemias - drug therapy; Hyperlipidemias - etiology; Hyperlipidemias - metabolism; Interleukin-10 - metabolism; Lactobacillus - physiology; Liver - drug effects; Liver - metabolism; Macrophages - drug effects; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; Obesity - drug therapy; Obesity - etiology; Obesity - metabolism; Probiotics - administration & dosage; Probiotics - pharmacology; Weight Gain - drug effects; Weissella - physiology; 생물학; liver steatosis; colitis; Gut bacteria; IL-10; obesity
• ISSN: 1017-7825; 1738-8872; 1738-8872
• DOI: 10.4014/jmb.1912.12014

In the present study, we examined the effects of interleukin (IL)-10 expression-inducing bacteria HP1, HP2, and HP3 on high-fat diet (HFD)-induced obesity and liver steatosis in mice. Oral gavage of HP1, HP2, and HP3 reduced HFD-induced bodyweight gain, triglycerides, and total cholesterol levels in the blood and liver. They also suppressed HFD-induced colitis and the fecal δ,γ-Proteobacteria population. Of the tested bacteria, HP2, which most potently inhibited IL-10 expression, also suppressed HFD-induced bodyweight gain, liver steatosis, and colitis most effectively. These findings suggest that IL-10 expression-inducing gut bacteria can suppress obesity and liver steatosis.