Actinidia arguta Sprout as a Natural Antioxidant: Ameliorating Effect on Lipopolysaccharide-Induced Cognitive Impairment

Here, we investigated the prebiotic and antioxidant effects of sprout water extract (AASWE) on lipopolysaccharide (LPS)-induced cognitive deficit mice. AASWE increased viable cell count, titratable acidity, and acetic acid production in strain and showed a cytoprotective effect on LPS-induced inflam...

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Published inJournal of microbiology and biotechnology Vol. 31; no. 1; pp. 51 - 62
Main Authors Kang, Jeong Eun, Park, Seon Kyeong, Kang, Jin Yong, Kim, Jong Min, Kwon, Bong Seok, Park, Sang Hyun, Lee, Chang Jun, Yoo, Seul Ki, Heo, Ho Jin
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Society for Microbiology and Biotechnology 28.01.2021
한국미생물·생명공학회
Subjects
Acetylcholinesterase - metabolism
Actinidia - chemistry
Animals
Anti-Inflammatory Agents - pharmacology
Antioxidants - pharmacology
Brain - metabolism
Cognitive Dysfunction - chemically induced
Cognitive Dysfunction - drug therapy
HT29 Cells
Humans
Inflammation - drug therapy
Interleukin-6
Limosilactobacillus reuteri
Lipopolysaccharides - adverse effects
Male
Mice
Neuroprotective Agents - pharmacology
NF-kappa B - metabolism
Phytochemicals - pharmacology
Plant Extracts - pharmacology
Research article
Superoxide Dismutase
생물학
anti-inflammation
Actinidia arguta sprout
lipopolysaccharide
antioxidants
neuroprotection
Online AccessGet full text
ISSN1017-7825
1738-8872
DOI10.4014/jmb.2009.09012

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Abstract Here, we investigated the prebiotic and antioxidant effects of sprout water extract (AASWE) on lipopolysaccharide (LPS)-induced cognitive deficit mice. AASWE increased viable cell count, titratable acidity, and acetic acid production in strain and showed a cytoprotective effect on LPS-induced inflammation in HT-29 cells. We assessed the behavior of LPSinduced cognitive deficit mice using Y-maze, passive avoidance and Morris water maze tests and found that administration of AASWE significantly improved learning and memory function. The AASWE group showed antioxidant activity through downregulation of malondialdehyde levels and upregulation of superoxide dismutase levels in brain tissue. In addition, the AASWE group exhibited activation of the cholinergic system with decreased acetylcholinesterase activity in brain tissue. Furthermore, AASWE effectively downregulated inflammatory mediators such as phosphorylated- JNK, phosphorylated-NF-κB, TNF-α and interleukin-6. The major bioactive compounds of AASWE were identified as quercetin-3- -arabinopyranosyl(1→2)-rhamnopyranosyl(1→6)-glucopyranose, quercetin-3- -apiosyl(1→2)-galactoside, rutin, and 3-caffeoylquinic acid. Based on these results, we suggest that AASWE not only increases the growth of beneficial bacteria in the intestines, but also shows an ameliorating effect on LPS-induced cognitive impairment.
AbstractList Here, we investigated the prebiotic and antioxidant effects of sprout water extract (AASWE) on lipopolysaccharide (LPS)-induced cognitive deficit mice. AASWE increased viable cell count, titratable acidity, and acetic acid production in strain and showed a cytoprotective effect on LPS-induced inflammation in HT-29 cells. We assessed the behavior of LPSinduced cognitive deficit mice using Y-maze, passive avoidance and Morris water maze tests and found that administration of AASWE significantly improved learning and memory function. The AASWE group showed antioxidant activity through downregulation of malondialdehyde levels and upregulation of superoxide dismutase levels in brain tissue. In addition, the AASWE group exhibited activation of the cholinergic system with decreased acetylcholinesterase activity in brain tissue. Furthermore, AASWE effectively downregulated inflammatory mediators such as phosphorylated- JNK, phosphorylated-NF-κB, TNF-α and interleukin-6. The major bioactive compounds of AASWE were identified as quercetin-3- -arabinopyranosyl(1→2)-rhamnopyranosyl(1→6)-glucopyranose, quercetin-3- -apiosyl(1→2)-galactoside, rutin, and 3-caffeoylquinic acid. Based on these results, we suggest that AASWE not only increases the growth of beneficial bacteria in the intestines, but also shows an ameliorating effect on LPS-induced cognitive impairment.
Here, we investigated the prebiotic and antioxidant effects of Actinidia arguta sprout water extract (AASWE) on lipopolysaccharide (LPS)-induced cognitive deficit mice. AASWE increased viable cell count, titratable acidity, and acetic acid production in Lactobacillus reuteri strain and showed a cytoprotective effect on LPS-induced inflammation in HT-29 cells. We assessed the behavior of LPSinduced cognitive deficit mice using Y-maze, passive avoidance and Morris water maze tests and found that administration of AASWE significantly improved learning and memory function. The AASWE group showed antioxidant activity through downregulation of malondialdehyde levels and upregulation of superoxide dismutase levels in brain tissue. In addition, the AASWE group exhibited activation of the cholinergic system with decreased acetylcholinesterase activity in brain tissue. Furthermore, AASWE effectively downregulated inflammatory mediators such as phosphorylated- JNK, phosphorylated-NF-κB, TNF-α and interleukin-6. The major bioactive compounds of AASWE were identified as quercetin-3-O-arabinopyranosyl(1→2)-rhamnopyranosyl(1→6)-glucopyranose, quercetin-3-O-apiosyl(1 →2)-galactoside, rutin, and 3-caffeoylquinic acid. Based on these results, we suggest that AASWE not only increases the growth of beneficial bacteria in the intestines, but also shows an ameliorating effect on LPS-induced cognitive impairment. KCI Citation Count: 0
Here, we investigated the prebiotic and antioxidant effects of Actinidia arguta sprout water extract (AASWE) on lipopolysaccharide (LPS)-induced cognitive deficit mice. AASWE increased viable cell count, titratable acidity, and acetic acid production in Lactobacillus reuteri strain and showed a cytoprotective effect on LPS-induced inflammation in HT-29 cells. We assessed the behavior of LPSinduced cognitive deficit mice using Y-maze, passive avoidance and Morris water maze tests and found that administration of AASWE significantly improved learning and memory function. The AASWE group showed antioxidant activity through downregulation of malondialdehyde levels and upregulation of superoxide dismutase levels in brain tissue. In addition, the AASWE group exhibited activation of the cholinergic system with decreased acetylcholinesterase activity in brain tissue. Furthermore, AASWE effectively downregulated inflammatory mediators such as phosphorylated- JNK, phosphorylated-NF-κB, TNF-α and interleukin-6. The major bioactive compounds of AASWE were identified as quercetin-3- O -arabinopyranosyl(1→2)-rhamnopyranosyl(1→6)-glucopyranose, quercetin-3- O -apiosyl(1→2)-galactoside, rutin, and 3-caffeoylquinic acid. Based on these results, we suggest that AASWE not only increases the growth of beneficial bacteria in the intestines, but also shows an ameliorating effect on LPS-induced cognitive impairment.
Author Lee, Chang Jun
Yoo, Seul Ki
Park, Seon Kyeong
Heo, Ho Jin
Kim, Jong Min
Kwon, Bong Seok
Park, Sang Hyun
Kang, Jin Yong
Kang, Jeong Eun
AuthorAffiliation 1 Division of Applied Life Science, Institute of Agriculture and Life Science (BK2), Gyeongsang National University, Jinju 52828, Republic of Korea
2 Korea Food Research Institute, Wanju-gun 55365, Republic of Korea
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Cites_doi 10.1002/eji.200425778
10.1111/ijfs.13697
10.1017/S0007114511005150
10.1111/nmo.12427
10.1016/j.foodchem.2016.11.058
10.1073/pnas.1102999108
10.1016/j.jff.2015.02.013
10.1136/gut.2006.117176
10.1111/j.1365-2982.2010.01664.x
10.1590/S0100-879X2001000300003
10.1016/j.immuni.2009.08.009
10.1002/rcm.1944
10.1016/j.foodchem.2010.04.030
10.1007/s00430-016-0481-y
10.3389/fnbeh.2017.00009
10.4161/gmic.22973
10.1007/s10068-014-0127-z
10.1016/0169-328X(95)00242-K
10.1016/j.cbi.2010.08.007
10.1254/jphs.CRJ04003X
10.1016/S0753-3322(02)00205-6
10.1002/mnfr.201400544
10.1016/j.micres.2012.04.003
10.2174/1381612053381684
10.1002/rcm.622
10.1016/j.jnutbio.2012.06.011
10.1155/2015/876484
10.1007/s12263-014-0398-2
10.1126/science.1223813
10.1016/j.mad.2013.11.011
10.1007/s005350300022
10.4162/nrp.2015.9.3.262
10.1007/s12602-012-9090-2
10.1016/j.bbi.2015.10.007
10.1016/j.jfda.2016.03.015
10.1080/1028415X.2015.1110952
10.1016/j.nutres.2014.08.019
10.1159/000072357
10.1016/j.carbpol.2010.04.079
10.1016/j.ijbiomac.2015.11.011
10.1016/j.neulet.2009.11.033
10.1016/j.neuropharm.2009.11.002
10.1021/jf402506c
10.1016/j.jneuroim.2008.08.015
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DocumentTitleAlternate Actinidia arguta Sprout as a Natural Antioxidant: Ameliorating Effect on Lipopolysaccharide-Induced Cognitive Impairment
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Keywords anti-inflammation
Actinidia arguta sprout
lipopolysaccharide
antioxidants
neuroprotection
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References ref13
ref35
ref12
ref34
ref15
ref37
ref14
ref36
ref31
ref30
ref11
ref33
ref10
ref32
ref2
ref1
ref17
ref39
ref16
ref38
ref19
ref18
ref24
ref23
ref45
ref26
ref25
ref20
ref42
ref41
ref22
ref44
ref21
ref43
ref28
ref27
ref29
ref8
ref7
ref9
ref4
ref3
ref6
ref5
ref40
References_xml – ident: ref45
  doi: 10.1002/eji.200425778
– ident: ref23
  doi: 10.1111/ijfs.13697
– ident: ref29
  doi: 10.1017/S0007114511005150
– ident: ref21
  doi: 10.1111/nmo.12427
– ident: ref18
  doi: 10.1016/j.foodchem.2016.11.058
– ident: ref20
  doi: 10.1073/pnas.1102999108
– ident: ref14
  doi: 10.1016/j.jff.2015.02.013
– ident: ref22
  doi: 10.1136/gut.2006.117176
– ident: ref8
  doi: 10.1111/j.1365-2982.2010.01664.x
– ident: ref33
  doi: 10.1590/S0100-879X2001000300003
– ident: ref1
  doi: 10.1016/j.immuni.2009.08.009
– ident: ref19
  doi: 10.1002/rcm.1944
– ident: ref16
  doi: 10.1016/j.foodchem.2010.04.030
– ident: ref36
  doi: 10.1007/s00430-016-0481-y
– ident: ref4
  doi: 10.3389/fnbeh.2017.00009
– ident: ref26
  doi: 10.4161/gmic.22973
– ident: ref31
  doi: 10.1007/s10068-014-0127-z
– ident: ref32
  doi: 10.1016/0169-328X(95)00242-K
– ident: ref40
  doi: 10.1016/j.cbi.2010.08.007
– ident: ref38
  doi: 10.1254/jphs.CRJ04003X
– ident: ref41
  doi: 10.1016/S0753-3322(02)00205-6
– ident: ref42
  doi: 10.1002/mnfr.201400544
– ident: ref44
  doi: 10.1016/j.micres.2012.04.003
– ident: ref34
  doi: 10.2174/1381612053381684
– ident: ref17
  doi: 10.1002/rcm.622
– ident: ref9
  doi: 10.1016/j.jnutbio.2012.06.011
– ident: ref11
  doi: 10.1155/2015/876484
– ident: ref24
  doi: 10.1007/s12263-014-0398-2
– ident: ref2
  doi: 10.1126/science.1223813
– ident: ref3
  doi: 10.1016/j.mad.2013.11.011
– ident: ref25
  doi: 10.1007/s005350300022
– ident: ref13
  doi: 10.4162/nrp.2015.9.3.262
– ident: ref7
  doi: 10.1007/s12602-012-9090-2
– ident: ref35
  doi: 10.1016/j.bbi.2015.10.007
– ident: ref15
  doi: 10.1016/j.jfda.2016.03.015
– ident: ref6
  doi: 10.1080/1028415X.2015.1110952
– ident: ref12
  doi: 10.1016/j.nutres.2014.08.019
– ident: ref27
  doi: 10.1159/000072357
– ident: ref37
  doi: 10.1016/j.carbpol.2010.04.079
– ident: ref5
  doi: 10.1016/j.ijbiomac.2015.11.011
– ident: ref10
– ident: ref28
  doi: 10.1016/j.neulet.2009.11.033
– ident: ref39
  doi: 10.1016/j.neuropharm.2009.11.002
– ident: ref43
  doi: 10.1021/jf402506c
– ident: ref30
  doi: 10.1016/j.jneuroim.2008.08.015
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Snippet Here, we investigated the prebiotic and antioxidant effects of sprout water extract (AASWE) on lipopolysaccharide (LPS)-induced cognitive deficit mice. AASWE...
Here, we investigated the prebiotic and antioxidant effects of Actinidia arguta sprout water extract (AASWE) on lipopolysaccharide (LPS)-induced cognitive...
Here, we investigated the prebiotic and antioxidant effects of Actinidia arguta sprout water extract (AASWE) on lipopolysaccharide (LPS)-induced cognitive...
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SubjectTerms Acetylcholinesterase - metabolism
Actinidia - chemistry
Animals
Anti-Inflammatory Agents - pharmacology
Antioxidants - pharmacology
Brain - metabolism
Cognitive Dysfunction - chemically induced
Cognitive Dysfunction - drug therapy
HT29 Cells
Humans
Inflammation - drug therapy
Interleukin-6
Limosilactobacillus reuteri
Lipopolysaccharides - adverse effects
Male
Mice
Neuroprotective Agents - pharmacology
NF-kappa B - metabolism
Phytochemicals - pharmacology
Plant Extracts - pharmacology
Research article
Superoxide Dismutase
생물학
Title Actinidia arguta Sprout as a Natural Antioxidant: Ameliorating Effect on Lipopolysaccharide-Induced Cognitive Impairment
URI https://www.ncbi.nlm.nih.gov/pubmed/33046678
https://pubmed.ncbi.nlm.nih.gov/PMC9705939
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