Heat-Killed and Live Enterococcus faecalis Attenuates Enlarged Prostate in an Animal Model of Benign Prostatic Hyperplasia

• Published in: Journal of microbiology and biotechnology Vol. 31; no. 8; pp. 1134 - 1143
• Main Authors: Choi, Young-Jin, Fan, Meiqi, Tang, Yujiao, Iwasa, Masahiro, Han, Kwon-Il, Lee, Hongchan, Hwang, Ji-Young, Lee, Bokyung, Kim, Eun-Kyung
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society for Microbiology and Biotechnology 28.08.2021; 한국미생물·생명공학회
• Subjects: Animals; Apoptosis - drug effects; Apoptosis - genetics; Dihydrotestosterone - metabolism; Disease Models, Animal; Enterococcus faecalis; Extracellular Signal-Regulated MAP Kinases - metabolism; Hot Temperature; Male; Phosphorylation; Probiotics - therapeutic use; Prostate - drug effects; Prostate - metabolism; Prostate - pathology; Prostatic Hyperplasia - chemically induced; Prostatic Hyperplasia - metabolism; Prostatic Hyperplasia - pathology; Prostatic Hyperplasia - therapy; Rats; Rats, Sprague-Dawley; Receptors, Androgen - metabolism; Research article; Signal Transduction - drug effects; Signal Transduction - genetics; Testosterone Propionate - pharmacology; 생물학; Enterococcus faecalis; Benign prostatic hyperplasia; heat-killed microorganism
• ISSN: 1017-7825; 1738-8872; 1738-8872
• DOI: 10.4014/jmb.2102.02032

In the present study, we investigated the inhibitory effect of heat-killed ( ) and live on benign prostatic hyperplasia (BPH). The BPH rat model was established by administering male rats with testosterone propionate (TP, 5 mg/kg, in corn oil) via subcutaneous injections daily for four weeks after castration. The rats were divided into five groups: Con, corn oil-injected (s.c.) + DW administration; BPH, TP (5 mg/kg, s.c.) + DW administration; BPH+K_EF, TP (5 mg/kg, s.c.) + heat-killed (7.5 × 10 CFU/g, 2.21 mg/kg) administration; BPH+L_EF, TP (5 mg/kg, s.c.) + live (1 × 10 CFU/g, 166 mg/kg) administration; BPH+Fi, TP (5 mg/kg, s.c.) + finasteride (1 mg/kg) administration. In both of BPH+K_EF and BPH+L_EF groups, the prostate weight decreased and histological changes due to TP treatment recovered to the level of the Con group. Both of these groups also showed regulation of androgen-signaling factors, growth factors, and apoptosis-related factors in prostate tissue. exhibited an inhibitory effect on benign prostatic hyperplasia, and even heat-killed showed similar efficacy on the live cells in the BPH rat model. As the first investigation into the effect of heat-killed and live on BPH, our study suggests that heat-killed might be a food additive candidate for use in various foods, regardless of heat processing.