Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression
Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association betwe...
Saved in:
| Published in | Psychiatry investigation Vol. 15; no. 6; pp. 593 - 601 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Neuropsychiatric Association
01.06.2018
대한신경정신의학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1738-3684 1976-3026 1976-3026 |
| DOI | 10.30773/pi.2017.12.17 |
Cover
| Abstract | Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD.
A total of 32 patients with MDD and 23 healthy controls (HCs) were examined. All participants were scored based on the Beck Depression Inventory and Beck Anxiety Inventory at baseline. All patients were also rated with the Hamilton Depression Rating Scale. We collected blood samples from all participants immediately after their enrollment and before the initiation of antidepressants in case of patients. Tract-based spatial statistics were used for all imaging analyses.
Lower fractional anisotropy (FA) and higher radial diffusivity (RD) values were found in the MDD group than in the HC group. Voxelwise correlation analysis revealed that the serum uric acid levels positively correlated with the FA and negatively with the RD in WM regions that previously showed significant group differences in the MDD group. The correlated areas were located in the left anterior corona radiata, left frontal lobe WM, and left anterior cingulate cortex WM.
The present study suggests a significant association between altered WM connectivity and serum uric acid levels in patients with MDD, possibly through demyelination. |
|---|---|
| AbstractList | Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD.
A total of 32 patients with MDD and 23 healthy controls (HCs) were examined. All participants were scored based on the Beck Depression Inventory and Beck Anxiety Inventory at baseline. All patients were also rated with the Hamilton Depression Rating Scale. We collected blood samples from all participants immediately after their enrollment and before the initiation of antidepressants in case of patients. Tract-based spatial statistics were used for all imaging analyses.
Lower fractional anisotropy (FA) and higher radial diffusivity (RD) values were found in the MDD group than in the HC group. Voxelwise correlation analysis revealed that the serum uric acid levels positively correlated with the FA and negatively with the RD in WM regions that previously showed significant group differences in the MDD group. The correlated areas were located in the left anterior corona radiata, left frontal lobe WM, and left anterior cingulate cortex WM.
The present study suggests a significant association between altered WM connectivity and serum uric acid levels in patients with MDD, possibly through demyelination. Objective Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD. Methods A total of 32 patients with MDD and 23 healthy controls (HCs) were examined. All participants were scored based on the Beck Depression Inventory and Beck Anxiety Inventory at baseline. All patients were also rated with the Hamilton Depression Rating Scale. We collected blood samples from all participants immediately after their enrollment and before the initiation of antidepressants in case of patients. Tract-based spatial statistics were used for all imaging analyses. Results Lower fractional anisotropy (FA) and higher radial diffusivity (RD) values were found in the MDD group than in the HC group. Voxelwise correlation analysis revealed that the serum uric acid levels positively correlated with the FA and negatively with the RD in WM regions that previously showed significant group differences in the MDD group. The correlated areas were located in the left anterior corona radiata, left frontal lobe WM, and left anterior cingulate cortex WM. Conclusion The present study suggests a significant association between altered WM connectivity and serum uric acid levels in patients with MDD, possibly through demyelination. KCI Citation Count: 0 Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD.OBJECTIVEUric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD.A total of 32 patients with MDD and 23 healthy controls (HCs) were examined. All participants were scored based on the Beck Depression Inventory and Beck Anxiety Inventory at baseline. All patients were also rated with the Hamilton Depression Rating Scale. We collected blood samples from all participants immediately after their enrollment and before the initiation of antidepressants in case of patients. Tract-based spatial statistics were used for all imaging analyses.METHODSA total of 32 patients with MDD and 23 healthy controls (HCs) were examined. All participants were scored based on the Beck Depression Inventory and Beck Anxiety Inventory at baseline. All patients were also rated with the Hamilton Depression Rating Scale. We collected blood samples from all participants immediately after their enrollment and before the initiation of antidepressants in case of patients. Tract-based spatial statistics were used for all imaging analyses.Lower fractional anisotropy (FA) and higher radial diffusivity (RD) values were found in the MDD group than in the HC group. Voxelwise correlation analysis revealed that the serum uric acid levels positively correlated with the FA and negatively with the RD in WM regions that previously showed significant group differences in the MDD group. The correlated areas were located in the left anterior corona radiata, left frontal lobe WM, and left anterior cingulate cortex WM.RESULTSLower fractional anisotropy (FA) and higher radial diffusivity (RD) values were found in the MDD group than in the HC group. Voxelwise correlation analysis revealed that the serum uric acid levels positively correlated with the FA and negatively with the RD in WM regions that previously showed significant group differences in the MDD group. The correlated areas were located in the left anterior corona radiata, left frontal lobe WM, and left anterior cingulate cortex WM.The present study suggests a significant association between altered WM connectivity and serum uric acid levels in patients with MDD, possibly through demyelination.CONCLUSIONThe present study suggests a significant association between altered WM connectivity and serum uric acid levels in patients with MDD, possibly through demyelination. |
| Author | Kim, Borah Kwon, Min-Soo Sohn, Hoyoung Lee, Sang-Hyuk Kim, Min-Kyoung Lee, Kang Soo Lee, Sun-Woo Oh, Jongsoo |
| Author_xml | – sequence: 1 givenname: Hoyoung surname: Sohn fullname: Sohn, Hoyoung – sequence: 2 givenname: Min-Soo surname: Kwon fullname: Kwon, Min-Soo – sequence: 3 givenname: Sun-Woo surname: Lee fullname: Lee, Sun-Woo – sequence: 4 givenname: Jongsoo surname: Oh fullname: Oh, Jongsoo – sequence: 5 givenname: Min-Kyoung surname: Kim fullname: Kim, Min-Kyoung – sequence: 6 givenname: Sang-Hyuk surname: Lee fullname: Lee, Sang-Hyuk – sequence: 7 givenname: Kang Soo surname: Lee fullname: Lee, Kang Soo – sequence: 8 givenname: Borah surname: Kim fullname: Kim, Borah |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29865782$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002361161$$DAccess content in National Research Foundation of Korea (NRF) |
| BookMark | eNqFUUtvEzEQtlARLaVXjshHOOzWr_XjghSF0lYqAqFWHC3H8RK3G3uxnVb593iT8pQQPnhsz_cYzzwHByEGB8BLjFqKhKCno28JwqLFpMXiCTjCSvCGIsIP6llQ2VAu2SE4yfkWTUsgzNUzcEiU5J2Q5Aj0Z33vbMkw9vAmeQtn1i9hDLCsHJwNxSVTfAy7_JeVLw5-MKW-wnkMoRL9vS9b6AP8VHEuVKEHX1YVdBsTfOfG5HKu_BfgaW-G7E4e4zG4eX92Pb9orj6eX85nV41lhJWGOU6NWhDl6r50Qihsp3u36DrRIdUTazvO6YJaYZaIc6sM76zshJCKWUmPwZu9bki9vrNeR-N38WvUd0nPPl9faqYIp0pU7Okeuwmj2T6YYdBj8muTthojvWuwHr2eGqwx0XhivN0zxs1i7Za2_jeZX6zJ689M8KvqfK85whIzXgVePwqk-G3jctFrn60bBhNc3OTq1SEmGWa0Ql_97vXT5MfoKqDdA2yKOSfX_7969hfB-rKbbq3VD_-ifQc2ob0A |
| CitedBy_id | crossref_primary_10_3390_antiox12040942 crossref_primary_10_1038_s41430_022_01165_8 crossref_primary_10_3390_brainsci10030160 crossref_primary_10_31083_j_jin2309170 crossref_primary_10_1093_schbul_sbae008 crossref_primary_10_9758_cpn_2021_19_3_449 |
| Cites_doi | 10.1038/npp.2010.166 10.1016/j.clinbiochem.2009.06.006 10.1002/mrm.20411 10.1176/jnp.6.4.379 10.1002/ana.20663 10.1176/ajp.2006.163.11.1905 10.1038/mp.2010.52 10.1136/jnnp.2004.055129 10.1038/tp.2017.84 10.1016/j.jad.2014.09.042 10.1016/j.brainres.2010.10.104 10.1016/j.jad.2012.05.022 10.1016/j.neuroimage.2009.02.010 10.1017/S1041610207004875 10.1097/00001756-200111160-00052 10.1007/s00406-017-0817-7 10.1016/S0893-133X(00)00159-7 10.1136/jnnp.23.1.56 10.1371/journal.pone.0112307 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8 10.1111/j.0924-2708.2004.00090.x 10.1016/j.neuroimage.2007.07.053 10.1097/PSY.0000000000000009 10.1016/j.jad.2017.09.003 10.1038/35072566 10.1016/j.biopsych.2006.03.052 10.1111/j.1747-4949.2012.00839.x 10.1080/14622200701767829 10.1097/01.WCB.0000053472.41007.F9 10.1016/S0165-0327(99)00121-4 10.1016/j.neuroimage.2007.02.049 10.1016/S0022-3999(02)00428-2 10.1006/cyto.1997.0238 10.1007/s40501-014-0022-5 10.1186/2045-5380-1-3 10.1016/j.neuroimage.2008.03.061 10.1007/s12291-010-0016-z 10.1002/hbm.1058 10.1097/WNR.0b013e3282f1939f 10.1016/j.jad.2015.03.007 10.4088/JCP.14r09179 10.1176/appi.ajp.159.11.1929 10.1016/0165-0327(82)90039-8 10.1038/srep09738 10.1038/nprot.2007.45 10.1001/archpsyc.1961.01710120031004 10.1016/j.neuroimage.2004.07.051 10.1016/j.brainres.2007.06.094 10.1016/j.clinbiochem.2011.10.010 10.1016/0278-5846(94)00101-M 10.1016/j.neubiorev.2014.05.007 10.1002/hbm.20345 10.1176/ajp.122.5.509 10.1016/j.jad.2009.04.023 10.1037/0022-006X.56.6.893 10.1017/S0033291714000440 10.1016/j.nurt.2007.05.011 10.1371/journal.pone.0037561 10.1192/bjp.113.504.1237 10.1176/appi.ajp.2012.11071105 10.1016/j.neuroimage.2004.06.018 10.1179/135100003225003393 10.1016/S0736-5748(98)00055-0 10.1210/edrv-17-2-187 10.1016/j.nbd.2012.05.008 10.1002/nbm.1940080707 10.1371/journal.pone.0138904 10.1016/j.psychres.2006.04.013 10.1001/archpsyc.1987.01800160032006 10.1111/pcn.12255 10.1016/S0197-4580(03)00031-9 10.4088/JCP.0208e04 10.1016/j.nicl.2017.01.013 10.1111/acps.12793 10.1073/pnas.78.11.6858 10.1159/000077941 |
| ContentType | Journal Article |
| Copyright | Copyright © 2018 Korean Neuropsychiatric Association 2018 |
| Copyright_xml | – notice: Copyright © 2018 Korean Neuropsychiatric Association 2018 |
| DBID | AAYXX CITATION NPM 7X8 5PM ADTOC UNPAY ACYCR |
| DOI | 10.30773/pi.2017.12.17 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall Korean Citation Index |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1976-3026 |
| EndPage | 601 |
| ExternalDocumentID | oai_kci_go_kr_ARTI_4926397 10.30773/pi.2017.12.17 PMC6018146 29865782 10_30773_pi_2017_12_17 |
| Genre | Journal Article |
| GroupedDBID | --- 5-W 8JR 8XY 9ZL AAKDD AAYXX ACHQT ACYCR ADBBV ADRAZ AENEX ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL CITATION DIK DU5 E3Z F5P HYE KQ8 M48 O5R O5S OK1 P5Y PGMZT RPM SJN W2D 53G FRP M~E NPM 7X8 5PM ADTOC UNPAY |
| ID | FETCH-LOGICAL-c424t-4e63a9b29ea9bde7791ca9b25b557509f2cc5663b3c7ad066c9a65c8577894c83 |
| IEDL.DBID | M48 |
| ISSN | 1738-3684 1976-3026 |
| IngestDate | Tue Nov 21 21:29:34 EST 2023 Wed Aug 20 00:07:28 EDT 2025 Thu Aug 21 14:11:27 EDT 2025 Wed Oct 01 14:02:02 EDT 2025 Thu Jan 02 22:54:57 EST 2025 Thu Apr 24 22:50:00 EDT 2025 Tue Jul 01 02:52:57 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Antioxidants Neuroimaging Oxidative stress Uric acid White matter Depressive disorder |
| Language | English |
| License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. cc-by-nc |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c424t-4e63a9b29ea9bde7791ca9b25b557509f2cc5663b3c7ad066c9a65c8577894c83 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://www.psychiatryinvestigation.org/upload/pdf/pi-2017-12-17.pdf |
| PMID | 29865782 |
| PQID | 2050484143 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | nrf_kci_oai_kci_go_kr_ARTI_4926397 unpaywall_primary_10_30773_pi_2017_12_17 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6018146 proquest_miscellaneous_2050484143 pubmed_primary_29865782 crossref_primary_10_30773_pi_2017_12_17 crossref_citationtrail_10_30773_pi_2017_12_17 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2018-06-01 |
| PublicationDateYYYYMMDD | 2018-06-01 |
| PublicationDate_xml | – month: 06 year: 2018 text: 2018-06-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Korea (South) |
| PublicationPlace_xml | – name: Korea (South) |
| PublicationTitle | Psychiatry investigation |
| PublicationTitleAlternate | Psychiatry Investig |
| PublicationYear | 2018 |
| Publisher | Korean Neuropsychiatric Association 대한신경정신의학회 |
| Publisher_xml | – name: Korean Neuropsychiatric Association – name: 대한신경정신의학회 |
| References | ref13 ref56 ref15 ref59 ref14 ref58 ref52 ref11 ref55 ref10 ref54 Cullen (ref69) 2010 ref17 ref16 ref19 ref18 ref51 ref50 ref46 ref89 ref48 ref47 Mori (ref53) 2005 ref42 ref86 ref85 ref44 ref88 ref87 ref49 ref8 ref7 Sheehan (ref39) 1998 ref9 ref4 ref3 ref6 Lee (ref43) 1991 ref5 ref82 ref81 ref40 ref84 ref83 ref80 ref35 ref79 Maes (ref27) 2008 ref34 Zou (ref71) 2008 ref78 ref31 Yook (ref45) 1997 ref75 ref30 ref74 ref33 ref77 ref32 ref76 ref2 ref1 ref70 ref73 ref72 (ref37) 2000 ref24 ref68 ref23 ref67 ref26 ref25 ref20 ref64 Yi (ref41) 2005 ref63 ref22 ref66 ref21 ref65 ref28 Talairach (ref57) 1988 ref29 Brigitta (ref12) 2002 Wise (ref36) 2014 Yoo (ref38) 2006 ref60 ref62 ref61 30032594 - Psychiatry Investig. 2018 Jul;15(7):743 |
| References_xml | – ident: ref35 doi: 10.1038/npp.2010.166 – ident: ref15 doi: 10.1016/j.clinbiochem.2009.06.006 – ident: ref78 doi: 10.1002/mrm.20411 – ident: ref86 doi: 10.1176/jnp.6.4.379 – ident: ref80 doi: 10.1002/ana.20663 – ident: ref4 doi: 10.1176/ajp.2006.163.11.1905 – ident: ref83 doi: 10.1038/mp.2010.52 – ident: ref65 doi: 10.1136/jnnp.2004.055129 – ident: ref88 doi: 10.1038/tp.2017.84 – ident: ref60 doi: 10.1016/j.jad.2014.09.042 – ident: ref70 doi: 10.1016/j.brainres.2010.10.104 – ident: ref31 doi: 10.1016/j.jad.2012.05.022 – start-page: 22 volume-title: The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 year: 1998 ident: ref39 – year: 2000 ident: ref37 – start-page: 185 volume-title: A clinical study on the Korean version of Beck anxiety inventory: comparative study of patient and non-patient year: 1997 ident: ref45 – ident: ref49 doi: 10.1016/j.neuroimage.2009.02.010 – ident: ref61 doi: 10.1017/S1041610207004875 – ident: ref19 doi: 10.1097/00001756-200111160-00052 – ident: ref25 doi: 10.1007/s00406-017-0817-7 – ident: ref5 doi: 10.1016/S0893-133X(00)00159-7 – ident: ref40 doi: 10.1136/jnnp.23.1.56 – ident: ref76 doi: 10.1371/journal.pone.0112307 – ident: ref56 doi: 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8 – ident: ref23 doi: 10.1111/j.0924-2708.2004.00090.x – ident: ref52 doi: 10.1016/j.neuroimage.2007.07.053 – ident: ref13 doi: 10.1097/PSY.0000000000000009 – ident: ref26 doi: 10.1016/j.jad.2017.09.003 – ident: ref11 doi: 10.1038/35072566 – ident: ref68 doi: 10.1016/j.biopsych.2006.03.052 – ident: ref81 doi: 10.1111/j.1747-4949.2012.00839.x – ident: ref89 doi: 10.1080/14622200701767829 – ident: ref30 doi: 10.1097/01.WCB.0000053472.41007.F9 – ident: ref16 doi: 10.1016/S0165-0327(99)00121-4 – ident: ref54 doi: 10.1016/j.neuroimage.2007.02.049 – ident: ref87 doi: 10.1016/S0022-3999(02)00428-2 – ident: ref10 doi: 10.1006/cyto.1997.0238 – start-page: 98 volume-title: A study of the reliability and the validity of the BDI, SDS, and MMPI-D scales year: 1991 ident: ref43 – ident: ref32 doi: 10.1007/s40501-014-0022-5 – ident: ref75 doi: 10.1186/2045-5380-1-3 – ident: ref51 doi: 10.1016/j.neuroimage.2008.03.061 – ident: ref20 doi: 10.1007/s12291-010-0016-z – start-page: 456 volume-title: Validity and Reliability of the Korean Version of the Hamilton Depression Rating Scale(K-HDRS) year: 2005 ident: ref41 – start-page: 173 volume-title: Altered white matter microstructure in adolescents with major depression: a preliminary study year: 2010 ident: ref69 – ident: ref50 doi: 10.1002/hbm.1058 – ident: ref63 doi: 10.1097/WNR.0b013e3282f1939f – ident: ref85 doi: 10.1016/j.jad.2015.03.007 – year: 2005 ident: ref53 – ident: ref24 doi: 10.4088/JCP.14r09179 – start-page: 50 volume-title: Validity of Korean version of the MINI-International Neuropsychiatric Interview year: 2006 ident: ref38 – ident: ref64 doi: 10.1176/appi.ajp.159.11.1929 – ident: ref7 doi: 10.1016/0165-0327(82)90039-8 – ident: ref58 doi: 10.1038/srep09738 – start-page: 7 volume-title: Pathophysiology of depression and mechanisms of treatment year: 2002 ident: ref12 – ident: ref47 doi: 10.1038/nprot.2007.45 – ident: ref42 doi: 10.1001/archpsyc.1961.01710120031004 – year: 1988 ident: ref57 – ident: ref46 doi: 10.1016/j.neuroimage.2004.07.051 – ident: ref62 doi: 10.1016/j.brainres.2007.06.094 – ident: ref22 doi: 10.1016/j.clinbiochem.2011.10.010 – ident: ref9 doi: 10.1016/0278-5846(94)00101-M – ident: ref14 doi: 10.1016/j.neubiorev.2014.05.007 – ident: ref55 doi: 10.1002/hbm.20345 – ident: ref3 doi: 10.1176/ajp.122.5.509 – start-page: 287 volume-title: The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression year: 2008 ident: ref27 – ident: ref59 doi: 10.1016/j.jad.2009.04.023 – ident: ref44 doi: 10.1037/0022-006X.56.6.893 – ident: ref73 doi: 10.1017/S0033291714000440 – ident: ref82 doi: 10.1016/j.nurt.2007.05.011 – ident: ref67 doi: 10.1371/journal.pone.0037561 – ident: ref2 doi: 10.1192/bjp.113.504.1237 – ident: ref34 doi: 10.1176/appi.ajp.2012.11071105 – ident: ref48 doi: 10.1016/j.neuroimage.2004.06.018 – start-page: 525 volume-title: Alterations of white matter integrity in adults with major depressive disorder: a magnetic resonance imaging study year: 2008 ident: ref71 – ident: ref17 doi: 10.1179/135100003225003393 – ident: ref29 doi: 10.1016/S0736-5748(98)00055-0 – ident: ref6 doi: 10.1210/edrv-17-2-187 – ident: ref33 doi: 10.1016/j.nbd.2012.05.008 – ident: ref77 doi: 10.1002/nbm.1940080707 – ident: ref21 doi: 10.1371/journal.pone.0138904 – ident: ref84 doi: 10.1016/j.psychres.2006.04.013 – ident: ref8 doi: 10.1001/archpsyc.1987.01800160032006 – start-page: 1509 volume-title: Diagnostic and therapeutic utility of neuroimaging in depression: an overview year: 2014 ident: ref36 – ident: ref74 doi: 10.1111/pcn.12255 – ident: ref79 doi: 10.1016/S0197-4580(03)00031-9 – ident: ref1 doi: 10.4088/JCP.0208e04 – ident: ref72 doi: 10.1016/j.nicl.2017.01.013 – ident: ref28 doi: 10.1111/acps.12793 – ident: ref18 doi: 10.1073/pnas.78.11.6858 – ident: ref66 doi: 10.1159/000077941 – reference: 30032594 - Psychiatry Investig. 2018 Jul;15(7):743 |
| SSID | ssj0000070169 |
| Score | 2.1373441 |
| Snippet | Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its... Objective Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known... |
| SourceID | nrf unpaywall pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 593 |
| SubjectTerms | Original 정신과학 |
| SummonAdditionalLinks | – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Zb9QwEB61Wwl44T7CJYOQ4CVbctiOH1eUqiBt1QdWKk-W48QlbJREuxsh-PXM5NilHAKJl0RORo4cj-0vmc_fALwIbWh4qlI_d4n1YyEMzoMm9WPnMoTjPEu7XWnzU3GyiN-f8_M9OBr3whCtcsfzLXZaE9gnFNdvm7I22WGTucOmwC7GOTYI_UBO8co-HAgKM03gYHF6NvvY7YXE8RyJpA8uS6J5haLXbkTnlhFWQvQuSb8Eu5xlu7Vpv1q538HOX9mTV9uqMV-_mLL8YWk6vgH52KiekbKctpt0ar_9pPf4v62-CdcH7MpmvbPdgr28ug1X5kN0_g64Xgp5zWrHFji_spktMlZXDEEmm5WdfjN5Od3vEvOxeafuyTq2je3zWLCiYme92Oua0V9iNPpcr9jRSNmt7sLi-O2HNyf-kMfBt3EYb_w4F5FRaahyPGa5lCqwVOYp5wRYXGgtosoojaw0GWIgq4zgNuFSJiq2SXQPJlVd5Q-AmUjlkUuyQLx2uJJGpL4XOcW5C1QcqNQDf-xBbQeRc8q1UWr82Ol6XDeFpheog1AH0oOXW_uml_f4o-VzdAi9tIUmRW46X9R6udL43fFOk-wiIjsPno3-onGYUuzFVHndrrEijnNljOjUg_u9_2wfGKpEUFYBD-Qlz9oa0AMv36mKT50UuCC9tVh48Grrg39px8N_N30E17CQ9MS4xzDZrNr8CUKwTfp0GGHfAW0rMQE priority: 102 providerName: Unpaywall |
| Title | Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/29865782 https://www.proquest.com/docview/2050484143 https://pubmed.ncbi.nlm.nih.gov/PMC6018146 https://www.psychiatryinvestigation.org/upload/pdf/pi-2017-12-17.pdf https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002361161 |
| UnpaywallVersion | publishedVersion |
| Volume | 15 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | PSYCHIATRY INVESTIGATION, 2018, 15(6), , pp.593-601 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1976-3026 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000070169 issn: 1976-3026 databaseCode: KQ8 dateStart: 20080101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1976-3026 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000070169 issn: 1976-3026 databaseCode: DIK dateStart: 20040101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVERR databaseName: KoreaMed Open Access customDbUrl: eissn: 1976-3026 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000070169 issn: 1976-3026 databaseCode: 5-W dateStart: 20080101 isFulltext: true titleUrlDefault: https://koreamed.org/journals providerName: Korean Association of Medical Journal Editors – providerCode: PRVAQN databaseName: PubMed Central (WRLC) customDbUrl: eissn: 1976-3026 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000070169 issn: 1976-3026 databaseCode: RPM dateStart: 20080101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 1976-3026 dateEnd: 20250930 omitProxy: true ssIdentifier: ssj0000070169 issn: 1976-3026 databaseCode: M48 dateStart: 20080301 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELb6kKAXxLvhsTIIAZdAE9txfEBoBVQFaaseiFROluPEEBo5aXZX0H_PTJJdsWIRXBJFduzEM_Z8tsffEPIstrERucrD0qU25EliYBw0ecidKwCOiyLvT6XNTpOTjH86F-c7ZOXKOzbgfOvUDuNJZV396ufl1Vvo8G9wxnkkJXvdVuijJXFdL5LP28sQg0rh5usYYWOX7IOhilHpZyP6H9CxRC6S_sgkdHuWpHygddxS6obZ2vWd24ZI_3SsvL70rbn6Yer6N6t1fJPcGOEmnQ76cYvslP42uTYbN9TvEDewF89p42gGQyKd2qqgjaeAC-m07imXUTExvY-lR2c9ISftHWTsEHqCVp6eDfysc4oLu5Dpe9PR9ysvW3-XZMcfPr87CcfQC6HlMV-EvEyYUXmsSrgWpZQqsvgsciEQY7jYWgCCLGdWmgJgi1UmETYVUqaK25TdI3u-8eUhoYapkrm0iJIjB8aPIWEec0oIFykeqTwg4apltR15yTE8Rq1hftJLQreVRknoKNaRDMiLdf52YOT4a86nICh9YSuNJNp4_9roi07DVOGjRqZEAGMBebKSo4aehdslxpfNcg4FCRjeOADKgNwf5LquMFZpgoEAAiI3JL7OgBVupvjqW8_enSBFGk8C8nKtG__4jwf_8YkPyQG8kA5ObI_I3qJblo8BLi3ySa_0k34da0L2s9Oz6ZdfXYIVAA |
| linkProvider | Scholars Portal |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Zb9QwEB61Wwl44T7CJYOQ4CVbctiOH1eUqiBt1QdWKk-W48QlbJREuxsh-PXM5NilHAKJl0RORo4cj-0vmc_fALwIbWh4qlI_d4n1YyEMzoMm9WPnMoTjPEu7XWnzU3GyiN-f8_M9OBr3whCtcsfzLXZaE9gnFNdvm7I22WGTucOmwC7GOTYI_UBO8co-HAgKM03gYHF6NvvY7YXE8RyJpA8uS6J5haLXbkTnlhFWQvQuSb8Eu5xlu7Vpv1q538HOX9mTV9uqMV-_mLL8YWk6vgH52KiekbKctpt0ar_9pPf4v62-CdcH7MpmvbPdgr28ug1X5kN0_g64Xgp5zWrHFji_spktMlZXDEEmm5WdfjN5Od3vEvOxeafuyTq2je3zWLCiYme92Oua0V9iNPpcr9jRSNmt7sLi-O2HNyf-kMfBt3EYb_w4F5FRaahyPGa5lCqwVOYp5wRYXGgtosoojaw0GWIgq4zgNuFSJiq2SXQPJlVd5Q-AmUjlkUuyQLx2uJJGpL4XOcW5C1QcqNQDf-xBbQeRc8q1UWr82Ol6XDeFpheog1AH0oOXW_uml_f4o-VzdAi9tIUmRW46X9R6udL43fFOk-wiIjsPno3-onGYUuzFVHndrrEijnNljOjUg_u9_2wfGKpEUFYBD-Qlz9oa0AMv36mKT50UuCC9tVh48Grrg39px8N_N30E17CQ9MS4xzDZrNr8CUKwTfp0GGHfAW0rMQE |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+Uric+Acid+on+the+Alterations+of+White+Matter+Connectivity+in+Patients+with+Major+Depression&rft.jtitle=Psychiatry+investigation&rft.au=Sohn%2C+Hoyoung&rft.au=Kwon%2C+Min-Soo&rft.au=Lee%2C+Sun-Woo&rft.au=Oh%2C+Jongsoo&rft.date=2018-06-01&rft.issn=1738-3684&rft.volume=15&rft.issue=6&rft.spage=593&rft_id=info:doi/10.30773%2Fpi.2017.12.17&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1738-3684&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1738-3684&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1738-3684&client=summon |