Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population

This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (n=88), exposed to MeHg from fish consumption, were enrolled in t...

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Published inBioMed research international Vol. 2014; no. 2014; pp. 1 - 8
Main Authors de Oliveira, Andréia Ávila Soares, Souza, Marilesia Ferreira de, Lengert, André van Helvoort, de Oliveira, Marcelo Tempesta, Camargo, Rossana Batista de Oliveira Godoy, Braga, Gilberto Úbida Leite, Cólus, Ilce Mara de Syllos, Barbosa Junior, Fernando, Barcelos, Gustavo Rafael Mazzaron
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2014
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Subjects
Animals
Biomarkers
Biomarkers - blood
Blood
Brazil
Enzymes
Feeding Behavior
Fishes
Gene Frequency - genetics
Genes
Genetic polymorphisms
Genotype
Glutathione - genetics
Glutathione transferase
Humans
Life Style
Meat
Mercury
Mercury - blood
Methylmercury
Methylmercury Compounds - blood
Multivariate Analysis
Plasma
Polymorphism, Genetic
Studies
Brazil
Online AccessGet full text
ISSN2314-6133
2314-6141
2314-6141
DOI10.1155/2014/940952

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Abstract This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (n=88), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were 10±4.2 and 37±21, whereas mean evels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were 4.3±2.9, 5.8±2.3 µg/L, and 0.33±0.15, respectively. GSTM1 and GCLC polymorphisms influence THgP and MeHgP (multivariate analyses, P<0.050). Null homozygotes for GSTM1 showed higher THgP and MeHgP levels compared to subjects with GSTM1 (THgP β=0.22, P=0.035; MeHgP β=0.30, P=0.050) and persons carrying at least one T allele for GCLC had significant higher MeHgP (β=0.59, P=0.046). Also, polymorphic GCLM subjects had lower THgP/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.
AbstractList This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (n = 88), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were 10 ± 4.2 and 37 ± 21, whereas mean levels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were 4.3 ± 2.9, 5.8 ± 2.3 µg/L, and 0.33 ± 0.15, respectively. GSTM1 and GCLC polymorphisms influence THgP and MeHgP (multivariate analyses, P < 0.050). Null homozygotes for GSTM1 showed higher THgP and MeHgP levels compared to subjects with GSTM1 (THgP β = 0.22, P = 0.035; MeHgP β = 0.30, P = 0.050) and persons carrying at least one T allele for GCLC had significant higher MeHgP (β = 0.59, P = 0.046). Also, polymorphic GCLM subjects had lower THgP/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (n = 88), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were 10 ± 4.2 and 37 ± 21, whereas mean levels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were 4.3 ± 2.9, 5.8 ± 2.3 µg/L, and 0.33 ± 0.15, respectively. GSTM1 and GCLC polymorphisms influence THgP and MeHgP (multivariate analyses, P < 0.050). Null homozygotes for GSTM1 showed higher THgP and MeHgP levels compared to subjects with GSTM1 (THgP β = 0.22, P = 0.035; MeHgP β = 0.30, P = 0.050) and persons carrying at least one T allele for GCLC had significant higher MeHgP (β = 0.59, P = 0.046). Also, polymorphic GCLM subjects had lower THgP/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.
This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (n = 88), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were 10 ± 4.2 and 37 ± 21, whereas mean evels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were 4.3 ± 2.9, 5.8 ± 2.3 µg/L, and 0.33 ± 0.15, respectively. GSTM1 and GCLC polymorphisms influence THgP and MeHgP (multivariate analyses, P < 0.050). Null homozygotes for GSTM1 showed higher THgP and MeHgP levels compared to subjects with GSTM1 (THgP β = 0.22, P = 0.035; MeHgP β = 0.30, P = 0.050) and persons carrying at least one T allele for GCLC had significant higher MeHgP (β = 0.59, P = 0.046). Also, polymorphic GCLM subjects had lower THgP/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.
This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (n=88), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were 10±4.2 and 37±21, whereas mean evels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were 4.3±2.9, 5.8±2.3 µg/L, and 0.33±0.15, respectively. GSTM1 and GCLC polymorphisms influence THgP and MeHgP (multivariate analyses, P<0.050). Null homozygotes for GSTM1 showed higher THgP and MeHgP levels compared to subjects with GSTM1 (THgP β=0.22, P=0.035; MeHgP β=0.30, P=0.050) and persons carrying at least one T allele for GCLC had significant higher MeHgP (β=0.59, P=0.046). Also, polymorphic GCLM subjects had lower THgP/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.
This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes ( GSTM1 , GSTT1 , GSTP1 , GCLM , and GCLC ) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects ( n = 88 ), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were 10 ± 4.2 and 37 ± 21 , whereas mean evels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were 4.3 ± 2.9 , 5.8 ± 2.3  µg/L, and 0.33 ± 0.15 , respectively. GSTM1 and GCLC polymorphisms influence THgP and MeHgP (multivariate analyses, P < 0.050 ). Null homozygotes for GSTM1 showed higher THgP and MeHgP levels compared to subjects with GSTM1 (THgP β = 0.22 , P = 0.035 ; MeHgP β = 0.30 , P = 0.050 ) and persons carrying at least one T allele for GCLC had significant higher MeHgP ( β = 0.59 , P = 0.046 ). Also, polymorphic GCLM subjects had lower THgP/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.
This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (n = 88), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were 10 ± 4.2 and 37 ± 21, whereas mean levels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were 4.3 ± 2.9, 5.8 ± 2.3 µg/L, and 0.33 ± 0.15, respectively. GSTM1 and GCLC polymorphisms influence THgP and MeHgP (multivariate analyses, P < 0.050). Null homozygotes for GSTM1 showed higher THgP and MeHgP levels compared to subjects with GSTM1 (THgP β = 0.22, P = 0.035; MeHgP β = 0.30, P = 0.050) and persons carrying at least one T allele for GCLC had significant higher MeHgP (β = 0.59, P = 0.046). Also, polymorphic GCLM subjects had lower THgP/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.
Audience Academic
Author Souza, Marilesia Ferreira de
de Oliveira, Andréia Ávila Soares
Camargo, Rossana Batista de Oliveira Godoy
Braga, Gilberto Úbida Leite
de Oliveira, Marcelo Tempesta
Barbosa Junior, Fernando
Cólus, Ilce Mara de Syllos
Lengert, André van Helvoort
Barcelos, Gustavo Rafael Mazzaron
AuthorAffiliation 2 Department of General Biology, Center for Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid km 380, 86051-990 Londrina, PR, Brazil
1 Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café s/n°, 14040-903 Ribeirão Preto, SP, Brazil
AuthorAffiliation_xml – name: 1 Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café s/n°, 14040-903 Ribeirão Preto, SP, Brazil
– name: 2 Department of General Biology, Center for Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid km 380, 86051-990 Londrina, PR, Brazil
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/24696865$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Contributor Souza, Marilesia Ferreira de
de Oliveira, Andréia Ávila Soares
Camargo, Rossana Batista de Oliveira Godoy
Braga, Gilberto Úbida Leite
de Oliveira, Marcelo Tempesta
Barbosa Junior, Fernando
Cólus, Ilce Mara de Syllos
Lengert, André van Helvoort
Barcelos, Gustavo Rafael Mazzaron
Contributor_xml – sequence: 1
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– sequence: 5
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– sequence: 7
  fullname: Cólus, Ilce Mara de Syllos
– sequence: 8
  fullname: Barbosa Junior, Fernando
– sequence: 9
  fullname: Barcelos, Gustavo Rafael Mazzaron
Copyright Copyright © 2014 Andréia Ávila Soares de Oliveira et al.
COPYRIGHT 2014 John Wiley & Sons, Inc.
Copyright © 2014 Andréia Ávila Soares de Oliveira et al. Andréia Ávila Soares de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2014 Andréia Ávila Soares de Oliveira et al. 2014
Copyright_xml – notice: Copyright © 2014 Andréia Ávila Soares de Oliveira et al.
– notice: COPYRIGHT 2014 John Wiley & Sons, Inc.
– notice: Copyright © 2014 Andréia Ávila Soares de Oliveira et al. Andréia Ávila Soares de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2014 Andréia Ávila Soares de Oliveira et al. 2014
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Issue 2014
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Academic Editor: Wilma De Grava Kempinas
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SSID ssj0000816096
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Snippet This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in...
This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes ( GSTM1 , GSTT1 , GSTP1 , GCLM , and GCLC ) in the distribution of...
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SourceType Open Access Repository
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StartPage 1
SubjectTerms Animals
Biomarkers
Biomarkers - blood
Blood
Brazil
Enzymes
Feeding Behavior
Fishes
Gene Frequency - genetics
Genes
Genetic polymorphisms
Genotype
Glutathione - genetics
Glutathione transferase
Humans
Life Style
Meat
Mercury
Mercury - blood
Methylmercury
Methylmercury Compounds - blood
Multivariate Analysis
Plasma
Polymorphism, Genetic
Studies
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Title Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population
URI https://search.emarefa.net/detail/BIM-509964
https://dx.doi.org/10.1155/2014/940952
https://www.ncbi.nlm.nih.gov/pubmed/24696865
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