Candida albicans and candidalysin in inflammatory disorders and cancer

Summary As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortal...

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Published inImmunology Vol. 162; no. 1; pp. 11 - 16
Main Authors Ho, Jemima, Camilli, Giorgio, Griffiths, James S., Richardson, Jonathan P., Kichik, Nessim, Naglik, Julian R.
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.01.2021
John Wiley and Sons Inc
Subjects
Animals
Candida albicans
Candida albicans - metabolism
candidalysin
Candidiasis - microbiology
Disorders
Fungal Proteins - metabolism
Fungi
gut barrier
Humans
IL‐17
Immunocompromised hosts
Inflammation - microbiology
Inflammatory diseases
mucosal disease
Mycology
Neoplasms - microbiology
Review
Toxins
Candida albicans
gut barrier
candidalysin
mucosal disease
IL-17
Online AccessGet full text
ISSN0019-2805
1365-2567
1365-2567
DOI10.1111/imm.13255

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Abstract Summary As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases. Candida albicans infections have been linked with a variety of inflammatory diseases. The ability for C. albicans to potentiate pathology in these instances is explored in this review.
AbstractList Summary As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases. Candida albicans infections have been linked with a variety of inflammatory diseases. The ability for C. albicans to potentiate pathology in these instances is explored in this review.
As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases.
As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases.
As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases.As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases.
As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases. Candida albicans infections have been linked with a variety of inflammatory diseases. The ability for C. albicans to potentiate pathology in these instances is explored in this review.
Author Richardson, Jonathan P.
Naglik, Julian R.
Kichik, Nessim
Ho, Jemima
Griffiths, James S.
Camilli, Giorgio
AuthorAffiliation 1 Centre for Host‐Microbiome Interactions Faculty of Dentistry, Oral & Craniofacial Sciences King's College London London UK
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  fullname: Griffiths, James S.
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Issue 1
Keywords Candida albicans
gut barrier
candidalysin
mucosal disease
IL-17
Language English
License Attribution
2020 The Authors. Immunology published by John Wiley & Sons Ltd.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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  text: January 2021
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PublicationTitle Immunology
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John Wiley and Sons Inc
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Snippet Summary As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a...
As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common...
As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common...
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StartPage 11
SubjectTerms Animals
Candida albicans
Candida albicans - metabolism
candidalysin
Candidiasis - microbiology
Disorders
Fungal Proteins - metabolism
Fungi
gut barrier
Humans
IL‐17
Immunocompromised hosts
Inflammation - microbiology
Inflammatory diseases
mucosal disease
Mycology
Neoplasms - microbiology
Review
Toxins
Title Candida albicans and candidalysin in inflammatory disorders and cancer
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fimm.13255
https://www.ncbi.nlm.nih.gov/pubmed/32880925
https://www.proquest.com/docview/2469005125
https://www.proquest.com/docview/2439974677
https://pubmed.ncbi.nlm.nih.gov/PMC7730014
Volume 162
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