BDNF levels are associated with autistic traits in the general population
•Autistic-like traits should be considered as a dimension in the general population.•BDNF correlates positively with autistic-like traits in controls.•BDNF may represent a marker of the continuum of autistic traits. Evidence supports the notion that autistic symptoms and behaviors should be regarded...
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| Published in | Psychoneuroendocrinology Vol. 89; pp. 131 - 133 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.03.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0306-4530 1873-3360 1873-3360 |
| DOI | 10.1016/j.psyneuen.2018.01.008 |
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| Abstract | •Autistic-like traits should be considered as a dimension in the general population.•BDNF correlates positively with autistic-like traits in controls.•BDNF may represent a marker of the continuum of autistic traits.
Evidence supports the notion that autistic symptoms and behaviors should be regarded as dimensional traits. The present study aimed to investigate the role of vasopressin (AVP), brain-derived neurotrophic factor (BDNF) and oxytocin (OXT) as potential biochemical correlates of subclinical autistic traits in a cohort of healthy young adults. One hundred and fifty-three subjects (80 males, 73 females) were recruited. Participants completed the Autism Spectrum Quotient (AQ), a widely used measure for the identification of autistic traits in the general population. Additionally, blood samples were obtained from all participants at the same time of the day to control for circadian variation. We conducted a multiple regression analysis using the AQ score as the dependent variable and age, sex, AVP, BDNF and OXT levels as the independent variables. The model explained approximately the 22% of the variance of the AQ score. Among the parameters included in the analysis, only BDNF levels were independent predictors of AQ score. |
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| AbstractList | Evidence supports the notion that autistic symptoms and behaviors should be regarded as dimensional traits. The present study aimed to investigate the role of vasopressin (AVP), brain-derived neurotrophic factor (BDNF) and oxytocin (OXT) as potential biochemical correlates of subclinical autistic traits in a cohort of healthy young adults. One hundred and fifty-three subjects (80 males, 73 females) were recruited. Participants completed the Autism Spectrum Quotient (AQ), a widely used measure for the identification of autistic traits in the general population. Additionally, blood samples were obtained from all participants at the same time of the day to control for circadian variation. We conducted a multiple regression analysis using the AQ score as the dependent variable and age, sex, AVP, BDNF and OXT levels as the independent variables. The model explained approximately the 22% of the variance of the AQ score. Among the parameters included in the analysis, only BDNF levels were independent predictors of AQ score.Evidence supports the notion that autistic symptoms and behaviors should be regarded as dimensional traits. The present study aimed to investigate the role of vasopressin (AVP), brain-derived neurotrophic factor (BDNF) and oxytocin (OXT) as potential biochemical correlates of subclinical autistic traits in a cohort of healthy young adults. One hundred and fifty-three subjects (80 males, 73 females) were recruited. Participants completed the Autism Spectrum Quotient (AQ), a widely used measure for the identification of autistic traits in the general population. Additionally, blood samples were obtained from all participants at the same time of the day to control for circadian variation. We conducted a multiple regression analysis using the AQ score as the dependent variable and age, sex, AVP, BDNF and OXT levels as the independent variables. The model explained approximately the 22% of the variance of the AQ score. Among the parameters included in the analysis, only BDNF levels were independent predictors of AQ score. •Autistic-like traits should be considered as a dimension in the general population.•BDNF correlates positively with autistic-like traits in controls.•BDNF may represent a marker of the continuum of autistic traits. Evidence supports the notion that autistic symptoms and behaviors should be regarded as dimensional traits. The present study aimed to investigate the role of vasopressin (AVP), brain-derived neurotrophic factor (BDNF) and oxytocin (OXT) as potential biochemical correlates of subclinical autistic traits in a cohort of healthy young adults. One hundred and fifty-three subjects (80 males, 73 females) were recruited. Participants completed the Autism Spectrum Quotient (AQ), a widely used measure for the identification of autistic traits in the general population. Additionally, blood samples were obtained from all participants at the same time of the day to control for circadian variation. We conducted a multiple regression analysis using the AQ score as the dependent variable and age, sex, AVP, BDNF and OXT levels as the independent variables. The model explained approximately the 22% of the variance of the AQ score. Among the parameters included in the analysis, only BDNF levels were independent predictors of AQ score. Evidence supports the notion that autistic symptoms and behaviors should be regarded as dimensional traits. The present study aimed to investigate the role of vasopressin (AVP), brain-derived neurotrophic factor (BDNF) and oxytocin (OXT) as potential biochemical correlates of subclinical autistic traits in a cohort of healthy young adults. One hundred and fifty-three subjects (80 males, 73 females) were recruited. Participants completed the Autism Spectrum Quotient (AQ), a widely used measure for the identification of autistic traits in the general population. Additionally, blood samples were obtained from all participants at the same time of the day to control for circadian variation. We conducted a multiple regression analysis using the AQ score as the dependent variable and age, sex, AVP, BDNF and OXT levels as the independent variables. The model explained approximately the 22% of the variance of the AQ score. Among the parameters included in the analysis, only BDNF levels were independent predictors of AQ score. |
| Author | Bloise, Nora Fusar-Poli, Laura Brondino, Natascia Visai, Livia Politi, Pierluigi Rocchetti, Matteo Bertoglio, Federico |
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| Cites_doi | 10.1002/aur.1781 10.1016/j.arcmed.2006.08.003 10.1016/j.psychres.2016.04.117 10.1038/mp.2014.132 10.1176/appi.ajp.2009.08121894 10.1007/s10803-008-0658-3 10.1016/j.neuron.2010.03.005 10.1001/archpedi.161.4.372 10.1007/s12264-016-0046-5 10.1023/A:1005653411471 10.1097/NEN.0b013e31824b27e4 10.1186/2040-2392-6-2 10.1016/j.neulet.2012.01.029 10.1007/s10803-016-3024-x 10.1007/s10571-016-0415-7 10.1017/S1461145710000738 10.1016/j.yhbeh.2004.10.002 10.1016/j.peptides.2014.08.003 |
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| Snippet | •Autistic-like traits should be considered as a dimension in the general population.•BDNF correlates positively with autistic-like traits in controls.•BDNF may... Evidence supports the notion that autistic symptoms and behaviors should be regarded as dimensional traits. The present study aimed to investigate the role of... |
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| SubjectTerms | Adult Autism spectrum disorder Autism Spectrum Disorder - metabolism Autism Spectrum Disorder - physiopathology Autistic Disorder - metabolism Autistic Disorder - physiopathology Autistic traits BDNF Biomarkers - blood Brain-Derived Neurotrophic Factor - analysis Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - physiology Continuum Female Humans Male Oxytocin Oxytocin - blood Oxytocin - physiology Regression Analysis Vasopressin Vasopressins - blood Vasopressins - physiology Young Adult |
| Title | BDNF levels are associated with autistic traits in the general population |
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