The endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses - Tolve, Marianna; Tutas, Janine; Özer-Yildiz, Ebru; Klein, Ines; Petzold, Anne; Fritz, Veronika J.; Overhoff, Melina; Silverman, Quinn; Koletsou, Ellie; Liebsch, Filip; Schwarz, Guenter; Korotkova, Tatiana; et al. (Cell reports (Cambridge), 2025)
Keywords: Adaptor Protein Complex 2 - genetics; Adaptor Protein Complex 2 - metabolism; Animals; AP-2; ataxia; Cerebellum - metabolism; climbing fibers; CP: Neuroscience; Endocytosis; GLURδ2; Glutamic Acid - metabolism; GRID2IP; Mice; Mice, Inbred C57BL; neurodegeneration; parallel fibers; Purkinje cell; Purkinje Cells - metabolism; Receptors, Glutamate - metabolism; Synapses - metabolism; parallel fibers; ataxia; CP: Neuroscience; neurodegeneration; AP-2; Purkinje cell; climbing fibers; GRID2IP; GLURδ2